CN114430756B - 担载短链脂肪酸酯的亲水-疏水性共聚物 - Google Patents
担载短链脂肪酸酯的亲水-疏水性共聚物 Download PDFInfo
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- CN114430756B CN114430756B CN202080069272.0A CN202080069272A CN114430756B CN 114430756 B CN114430756 B CN 114430756B CN 202080069272 A CN202080069272 A CN 202080069272A CN 114430756 B CN114430756 B CN 114430756B
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- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
- C08F290/06—Polymers provided for in subclass C08G
- C08F290/062—Polyethers
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- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/337—Polymers modified by chemical after-treatment with organic compounds containing other elements
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
- A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
- C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
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- C—CHEMISTRY; METALLURGY
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- C08F8/14—Esterification
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
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- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
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- C—CHEMISTRY; METALLURGY
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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- C08G65/3344—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
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- C08G65/3344—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur
- C08G65/3346—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur having sulfur bound to carbon and oxygen
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08F2438/03—Use of a di- or tri-thiocarbonylthio compound, e.g. di- or tri-thioester, di- or tri-thiocarbamate, or a xanthate as chain transfer agent, e.g . Reversible Addition Fragmentation chain Transfer [RAFT] or Macromolecular Design via Interchange of Xanthates [MADIX]
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- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
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- C08L2201/54—Aqueous solutions or dispersions
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- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nanotechnology (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Graft Or Block Polymers (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019-143619 | 2019-08-05 | ||
| JP2019143619 | 2019-08-05 | ||
| PCT/JP2020/029239 WO2021024906A1 (ja) | 2019-08-05 | 2020-07-30 | 短鎖脂肪酸エステルを担持する親水-疎水性共重合体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114430756A CN114430756A (zh) | 2022-05-03 |
| CN114430756B true CN114430756B (zh) | 2025-07-11 |
Family
ID=74503809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080069272.0A Active CN114430756B (zh) | 2019-08-05 | 2020-07-30 | 担载短链脂肪酸酯的亲水-疏水性共聚物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220332876A1 (https=) |
| EP (1) | EP4011444A4 (https=) |
| JP (1) | JP7548586B2 (https=) |
| CN (1) | CN114430756B (https=) |
| AU (1) | AU2020324649B8 (https=) |
| CA (1) | CA3152003A1 (https=) |
| WO (1) | WO2021024906A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025069980A1 (ja) | 2023-09-28 | 2025-04-03 | 国立大学法人筑波大学 | ジクロロ酢酸を側鎖に担持する親水-疎水性共重合体及びそれらの医療用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4212768A1 (de) * | 1992-04-16 | 1993-10-21 | Huels Chemische Werke Ag | Verfahren zur Herstellung von wäßrigen Polymerdispersionen |
| JP3228482B2 (ja) * | 1992-06-29 | 2001-11-12 | 株式会社クラレ | 分散安定剤および水性分散液 |
| DE60041978D1 (de) * | 1999-11-15 | 2009-05-20 | Biocure Inc | Auf äussere bedingungen ansprechende polymere hohle partikel |
| US20070122443A1 (en) * | 2005-11-29 | 2007-05-31 | Narayanan Pallassana V | Amphiphilic copolymer compositions |
| JP5737705B2 (ja) | 2008-05-02 | 2015-06-17 | 国立大学法人 筑波大学 | 高分子化環状ニトロキシドラジカル化合物およびその使用 |
| US10208152B2 (en) | 2014-09-30 | 2019-02-19 | University Of Tsukuba | Poly(ethylene glycol)-b-poly(halomethylstyrene), derivative thereof, and method for producing same |
| US12049543B2 (en) * | 2017-01-19 | 2024-07-30 | Crestecbio Inc. | Copolymer containing cyclic nitroxide radical and trialkoxysilyl in side chain, and use thereof |
| EP3612570A4 (en) * | 2017-04-17 | 2021-01-13 | The University of Chicago | POLYMERIC MATERIALS FOR THE ADMINISTRATION OF SHORT-CHAIN FATTY ACIDS TO THE INTESTINE FOR HUMAN HEALTH AND DISEASE TREATMENT APPLICATIONS |
| JP7116428B2 (ja) * | 2017-06-19 | 2022-08-10 | 国立大学法人 筑波大学 | 感染症治療薬 |
| JPWO2019208617A1 (ja) * | 2018-04-27 | 2021-05-13 | 国立大学法人 筑波大学 | ソラフェニブの経口デリバリー用組成物及びその使用 |
-
2020
- 2020-07-30 AU AU2020324649A patent/AU2020324649B8/en not_active Expired - Fee Related
- 2020-07-30 WO PCT/JP2020/029239 patent/WO2021024906A1/ja not_active Ceased
- 2020-07-30 CA CA3152003A patent/CA3152003A1/en active Pending
- 2020-07-30 EP EP20848934.4A patent/EP4011444A4/en active Pending
- 2020-07-30 JP JP2021537269A patent/JP7548586B2/ja active Active
- 2020-07-30 CN CN202080069272.0A patent/CN114430756B/zh active Active
- 2020-07-30 US US17/631,593 patent/US20220332876A1/en not_active Abandoned
Non-Patent Citations (3)
| Title |
|---|
| Block Copolymers of Poly(ethylene oxide) and Poly(vinyl alcohol) Synthesized by the RAFT Methodology;YIN-YIN TONG et al.;JOURNAL OF POLYMER SCIENCE RAFT A: POLYMER CHEMISTRY;第47卷(第7期);第1901-1910页 * |
| Synthesis of functionalized poly(vinyl acetate) mediated by alkyne-terminated RAFT agents;Joana. R. G´ois et al.;RSC Advances;第5卷(第111期);第91225-91234页 * |
| Xanthate-Mediated Copolymerization of Vinyl Monomers for Amphiphilic and Double-Hydrophilic Block Copolymers with Poly(ethylene glycol);Gwenaelle Pound et al.;Macromolecules;第40卷(第25期);第8861-8871页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020324649B1 (en) | 2025-07-17 |
| JPWO2021024906A1 (https=) | 2021-02-11 |
| WO2021024906A1 (ja) | 2021-02-11 |
| EP4011444A4 (en) | 2023-10-25 |
| JP7548586B2 (ja) | 2024-09-10 |
| AU2020324649B8 (en) | 2025-08-07 |
| AU2020324649A1 (en) | 2022-03-17 |
| CA3152003A1 (en) | 2021-02-11 |
| US20220332876A1 (en) | 2022-10-20 |
| EP4011444A1 (en) | 2022-06-15 |
| CN114430756A (zh) | 2022-05-03 |
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