JPWO2021092491A5 - - Google Patents
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- JPWO2021092491A5 JPWO2021092491A5 JP2022526215A JP2022526215A JPWO2021092491A5 JP WO2021092491 A5 JPWO2021092491 A5 JP WO2021092491A5 JP 2022526215 A JP2022526215 A JP 2022526215A JP 2022526215 A JP2022526215 A JP 2022526215A JP WO2021092491 A5 JPWO2021092491 A5 JP WO2021092491A5
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- JP
- Japan
- Prior art keywords
- poly
- arm
- linker
- arms
- gastroretention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 229920001610 polycaprolactone Polymers 0.000 claims 70
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- 229920002803 thermoplastic polyurethane Polymers 0.000 claims 50
- 239000002202 Polyethylene glycol Substances 0.000 claims 45
- 229920001223 polyethylene glycol Polymers 0.000 claims 45
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 44
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 claims 43
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- 239000004698 Polyethylene Substances 0.000 claims 15
- 239000004743 Polypropylene Substances 0.000 claims 15
- 229920001400 block copolymer Polymers 0.000 claims 15
- 229920000573 polyethylene Polymers 0.000 claims 15
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- 239000007864 aqueous solution Substances 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 12
- 229920006237 degradable polymer Polymers 0.000 claims 11
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 8
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- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 2
- 239000002327 cardiovascular agent Substances 0.000 claims 2
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- BLUAFEHZUWYNDE-XRNKLDBLSA-N chembl77 Chemical compound C([C@@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4C31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-XRNKLDBLSA-N 0.000 claims 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims 2
- 229960003722 doxycycline Drugs 0.000 claims 2
- XQTWDDCIUJNLTR-CVHRZJFOSA-N doxycycline monohydrate Chemical compound O.O=C1C2=C(O)C=CC=C2[C@H](C)[C@@H]2C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]1[C@H]2O XQTWDDCIUJNLTR-CVHRZJFOSA-N 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
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- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- WKSAUQYGYAYLPV-UHFFFAOYSA-N pyrimethamine Chemical compound CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C=C1 WKSAUQYGYAYLPV-UHFFFAOYSA-N 0.000 claims 2
- 229960000611 pyrimethamine Drugs 0.000 claims 2
- 229960001534 risperidone Drugs 0.000 claims 2
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 claims 2
- 229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims 2
- 239000012896 selective serotonin reuptake inhibitor Substances 0.000 claims 2
- 239000000021 stimulant Substances 0.000 claims 2
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims 2
- XEEQGYMUWCZPDN-DOMZBBRYSA-N (-)-(11S,2'R)-erythro-mefloquine Chemical compound C([C@@H]1[C@@H](O)C=2C3=CC=CC(=C3N=C(C=2)C(F)(F)F)C(F)(F)F)CCCN1 XEEQGYMUWCZPDN-DOMZBBRYSA-N 0.000 claims 1
- HFVMEOPYDLEHBR-UHFFFAOYSA-N (2-fluorophenyl)-phenylmethanol Chemical compound C=1C=CC=C(F)C=1C(O)C1=CC=CC=C1 HFVMEOPYDLEHBR-UHFFFAOYSA-N 0.000 claims 1
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 claims 1
- WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 claims 1
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims 1
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims 1
- 208000016583 Anus disease Diseases 0.000 claims 1
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 claims 1
