JPWO2021005129A5 - - Google Patents
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- Publication number
- JPWO2021005129A5 JPWO2021005129A5 JP2022501259A JP2022501259A JPWO2021005129A5 JP WO2021005129 A5 JPWO2021005129 A5 JP WO2021005129A5 JP 2022501259 A JP2022501259 A JP 2022501259A JP 2022501259 A JP2022501259 A JP 2022501259A JP WO2021005129 A5 JPWO2021005129 A5 JP WO2021005129A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- ibuprofen
- pharmaceutically acceptable
- composition according
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 229960001680 ibuprofen Drugs 0.000 claims 14
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 8
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims 5
- 229960004380 tramadol Drugs 0.000 claims 5
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 claims 5
- PPKXEPBICJTCRU-XMZRARIVSA-N (R,R)-tramadol hydrochloride Chemical compound Cl.COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-XMZRARIVSA-N 0.000 claims 4
- 239000004475 Arginine Substances 0.000 claims 4
- 208000002193 Pain Diseases 0.000 claims 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 4
- 229960003107 tramadol hydrochloride Drugs 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- 229940072056 alginate Drugs 0.000 claims 2
- 235000010443 alginic acid Nutrition 0.000 claims 2
- 229920000615 alginic acid Polymers 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- IHHXIUAEPKVVII-ZSCHJXSPSA-N [(1s)-5-amino-1-carboxypentyl]azanium;2-[4-(2-methylpropyl)phenyl]propanoate Chemical compound OC(=O)[C@@H](N)CCCC[NH3+].CC(C)CC1=CC=C(C(C)C([O-])=O)C=C1 IHHXIUAEPKVVII-ZSCHJXSPSA-N 0.000 claims 1
- 208000005298 acute pain Diseases 0.000 claims 1
- 229940000425 combination drug Drugs 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19382583.3 | 2019-07-09 | ||
| EP19382583 | 2019-07-09 | ||
| PCT/EP2020/069306 WO2021005129A1 (en) | 2019-07-09 | 2020-07-08 | Combination of ibuprofen and tramadol for relieving pain |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022540854A JP2022540854A (ja) | 2022-09-20 |
| JPWO2021005129A5 true JPWO2021005129A5 (https=) | 2023-07-19 |
| JP2022540854A5 JP2022540854A5 (https=) | 2023-07-19 |
| JP7656339B2 JP7656339B2 (ja) | 2025-04-03 |
Family
ID=67480112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022501259A Active JP7656339B2 (ja) | 2019-07-09 | 2020-07-08 | 疼痛を緩和するためのイブプロフェン及びトラマドールの組合せ |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US12514833B2 (https=) |
| EP (1) | EP3996699B1 (https=) |
| JP (1) | JP7656339B2 (https=) |
| CN (1) | CN114080221B (https=) |
| AU (1) | AU2020309160B2 (https=) |
| BR (1) | BR112022000242A2 (https=) |
| CA (1) | CA3145632C (https=) |
| DK (1) | DK3996699T3 (https=) |
| ES (1) | ES2952013T3 (https=) |
| FI (1) | FI3996699T3 (https=) |
| HR (1) | HRP20230677T1 (https=) |
| HU (1) | HUE062529T2 (https=) |
| MA (1) | MA56341B1 (https=) |
| MD (1) | MD3996699T2 (https=) |
| MX (1) | MX2022000373A (https=) |
| MY (1) | MY207573A (https=) |
| PL (1) | PL3996699T3 (https=) |
| PT (1) | PT3996699T (https=) |
| RS (1) | RS64500B1 (https=) |
| SI (1) | SI3996699T1 (https=) |
| WO (1) | WO2021005129A1 (https=) |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB971700A (en) | 1961-02-02 | 1964-09-30 | Boots Pure Drug Co Ltd | Anti-Inflammatory Agents |
| US3652589A (en) | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| GB1497044A (en) | 1974-03-07 | 1978-01-05 | Prodotti Antibiotici Spa | Salts of phenyl-alkanoic acids |
| US5516803A (en) * | 1991-10-30 | 1996-05-14 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
| AU661723B2 (en) | 1991-10-30 | 1995-08-03 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
| IT1264857B1 (it) | 1993-06-21 | 1996-10-17 | Zambon Spa | Composizione farmaceutica liquida per uso orale contenente acido 2-(4-isobutilfenil) propionico |
| IT1264855B1 (it) | 1993-06-21 | 1996-10-17 | Zambon Spa | Composizioni farmaceutiche contenenti sali dell'acido s(+)-2-(4-isobutilfenil) propionico con amminoacidi basici |
| US6348216B1 (en) | 1996-06-10 | 2002-02-19 | Knoll Pharmaceutical Company | Ibuprofen and narcotic analgesic compositions |
