JP2023526057A5 - - Google Patents

Info

Publication number
JP2023526057A5
JP2023526057A5 JP2022568828A JP2022568828A JP2023526057A5 JP 2023526057 A5 JP2023526057 A5 JP 2023526057A5 JP 2022568828 A JP2022568828 A JP 2022568828A JP 2022568828 A JP2022568828 A JP 2022568828A JP 2023526057 A5 JP2023526057 A5 JP 2023526057A5
Authority
JP
Japan
Prior art keywords
crrna
tracrrna
group
modification
guide rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022568828A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023526057A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/032038 external-priority patent/WO2021231606A2/en
Publication of JP2023526057A publication Critical patent/JP2023526057A/ja
Publication of JP2023526057A5 publication Critical patent/JP2023526057A5/ja
Pending legal-status Critical Current

Links

JP2022568828A 2020-05-12 2021-05-12 Crisprゲノム編集のための修飾されたガイドrna Pending JP2023526057A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063023313P 2020-05-12 2020-05-12
US63/023,313 2020-05-12
PCT/US2021/032038 WO2021231606A2 (en) 2020-05-12 2021-05-12 Modified guide rnas for crispr genome editing

Publications (2)

Publication Number Publication Date
JP2023526057A JP2023526057A (ja) 2023-06-20
JP2023526057A5 true JP2023526057A5 (https=) 2024-05-22

Family

ID=78524997

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022568828A Pending JP2023526057A (ja) 2020-05-12 2021-05-12 Crisprゲノム編集のための修飾されたガイドrna

Country Status (7)

Country Link
US (1) US20210388348A1 (https=)
EP (1) EP4150091A4 (https=)
JP (1) JP2023526057A (https=)
CN (1) CN115956120A (https=)
AU (1) AU2021271004A1 (https=)
CA (1) CA3177463A1 (https=)
WO (1) WO2021231606A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240034661A (ko) * 2022-09-06 2024-03-14 주식회사 툴젠 캄필로박터 제주니 유래 Cas9의 가이드 RNA 구조변화를 통한 유전자교정 향상 시스템
AU2024270764A1 (en) 2023-05-15 2025-12-04 Nchroma Bio, Inc. Compositions and methods for epigenetic regulation of hbv gene expression

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2745769T3 (es) * 2014-03-10 2020-03-03 Editas Medicine Inc Procedimientos y composiciones relacionados con CRISPR/CAS para tratar la amaurosis congénita de Leber 10 (LCA10)
CA2970683A1 (en) * 2014-12-18 2016-06-23 Integrated Dna Technologies, Inc. Crispr-based compositions and methods of use
US9650617B2 (en) * 2015-01-28 2017-05-16 Pioneer Hi-Bred International. Inc. CRISPR hybrid DNA/RNA polynucleotides and methods of use
JP2018515142A (ja) * 2015-05-15 2018-06-14 ダーマコン,インコーポレイテッド. Cas9介在遺伝子編集用の合成シングルガイドrna
WO2017004261A1 (en) * 2015-06-29 2017-01-05 Ionis Pharmaceuticals, Inc. Modified crispr rna and modified single crispr rna and uses thereof
EP3356533A1 (en) * 2015-09-28 2018-08-08 North Carolina State University Methods and compositions for sequence specific antimicrobials
CA2947904A1 (en) * 2015-11-12 2017-05-12 Pfizer Inc. Tissue-specific genome engineering using crispr-cas9
CA3034931A1 (en) * 2016-09-23 2018-03-29 Board Of Trustees Of Southern Illinois University Tuning crispr/cas9 activity with chemically modified nucleotide substitutions
SG10202106058WA (en) * 2016-12-08 2021-07-29 Intellia Therapeutics Inc Modified guide rnas
US20190032131A1 (en) * 2016-12-12 2019-01-31 Integrated Dna Technologies, Inc. Genome editing detection
US20210130817A1 (en) * 2017-07-14 2021-05-06 Cure Genetics Co., Ltd. Gene Editing System and Gene Editing Method
US20210363518A1 (en) * 2018-03-19 2021-11-25 University Of Massachusetts Modified guide rnas for crispr genome editing
KR20210045360A (ko) * 2018-05-16 2021-04-26 신테고 코포레이션 가이드 rna 설계 및 사용을 위한 방법 및 시스템
AU2019282824C1 (en) * 2018-06-08 2026-04-23 Intellia Therapeutics, Inc. Modified guide RNAS for gene editing

Similar Documents

Publication Publication Date Title
JP7209682B2 (ja) 多標的単一体コンジュゲート
Rayburn et al. Antisense, RNAi, and gene silencing strategies for therapy: mission possible or impossible?
JP7478210B2 (ja) 修飾オリゴヌクレオチド及び使用方法
US7723512B2 (en) Oligonucleotides comprising a non-phosphate backbone linkage
EP3523437A1 (en) Oligonucleotide compositions and methods thereof
CN105705638B (zh) 改善的具有高效能的纳米颗粒型寡核苷酸结构及其制备方法
JP2021533804A5 (https=)
JP2020533009A (ja) GalNAc誘導体
JP2021529173A5 (https=)
CA3092148A1 (en) Modified guide rnas for crispr genome editing
JP2023537798A5 (https=)
JP2022551269A (ja) 最小フッ素含有量を用いた低分子干渉rnaの化学修飾
JP2023526057A5 (https=)
CN104011209A (zh) 病毒基因表达的抑制
JP2020050670A (ja) オリゴヌクレオチド組成物及びその作製方法
CN110997918A (zh) 单链寡核苷酸
TW201706284A (zh) 使用多價陽離子鹽組合物之聚核苷酸製備方法
Brzezinska et al. Synthesis of 2′-O-guanidinopropyl-modified nucleoside phosphoramidites and their incorporation into siRNAs targeting hepatitis B virus
JP7128517B2 (ja) 副作用を減じたアンチセンス核酸
CN121816417A (zh) 双链寡核苷酸药剂和其用途
JP2025513757A5 (https=)
US20250250570A1 (en) Translation enhancing nucleic acid compounds: aso coupled translation – upregulation 1 (act-up1) and uses thereof
WO2025223315A1 (zh) 一种用于肝脏特异性递送的多靶标双链rna偶联物及药物组合物
WO2025165891A1 (en) Translation enhancing nucleic acid compounds: aso coupled translation - upregulation 1 (act-up1) and uses thereof
WO2024006672A2 (en) Modified guide rnas for crispr genome editing