CA3145632C - Combination of ibuprofen and tramadol for relieving pain - Google Patents

Combination of ibuprofen and tramadol for relieving pain Download PDF

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Publication number
CA3145632C
CA3145632C CA3145632A CA3145632A CA3145632C CA 3145632 C CA3145632 C CA 3145632C CA 3145632 A CA3145632 A CA 3145632A CA 3145632 A CA3145632 A CA 3145632A CA 3145632 C CA3145632 C CA 3145632C
Authority
CA
Canada
Prior art keywords
ibuprofen
combination
tramadol
pain
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3145632A
Other languages
English (en)
French (fr)
Other versions
CA3145632A1 (en
Inventor
Antonio Portoles Perez
Luis Narciso Sante Serna
Maria Del Rosario Salas Butron
Emilio VARGAS CASTRILLON
Carlos Calandria Perez
Raquel HORCAJADA CORDOBA
Angel Jose Munoz Ruiz
Marta Vicario De La Torre
Nuria Sanz Menendez
Antonia Gomez Calvo
Jose Angel Sanchez Garcia
Ester DUART GONZALEZ
Fernando Garcia Alonso
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Farmalider SA
Original Assignee
Farmalider SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmalider SA filed Critical Farmalider SA
Publication of CA3145632A1 publication Critical patent/CA3145632A1/en
Application granted granted Critical
Publication of CA3145632C publication Critical patent/CA3145632C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
CA3145632A 2019-07-09 2020-07-08 Combination of ibuprofen and tramadol for relieving pain Active CA3145632C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19382583.3 2019-07-09
EP19382583 2019-07-09
PCT/EP2020/069306 WO2021005129A1 (en) 2019-07-09 2020-07-08 Combination of ibuprofen and tramadol for relieving pain

Publications (2)

Publication Number Publication Date
CA3145632A1 CA3145632A1 (en) 2021-01-14
CA3145632C true CA3145632C (en) 2024-03-12

Family

ID=67480112

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3145632A Active CA3145632C (en) 2019-07-09 2020-07-08 Combination of ibuprofen and tramadol for relieving pain

Country Status (21)

Country Link
US (1) US12514833B2 (https=)
EP (1) EP3996699B1 (https=)
JP (1) JP7656339B2 (https=)
CN (1) CN114080221B (https=)
AU (1) AU2020309160B2 (https=)
BR (1) BR112022000242A2 (https=)
CA (1) CA3145632C (https=)
DK (1) DK3996699T3 (https=)
ES (1) ES2952013T3 (https=)
FI (1) FI3996699T3 (https=)
HR (1) HRP20230677T1 (https=)
HU (1) HUE062529T2 (https=)
MA (1) MA56341B1 (https=)
MD (1) MD3996699T2 (https=)
MX (1) MX2022000373A (https=)
MY (1) MY207573A (https=)
PL (1) PL3996699T3 (https=)
PT (1) PT3996699T (https=)
RS (1) RS64500B1 (https=)
SI (1) SI3996699T1 (https=)
WO (1) WO2021005129A1 (https=)

