JPWO2021167012A5 - - Google Patents
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- JPWO2021167012A5 JPWO2021167012A5 JP2022501978A JP2022501978A JPWO2021167012A5 JP WO2021167012 A5 JPWO2021167012 A5 JP WO2021167012A5 JP 2022501978 A JP2022501978 A JP 2022501978A JP 2022501978 A JP2022501978 A JP 2022501978A JP WO2021167012 A5 JPWO2021167012 A5 JP WO2021167012A5
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- JP
- Japan
- Prior art keywords
- dementia
- improvement
- group
- memory
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 206010012289 Dementia Diseases 0.000 claims 15
- CWVRJTMFETXNAD-GMZLATJGSA-N 5-Caffeoyl quinic acid Natural products O[C@H]1C[C@](O)(C[C@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-GMZLATJGSA-N 0.000 claims 8
- 208000010877 cognitive disease Diseases 0.000 claims 8
- 239000000463 material Substances 0.000 claims 8
- CWVRJTMFETXNAD-NXLLHMKUSA-N trans-5-O-caffeoyl-D-quinic acid Chemical compound O[C@H]1[C@H](O)C[C@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-NXLLHMKUSA-N 0.000 claims 8
- 210000002569 neuron Anatomy 0.000 claims 6
- ODBRNZZJSYPIDI-UHFFFAOYSA-N 3',4',5,7-tetrahydroxy-6-C-glucopyranosylflavone Natural products OC1C(O)C(O)C(CO)OC1C1=C(O)C=C(OC(=CC2=O)C=3C=C(O)C(O)=CC=3)C2=C1O ODBRNZZJSYPIDI-UHFFFAOYSA-N 0.000 claims 5
- PLAPMLGJVGLZOV-UHFFFAOYSA-N Epi-orientin Natural products OC1C(O)C(O)C(CO)OC1C1=C(O)C=C(O)C2=C1OC(C=1C=C(O)C(O)=CC=1)=CC2=O PLAPMLGJVGLZOV-UHFFFAOYSA-N 0.000 claims 5
- WJJFWGUVMIUWGG-UHFFFAOYSA-N Stereolensin Natural products OC1C(O)C(O)C(CO)OC1OC1=C(O)C=C(OC(=CC2=O)C=3C=C(O)C(O)=CC=3)C2=C1O WJJFWGUVMIUWGG-UHFFFAOYSA-N 0.000 claims 5
- 235000013305 food Nutrition 0.000 claims 5
- ODBRNZZJSYPIDI-VJXVFPJBSA-N isoorientin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=C(OC(=CC2=O)C=3C=C(O)C(O)=CC=3)C2=C1O ODBRNZZJSYPIDI-VJXVFPJBSA-N 0.000 claims 5
- UYJGIAWJIRZBNU-UHFFFAOYSA-N isoorientin Natural products OCC1OC(C(O)C(O)C1O)c2cc(O)c(O)c3C(=O)C=C(Oc23)c4ccc(O)c(O)c4 UYJGIAWJIRZBNU-UHFFFAOYSA-N 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 230000008450 motivation Effects 0.000 claims 5
- 210000001178 neural stem cell Anatomy 0.000 claims 5
- RAGZUCNPTLULOL-ZLCRQKIYSA-N (1s,3s,4s,5s)-1,3,4-trihydroxy-5-[(e)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]oxycyclohexane-1-carboxylic acid Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)O[C@@H]2[C@H]([C@@H](O)C[C@](O)(C2)C(O)=O)O)=C1 RAGZUCNPTLULOL-ZLCRQKIYSA-N 0.000 claims 4
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 claims 4
- RAGZUCNPTLULOL-MDRZDLKXSA-N 5-O-feruloylquinic acid Natural products O[C@@]1(C[C@H]([C@@H]([C@@H](C1)O)O)OC(C=CC1=CC(=C(C=C1)O)OC)=O)C(=O)O RAGZUCNPTLULOL-MDRZDLKXSA-N 0.000 claims 4
- RAGZUCNPTLULOL-JSHWQEIDSA-N 5-O-feruoylquinic acid Natural products O[C@@]1(C[C@H]([C@@H]([C@@H](C1)OC(C=CC1=CC(=C(C=C1)O)OC)=O)O)O)C(=O)O RAGZUCNPTLULOL-JSHWQEIDSA-N 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 claims 4
- MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Natural products C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 claims 4
- 230000006698 induction Effects 0.000 claims 4
- 230000006993 memory improvement Effects 0.000 claims 4
- 208000027061 mild cognitive impairment Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- RAGZUCNPTLULOL-UHFFFAOYSA-N trans-3-feruloylquinic acid Natural products C1=C(O)C(OC)=CC(C=CC(=O)OC2C(C(O)CC(O)(C2)C(O)=O)O)=C1 RAGZUCNPTLULOL-UHFFFAOYSA-N 0.000 claims 4
- 208000000044 Amnesia Diseases 0.000 claims 3
- 208000026139 Memory disease Diseases 0.000 claims 3
- 240000000111 Saccharum officinarum Species 0.000 claims 3
- 235000007201 Saccharum officinarum Nutrition 0.000 claims 3
- 239000003125 aqueous solvent Substances 0.000 claims 3
- 230000027288 circadian rhythm Effects 0.000 claims 3
- 230000006984 memory degeneration Effects 0.000 claims 3
- 208000023060 memory loss Diseases 0.000 claims 3
- 210000005036 nerve Anatomy 0.000 claims 3
- 230000002407 ATP formation Effects 0.000 claims 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 208000010886 Peripheral nerve injury Diseases 0.000 claims 2
- 206010039966 Senile dementia Diseases 0.000 claims 2
- 208000037132 Subdural Chronic Hematoma Diseases 0.000 claims 2
- 208000002667 Subdural Hematoma Diseases 0.000 claims 2
- 230000032683 aging Effects 0.000 claims 2
