JPWO2020243415A5 - - Google Patents

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JPWO2020243415A5
JPWO2020243415A5 JP2021570918A JP2021570918A JPWO2020243415A5 JP WO2020243415 A5 JPWO2020243415 A5 JP WO2020243415A5 JP 2021570918 A JP2021570918 A JP 2021570918A JP 2021570918 A JP2021570918 A JP 2021570918A JP WO2020243415 A5 JPWO2020243415 A5 JP WO2020243415A5
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Japan
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compound
pharmaceutically acceptable
acceptable salt
formula
aliphatic
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JP2021570918A
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Japanese (ja)
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JP2022534426A (ja
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Priority claimed from PCT/US2020/035098 external-priority patent/WO2020243415A2/en
Publication of JP2022534426A publication Critical patent/JP2022534426A/ja
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JP2021570918A 2019-05-31 2020-05-29 Tead阻害剤およびその使用 Pending JP2022534426A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962855082P 2019-05-31 2019-05-31
US62/855,082 2019-05-31
US201962928931P 2019-10-31 2019-10-31
US62/928,931 2019-10-31
US201962944567P 2019-12-06 2019-12-06
US62/944,567 2019-12-06
US202063025219P 2020-05-15 2020-05-15
US63/025,219 2020-05-15
PCT/US2020/035098 WO2020243415A2 (en) 2019-05-31 2020-05-29 Tead inhibitors and uses thereof

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JP2022534426A JP2022534426A (ja) 2022-07-29
JPWO2020243415A5 true JPWO2020243415A5 (US07943609-20110517-C00101.png) 2023-06-06

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JP2021570918A Pending JP2022534426A (ja) 2019-05-31 2020-05-29 Tead阻害剤およびその使用

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US (3) US11274082B2 (US07943609-20110517-C00101.png)
EP (1) EP3976194A2 (US07943609-20110517-C00101.png)
JP (1) JP2022534426A (US07943609-20110517-C00101.png)
KR (1) KR20220030222A (US07943609-20110517-C00101.png)
CN (1) CN114466839A (US07943609-20110517-C00101.png)
AU (1) AU2020282757A1 (US07943609-20110517-C00101.png)
BR (1) BR112021024108A2 (US07943609-20110517-C00101.png)
CA (1) CA3142351A1 (US07943609-20110517-C00101.png)
CL (1) CL2021003190A1 (US07943609-20110517-C00101.png)
CO (1) CO2021016015A2 (US07943609-20110517-C00101.png)
IL (1) IL288384A (US07943609-20110517-C00101.png)
MX (1) MX2021014443A (US07943609-20110517-C00101.png)
SG (1) SG11202113129UA (US07943609-20110517-C00101.png)
TW (1) TW202108571A (US07943609-20110517-C00101.png)
WO (1) WO2020243415A2 (US07943609-20110517-C00101.png)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114502540A (zh) 2019-05-31 2022-05-13 医肯纳肿瘤学公司 Tead抑制剂和其用途
JP2022534426A (ja) 2019-05-31 2022-07-29 イケナ オンコロジー, インコーポレイテッド Tead阻害剤およびその使用
KR20220027871A (ko) 2019-05-31 2022-03-08 얀센 파마슈티카 엔.브이. NF-kB 유도 키나아제의 소분자 억제제
WO2022120353A1 (en) * 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead inhibitors and uses thereof
WO2022120355A1 (en) * 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead degraders and uses thereof
CA3205726A1 (en) 2021-01-25 2022-07-28 Alfredo C. Castro Combination of a 3-(imidazol-4-yl)-4-(amino)-benzenesulfonamide tead inhibitor with an egfr inhibitor and/or mek inhibitor for use in the treatment of lung cancer
US20240083903A1 (en) * 2021-02-18 2024-03-14 Merck Sharp & Dohme Llc Aryl ether compounds as tead modulators
CN113072479A (zh) * 2021-03-26 2021-07-06 罗田县新普生药业有限公司 一种从褪黑素结晶母液中提取褪黑素的方法
