JPWO2021142234A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021142234A5 JPWO2021142234A5 JP2022542364A JP2022542364A JPWO2021142234A5 JP WO2021142234 A5 JPWO2021142234 A5 JP WO2021142234A5 JP 2022542364 A JP2022542364 A JP 2022542364A JP 2022542364 A JP2022542364 A JP 2022542364A JP WO2021142234 A5 JPWO2021142234 A5 JP WO2021142234A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cdr
- optionally
- oligonucleotide
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062959776P | 2020-01-10 | 2020-01-10 | |
| US62/959,776 | 2020-01-10 | ||
| US202062965712P | 2020-01-24 | 2020-01-24 | |
| US62/965,712 | 2020-01-24 | ||
| US202062968383P | 2020-01-31 | 2020-01-31 | |
| US62/968,383 | 2020-01-31 | ||
| US202063055499P | 2020-07-23 | 2020-07-23 | |
| US63/055,499 | 2020-07-23 | ||
| US202063069063P | 2020-08-23 | 2020-08-23 | |
| US63/069,063 | 2020-08-23 | ||
| US202063132856P | 2020-12-31 | 2020-12-31 | |
| US63/132,856 | 2020-12-31 | ||
| PCT/US2021/012667 WO2021142234A1 (en) | 2020-01-10 | 2021-01-08 | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023509793A JP2023509793A (ja) | 2023-03-09 |
| JPWO2021142234A5 true JPWO2021142234A5 (https=) | 2024-01-17 |
| JP2023509793A5 JP2023509793A5 (https=) | 2024-01-17 |
| JP7829488B2 JP7829488B2 (ja) | 2026-03-13 |
Family
ID=76788870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022542364A Active JP7829488B2 (ja) | 2020-01-10 | 2021-01-08 | 筋緊張性ジストロフィーを処置するための筋標的化複合体およびその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230144436A1 (https=) |
| EP (1) | EP4087653A4 (https=) |
| JP (1) | JP7829488B2 (https=) |
| KR (1) | KR20220125800A (https=) |
| CN (1) | CN115427108A (https=) |
| AU (1) | AU2021206234A1 (https=) |
| BR (1) | BR112022013686A2 (https=) |
| CA (1) | CA3163295A1 (https=) |
| IL (1) | IL294479A (https=) |
| MX (1) | MX2022008533A (https=) |
| WO (1) | WO2021142234A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11911484B2 (en) | 2018-08-02 | 2024-02-27 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US12097263B2 (en) | 2018-08-02 | 2024-09-24 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| EP3829595A4 (en) | 2018-08-02 | 2022-08-24 | Dyne Therapeutics, Inc. | MUSCLE-DIRECTED COMPLEXES AND USES THEREOF IN THE TREATMENT OF DYSTROPHINOPATHIES |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| US20220193250A1 (en) | 2018-08-02 | 2022-06-23 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US12370264B1 (en) | 2018-08-02 | 2025-07-29 | Dyne Therapeutics, Inc. | Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject |
| JP7780691B2 (ja) * | 2020-01-10 | 2025-12-05 | ダイン セラピューティクス，インコーポレーテッド | ジストロフィン異常症を処置するための筋標的化複合体およびそれらの使用 |
| US20240117356A1 (en) * | 2020-12-31 | 2024-04-11 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US11672872B2 (en) | 2021-07-09 | 2023-06-13 | Dyne Therapeutics, Inc. | Anti-transferrin receptor antibody and uses thereof |
| US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| IL309936A (en) | 2021-07-09 | 2024-03-01 | Dyne Therapeutics Inc | Muscle targeting complexes and formulations for the treatment of dystrophinopathy |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US11633498B2 (en) | 2021-07-09 | 2023-04-25 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| EP4396352A4 (en) * | 2021-09-01 | 2025-10-01 | Ionis Pharmaceuticals Inc | COMPOUNDS AND METHODS FOR REDUCING DMPK EXPRESSION |
| EP4396231A1 (en) | 2021-09-01 | 2024-07-10 | Biogen MA Inc. | Anti-transferrin receptor antibodies and uses thereof |
| IL311507A (en) * | 2021-09-16 | 2024-05-01 | Dyne Therapeutics Inc | Dosing of muscle targeting complexes for the treatment of dystrophinopathy |
| KR20240099448A (ko) * | 2021-11-12 | 2024-06-28 | 다인 세라퓨틱스, 인크. | 안면견갑상완 근육 이영양증을 치료하기 위한 근육 표적화 복합체 |
| US20250339553A1 (en) * | 2022-04-15 | 2025-11-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating myotonic dystrophy |
| WO2024257848A1 (ja) * | 2023-06-16 | 2024-12-19 | ルクサナバイオテク株式会社 | 遅発性中枢毒性が低減されているアンチセンスオリゴヌクレオチドの設計方法、及びその製造方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60312639T2 (de) * | 2002-01-18 | 2007-11-29 | Pierre Fabre Médicament | Antikörper gegen igf-ir und ihre verwendungen |
