MD3996699T2 - Combinație de ibuprofen și tramadol pentru calmarea durerii - Google Patents
Combinație de ibuprofen și tramadol pentru calmarea dureriiInfo
- Publication number
- MD3996699T2 MD3996699T2 MDE20220551T MDE20220551T MD3996699T2 MD 3996699 T2 MD3996699 T2 MD 3996699T2 MD E20220551 T MDE20220551 T MD E20220551T MD E20220551 T MDE20220551 T MD E20220551T MD 3996699 T2 MD3996699 T2 MD 3996699T2
- Authority
- MD
- Moldova
- Prior art keywords
- combination
- tramadol
- ibuprofen
- dose
- pain
- Prior art date
Links
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 title abstract 4
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title abstract 4
- 229960001680 ibuprofen Drugs 0.000 title abstract 4
- 229960004380 tramadol Drugs 0.000 title abstract 4
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 abstract 2
- PPKXEPBICJTCRU-XMZRARIVSA-N (R,R)-tramadol hydrochloride Chemical compound Cl.COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 PPKXEPBICJTCRU-XMZRARIVSA-N 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 229940000425 combination drug Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960003107 tramadol hydrochloride Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Prezenta invenţie se referă la combinaţia de ibuprofen sub formă de sare acceptabilă farmaceutic şi tramadol sau o sare acceptabilă farmaceutic a acestuia, pentru utilizare în tratamentul durerii la oameni, în care doza de ibuprofen în combinaţie este cuprinsă între 350 mg şi 450 mg şi doza de tramadol este cuprinsă între 35 mg şi 40 mg, exprimată ca greutate echivalentă a clorhidratului de tramadol. Combinaţia este potrivită pentru tratamentul durerii moderate până la severe, de origine cronică sau acută şi este deosebit de eficientă pentru acei pacienţi care suferă de dureri mai intense. De asemenea, se referă la o compoziţie farmaceutică care cuprinde respectiva combinaţie în doză fixă de ibuprofen şi tramadol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19382583 | 2019-07-09 | ||
| PCT/EP2020/069306 WO2021005129A1 (en) | 2019-07-09 | 2020-07-08 | Combination of ibuprofen and tramadol for relieving pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD3996699T2 true MD3996699T2 (ro) | 2023-11-30 |
Family
ID=67480112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDE20220551T MD3996699T2 (ro) | 2019-07-09 | 2020-07-08 | Combinație de ibuprofen și tramadol pentru calmarea durerii |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20220249414A1 (ro) |
| EP (1) | EP3996699B1 (ro) |
| JP (1) | JP2022540854A (ro) |
| CN (1) | CN114080221B (ro) |
| AU (1) | AU2020309160A1 (ro) |
| BR (1) | BR112022000242A2 (ro) |
| CA (1) | CA3145632C (ro) |
| DK (1) | DK3996699T3 (ro) |
| ES (1) | ES2952013T3 (ro) |
| FI (1) | FI3996699T3 (ro) |
| HR (1) | HRP20230677T1 (ro) |
| HU (1) | HUE062529T2 (ro) |
| MA (1) | MA56341B1 (ro) |
| MD (1) | MD3996699T2 (ro) |
| MX (1) | MX2022000373A (ro) |
| PL (1) | PL3996699T3 (ro) |
| PT (1) | PT3996699T (ro) |
| RS (1) | RS64500B1 (ro) |
| SI (1) | SI3996699T1 (ro) |
| WO (1) | WO2021005129A1 (ro) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB971700A (en) | 1961-02-02 | 1964-09-30 | Boots Pure Drug Co Ltd | Anti-Inflammatory Agents |