| WO2000025769A1 (en) | 1998-11-02 | 2000-05-11 | Ortho-Mcneil Pharmaceutical, Inc. | Analgesic regimen |
| US6251945B1 (en) | 1999-01-14 | 2001-06-26 | Knoll Aktiengesellschaft | Pharmaceutical mixture comprising a combination of a profen and other active compounds |
| US6211246B1 (en) | 1999-06-10 | 2001-04-03 | Mcneil-Ppc, Inc. | Rapidly absorbed liquid compositions |
| US6342530B1 (en) | 2000-11-14 | 2002-01-29 | Farmacon-Il, Llc | Composition and method for parenteral administration of ibuprofen d,l- or l-lysine salt |
| US6727286B2 (en) | 2001-11-02 | 2004-04-27 | Cumberland Pharmaceuticals Inc. | Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid |
| JP5185488B2 (ja) | 2001-11-02 | 2013-04-17 | カンバーランド ファーマシューティカルズ，インコーポレーテッド | ２−（４−イソブチルフェニル）プロピオン酸の医薬組成物 |
| ES2287519T3 (es) | 2002-10-25 | 2007-12-16 | Dompe S.P.A. | Composiciones inyectables indoloras que contienen sal de acidos 2-arilpropionicos. |
| US20070117826A1 (en) * | 2005-11-23 | 2007-05-24 | Forest Laboratories, Inc. | Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone |
| EP2149546A1 (en) * | 2008-07-31 | 2010-02-03 | Laboratorios Del. Dr. Esteve, S.A. | Salts of tramadol and ibuprofen and their crystal form in the treatment of pain |
| WO2010078486A2 (en) | 2008-12-31 | 2010-07-08 | Upsher-Smith Laboratories, Inc. | Opioid-containing oral pharmaceutical compositions and methods |
| AU2010224063B2 (en) | 2009-03-12 | 2015-04-16 | Cumberland Pharmaceuticals Inc | Administration of intravenous ibuprofen |
| US8735452B2 (en) | 2009-07-15 | 2014-05-27 | Cumberland Pharmaceuticals Inc. | Treating patients with intravenous ibuprofen |
| US8871810B2 (en) | 2009-07-15 | 2014-10-28 | Cumberland Pharmaceuticals Inc. | Treating critically ill patients with intravenous ibuprofen |
| ES2356762B1 (es) * | 2009-09-04 | 2011-11-24 | Farmalider S.A. | Composicion farmaceutica de ibuprofeno, tramadol y un aminoacido basico, procedimiento para su preparacion y utilizacion de la misma. |
| MX2010004974A (es) | 2010-05-04 | 2011-11-23 | Senosiain S A De C V Lab | Combinacion de un aine y un aminoacido. |
| CA2833307C (en) | 2011-04-12 | 2018-01-23 | Revogenex Inc. | Intravenous administration of tramadol |
| ES2552521T3 (es) | 2012-02-20 | 2015-11-30 | Pharmaceutical Solutions Industry Ltd | Infusión intravenosa de ibuprofeno |
| ES2423866B1 (es) | 2012-02-22 | 2014-06-10 | Farmalider, S.A. | Composición farmaceútica de ibuprofeno y tramadol para inyección |
| ES2540151B1 (es) * | 2013-10-11 | 2016-02-29 | Farmalider S.A. | Composición farmacéutica de ibuprofeno y tramadol para uso oftálmico |
| US20150290211A1 (en) * | 2014-04-10 | 2015-10-15 | Locl Pharma, Inc. | Pharmaceutical compositions |
-
2020
- 2020-07-08 SI SI202030232T patent/SI3996699T1/sl unknown
- 2020-07-08 JP JP2022501259A patent/JP7656339B2/ja active Active
- 2020-07-08 HR HRP20230677TT patent/HRP20230677T1/hr unknown
- 2020-07-08 MA MA56341A patent/MA56341B1/fr unknown
- 2020-07-08 HU HUE20740266A patent/HUE062529T2/hu unknown
- 2020-07-08 CN CN202080049962.XA patent/CN114080221B/zh active Active
- 2020-07-08 CA CA3145632A patent/CA3145632C/en active Active
- 2020-07-08 WO PCT/EP2020/069306 patent/WO2021005129A1/en not_active Ceased
- 2020-07-08 MX MX2022000373A patent/MX2022000373A/es unknown
- 2020-07-08 ES ES20740266T patent/ES2952013T3/es active Active
- 2020-07-08 FI FIEP20740266.0T patent/FI3996699T3/fi active
- 2020-07-08 DK DK20740266.0T patent/DK3996699T3/da active
- 2020-07-08 AU AU2020309160A patent/AU2020309160B2/en active Active
- 2020-07-08 PL PL20740266.0T patent/PL3996699T3/pl unknown
- 2020-07-08 EP EP20740266.0A patent/EP3996699B1/en active Active
- 2020-07-08 MD MDE20220551T patent/MD3996699T2/ro unknown
- 2020-07-08 RS RS20230732A patent/RS64500B1/sr unknown
- 2020-07-08 PT PT207402660T patent/PT3996699T/pt unknown
- 2020-07-08 BR BR112022000242A patent/BR112022000242A2/pt unknown
- 2020-07-08 MY MYPI2021007550A patent/MY207573A/en unknown
- 2020-07-08 US US17/624,601 patent/US12514833B2/en active Active
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