| US20100016215A1 (en) * | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
| PE20190658A1 (es) * | 2012-02-24 | 2019-05-08 | Abbvie Stemcentrx Llc | Moduladores y metodos de empleo novedosos |
| US9610362B2 (en) * | 2012-03-16 | 2017-04-04 | Valerion Therapeutics, Llc | Antisense conjugates for decreasing expression of DMPK |
| CA2889788A1 (en) * | 2012-12-21 | 2014-06-26 | F. Hoffmann-La Roche Ag | Disulfide-linked multivalent mhc class i comprising multi-function proteins |
| EP3152235B1 (en) * | 2014-05-29 | 2021-08-25 | MacroGenics, Inc. | Tri-specific binding molecules and methods of use thereof |
| EP3353306A4 (en) * | 2015-09-25 | 2019-06-05 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| CN109310765A (zh) * | 2016-06-20 | 2019-02-05 | 领先基因生物技术股份有限公司 | 抗体-药物偶联物 |
| TWI761413B (zh) * | 2016-12-26 | 2022-04-21 | 日商Ｊｃｒ製藥股份有限公司 | 通過血腦障壁之新穎抗人類運鐵蛋白受體抗體 |
| JP7506601B2 (ja) * | 2017-12-06 | 2024-06-26 | アビディティー バイオサイエンシーズ，インク． | 筋萎縮症と筋緊張性ジストロフィーを処置するための組成物および方法 |
| JP7576542B2 (ja) * | 2018-08-02 | 2024-10-31 | ダイン セラピューティクス，インコーポレーテッド | 筋標的化複合体およびそれらの使用 |
| CA3163283A1 (en) * | 2020-01-10 | 2021-07-15 | Romesh R. Subramanian | Muscle targeting complexes and uses thereof for modulation of genes associated with muscle health |
| WO2021142313A1 (en) * | 2020-01-10 | 2021-07-15 | Dyne Therapeutics, Inc. | Muscle-targeting complexes and uses thereof |
| KR20220125801A (ko) * | 2020-01-10 | 2022-09-14 | 다인 세라퓨틱스, 인크. | 근육 표적화 복합체 및 안면견갑상완 근육 이영양증을 치료하기 위한 그의 용도 |
| JP7780691B2 (ja) * | 2020-01-10 | 2025-12-05 | ダイン セラピューティクス，インコーポレーテッド | ジストロフィン異常症を処置するための筋標的化複合体およびそれらの使用 |
| WO2021150382A1 (en) * | 2020-01-24 | 2021-07-29 | Dyne Therapeutics, Inc. | Muscle-targeting complexes and uses thereof in treating muscle atrophy |
| CN115427059A (zh) * | 2020-01-31 | 2022-12-02 | 达因疗法公司 | 抗转铁蛋白受体（tfr）抗体及其用途 |
-
2021
- 2021-01-08 AU AU2021206234A patent/AU2021206234A1/en active Pending
- 2021-01-08 US US17/791,681 patent/US20230144436A1/en active Pending
- 2021-01-08 BR BR112022013686A patent/BR112022013686A2/pt unknown
- 2021-01-08 IL IL294479A patent/IL294479A/en unknown
- 2021-01-08 EP EP21738259.7A patent/EP4087653A4/en active Pending
- 2021-01-08 KR KR1020227027136A patent/KR20220125800A/ko active Pending
- 2021-01-08 JP JP2022542364A patent/JP7829488B2/ja active Active
- 2021-01-08 MX MX2022008533A patent/MX2022008533A/es unknown
- 2021-01-08 CN CN202180019691.8A patent/CN115427108A/zh active Pending
- 2021-01-08 CA CA3163295A patent/CA3163295A1/en active Pending
- 2021-01-08 WO PCT/US2021/012667 patent/WO2021142234A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2021142234A5 (https=) | ||
| JPWO2021142313A5 (https=) | ||
| JPWO2021142307A5 (https=) | ||
| JPWO2021142275A5 (https=) | ||
| JP2025067909A5 (https=) | ||
| IL315944A (en) | Muscle targeting complexes and uses thereof for treating myotonic dystrophy | |
| IL309910A (en) | Muscle targeting complexes and their uses for the treatment of myotonic dystrophy | |
| IL316143A (en) | Muscle targeting complexes and formulations for the treatment of myotonic dystrophy | |
| IL317871A (en) | Muscle targeting complexes and their uses for the treatment of FACIOSCAPULOHUMERAL muscular dystrophy | |
| JPWO2021142227A5 (https=) | ||
| JPWO2022026152A5 (https=) | ||
| JP2021533199A5 (https=) | ||
| JP2021533200A5 (https=) | ||
| IL312170A (en) | Muscle targeting complexes for treating facioscapulohumeral muscular dystrophy | |
| CA3226307A1 (en) | Muscle targeting complexes and uses thereof for treating dystrophinopathies | |
| IL316206A (en) | Dosage of muscle targeting complexes for the treatment of myotonic dystrophy | |
| IL309937A (en) | Muscle targeting complexes and uses thereof for treating dystrophinopathies | |
| IL309936A (en) | Muscle targeting complexes and formulations for the treatment of dystrophinopathy | |
| JP2021533197A5 (https=) | ||
| IL309911A (en) | Muscle targeting complexes and uses thereof for treating dystrophinopathies | |
| JPWO2022020107A5 (https=) | ||
| JPWO2020132584A5 (https=) | ||
| JPWO2018129384A5 (https=) | ||
| JPWO2020028832A5 (https=) | ||
| JPWO2020028864A5 (https=) |