JP2024514879A (ja) 2021-04-16 2024-04-03 イケナ オンコロジー, インコーポレイテッド Mek阻害剤及びその使用
WO2022258040A1 (zh) * 2021-06-11 2022-12-15 武汉人福创新药物研发中心有限公司 用于tead抑制剂的杂环化合物
CN115594680A (zh) * 2021-07-07 2023-01-13 武汉人福创新药物研发中心有限公司(Cn) 一种tead抑制剂
WO2023031781A1 (en) 2021-09-01 2023-03-09 Novartis Ag Pharmaceutical combinations comprising a tead inhibitor and uses thereof for the treatment of cancers
AU2022340987A1 (en) 2021-09-01 2024-01-18 Novartis Ag Dosing regimen for a tead inhibitor
WO2023060227A1 (en) 2021-10-07 2023-04-13 Ikena Oncology, Inc. Tead inhibitors and uses thereof
WO2023114984A1 (en) 2021-12-17 2023-06-22 Ikena Oncology, Inc. Tead inhibitors and uses thereof
TW202340180A (zh) * 2022-01-30 2023-10-16 大陸商希格生科(深圳)有限公司 三環化合物及其應用
WO2023173053A1 (en) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Mek inhibitors and uses thereof
WO2023173057A1 (en) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Mek inhibitors and uses thereof
US20230339851A1 (en) * 2022-03-21 2023-10-26 Chemocentryx, Inc. Cxcr6 sulfonamide compounds
WO2023204822A1 (en) * 2022-04-22 2023-10-26 Vivace Therapeutics, Inc. Phenyl phosphine oxide compounds and methods of use thereof
WO2023211889A1 (en) 2022-04-25 2023-11-02 Ikena Oncology, Inc. Polymorphic compounds and uses thereof
TW202404581A (zh) 2022-05-25 2024-02-01 美商醫肯納腫瘤學公司 Mek抑制劑及其用途
CN117756855A (zh) * 2022-09-23 2024-03-26 杭州天玑济世生物科技有限公司 具有磷酰化芳基结构的小分子化合物及其应用
KR20240051859A (ko) 2022-10-13 2024-04-22 한미약품 주식회사 Yap-tead 상호작용 억제를 위한 신규한 헤테로비시클릭 화합물 및 이를 포함하는 약학적 조성물
WO2024080792A1 (en) 2022-10-13 2024-04-18 Hanmi Pharm. Co., Ltd. Novel heterobicyclic compound for inhibiting yap-tead interaction and pharmaceutical composition comprising same
WO2024092116A1 (en) 2022-10-26 2024-05-02 Ikena Oncology, Inc. Combination of tead inhibitors and egfr inhibitors and uses thereof
WO2024099435A1 (zh) * 2022-11-10 2024-05-16 武汉人福创新药物研发中心有限公司 Tead抑制剂
US20240197715A1 (en) 2022-11-18 2024-06-20 Novartis Ag Pharmaceutical combinations and uses thereof

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3120564A (en) 1960-01-13 1964-02-04 American Cyanamid Co Alkenoylamino benzophenones
ZA825719B (en) 1981-09-03 1983-06-29 Recordati Chem Pharm Alkanoylanilides
JPS58179838A (ja) 1982-04-14 1983-10-21 Konishiroku Photo Ind Co Ltd 画像形成方法
US5256791A (en) 1992-03-02 1993-10-26 Pfizer Inc. Preparation of intermediates in the synthesis of quinoline antibiotics
DE4341403A1 (de) 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
US5475116A (en) 1994-04-29 1995-12-12 Pfizer Inc. Aza bicyclo[3,1,0]hexane intermediates useful in the synthesis of quinolones
JPH0912547A (ja) 1995-06-23 1997-01-14 Chisso Corp ニューキノロン系化合物中間体の製造方法
AU1671597A (en) 1996-02-13 1997-09-02 Chugai Seiyaku Kabushiki Kaisha Indole derivatives
JPH1072434A (ja) * 1996-04-08 1998-03-17 Nissan Chem Ind Ltd 2,4−置換アニリン誘導体
US5968929A (en) 1996-10-30 1999-10-19 Schering Corporation Piperazino derivatives as neurokinin antagonists
US6184380B1 (en) 1999-01-25 2001-02-06 Pfizer Inc. Process for preparing naphthyridones and intermediates
US7019142B2 (en) 1998-01-16 2006-03-28 Pfizer Inc. Process for preparing naphthyridones and intermediates
US6590118B1 (en) 1999-09-29 2003-07-08 Novo Nordisk A/S Aromatic compounds
HUP0301391A3 (en) 2000-02-11 2010-03-29 Vertex Pharma Piperazine and piperidine derivatives pharmaceutical compositions containing them and their use
ATE324365T1 (de) * 2000-08-31 2006-05-15 Pfizer Phenoxyphenylheterozyklen als serotonin- wiederaufnahmehemmer
MXPA03003475A (es) 2000-10-19 2003-07-14 Pfizer Prod Inc Derivados puente de piperazina.
