JPWO2021170658A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021170658A5 JPWO2021170658A5 JP2022551040A JP2022551040A JPWO2021170658A5 JP WO2021170658 A5 JPWO2021170658 A5 JP WO2021170658A5 JP 2022551040 A JP2022551040 A JP 2022551040A JP 2022551040 A JP2022551040 A JP 2022551040A JP WO2021170658 A5 JPWO2021170658 A5 JP WO2021170658A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- heteroaryl
- cancer
- alkyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000003118 aryl group Chemical group 0.000 claims 15
- 125000001072 heteroaryl group Chemical group 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 5
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 5
- 125000001475 halogen functional group Chemical group 0.000 claims 5
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 208000009527 Refractory anemia Diseases 0.000 claims 4
- 206010072684 Refractory cytopenia with unilineage dysplasia Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 208000010643 digestive system disease Diseases 0.000 claims 3
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- -1 -CH 2 -heterocyclyl Chemical group 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 206010019708 Hepatic steatosis Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 239000003098 androgen Substances 0.000 claims 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 1
- 206010073128 Anaplastic oligodendroglioma Diseases 0.000 claims 1
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 208000032800 BCR-ABL1 positive blast phase chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 208000004860 Blast Crisis Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 206010055113 Breast cancer metastatic Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000014997 Crohn colitis Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 1
- 206010066476 Haematological malignancy Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 101000633516 Homo sapiens Nuclear receptor subfamily 2 group F member 6 Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 206010050513 Metastatic renal cell carcinoma Diseases 0.000 claims 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 1
- 206010052399 Neuroendocrine tumour Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 102100029528 Nuclear receptor subfamily 2 group F member 6 Human genes 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 208000026149 Primary peritoneal carcinoma Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 1
- 208000030002 adult glioblastoma Diseases 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 201000005795 chronic inflammatory demyelinating polyneuritis Diseases 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000003444 follicular lymphoma Diseases 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005249 lung adenocarcinoma Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 230000002071 myeloproliferative effect Effects 0.000 claims 1
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims 1
- 208000016065 neuroendocrine neoplasm Diseases 0.000 claims 1
- 201000011519 neuroendocrine tumor Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 201000000498 stomach carcinoma Diseases 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062981418P | 2020-02-25 | 2020-02-25 | |
| US62/981,418 | 2020-02-25 | ||
| US202163139262P | 2021-01-19 | 2021-01-19 | |
| US63/139,262 | 2021-01-19 | ||
| PCT/EP2021/054559 WO2021170658A1 (en) | 2020-02-25 | 2021-02-24 | Heterocyclic compounds for modulating nr2f6 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023515565A JP2023515565A (ja) | 2023-04-13 |
| JPWO2021170658A5 true JPWO2021170658A5 (ko) | 2024-02-29 |
Family
ID=74797908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022551040A Pending JP2023515565A (ja) | 2020-02-25 | 2021-02-24 | Ｎｒ２ｆ６を調節する複素環式化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20220213061A9 (ko) |
