JPWO2021117759A5 - - Google Patents
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- Publication number
- JPWO2021117759A5 JPWO2021117759A5 JP2021563996A JP2021563996A JPWO2021117759A5 JP WO2021117759 A5 JPWO2021117759 A5 JP WO2021117759A5 JP 2021563996 A JP2021563996 A JP 2021563996A JP 2021563996 A JP2021563996 A JP 2021563996A JP WO2021117759 A5 JPWO2021117759 A5 JP WO2021117759A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- unsubstituted
- substituted
- substituent group
- aromatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000001424 substituent group Chemical group 0.000 claims 29
- 150000001875 compounds Chemical class 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 16
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 14
- 125000002837 carbocyclic group Chemical group 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000001188 haloalkyl group Chemical group 0.000 claims 8
- 125000004438 haloalkoxy group Chemical group 0.000 claims 7
- -1 cyano, hydroxy Chemical group 0.000 claims 6
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000002950 monocyclic group Chemical group 0.000 claims 3
- 102100039999 Histone deacetylase 2 Human genes 0.000 claims 2
- 101001035011 Homo sapiens Histone deacetylase 2 Proteins 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019222560 | 2019-12-10 | ||
| PCT/JP2020/045829 WO2021117759A1 (ja) | 2019-12-10 | 2020-12-09 | 含窒素芳香族複素環式基を有するヒストン脱アセチル化酵素阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2021117759A1 JPWO2021117759A1 (https=) | 2021-06-17 |
| JPWO2021117759A5 true JPWO2021117759A5 (https=) | 2023-10-27 |
Family
ID=76329869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021563996A Pending JPWO2021117759A1 (https=) | 2019-12-10 | 2020-12-09 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20230119479A1 (https=) |
| EP (1) | EP4074700A4 (https=) |
| JP (1) | JPWO2021117759A1 (https=) |
| WO (1) | WO2021117759A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230096380A1 (en) * | 2020-02-06 | 2023-03-30 | Children's Hospital Medical Center | Compounds, compositions, methods for treating diseases and nerve damage, and methods for preparing compounds |
| AU2024271907A1 (en) * | 2023-05-15 | 2025-12-11 | Wigen Biomedicine Technology (shanghai) Co., Ltd. | Hdac1/2 selective inhibitor and use thereof |
| CN119176770A (zh) * | 2023-12-21 | 2024-12-24 | 艾立康药业股份有限公司 | Hdac抑制剂、组合物及其用途 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005030705A1 (en) * | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| CN101466670B (zh) | 2006-04-07 | 2013-04-17 | 梅特希尔基因公司 | 组蛋白脱乙酰酶抑制剂 |
| EP2023924B1 (en) | 2006-05-18 | 2016-08-03 | Merck Sharp & Dohme Corp. | Aryl-fused spirocyclic compounds |
| CL2008001933A1 (es) * | 2007-06-29 | 2009-09-25 | Millennium Pharm Inc | Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros. |
| US7968536B2 (en) | 2007-06-29 | 2011-06-28 | Millennium Pharmaceuticals, Inc. | Heterocyclic compounds useful as RAF kinase inhibitors |
| US8440830B2 (en) | 2007-09-19 | 2013-05-14 | 4Sc Ag | Tetrahydro-fused pyridines as histone deacetylase inhibitors |
| NZ593447A (en) | 2008-12-03 | 2012-12-21 | Harvard College | Inhibition of hdac2 to promote memory |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
| CA2834548C (en) * | 2011-04-28 | 2021-06-01 | The Broad Institute, Inc. | Inhibitors of histone deacetylase |
| JP5881460B2 (ja) | 2012-02-23 | 2016-03-09 | 公立大学法人名古屋市立大学 | 新規アミド化合物及びその用途 |
| US9145412B2 (en) | 2012-11-02 | 2015-09-29 | Acetylon Pharmaceuticals, Inc. | Selective HDAC1 and HDAC2 inhibitors |
| WO2015191630A1 (en) | 2014-06-10 | 2015-12-17 | Sanford-Burnham Medical Research Institute | Metabotropic glutamate receptor negative allosteric modulators (nams) and uses thereof |
| US20160137630A1 (en) | 2014-10-08 | 2016-05-19 | Acetylon Pharmaceuticals, Inc. | Induction of gata2 by hdac1 and hdac2 inhibitors |
| KR20180022840A (ko) | 2015-07-02 | 2018-03-06 | 바이오마린 파머수티컬 인크. | 히스톤 데아세틸라제 저해제 |
| WO2017007756A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc | Hetero-halo inhibitors of histone deacetylase |
| EP3319968A1 (en) * | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| US9603950B1 (en) | 2015-10-25 | 2017-03-28 | Institute Of Nuclear Energy Research | Compounds of imaging agent with HDAC inhibitor for treatment of Alzheimer syndrome and method of synthesis thereof |
| US20170240535A1 (en) | 2016-02-01 | 2017-08-24 | Regenacy Pharmaceuticals, Llc | Hdac1/2 inhibitors for the treatment of neurodegenerative and/or cognitive disorders |
| US10385031B2 (en) * | 2016-11-23 | 2019-08-20 | Regenacy Pharmaceuticals, Llc | Substituted piperazines as selective HDAC1,2 inhibitors |
| ES2911040T3 (es) * | 2017-07-10 | 2022-05-17 | Medibiofarma S L | Nuevos derivados de heteroaril amida como inhibidores selectivos de histona deacetilasa 1 y 2 (HDAC1/2) |
| LT3664802T (lt) * | 2017-08-07 | 2022-06-27 | Alkermes, Inc. | Bicikliniai histonų deacetilazės inhibitoriai |
| US10507250B2 (en) | 2017-09-08 | 2019-12-17 | Institute Of Nuclear Energy Research, Atomic Energy Council, Executive Yuan | Precursor of a histone deacetylase inhibitor PET imaging compound for tracking cerebral neurodegenerative and tumor diseases |
| WO2019112171A1 (ko) * | 2017-12-07 | 2019-06-13 | 엘지전자 주식회사 | 반도체 발광 소자를 이용한 차량 내 디스플레이 장치 |
| WO2020068950A1 (en) | 2018-09-25 | 2020-04-02 | Regenacy Pharmaceuticals, Llc | Hdac1,2 inhibitors |
| CA3113819A1 (en) | 2018-10-10 | 2020-04-16 | Regenacy Pharmaceuticals, Llc | Pyrimidine and pyrazine hdac1,2 inhibitors |
-
2020
- 2020-12-09 WO PCT/JP2020/045829 patent/WO2021117759A1/ja not_active Ceased
- 2020-12-09 JP JP2021563996A patent/JPWO2021117759A1/ja active Pending
- 2020-12-09 EP EP20900486.0A patent/EP4074700A4/en not_active Withdrawn
- 2020-12-09 US US17/757,143 patent/US20230119479A1/en not_active Abandoned
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