JPWO2021030657A5 - - Google Patents
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- Publication number
- JPWO2021030657A5 JPWO2021030657A5 JP2022507875A JP2022507875A JPWO2021030657A5 JP WO2021030657 A5 JPWO2021030657 A5 JP WO2021030657A5 JP 2022507875 A JP2022507875 A JP 2022507875A JP 2022507875 A JP2022507875 A JP 2022507875A JP WO2021030657 A5 JPWO2021030657 A5 JP WO2021030657A5
- Authority
- JP
- Japan
- Prior art keywords
- cys
- scfv
- seq
- exposed
- disulfide bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962887529P | 2019-08-15 | 2019-08-15 | |
| US201962887524P | 2019-08-15 | 2019-08-15 | |
| US201962887514P | 2019-08-15 | 2019-08-15 | |
| US201962887519P | 2019-08-15 | 2019-08-15 | |
| US201962887527P | 2019-08-15 | 2019-08-15 | |
| US62/887,519 | 2019-08-15 | ||
| US62/887,514 | 2019-08-15 | ||
| US62/887,524 | 2019-08-15 | ||
| US62/887,529 | 2019-08-15 | ||
| US62/887,527 | 2019-08-15 | ||
| US201962946882P | 2019-12-11 | 2019-12-11 | |
| US201962946886P | 2019-12-11 | 2019-12-11 | |
| US201962946877P | 2019-12-11 | 2019-12-11 | |
| US201962946897P | 2019-12-11 | 2019-12-11 | |
| US201962946865P | 2019-12-11 | 2019-12-11 | |
| US62/946,865 | 2019-12-11 | ||
| US62/946,897 | 2019-12-11 | ||
| US62/946,877 | 2019-12-11 | ||
| US62/946,886 | 2019-12-11 | ||
| US62/946,882 | 2019-12-11 | ||
| PCT/US2020/046303 WO2021030657A1 (fr) | 2019-08-15 | 2020-08-14 | Matériaux et procédés pour des fragments variables à chaîne unique améliorés |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022544760A JP2022544760A (ja) | 2022-10-21 |
| JPWO2021030657A5 true JPWO2021030657A5 (fr) | 2023-08-15 |
Family
ID=72243247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022507875A Pending JP2022544760A (ja) | 2019-08-15 | 2020-08-14 | 改善された単鎖可変断片のための材料及び方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11787875B2 (fr) |
| EP (1) | EP4013783A1 (fr) |
| JP (1) | JP2022544760A (fr) |
| KR (1) | KR20220062494A (fr) |
| CN (1) | CN114258400A (fr) |
| AU (1) | AU2020328049A1 (fr) |
| BR (1) | BR112022002540A2 (fr) |
| CA (1) | CA3148121A1 (fr) |
| CO (1) | CO2022001222A2 (fr) |
| CR (1) | CR20220054A (fr) |
| DO (1) | DOP2022000032A (fr) |
| EC (1) | ECSP22011199A (fr) |
| IL (1) | IL290436A (fr) |
| JO (1) | JOP20220035A1 (fr) |
| MX (1) | MX2022001799A (fr) |
| PE (1) | PE20220299A1 (fr) |
| TW (1) | TW202120537A (fr) |
| WO (1) | WO2021030657A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220130687A (ko) * | 2019-12-11 | 2022-09-27 | 시락 게엠베하 인터내셔날 | Ltbr 및 edb 결합 도메인을 포함하는 다중특이성 결합 분자 및 이의 용도 |
| AU2022392829A1 (en) * | 2021-11-22 | 2024-07-11 | Janssen Biotech, Inc. | Compositions comprising enhanced multispecific binding agents for an immune response |
| WO2023152581A1 (fr) | 2022-02-09 | 2023-08-17 | Janssen Biotech, Inc. | Méthode de traitement du cancer à l'aide d'un anticorps anti-psmaxcd3 |
| WO2023164510A1 (fr) * | 2022-02-23 | 2023-08-31 | Xencor, Inc. | Anticorps anti-cd28 x anti-psma |
| WO2024028732A1 (fr) | 2022-08-05 | 2024-02-08 | Janssen Biotech, Inc. | Constructions de liaison à cd98 pour le traitement de tumeurs cérébrales |
| WO2024028731A1 (fr) | 2022-08-05 | 2024-02-08 | Janssen Biotech, Inc. | Protéines de liaison de récepteur de transferrine pour traitement de tumeurs cérébrales |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| US5932448A (en) | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
| US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| DE60131456T2 (de) | 2000-11-30 | 2008-07-10 | Medarex, Inc., Milpitas | Transchromosomale transgen-nagetiere zur herstellung von humanen antikörpern |
| US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US6833441B2 (en) | 2001-08-01 | 2004-12-21 | Abmaxis, Inc. | Compositions and methods for generating chimeric heteromultimers |
| AU2006232287B2 (en) | 2005-03-31 | 2011-10-06 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| DE102005028778A1 (de) | 2005-06-22 | 2006-12-28 | SUNJÜT Deutschland GmbH | Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage |
| CA2646965C (fr) | 2006-03-24 | 2016-06-21 | Jonathan H. Davis | Domaines de proteine heterodimerique d'ingenierie |
| US20090182127A1 (en) | 2006-06-22 | 2009-07-16 | Novo Nordisk A/S | Production of Bispecific Antibodies |
| US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