AU2002226634B2 (en) 2001-03-30 2007-01-25 Pfizer Products Inc. Pyridazinone aldose reductase inhibitors
MXPA04001286A (es) * 2001-08-15 2004-05-27 Du Pont Arilamidas orto-heterociclicas sustituidas para controlar plagas de invertebrados.
US20040034019A1 (en) 2002-08-08 2004-02-19 Ronald Tomlinson Piperazine and piperidine derivatives
US20040082641A1 (en) 2002-10-28 2004-04-29 Rytved Klaus Asger Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases
EP1558245A2 (en) 2002-10-28 2005-08-03 Novo Nordisk A/S Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases
WO2004052857A1 (en) 2002-12-10 2004-06-24 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives as muscarinic receptor antagonists
WO2004056811A1 (en) 2002-12-23 2004-07-08 Ranbaxy Laboratories Limited Flavaxate derivatives as muscarinic receptor antagonists
EP1590345A1 (en) 2002-12-23 2005-11-02 Ranbaxy Laboratories, Ltd. Xanthine derivatives as muscarinic receptor antagonists
US7488748B2 (en) 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2004281794B2 (en) 2003-10-14 2010-04-22 Pfizer Products Inc. Bicyclic [3.1.0] derivatives as glycine transporter inhibitors
CN1922139B (zh) 2004-02-18 2010-12-29 杏林制药株式会社 双环酰胺衍生物
CN101005838A (zh) 2004-06-22 2007-07-25 先灵公司 大麻素受体配体
DE102004039280A1 (de) * 2004-08-13 2006-02-23 Merck Patent Gmbh 1,5-Diphenyl-pyrazole
WO2006024955A1 (en) 2004-09-01 2006-03-09 Pfizer Products Inc. Azabicyclic amine histamine-3 receptor antagonists
US20100016400A1 (en) 2004-11-19 2010-01-21 Naresh Kumar Azabicyclic muscarinic receptor antagonists
CN1944398A (zh) 2005-01-11 2007-04-11 中国医学科学院药物研究所 新的苯甲酰胺类化合物及其制法和药物用途
JP4193949B2 (ja) 2005-04-08 2008-12-10 ファイザー・プロダクツ・インク I型グリシン輸送阻害剤としての二環式[3.1.0]ヘテロアリールアミド
US20090124600A1 (en) 2005-04-19 2009-05-14 Layton Mark E N-Alkyl-Azacycloalkyl NMDA/NR2B Antagonists
EP1891063B1 (en) 2005-05-10 2012-07-25 Vertex Pharmaceuticals, Inc. Bicyclic derivatives as modulators of ion channels
GB0510204D0 (en) 2005-05-19 2005-06-22 Chroma Therapeutics Ltd Enzyme inhibitors
EP1931633A2 (en) 2005-09-05 2008-06-18 Ranbaxy Laboratories Limited Derivatives of 3-azabicyclo[3.1.0]hexane as dipeptidyl peptidase-iv inhibitors
US20090221664A1 (en) 2005-10-19 2009-09-03 Abhijit Ray Pharmaceutical compositions of muscarinic receptor antagonists
US7560551B2 (en) 2006-01-23 2009-07-14 Amgen Inc. Aurora kinase modulators and method of use
WO2008010061A2 (en) 2006-07-17 2008-01-24 Glenmark Pharmaceuticals S.A. 3-azabicyclo [3.1.0] hexane vanilloid receptor ligands, pharmaceutical compositions containing them, and processes for their preparation
WO2008010238A2 (en) 2006-07-21 2008-01-24 Lupin Limited Antidiabetic azabicyclo [3. 1. 0] hexan compounds
EP2059505A2 (en) 2006-09-04 2009-05-20 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
JP2010513458A (ja) 2006-12-19 2010-04-30 ファイザー・プロダクツ・インク H−pgdsの阻害剤としてのニコチンアミド誘導体、およびプロスタグランジンd2の仲介による疾患を治療するためのその使用
EP2132196A1 (en) 2007-02-26 2009-12-16 Pfizer Products Inc. Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases
