JPWO2021024906A5 - - Google Patents
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- Publication number
- JPWO2021024906A5 JPWO2021024906A5 JP2021537269A JP2021537269A JPWO2021024906A5 JP WO2021024906 A5 JPWO2021024906 A5 JP WO2021024906A5 JP 2021537269 A JP2021537269 A JP 2021537269A JP 2021537269 A JP2021537269 A JP 2021537269A JP WO2021024906 A5 JPWO2021024906 A5 JP WO2021024906A5
- Authority
- JP
- Japan
- Prior art keywords
- prevention
- treatment
- hydrophilic
- hydrophobic
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002265 prevention Effects 0.000 claims 12
- 229920001577 copolymer Polymers 0.000 claims 10
- 239000002105 nanoparticle Substances 0.000 claims 6
- 230000001629 suppression Effects 0.000 claims 6
- 206010009900 Colitis ulcerative Diseases 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 208000008589 Obesity Diseases 0.000 claims 5
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 208000019425 cirrhosis of liver Diseases 0.000 claims 5
- 206010012601 diabetes mellitus Diseases 0.000 claims 5
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 5
- 235000020824 obesity Nutrition 0.000 claims 5
- 230000005855 radiation Effects 0.000 claims 5
- 238000001959 radiotherapy Methods 0.000 claims 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 4
- 206010020575 Hyperammonaemia Diseases 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 230000002209 hydrophobic effect Effects 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 229910021529 ammonia Inorganic materials 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 239000000693 micelle Substances 0.000 claims 1
- -1 phenethylamino group Chemical group 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019143619 | 2019-08-05 | ||
| JP2019143619 | 2019-08-05 | ||
| PCT/JP2020/029239 WO2021024906A1 (ja) | 2019-08-05 | 2020-07-30 | 短鎖脂肪酸エステルを担持する親水－疎水性共重合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021024906A1 JPWO2021024906A1 (https=) | 2021-02-11 |
| JPWO2021024906A5 true JPWO2021024906A5 (https=) | 2022-06-23 |
| JP7548586B2 JP7548586B2 (ja) | 2024-09-10 |
Family
ID=74503809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021537269A Active JP7548586B2 (ja) | 2019-08-05 | 2020-07-30 | 短鎖脂肪酸エステルを担持する親水－疎水性共重合体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220332876A1 (https=) |
| EP (1) | EP4011444A4 (https=) |
| JP (1) | JP7548586B2 (https=) |
| CN (1) | CN114430756B (https=) |
| AU (1) | AU2020324649B8 (https=) |
| CA (1) | CA3152003A1 (https=) |
| WO (1) | WO2021024906A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025069980A1 (ja) | 2023-09-28 | 2025-04-03 | 国立大学法人筑波大学 | ジクロロ酢酸を側鎖に担持する親水－疎水性共重合体及びそれらの医療用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4212768A1 (de) * | 1992-04-16 | 1993-10-21 | Huels Chemische Werke Ag | Verfahren zur Herstellung von wäßrigen Polymerdispersionen |
| JP3228482B2 (ja) * | 1992-06-29 | 2001-11-12 | 株式会社クラレ | 分散安定剤および水性分散液 |
| US6616946B1 (en) * | 1999-11-15 | 2003-09-09 | Biocure, Inc. | Triblock copolymer hollow particles for agent delivery by permeability change |
| US20070122443A1 (en) | 2005-11-29 | 2007-05-31 | Narayanan Pallassana V | Amphiphilic copolymer compositions |
| CA2723118C (en) | 2008-05-02 | 2016-05-17 | University Of Tsukuba | Polymerized cyclic nitroxide radical compound and use thereof |
| US10208152B2 (en) | 2014-09-30 | 2019-02-19 | University Of Tsukuba | Poly(ethylene glycol)-b-poly(halomethylstyrene), derivative thereof, and method for producing same |
| JP7133219B2 (ja) * | 2017-01-19 | 2022-09-08 | 国立大学法人 筑波大学 | 側鎖に環状ニトロキシドラジカルとトリアルコキシシリルを含む共重合体およびその使用 |
| JP7136807B2 (ja) * | 2017-04-17 | 2022-09-13 | ザ・ユニバーシティ・オブ・シカゴ | ヒトの健康及び疾患の治療用途向けの短鎖脂肪酸の腸への送達用ポリマー材料 |
| JP7116428B2 (ja) * | 2017-06-19 | 2022-08-10 | 国立大学法人 筑波大学 | 感染症治療薬 |
| JPWO2019208617A1 (ja) * | 2018-04-27 | 2021-05-13 | 国立大学法人 筑波大学 | ソラフェニブの経口デリバリー用組成物及びその使用 |
-
2020
- 2020-07-30 CA CA3152003A patent/CA3152003A1/en active Pending
- 2020-07-30 AU AU2020324649A patent/AU2020324649B8/en not_active Expired - Fee Related
- 2020-07-30 WO PCT/JP2020/029239 patent/WO2021024906A1/ja not_active Ceased
- 2020-07-30 JP JP2021537269A patent/JP7548586B2/ja active Active
- 2020-07-30 US US17/631,593 patent/US20220332876A1/en not_active Abandoned
- 2020-07-30 EP EP20848934.4A patent/EP4011444A4/en active Pending
- 2020-07-30 CN CN202080069272.0A patent/CN114430756B/zh active Active
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