CN114080221B - 用于减轻疼痛的布洛芬与曲马多的组合 - Google Patents

用于减轻疼痛的布洛芬与曲马多的组合 Download PDF

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Publication number
CN114080221B
CN114080221B CN202080049962.XA CN202080049962A CN114080221B CN 114080221 B CN114080221 B CN 114080221B CN 202080049962 A CN202080049962 A CN 202080049962A CN 114080221 B CN114080221 B CN 114080221B
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CN
China
Prior art keywords
ibuprofen
tramadol
pain
arginine
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
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CN202080049962.XA
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English (en)
Chinese (zh)
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CN114080221A (zh
Inventor
安东尼奥·波托莱斯佩雷斯
路易斯·纳西索·桑特塞尔纳
玛利亚·戴尔·罗萨里奥·萨拉斯布特龙
埃米利奥·巴尔加斯卡斯特里隆
卡洛斯·卡兰德里亚佩雷斯
拉克尔·奥卡哈达科尔多巴
安格尔·何塞·穆尼奥斯鲁伊斯
玛尔塔·比卡里奥德拉托雷
努里亚·桑斯梅嫩德斯
安东尼娅·戈麦斯卡尔沃
何塞·安格尔·桑切斯加西亚
埃斯特尔·杜阿尔特冈萨雷斯
费尔南多·加西亚阿隆索
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Farmalider SA
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Farmalider SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
CN202080049962.XA 2019-07-09 2020-07-08 用于减轻疼痛的布洛芬与曲马多的组合 Active CN114080221B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19382583.3 2019-07-09
EP19382583 2019-07-09
PCT/EP2020/069306 WO2021005129A1 (en) 2019-07-09 2020-07-08 Combination of ibuprofen and tramadol for relieving pain

Publications (2)

Publication Number Publication Date
CN114080221A CN114080221A (zh) 2022-02-22
CN114080221B true CN114080221B (zh) 2023-12-05

Family

ID=67480112

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080049962.XA Active CN114080221B (zh) 2019-07-09 2020-07-08 用于减轻疼痛的布洛芬与曲马多的组合

Country Status (21)

Country Link
US (1) US12514833B2 (https=)
EP (1) EP3996699B1 (https=)
JP (1) JP7656339B2 (https=)
CN (1) CN114080221B (https=)
AU (1) AU2020309160B2 (https=)
BR (1) BR112022000242A2 (https=)
CA (1) CA3145632C (https=)
DK (1) DK3996699T3 (https=)
ES (1) ES2952013T3 (https=)
FI (1) FI3996699T3 (https=)
HR (1) HRP20230677T1 (https=)
HU (1) HUE062529T2 (https=)
MA (1) MA56341B1 (https=)
MD (1) MD3996699T2 (https=)
MX (1) MX2022000373A (https=)
MY (1) MY207573A (https=)
PL (1) PL3996699T3 (https=)
PT (1) PT3996699T (https=)
RS (1) RS64500B1 (https=)
SI (1) SI3996699T1 (https=)
WO (1) WO2021005129A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516803A (en) * 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
WO2011027009A1 (es) * 2009-09-04 2011-03-10 Farmalider, S.A. Composición farmacéutica de ibuprofeno, tramadol y un aminoácido básico, procedimiento para su preparación y utilización de la misma

Family Cites Families (26)