WO2008117229A1 (en) 2007-03-23 2008-10-02 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
PA8802501A1 (es) 2007-10-31 2009-06-23 Janssen Pharmaceutica Nv Diaminas en puente o fusionadas sustituidas con arilo como moduladores de leucotrieno, hidrolasa
WO2009152027A1 (en) 2008-06-12 2009-12-17 Merck & Co., Inc. 5,7-dihydro-6h-pyrrolo[2,3-d]pyrimidin-6-one derivatives for mark inhibition
NZ592425A (en) 2008-10-29 2013-04-26 Celgene Corp Isoindoline compounds for use in the treatment of cancer
US9149465B2 (en) 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
AR076687A1 (es) 2009-05-18 2011-06-29 Infinity Pharmaceuticals Inc Isoxazolinas como inhibidores de la amidahidrolasa de acidos grasos y com-posiciones farmaceuticas que los contienen
CN103140134B (zh) 2010-07-23 2015-07-29 默沙东公司 新吡咯烷衍生的β3肾上腺素能受体激动剂
WO2013018929A1 (en) 2011-08-04 2013-02-07 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound
US9527830B2 (en) 2011-09-16 2016-12-27 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
TWI566701B (zh) 2012-02-01 2017-01-21 日本農藥股份有限公司 芳烷氧基嘧啶衍生物及包含該衍生物作為有效成分的農園藝用殺蟲劑及其使用方法
EP2925322B1 (en) 2012-11-29 2018-10-24 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
CN105188705A (zh) 2013-03-13 2015-12-23 密歇根大学董事会 包含噻吩并嘧啶和噻吩并吡啶化合物的组合物及其使用方法
BR112015022483A2 (pt) 2013-03-14 2017-07-18 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inibidores de idh mutante
KR101556318B1 (ko) 2013-05-15 2015-10-01 한국과학기술연구원 칼슘이온 채널 조절제로서 유효한 6-피라졸일아미도-3-치환된 아자바이사이클로[3.1.0]헥산 유도체
WO2014199164A1 (en) 2013-06-12 2014-12-18 Ampla Pharmaceuticals, Inc. Diaryl substituted heteroaromatic compounds
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
US10696642B2 (en) 2015-09-23 2020-06-30 The General Hospital Corporation TEAD transcription factor autopalmitoylation inhibitors
WO2017096045A1 (en) 2015-12-02 2017-06-08 Kyras Therapeutics, Inc. Multivalent ras binding compounds
KR20180094923A (ko) 2015-12-24 2018-08-24 교와 핫꼬 기린 가부시키가이샤 α, β 불포화 아미드 화합물
PE20190176A1 (es) 2016-05-31 2019-02-01 Chiesi Farm Spa Compuestos de imidazolona como inhibidores de la elastasa de neutrofilos humana
KR102014320B1 (ko) 2016-06-27 2019-08-26 (주)목우연구소 이속사졸린 고리를 포함하는 피리딘계 화합물 및 제초제로서의 이의 용도
US10793504B2 (en) 2016-08-23 2020-10-06 Recurium Ip Holdings, Llc Methods for cross coupling
AU2017341723B2 (en) 2016-10-11 2021-12-16 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of androgen receptor
WO2018102751A1 (en) 2016-12-02 2018-06-07 Quentis Therapeutics, Inc. Ire1 small molecule inhibitors
CN111132673A (zh) 2017-05-03 2020-05-08 维瓦斯治疗公司 非稠合三环化合物
US20200095236A1 (en) 2017-05-10 2020-03-26 Forge Therapeutics, Inc. Antibacterial compounds
JP7221202B2 (ja) 2017-06-23 2023-02-13 協和キリン株式会社 α、β不飽和アミド化合物
US11192865B2 (en) * 2017-08-21 2021-12-07 Vivace Therapeutics, Inc. Benzosulfonyl compounds
TWI793151B (zh) 2017-08-23 2023-02-21 瑞士商諾華公司 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途
TW201920108A (zh) 2017-09-25 2019-06-01 日商武田藥品工業有限公司 N-(氰基取代之苄基或吡啶基甲基)-3-羥基吡啶醯胺衍生物