- 210000001130 astrocyte Anatomy 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 206010008118 cerebral infarction Diseases 0.000 claims 2
- 208000013677 cerebrovascular dementia Diseases 0.000 claims 2
- 208000026106 cerebrovascular disease Diseases 0.000 claims 2
- 235000001368 chlorogenic acid Nutrition 0.000 claims 2
- 230000006999 cognitive decline Effects 0.000 claims 2
- 230000006735 deficit Effects 0.000 claims 2
- 230000018109 developmental process Effects 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 230000006870 function Effects 0.000 claims 2
- 229930182470 glycoside Natural products 0.000 claims 2
- 150000002338 glycosides Chemical class 0.000 claims 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims 2
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 claims 2
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 claims 2
- 235000009498 luteolin Nutrition 0.000 claims 2
- 206010027175 memory impairment Diseases 0.000 claims 2
- 230000004766 neurogenesis Effects 0.000 claims 2
- 239000002858 neurotransmitter agent Substances 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 208000018726 traumatic encephalopathy Diseases 0.000 claims 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 206010048962 Brain oedema Diseases 0.000 claims 1
- 208000020358 Learning disease Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 claims 1
- 208000006752 brain edema Diseases 0.000 claims 1
- 230000009028 cell transition Effects 0.000 claims 1
- 201000003723 learning disability Diseases 0.000 claims 1
- 230000007087 memory ability Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000003077 normal pressure hydrocephalus Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 208000012201 sexual and gender identity disease Diseases 0.000 claims 1
- 208000015891 sexual disease Diseases 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020025496 | 2020-02-18 | ||
| JP2020025496 | 2020-02-18 | ||
| PCT/JP2021/006166 WO2021167012A1 (ja) | 2020-02-18 | 2021-02-18 | 神経機能調節用組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021167012A1 JPWO2021167012A1 (https=) | 2021-08-26 |
| JPWO2021167012A5 true JPWO2021167012A5 (https=) | 2023-04-24 |
| JP7642212B2 JP7642212B2 (ja) | 2025-03-10 |
Family
ID=77392155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022501978A Active JP7642212B2 (ja) | 2020-02-18 | 2021-02-18 | 神経機能調節用組成物 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP7642212B2 (https=) |
| WO (1) | WO2021167012A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113694054A (zh) * | 2021-09-29 | 2021-11-26 | 深圳市人民医院 | 一种化合物4-o-阿魏酰-5-o-咖啡酰奎宁酸甲酯在药物中的应用 |
| JP7610209B2 (ja) * | 2022-10-13 | 2025-01-08 | 国立大学法人 筑波大学 | ミトコンドリア活性向上用組成物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3793779B2 (ja) * | 2000-11-27 | 2006-07-05 | 沖縄県 | サトウキビポリフェノール含有物の製造方法 |
| JP4199448B2 (ja) * | 2001-10-30 | 2008-12-17 | 琉球セメント株式会社 | サトウキビポリフェノール含有物を有効成分とする医薬剤並びにその用途 |
| NZ533439A (en) | 2001-12-19 | 2006-06-30 | The Quigley Corp | Methods for the treatment of peripheral neural and vascular ailments using flavonoid compositions |
| AU2002950627A0 (en) * | 2002-08-07 | 2002-09-12 | Queen Bioactives Pty Ltd | Method of lowering glycemic index of foods |
| US20150201660A1 (en) | 2012-08-28 | 2015-07-23 | The Product Makers (Austrilia) Pty Ltd | Extraction Method |
| KR20150019505A (ko) | 2013-08-14 | 2015-02-25 | 대화제약 주식회사 | 플라본-6-c-글루코스 유도체를 유효성분으로 함유하는 신경정신질환의 치료 또는 예방용 약학적 조성물 |
| JP6289218B2 (ja) * | 2014-03-31 | 2018-03-07 | 大阪瓦斯株式会社 | ＰＰＡＲα活性組成物の活性化方法 |
| KR101766233B1 (ko) | 2016-06-10 | 2017-08-08 | 한약진흥재단 | 루테올린 5-글루코사이드를 유효성분으로 포함하는 신경 질환의 예방 또는 치료용 조성물 |
| JP2018039797A (ja) | 2016-09-02 | 2018-03-15 | 花王株式会社 | 脳機能改善剤 |
| WO2018199109A1 (ja) | 2017-04-24 | 2018-11-01 | 学校法人産業医科大学 | 神経変性疾患治療剤 |
| WO2018207791A1 (ja) | 2017-05-12 | 2018-11-15 | 花王株式会社 | Ａｒｃ発現促進剤 |
| WO2018207790A1 (ja) | 2017-05-12 | 2018-11-15 | 花王株式会社 | アミロイドβ分解排出促進剤 |
| CN111093394A (zh) | 2017-08-31 | 2020-05-01 | 产品制造商（澳大利亚）有限公司 | 改善消费品的味道 |
| CN108904488A (zh) | 2018-04-24 | 2018-11-30 | 东北师范大学 | 一种化合物在降低蛋白聚积治疗老年痴呆方面的应用 |
| CN109198628A (zh) | 2018-10-10 | 2019-01-15 | 陶燃 | 一种治疗抑郁症及焦虑症的组合物及其用途 |
| CN110507645A (zh) | 2019-09-24 | 2019-11-29 | 广东工业大学 | 木犀草素的应用 |
-
2021
- 2021-02-18 WO PCT/JP2021/006166 patent/WO2021167012A1/ja not_active Ceased
- 2021-02-18 JP JP2022501978A patent/JP7642212B2/ja active Active
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