| EP (1) | EP4110758A1 (ko) |
| JP (1) | JP2023515565A (ko) |
| KR (1) | KR20220158228A (ko) |
| CN (1) | CN115427394A (ko) |
| AU (1) | AU2021226974A1 (ko) |
| BR (1) | BR112022016941A2 (ko) |
| CA (1) | CA3167785A1 (ko) |
| IL (1) | IL295456A (ko) |
| MX (1) | MX2022010456A (ko) |
| TW (1) | TW202140447A (ko) |
| WO (1) | WO2021170658A1 (ko) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023042914A1 (en) * | 2021-09-17 | 2023-03-23 | Otsuka Pharmaceutical Co., Ltd. | Pyrrolidine compounds as histone deacetylase inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7138423B2 (en) * | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
| CN101316816B (zh) * | 2005-12-01 | 2011-07-27 | 弗·哈夫曼-拉罗切有限公司 | 5-羟色胺转运体(sert)抑制剂 |
| US8450344B2 (en) * | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| WO2010059922A1 (en) * | 2008-11-21 | 2010-05-27 | Ligand Pharmaceuticals Incorporated | Pyrrolidine carboxamide compounds |
| US9617214B2 (en) * | 2013-11-08 | 2017-04-11 | The Translational Genomics Research Institute | Compounds for cognitive enhancement and methods of use thereof |
| US11324719B2 (en) * | 2016-07-18 | 2022-05-10 | Kcl Therapeutics, Inc. | Small molecule agonists and antagonists of NR2F6 activity in humans |
| US10472351B2 (en) * | 2016-07-18 | 2019-11-12 | Zander Therapeutics, Inc. | Small molecule agonists and antagonists of NR2F6 activity in animals |
| KR20190129867A (ko) * | 2017-02-17 | 2019-11-20 | 트레베나, 인코포레이티드. | 5-원 아자-헤테로고리 함유 델타-오피오이드 수용체 조절 화합물, 및 그의 사용 및 제조 방법 |
| CN110776521A (zh) * | 2019-10-24 | 2020-02-11 | 秦源生物医药科技(上海)有限公司 | 一种1,2,4-三唑-1,3,4-噻二唑类化合物及其应用 |
-
2021
- 2021-02-24 EP EP21708591.9A patent/EP4110758A1/en active Pending
- 2021-02-24 TW TW110106395A patent/TW202140447A/zh unknown
- 2021-02-24 WO PCT/EP2021/054559 patent/WO2021170658A1/en unknown
- 2021-02-24 BR BR112022016941A patent/BR112022016941A2/pt unknown
- 2021-02-24 CA CA3167785A patent/CA3167785A1/en active Pending
- 2021-02-24 MX MX2022010456A patent/MX2022010456A/es unknown
- 2021-02-24 US US17/184,431 patent/US20220213061A9/en active Pending
- 2021-02-24 CN CN202180029911.5A patent/CN115427394A/zh active Pending
- 2021-02-24 IL IL295456A patent/IL295456A/en unknown
- 2021-02-24 AU AU2021226974A patent/AU2021226974A1/en active Pending
- 2021-02-24 KR KR1020227031938A patent/KR20220158228A/ko unknown
- 2021-02-24 JP JP2022551040A patent/JP2023515565A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2868175T3 (es) | Compuestos de tetrahidroquinolinona sustituida como moduladores de ror gamma | |
| US6252116B1 (en) | Intermediates useful in a process for synthesizing COX-2 inhibitors | |
| JP2019163290A5 (ko) | ||
| JP2020529405A5 (ko) | ||
| JP2021529814A (ja) | 化学化合物 | |
| WO2006019962B1 (en) | Compositions and methods for treatment of colitis | |
| WO2011078221A1 (ja) | イミダゾピリダジン化合物 | |
| AU2019414550A1 (en) | Fak inhibitor and drug combination thereof | |
| JPWO2019191470A5 (ko) | ||
| JP4966186B2 (ja) | 新規ピリミジンヌクレオシド化合物又はその塩 | |
| JP2020504716A5 (ko) | ||
| AU2020205842A1 (en) | Dihydroorotate dehydrogenase inhibitors | |
| WO2019137201A1 (zh) | 杂芳基并四氢吡啶类化合物、其制备方法、药物组合物及应用 | |
| IL278368B1 (en) | Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods for its use | |
| WO2023061463A1 (zh) | 新的嘧啶并吡啶化合物、其药物组合物及其用途 | |
| CN113939296A (zh) | 杂环化合物及其用途 | |
| AU2021341258A1 (en) | CD73 inhibitor and application thereof in medicine | |
| JPWO2021170658A5 (ko) | ||
| WO2023217227A1 (zh) | 喜树碱类衍生物及配体-药物偶联物 | |
| JP2022541467A (ja) | オーロラキナーゼ阻害剤およびその使用 | |
| EP4003961A2 (en) | Small molecule inhibitors of acetyl coenzyme a synthetase short chain 2 (acss2) | |
| KR920000647B1 (ko) | 피리미딘 2'-메틸리덴 뉴클레오시드 화합물 | |
| TW202023572A (zh) | 環狀二核苷酸類似物、其藥物組合物及應用 | |
| JPS62175486A (ja) | ビンブラスチン誘導体 | |
| ES2970180T3 (es) | Inhibidores de la dihidroorotato deshidrogenasa bi-arilo |