US10287222B1 (en) 2017-10-20 2019-05-14 Uop Llc Process and apparatus for desorbent recovery
SG11202003827YA (en) 2017-11-01 2020-05-28 Bristol Myers Squibb Co Bridged bicyclic compounds as farnesoid x receptor modulators
ES2944657T3 (es) 2017-11-01 2023-06-23 Bristol Myers Squibb Co Compuestos de alqueno como moduladores del receptor farnesoide X
US11524943B1 (en) 2017-12-06 2022-12-13 Vivace Therapeutics, Inc. Benzocarbonyl compounds
WO2019152809A1 (en) 2018-02-02 2019-08-08 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
WO2019195959A1 (en) 2018-04-08 2019-10-17 Cothera Biosciences, Inc. Combination therapy for cancers with braf mutation
WO2019204505A2 (en) 2018-04-18 2019-10-24 Theras, Inc. K-ras modulators with a vinyl sulfonamide moiety
WO2019232216A1 (en) 2018-05-31 2019-12-05 Genentech, Inc. Therapeutic compounds
CN112805267B (zh) 2018-09-03 2024-03-08 豪夫迈·罗氏有限公司 用作tead调节剂的甲酰胺和磺酰胺衍生物
WO2020073031A1 (en) 2018-10-05 2020-04-09 New York University Fused bicyclic heterocycles as thereapeutic agents
US20220402869A1 (en) 2018-10-15 2022-12-22 Dana-Farber Cancer Institute, Inc. Transcriptional enhanced associate domain (tead) transcription factor inhibitors and uses thereof
CN113412259A (zh) 2018-10-15 2021-09-17 紐力克斯治疗公司 通过泛素蛋白酶体途径降解btk的双官能化合物
WO2020087063A1 (en) 2018-10-26 2020-04-30 The Trustees Of Indiana University Compounds and methods to attenuate tumor progression and metastasis
US20220144807A1 (en) 2019-02-15 2022-05-12 Novartis Ag 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
CN113811300A (zh) 2019-03-15 2021-12-17 总医院公司 Tead转录因子的新型小分子抑制剂
WO2020206137A1 (en) 2019-04-04 2020-10-08 Dana-Farber Cancer Institute, Inc. Cdk2/5 degraders and uses thereof
CA3132387A1 (en) 2019-04-23 2020-10-29 Dana-Farber Cancer Institute, Inc. Degraders of cyclin-dependent kinase 12 (cdk12) and uses thereof
JP2022534426A (ja) 2019-05-31 2022-07-29 イケナ オンコロジー, インコーポレイテッド Tead阻害剤およびその使用
CN114502540A (zh) 2019-05-31 2022-05-13 医肯纳肿瘤学公司 Tead抑制剂和其用途
MX2022005775A (es) 2019-11-13 2022-06-09 Genentech Inc Compuestos terapeuticos y metodos de uso.
CN115103670A (zh) 2019-12-24 2022-09-23 达纳-法伯癌症研究所股份有限公司 转录增强相关结构域(tead)转录因子抑制剂及其用途
EP4114830A1 (en) 2020-03-04 2023-01-11 Genentech, Inc. Heterobifunctional molecules as tead inhibitors
EP4164752A1 (en) 2020-06-03 2023-04-19 Dana-Farber Cancer Institute, Inc. Inhibitors of transcriptional enhanced associate domain (tead) and uses thereof
WO2022120353A1 (en) 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead inhibitors and uses thereof
KR20230131189A (ko) 2020-12-02 2023-09-12 이케나 온콜로지, 인코포레이티드 Tead 억제제 및 이의 용도
WO2022120355A1 (en) 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead degraders and uses thereof
CA3205726A1 (en) 2021-01-25 2022-07-28 Alfredo C. Castro Combination of a 3-(imidazol-4-yl)-4-(amino)-benzenesulfonamide tead inhibitor with an egfr inhibitor and/or mek inhibitor for use in the treatment of lung cancer

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