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Publication number Priority date Publication date Assignee Title
GB971700A (en) 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents
US3652589A (en) 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
GB1497044A (en) 1974-03-07 1978-01-05 Prodotti Antibiotici Spa Salts of phenyl-alkanoic acids
AU661723B2 (en) 1991-10-30 1995-08-03 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
IT1264857B1 (it) 1993-06-21 1996-10-17 Zambon Spa Composizione farmaceutica liquida per uso orale contenente acido 2-(4-isobutilfenil) propionico
IT1264855B1 (it) 1993-06-21 1996-10-17 Zambon Spa Composizioni farmaceutiche contenenti sali dell'acido s(+)-2-(4-isobutilfenil) propionico con amminoacidi basici
US6348216B1 (en) 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
WO2000025769A1 (en) 1998-11-02 2000-05-11 Ortho-Mcneil Pharmaceutical, Inc. Analgesic regimen
US6251945B1 (en) 1999-01-14 2001-06-26 Knoll Aktiengesellschaft Pharmaceutical mixture comprising a combination of a profen and other active compounds
US6211246B1 (en) 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions
US6342530B1 (en) 2000-11-14 2002-01-29 Farmacon-Il, Llc Composition and method for parenteral administration of ibuprofen d,l- or l-lysine salt
US6727286B2 (en) 2001-11-02 2004-04-27 Cumberland Pharmaceuticals Inc. Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid
JP5185488B2 (ja) 2001-11-02 2013-04-17 カンバーランド ファーマシューティカルズ，インコーポレーテッド ２−（４−イソブチルフェニル）プロピオン酸の医薬組成物
ES2287519T3 (es) 2002-10-25 2007-12-16 Dompe S.P.A. Composiciones inyectables indoloras que contienen sal de acidos 2-arilpropionicos.
US20070117826A1 (en) * 2005-11-23 2007-05-24 Forest Laboratories, Inc. Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
EP2149546A1 (en) * 2008-07-31 2010-02-03 Laboratorios Del. Dr. Esteve, S.A. Salts of tramadol and ibuprofen and their crystal form in the treatment of pain
WO2010078486A2 (en) 2008-12-31 2010-07-08 Upsher-Smith Laboratories, Inc. Opioid-containing oral pharmaceutical compositions and methods
AU2010224063B2 (en) 2009-03-12 2015-04-16 Cumberland Pharmaceuticals Inc Administration of intravenous ibuprofen
US8735452B2 (en) 2009-07-15 2014-05-27 Cumberland Pharmaceuticals Inc. Treating patients with intravenous ibuprofen
US8871810B2 (en) 2009-07-15 2014-10-28 Cumberland Pharmaceuticals Inc. Treating critically ill patients with intravenous ibuprofen
MX2010004974A (es) 2010-05-04 2011-11-23 Senosiain S A De C V Lab Combinacion de un aine y un aminoacido.
CA2833307C (en) 2011-04-12 2018-01-23 Revogenex Inc. Intravenous administration of tramadol
ES2552521T3 (es) 2012-02-20 2015-11-30 Pharmaceutical Solutions Industry Ltd Infusión intravenosa de ibuprofeno
ES2423866B1 (es) 2012-02-22 2014-06-10 Farmalider, S.A. Composición farmaceútica de ibuprofeno y tramadol para inyección
ES2540151B1 (es) * 2013-10-11 2016-02-29 Farmalider S.A. Composición farmacéutica de ibuprofeno y tramadol para uso oftálmico
US20150290211A1 (en) * 2014-04-10 2015-10-15 Locl Pharma, Inc. Pharmaceutical compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516803A (en) * 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
WO2011027009A1 (es) * 2009-09-04 2011-03-10 Farmalider, S.A. Composición farmacéutica de ibuprofeno, tramadol y un aminoácido básico, procedimiento para su preparación y utilización de la misma
EP2474309A1 (en) * 2009-09-04 2012-07-11 Farmalider, S.A. Pharmaceutical composition comprising ibuprofen, tramadol and a basic amino acid, preparation method thereof and use of same

Also Published As

Publication number Publication date
EP3996699A1 (en) 2022-05-18
EP3996699B1 (en) 2023-06-28
SI3996699T1 (sl) 2023-10-30
AU2020309160B2 (en) 2025-06-26
WO2021005129A1 (en) 2021-01-14
PT3996699T (pt) 2023-07-27
MA56341B1 (fr) 2023-07-31
HUE062529T2 (hu) 2023-11-28
CN114080221A (zh) 2022-02-22
US12514833B2 (en) 2026-01-06
DK3996699T3 (da) 2023-07-24
BR112022000242A2 (pt) 2022-05-31
CA3145632C (en) 2024-03-12
RS64500B1 (sr) 2023-09-29
MY207573A (en) 2025-03-05
HRP20230677T1 (hr) 2023-10-13
MX2022000373A (es) 2022-02-10
PL3996699T3 (pl) 2023-10-30
JP7656339B2 (ja) 2025-04-03
AU2020309160A1 (en) 2022-02-17
FI3996699T3 (fi) 2023-08-01
CA3145632A1 (en) 2021-01-14
JP2022540854A (ja) 2022-09-20
MD3996699T2 (ro) 2023-11-30
ES2952013T3 (es) 2023-10-26
US20220249414A1 (en) 2022-08-11

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