| US3652589A (en) | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| GB1497044A (en) | 1974-03-07 | 1978-01-05 | Prodotti Antibiotici Spa | Salts of phenyl-alkanoic acids |
| US5516803A (en) * | 1991-10-30 | 1996-05-14 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
| AU661723B2 (en) * | 1991-10-30 | 1995-08-03 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
| EP2149546A1 (en) * | 2008-07-31 | 2010-02-03 | Laboratorios Del. Dr. Esteve, S.A. | Salts of tramadol and ibuprofen and their crystal form in the treatment of pain |
| ES2356762B1 (es) | 2009-09-04 | 2011-11-24 | Farmalider S.A. | Composicion farmaceutica de ibuprofeno, tramadol y un aminoacido basico, procedimiento para su preparacion y utilizacion de la misma. |
| ES2423866B1 (es) | 2012-02-22 | 2014-06-10 | Farmalider, S.A. | Composición farmaceútica de ibuprofeno y tramadol para inyección |
| ES2540151B1 (es) * | 2013-10-11 | 2016-02-29 | Farmalider S.A. | Composición farmacéutica de ibuprofeno y tramadol para uso oftálmico |
-
2020
- 2020-07-08 HU HUE20740266A patent/HUE062529T2/hu unknown
- 2020-07-08 MX MX2022000373A patent/MX2022000373A/es unknown
- 2020-07-08 PT PT207402660T patent/PT3996699T/pt unknown
- 2020-07-08 WO PCT/EP2020/069306 patent/WO2021005129A1/en active Application Filing
- 2020-07-08 EP EP20740266.0A patent/EP3996699B1/en active Active
- 2020-07-08 ES ES20740266T patent/ES2952013T3/es active Active
- 2020-07-08 JP JP2022501259A patent/JP2022540854A/ja active Pending
- 2020-07-08 HR HRP20230677TT patent/HRP20230677T1/hr unknown
- 2020-07-08 CA CA3145632A patent/CA3145632C/en active Active
- 2020-07-08 DK DK20740266.0T patent/DK3996699T3/da active
- 2020-07-08 MD MDE20220551T patent/MD3996699T2/ro unknown
- 2020-07-08 SI SI202030232T patent/SI3996699T1/sl unknown
- 2020-07-08 BR BR112022000242A patent/BR112022000242A2/pt unknown
- 2020-07-08 AU AU2020309160A patent/AU2020309160A1/en active Pending
- 2020-07-08 MA MA56341A patent/MA56341B1/fr unknown
- 2020-07-08 RS RS20230732A patent/RS64500B1/sr unknown
- 2020-07-08 PL PL20740266.0T patent/PL3996699T3/pl unknown
- 2020-07-08 US US17/624,601 patent/US20220249414A1/en active Pending
- 2020-07-08 FI FIEP20740266.0T patent/FI3996699T3/fi active
- 2020-07-08 CN CN202080049962.XA patent/CN114080221B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2020309160A1 (en) | 2022-02-17 |
| HUE062529T2 (hu) | 2023-11-28 |
| US20220249414A1 (en) | 2022-08-11 |
| DK3996699T3 (da) | 2023-07-24 |
| ES2952013T3 (es) | 2023-10-26 |
| FI3996699T3 (fi) | 2023-08-01 |
| MX2022000373A (es) | 2022-02-10 |
| CA3145632C (en) | 2024-03-12 |
| SI3996699T1 (sl) | 2023-10-30 |
| EP3996699A1 (en) | 2022-05-18 |
| EP3996699B1 (en) | 2023-06-28 |
| CA3145632A1 (en) | 2021-01-14 |
| WO2021005129A1 (en) | 2021-01-14 |
| MA56341B1 (fr) | 2023-07-31 |
| PL3996699T3 (pl) | 2023-10-30 |
| RS64500B1 (sr) | 2023-09-29 |
| JP2022540854A (ja) | 2022-09-20 |
| CN114080221B (zh) | 2023-12-05 |
| CN114080221A (zh) | 2022-02-22 |
| HRP20230677T1 (hr) | 2023-10-13 |
| PT3996699T (pt) | 2023-07-27 |
| BR112022000242A2 (pt) | 2022-05-31 |
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