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 claims 1
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- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 1
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- UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 claims 1
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- YXPVEXCTPGULBZ-WQYNNSOESA-N entecavir hydrate Chemical compound O.C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)C1=C YXPVEXCTPGULBZ-WQYNNSOESA-N 0.000 claims 1
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| WO2020117855A1 (en) | 2018-12-03 | 2020-06-11 | Lyndra, Inc. | Stomach simulating device |
| MX2021011314A (es) | 2019-03-20 | 2021-12-10 | Lyndra Therapeutics Inc | Capsulas y recubrimientos de capsulas para formas de dosificacion de residencia gastrica. |
| JP2022525482A (ja) | 2019-03-20 | 2022-05-16 | リンドラ セラピューティクス， インコーポレイティド | 胃内滞留剤形用のコーティング |
| CN116234540A (zh) | 2020-07-29 | 2023-06-06 | 赛康特集团有限责任公司 | 具有包括交联聚(癸二酸甘油酯)的结构的形状引导控释和滞留 |
| AU2022210426A1 (en) * | 2021-01-19 | 2023-08-24 | Nortiva Bio, Inc. | Gastric residence systems for administration of risperidone |
| CA3248763A1 (en) * | 2022-01-19 | 2023-07-27 | Nortiva Bio, Inc. | Dosage forms for gastric retention |
| CN115227879B (zh) * | 2022-09-15 | 2023-01-06 | 北京天星博迈迪医疗器械有限公司 | 一种用于可降解关节球囊的组合物及其应用、一种可降解关节球囊及其制备方法 |
| WO2024249946A2 (en) * | 2023-06-02 | 2024-12-05 | Lyndra Therapeutics, Inc. | Manufacturing methods for gastric residence systems |
| WO2025042350A1 (en) * | 2023-08-24 | 2025-02-27 | Junion Therapeutics (Xiamen) Co., Ltd. | A gastric residence article for oral administration |
| WO2025042349A1 (en) * | 2023-08-24 | 2025-02-27 | Junion Therapeutics (Xiamen) Co., Ltd. | A gastric residence article for oral administration |
| WO2025148850A1 (zh) * | 2024-01-09 | 2025-07-17 | 厦门君德医药科技有限公司 | 一种胃滞留装置 |
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| WO2025195482A1 (zh) * | 2024-03-22 | 2025-09-25 | 厦门君德医药科技有限公司 | 一种胃滞留装置 |
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| GB9925962D0 (en) * | 1999-11-02 | 1999-12-29 | Novartis Ag | Organic compounds |
| MX2008009125A (es) * | 2006-01-18 | 2008-10-23 | Qps Llc | Composiciones farmaceuticas con estabilidad mejorada. |
| ES2368356T3 (es) * | 2007-07-06 | 2011-11-16 | Basf Corporation | Composición de retención gástrica basada en un producto de reacción hidrosoluble procedente de un precursor que contiene un grupo vinilo. |
| JP5905872B2 (ja) * | 2010-04-07 | 2016-04-20 | ルピン・リミテッド | タペンタドールの制御放出医薬組成物 |
| JP5954669B2 (ja) * | 2010-08-06 | 2016-07-20 | エンドゥーシェイプ インコーポレイテッド | 医療デバイス用放射線不透過性形状記憶ポリマー |
| WO2015191922A1 (en) * | 2014-06-11 | 2015-12-17 | Massachusetts Institute Of Technology | Enteric elastomers |
| HK1258050A1 (zh) * | 2015-10-23 | 2019-11-01 | Lyndra Therapeutics, Inc. | 用於治疗剂缓释的胃驻留系统及其使用方法 |
| EP3386488B1 (en) * | 2015-12-08 | 2023-09-06 | Lyndra Therapeutics, Inc. | Geometric configurations for gastric residence systems |
| AU2017268840B2 (en) * | 2016-05-27 | 2022-02-10 | Nortiva Bio, Inc. | Materials architecture for gastric residence systems |
| US11576866B2 (en) * | 2016-09-30 | 2023-02-14 | Lyndra Therapeutics, Inc. | Gastric residence systems for sustained delivery of adamantane-class drugs |
| US12023406B2 (en) * | 2017-06-09 | 2024-07-02 | Lyndra Therapeutics, Inc. | Gastric residence systems with release rate-modulating films |
| AU2018337837B2 (en) * | 2017-09-20 | 2024-03-07 | Nortiva Bio, Inc. | Encapsulation of gastric residence systems |
| KR20220002905A (ko) * | 2019-03-25 | 2022-01-07 | 더글라스 파머수티클스 리미티드 | 서방형 약학 제제 |
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