JPWO2021010221A5 - - Google Patents
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- Publication number
- JPWO2021010221A5 JPWO2021010221A5 JP2021532987A JP2021532987A JPWO2021010221A5 JP WO2021010221 A5 JPWO2021010221 A5 JP WO2021010221A5 JP 2021532987 A JP2021532987 A JP 2021532987A JP 2021532987 A JP2021532987 A JP 2021532987A JP WO2021010221 A5 JPWO2021010221 A5 JP WO2021010221A5
- Authority
- JP
- Japan
- Prior art keywords
- preparing
- sample
- analysis
- analytical
- sialic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims description 9
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims description 9
- 150000002596 lactones Chemical class 0.000 claims description 6
- 238000000034 method Methods 0.000 claims 28
- 239000000523 sample Substances 0.000 claims 25
- 239000000538 analytical sample Substances 0.000 claims 19
- 238000004458 analytical method Methods 0.000 claims 18
- 238000007112 amidation reaction Methods 0.000 claims 11
- 125000004432 carbon atom Chemical group C* 0.000 claims 11
- 239000000243 solution Substances 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 239000000872 buffer Substances 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 6
- 230000003113 alkalizing effect Effects 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 6
- 150000003141 primary amines Chemical class 0.000 claims 5
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 4
- 150000002357 guanidines Chemical class 0.000 claims 4
- 150000002429 hydrazines Chemical class 0.000 claims 4
- 238000007273 lactonization reaction Methods 0.000 claims 4
- 239000000376 reactant Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 3
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 3
- 229910021529 ammonia Inorganic materials 0.000 claims 3
- 230000018044 dehydration Effects 0.000 claims 3
- 238000006297 dehydration reaction Methods 0.000 claims 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 3
- 150000003335 secondary amines Chemical group 0.000 claims 3
- 150000003512 tertiary amines Chemical class 0.000 claims 3
- 239000006173 Good's buffer Substances 0.000 claims 2
- 239000007983 Tris buffer Substances 0.000 claims 2
- 229910052783 alkali metal Inorganic materials 0.000 claims 2
- 150000001340 alkali metals Chemical class 0.000 claims 2
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 claims 2
- 230000002862 amidating effect Effects 0.000 claims 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 2
- 239000004327 boric acid Substances 0.000 claims 2
- 229940083094 guanine derivative acting on arteriolar smooth muscle Drugs 0.000 claims 2
- 150000004679 hydroxides Chemical class 0.000 claims 2
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 2
- 150000005622 tetraalkylammonium hydroxides Chemical class 0.000 claims 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 238000005464 sample preparation method Methods 0.000 claims 1
- 238000001212 derivatisation Methods 0.000 description 2
- 238000007098 aminolysis reaction Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 150000002339 glycosphingolipids Chemical class 0.000 description 1
- 238000005580 one pot reaction Methods 0.000 description 1
- 238000007142 ring opening reaction Methods 0.000 description 1
- 125000005630 sialyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019130188 | 2019-07-12 | ||
| JP2019130188 | 2019-07-12 | ||
| PCT/JP2020/026489 WO2021010221A1 (ja) | 2019-07-12 | 2020-07-06 | 分析用試料の調製方法、分析方法および分析用試料の調製用キット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021010221A1 JPWO2021010221A1 (https=) | 2021-01-21 |
| JPWO2021010221A5 true JPWO2021010221A5 (https=) | 2022-05-31 |
| JP7375816B2 JP7375816B2 (ja) | 2023-11-08 |
Family
ID=74209832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021532987A Active JP7375816B2 (ja) | 2019-07-12 | 2020-07-06 | 分析用試料の調製方法、分析方法および分析用試料の調製用キット |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220299408A1 (https=) |
| EP (1) | EP3998274A4 (https=) |
| JP (1) | JP7375816B2 (https=) |
| CN (1) | CN114127553B (https=) |
| WO (1) | WO2021010221A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20250327781A1 (en) * | 2022-06-14 | 2025-10-23 | Shimadzu Corporation | Method for Preparing Specimen for Analysis and Method for Analyzing Same |
| JPWO2024180872A1 (https=) * | 2023-03-01 | 2024-09-06 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54109785A (en) | 1978-02-16 | 1979-08-28 | Nec Corp | Semiconductor device |
| US5496937A (en) * | 1993-05-14 | 1996-03-05 | Nakano Vinegar Co., Ltd. | Polysaccharide substances, process for producing them and use of them |
| JP2009162530A (ja) * | 2007-12-28 | 2009-07-23 | National Institute Of Advanced Industrial & Technology | 生体成分を化学修飾する方法 |
| WO2016159291A1 (ja) | 2015-03-31 | 2016-10-06 | 株式会社島津製作所 | 分析用試料の調製方法および分析方法 |
| JP6135710B2 (ja) * | 2015-03-31 | 2017-05-31 | 株式会社島津製作所 | 分析用試料の調製方法および分析方法 |
| JP6852397B2 (ja) * | 2016-12-28 | 2021-03-31 | 株式会社島津製作所 | 分析用試料の調製方法および分析方法 |
| JP2019130188A (ja) | 2018-02-01 | 2019-08-08 | 株式会社平和 | 遊技機 |
| JP7010061B2 (ja) * | 2018-03-01 | 2022-01-26 | 株式会社島津製作所 | 試料の調製方法および分析方法 |
| JP7047669B2 (ja) * | 2018-08-24 | 2022-04-05 | 株式会社島津製作所 | 分析用試料の調製方法、分析方法および分析用試料の調製用キット |
| JP7087900B2 (ja) * | 2018-10-03 | 2022-06-21 | 株式会社島津製作所 | 分析用試料の調製方法、分析方法および分析用試料の調製用キット |
-
2020
- 2020-07-06 EP EP20840389.9A patent/EP3998274A4/en active Pending
- 2020-07-06 CN CN202080050575.8A patent/CN114127553B/zh active Active
- 2020-07-06 JP JP2021532987A patent/JP7375816B2/ja active Active
- 2020-07-06 WO PCT/JP2020/026489 patent/WO2021010221A1/ja not_active Ceased
- 2020-07-06 US US17/597,405 patent/US20220299408A1/en active Pending
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