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971700A (en) 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents
US3652589A (en) 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
GB1497044A (en) 1974-03-07 1978-01-05 Prodotti Antibiotici Spa Salts of phenyl-alkanoic acids
US5516803A (en) * 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
AU661723B2 (en) 1991-10-30 1995-08-03 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
IT1264857B1 (it) 1993-06-21 1996-10-17 Zambon Spa Composizione farmaceutica liquida per uso orale contenente acido 2-(4-isobutilfenil) propionico
IT1264855B1 (it) 1993-06-21 1996-10-17 Zambon Spa Composizioni farmaceutiche contenenti sali dell'acido s(+)-2-(4-isobutilfenil) propionico con amminoacidi basici
US6348216B1 (en) 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
WO2000025769A1 (en) 1998-11-02 2000-05-11 Ortho-Mcneil Pharmaceutical, Inc. Analgesic regimen
US6251945B1 (en) 1999-01-14 2001-06-26 Knoll Aktiengesellschaft Pharmaceutical mixture comprising a combination of a profen and other active compounds
US6211246B1 (en) 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions
US6342530B1 (en) 2000-11-14 2002-01-29 Farmacon-Il, Llc Composition and method for parenteral administration of ibuprofen d,l- or l-lysine salt
US6727286B2 (en) 2001-11-02 2004-04-27 Cumberland Pharmaceuticals Inc. Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid
JP5185488B2 (ja) 2001-11-02 2013-04-17 カンバーランド ファーマシューティカルズ，インコーポレーテッド ２−（４−イソブチルフェニル）プロピオン酸の医薬組成物
ES2287519T3 (es) 2002-10-25 2007-12-16 Dompe S.P.A. Composiciones inyectables indoloras que contienen sal de acidos 2-arilpropionicos.
US20070117826A1 (en) * 2005-11-23 2007-05-24 Forest Laboratories, Inc. Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
EP2149546A1 (en) * 2008-07-31 2010-02-03 Laboratorios Del. Dr. Esteve, S.A. Salts of tramadol and ibuprofen and their crystal form in the treatment of pain
WO2010078486A2 (en) 2008-12-31 2010-07-08 Upsher-Smith Laboratories, Inc. Opioid-containing oral pharmaceutical compositions and methods
AU2010224063B2 (en) 2009-03-12 2015-04-16 Cumberland Pharmaceuticals Inc Administration of intravenous ibuprofen
US8735452B2 (en) 2009-07-15 2014-05-27 Cumberland Pharmaceuticals Inc. Treating patients with intravenous ibuprofen
US8871810B2 (en) 2009-07-15 2014-10-28 Cumberland Pharmaceuticals Inc. Treating critically ill patients with intravenous ibuprofen
ES2356762B1 (es) * 2009-09-04 2011-11-24 Farmalider S.A. Composicion farmaceutica de ibuprofeno, tramadol y un aminoacido basico, procedimiento para su preparacion y utilizacion de la misma.
MX2010004974A (es) 2010-05-04 2011-11-23 Senosiain S A De C V Lab Combinacion de un aine y un aminoacido.
CA2833307C (en) 2011-04-12 2018-01-23 Revogenex Inc. Intravenous administration of tramadol
ES2552521T3 (es) 2012-02-20 2015-11-30 Pharmaceutical Solutions Industry Ltd Infusión intravenosa de ibuprofeno
ES2423866B1 (es) 2012-02-22 2014-06-10 Farmalider, S.A. Composición farmaceútica de ibuprofeno y tramadol para inyección
ES2540151B1 (es) * 2013-10-11 2016-02-29 Farmalider S.A. Composición farmacéutica de ibuprofeno y tramadol para uso oftálmico
US20150290211A1 (en) * 2014-04-10 2015-10-15 Locl Pharma, Inc. Pharmaceutical compositions

Also Published As

Publication number Publication date
EP3996699A1 (en) 2022-05-18
EP3996699B1 (en) 2023-06-28
SI3996699T1 (sl) 2023-10-30
AU2020309160B2 (en) 2025-06-26
WO2021005129A1 (en) 2021-01-14
PT3996699T (pt) 2023-07-27
MA56341B1 (fr) 2023-07-31
HUE062529T2 (hu) 2023-11-28
CN114080221A (zh) 2022-02-22
US12514833B2 (en) 2026-01-06
DK3996699T3 (da) 2023-07-24
BR112022000242A2 (pt) 2022-05-31
RS64500B1 (sr) 2023-09-29
MY207573A (en) 2025-03-05
HRP20230677T1 (hr) 2023-10-13
MX2022000373A (es) 2022-02-10
PL3996699T3 (pl) 2023-10-30
JP7656339B2 (ja) 2025-04-03
AU2020309160A1 (en) 2022-02-17
FI3996699T3 (fi) 2023-08-01
CA3145632A1 (en) 2021-01-14
JP2022540854A (ja) 2022-09-20
CN114080221B (zh) 2023-12-05
MD3996699T2 (ro) 2023-11-30
ES2952013T3 (es) 2023-10-26
US20220249414A1 (en) 2022-08-11

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