| EA018985B1 (ru) | 2007-04-02 | 2013-12-30 | Филоджен С.П.А. | Новый антиген, ассоциированный с новообразованными сосудами опухолевых метастазов |
| AU2008343589A1 (en) | 2007-12-19 | 2009-07-09 | Centocor Ortho Biotech Inc. | Design and generation of human de novo pIX phage display libraries via fusion to pIX or pVII, vectors, antibodies and methods |
| EP2282769A4 (fr) | 2008-04-29 | 2012-04-25 | Abbott Lab | Immunoglobulines à double domaine variable et utilisations |
| MX344076B (es) * | 2008-06-30 | 2016-12-05 | Esbatech Alcon Biomed Res Unit | Polipeptidos funcionalizados. |
| US9067986B2 (en) | 2009-04-27 | 2015-06-30 | Oncomed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
| DK2975051T3 (da) | 2009-06-26 | 2021-04-26 | Regeneron Pharma | Let-at-isolere bispecifikke antistoffer med nativt immunoglobulinformat |
| PE20120630A1 (es) | 2009-08-17 | 2012-05-26 | Roche Glycart Ag | Inmunoconjugados dirigidos |
| US20120283415A1 (en) * | 2009-09-10 | 2012-11-08 | Ucb Pharma S.A. | Multivalent Antibodies |
| SG181814A1 (en) * | 2009-12-23 | 2012-07-30 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them 2 |
| MX353144B (es) | 2010-04-20 | 2017-12-20 | Genmab As | Proteinas que contienen fc de anticuerpos heterodimericos y metodos para produccion de las mismas. |
| CA2797981C (fr) | 2010-05-14 | 2019-04-23 | Rinat Neuroscience Corporation | Proteines heterodimeriques et leurs procedes de production et de purification |
| EP2420253A1 (fr) | 2010-08-20 | 2012-02-22 | Leadartis, S.L. | Synthèse de molécules polyvalentes et multifonctionnelles avec un domaine de trimérisation de collagène XV |
| CA2807278A1 (fr) * | 2010-08-24 | 2012-03-01 | F. Hoffmann - La Roche Ag | Anticorps bispecifiques comprenant un fragment fv stabilise par bisulfure |
| PT2635607T (pt) | 2010-11-05 | 2019-12-11 | Zymeworks Inc | Design de anticorpo heterodimérico estável com mutações no domínio do fc |
| TWI671315B (zh) * | 2011-03-28 | 2019-09-11 | 法商賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
| RS59166B1 (sr) | 2011-10-27 | 2019-10-31 | Genmab As | Proizvodnja heterodimernih proteina |
| PT2773671T (pt) | 2011-11-04 | 2021-12-14 | Zymeworks Inc | Geração de anticorpo heterodimérico estável com mutações no domínio fc |
| PT2794905T (pt) | 2011-12-20 | 2020-06-30 | Medimmune Llc | Polipéptidos modificados para estrutura de anticorpos bispecíficos |
| KR20200126007A (ko) | 2012-04-20 | 2020-11-05 | 메뤼스 엔.페. | Ig-유사 분자의 제조방법 및 제조수단 |
| WO2013175678A1 (fr) | 2012-05-24 | 2013-11-28 | パナソニック株式会社 | Protéine variante pouvant se lier spécifiquement et rapidement à la troponine cardiaque humaine i |
| JP2016512029A (ja) | 2013-03-15 | 2016-04-25 | ヤンセン バイオテツク，インコーポレーテツド | 遺伝子組換えタンパク質中のｃ末端リジン、ガラクトース、及びシアル酸含量を制御する製造方法 |
| PL3519437T3 (pl) | 2016-09-30 | 2022-01-17 | F. Hoffmann-La Roche Ag | Przeciwciała dwuswoiste przeciwko p95HER2 |
| SG11202002533QA (en) | 2017-09-22 | 2020-04-29 | Kite Pharma Inc | Chimeric polypeptides and uses thereof |
-
2020
- 2020-08-14 AU AU2020328049A patent/AU2020328049A1/en active Pending
- 2020-08-14 MX MX2022001799A patent/MX2022001799A/es unknown
- 2020-08-14 US US16/994,065 patent/US11787875B2/en active Active
- 2020-08-14 TW TW109127754A patent/TW202120537A/zh unknown
- 2020-08-14 CN CN202080057404.8A patent/CN114258400A/zh active Pending
- 2020-08-14 CA CA3148121A patent/CA3148121A1/fr active Pending
- 2020-08-14 JO JOP/2022/0035A patent/JOP20220035A1/ar unknown
- 2020-08-14 BR BR112022002540A patent/BR112022002540A2/pt unknown
- 2020-08-14 PE PE2022000220A patent/PE20220299A1/es unknown
- 2020-08-14 JP JP2022507875A patent/JP2022544760A/ja active Pending
- 2020-08-14 WO PCT/US2020/046303 patent/WO2021030657A1/fr active Application Filing
- 2020-08-14 CR CR20220054A patent/CR20220054A/es unknown
- 2020-08-14 EP EP20761987.5A patent/EP4013783A1/fr active Pending
- 2020-08-14 KR KR1020227004708A patent/KR20220062494A/ko unknown
-
2022
- 2022-02-07 CO CONC2022/0001222A patent/CO2022001222A2/es unknown
- 2022-02-08 DO DO2022000032A patent/DOP2022000032A/es unknown
- 2022-02-08 IL IL290436A patent/IL290436A/en unknown
- 2022-02-11 EC ECSENADI202211199A patent/ECSP22011199A/es unknown
-
2023
- 2023-09-05 US US18/461,191 patent/US20240067754A1/en active Pending
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