JPWO2021075545A5 - - Google Patents
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- Publication number
- JPWO2021075545A5 JPWO2021075545A5 JP2021552463A JP2021552463A JPWO2021075545A5 JP WO2021075545 A5 JPWO2021075545 A5 JP WO2021075545A5 JP 2021552463 A JP2021552463 A JP 2021552463A JP 2021552463 A JP2021552463 A JP 2021552463A JP WO2021075545 A5 JPWO2021075545 A5 JP WO2021075545A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- antigen
- humanized antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 63
- 230000027455 binding Effects 0.000 claims 32
- 239000000427 antigen Substances 0.000 claims 30
- 102000036639 antigens Human genes 0.000 claims 30
- 108091007433 antigens Proteins 0.000 claims 30
- 239000012634 fragment Substances 0.000 claims 29
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 239000013604 expression vector Substances 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 238000001514 detection method Methods 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 238000011097 chromatography purification Methods 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000012228 culture supernatant Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000004228 ovarian endometrial cancer Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019191560 | 2019-10-18 | ||
| JP2019191560 | 2019-10-18 | ||
| PCT/JP2020/039075 WO2021075545A1 (ja) | 2019-10-18 | 2020-10-16 | ヒト化抗体およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021075545A1 JPWO2021075545A1 (https=) | 2021-04-22 |
| JPWO2021075545A5 true JPWO2021075545A5 (https=) | 2022-08-09 |
| JP7291797B2 JP7291797B2 (ja) | 2023-06-15 |
Family
ID=75538260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021552463A Active JP7291797B2 (ja) | 2019-10-18 | 2020-10-16 | ヒト化抗体およびその使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20220144927A1 (https=) |
| EP (1) | EP4046654A4 (https=) |
| JP (1) | JP7291797B2 (https=) |
| KR (1) | KR20220083785A (https=) |
| CN (1) | CN114641491A (https=) |
| AU (1) | AU2020366846A1 (https=) |
| BR (1) | BR112022007271A2 (https=) |
| CA (1) | CA3158326A1 (https=) |
| IL (1) | IL292176B2 (https=) |
| MX (1) | MX2022004569A (https=) |
| PH (1) | PH12022550907A1 (https=) |
| TW (1) | TWI877240B (https=) |
| WO (1) | WO2021075545A1 (https=) |
| ZA (1) | ZA202205288B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL292133A (en) * | 2019-10-18 | 2022-06-01 | Nihon Mediphysics Co Ltd | Ri-labeled humanized antibody |
| EP4397320A1 (en) | 2021-08-31 | 2024-07-10 | Nihon Medi-Physics Co., Ltd. | Radioactive complex of deglycosylated antibody and radioactive pharmaceutical product |
| KR20250093372A (ko) | 2022-10-26 | 2025-06-24 | 니혼 메디피직스 가부시키가이샤 | 방사성 의약 조성물 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07203974A (ja) | 1994-01-13 | 1995-08-08 | Tosoh Corp | 癌特異的ムチンを認識する抗体の遺伝子断片等 |
| JPH115749A (ja) | 1997-06-13 | 1999-01-12 | Tosoh Corp | 癌治療医薬品組成物 |
| EP2451487A1 (en) * | 2009-07-09 | 2012-05-16 | F. Hoffmann-La Roche AG | In vivi tumor vasculature imaging |
| EP2675485A4 (en) * | 2011-02-15 | 2014-10-15 | Immunomedics Inc | ANTI-MUCIN ANTIBODY FOR THE EARLY RECOGNITION AND TREATMENT OF PANCREATIC CANCER |
| WO2013157105A1 (ja) * | 2012-04-18 | 2013-10-24 | 公立大学法人大阪市立大学 | ムチンサブタイプ５ａｃ特異的ヒト化抗体およびその利用 |
| WO2013157102A1 (ja) * | 2012-04-18 | 2013-10-24 | 公立大学法人大阪市立大学 | ムチンサブタイプ５ａｃ特異的ヒト化抗体およびその利用 |
| CA2948013A1 (en) * | 2014-06-30 | 2016-01-07 | Immunomedics, Inc. | Antibodies reactive with an epitope located in the n-terminal region of muc5ac comprising cysteine-rich subdomain 2 (cys2) |
| JP2019191560A (ja) | 2018-04-24 | 2019-10-31 | 住友化学株式会社 | 光学積層体及びその製造方法 |
-
2020
- 2020-10-16 AU AU2020366846A patent/AU2020366846A1/en active Pending
- 2020-10-16 MX MX2022004569A patent/MX2022004569A/es unknown
- 2020-10-16 TW TW109135915A patent/TWI877240B/zh active
- 2020-10-16 KR KR1020227016478A patent/KR20220083785A/ko active Pending
- 2020-10-16 CN CN202080072096.6A patent/CN114641491A/zh active Pending
- 2020-10-16 US US17/430,704 patent/US20220144927A1/en active Pending
- 2020-10-16 BR BR112022007271A patent/BR112022007271A2/pt unknown
- 2020-10-16 CA CA3158326A patent/CA3158326A1/en active Pending
- 2020-10-16 WO PCT/JP2020/039075 patent/WO2021075545A1/ja not_active Ceased
- 2020-10-16 JP JP2021552463A patent/JP7291797B2/ja active Active
- 2020-10-16 EP EP20877846.4A patent/EP4046654A4/en active Pending
- 2020-10-16 PH PH1/2022/550907A patent/PH12022550907A1/en unknown
- 2020-10-16 IL IL292176A patent/IL292176B2/en unknown
-
2022
- 2022-05-12 ZA ZA2022/05288A patent/ZA202205288B/en unknown
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