JPWO2020236841A5 - - Google Patents
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- JPWO2020236841A5 JPWO2020236841A5 JP2021568944A JP2021568944A JPWO2020236841A5 JP WO2020236841 A5 JPWO2020236841 A5 JP WO2020236841A5 JP 2021568944 A JP2021568944 A JP 2021568944A JP 2021568944 A JP2021568944 A JP 2021568944A JP WO2020236841 A5 JPWO2020236841 A5 JP WO2020236841A5
- Authority
- JP
- Japan
- Prior art keywords
- attachment
- point
- indicates
- nhc
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962850094P | 2019-05-20 | 2019-05-20 | |
| US62/850,094 | 2019-05-20 | ||
| PCT/US2020/033648 WO2020236841A2 (en) | 2019-05-20 | 2020-05-19 | Antibody drug conjugates having linkers comprising hydrophilic groups |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022533215A JP2022533215A (ja) | 2022-07-21 |
| JPWO2020236841A5 true JPWO2020236841A5 (de) | 2023-05-26 |
Family
ID=71070004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021568944A Pending JP2022533215A (ja) | 2019-05-20 | 2020-05-19 | 親水性基を含むリンカーを有する抗体薬剤コンジュゲート |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230091510A1 (de) |
| EP (1) | EP3972650A2 (de) |
| JP (1) | JP2022533215A (de) |
| KR (1) | KR20220010527A (de) |
| CN (1) | CN113853219A (de) |
| AU (1) | AU2020279731A1 (de) |
| CA (1) | CA3140063A1 (de) |
| IL (1) | IL287596A (de) |
| WO (1) | WO2020236841A2 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022228494A1 (zh) * | 2021-04-29 | 2022-11-03 | 上海汇连生物医药有限公司 | 抗体偶联药物的制备方法及应用 |
| EP4349373A1 (de) | 2021-06-01 | 2024-04-10 | Ajinomoto Co., Inc. | Konjugat aus antikörper und funktioneller substanz oder salz dieses konjugats und verbindung zur verwendung bei der herstellung dieses konjugats oder salzes dieser verbindung |
| CN117295524A (zh) * | 2021-06-02 | 2023-12-26 | 百奥泰生物制药股份有限公司 | 药物偶联物及其用途 |
| WO2022262516A1 (zh) * | 2021-06-18 | 2022-12-22 | 北京海步医药科技有限公司 | 连接子及其缀合物 |
| WO2023198079A1 (zh) * | 2022-04-12 | 2023-10-19 | 百奥泰生物制药股份有限公司 | 治疗her2阳性实体瘤的方法 |
| WO2023223097A1 (en) * | 2022-05-20 | 2023-11-23 | Novartis Ag | Antibody drug conjugates |
| WO2024083162A1 (en) * | 2022-10-19 | 2024-04-25 | Multitude Therapeutics Inc. | Antibodies, antibody-drug conjugates, preparations and uses thereof |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US4880078A (en) | 1987-06-29 | 1989-11-14 | Honda Giken Kogyo Kabushiki Kaisha | Exhaust muffler |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| JPH06507404A (ja) | 1991-05-01 | 1994-08-25 | ヘンリー エム．ジャクソン ファウンデイション フォー ザ アドバンスメント オブ ミリタリー メディスン | 感染性の呼吸性疾患の治療方法 |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| CA2118508A1 (en) | 1992-04-24 | 1993-11-11 | Elizabeth S. Ward | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
| US5934272A (en) | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
| JPH08511420A (ja) | 1993-06-16 | 1996-12-03 | セルテック・セラピューテイクス・リミテッド | 抗 体 |
| US6132764A (en) | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| JP2000506165A (ja) | 1996-03-04 | 2000-05-23 | ザ ペン ステイト リサーチ ファウンデーション | 細胞インターナリゼーションを増強するための物質および方法 |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| ATE287257T1 (de) | 1997-01-16 | 2005-02-15 | Massachusetts Inst Technology | Zubereitung von partikelhaltigen arzneimitteln zur inhalation |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| WO1998052976A1 (en) | 1997-05-21 | 1998-11-26 | Biovation Limited | Method for the production of non-immunogenic proteins |
| CA2293632C (en) | 1997-06-12 | 2011-11-29 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| PT1071700E (pt) | 1998-04-20 | 2010-04-23 | Glycart Biotechnology Ag | Modificação por glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
| ES2198922T3 (es) | 1998-06-24 | 2004-02-01 | Advanced Inhalation Research, Inc. | Particulas porosas grandes emitadas por un inhalador. |
| PL209786B1 (pl) | 1999-01-15 | 2011-10-31 | Genentech Inc | Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna |
| ES2569919T3 (es) | 1999-04-09 | 2016-05-13 | Kyowa Hakko Kirin Co., Ltd. | Procedimiento para controlar la actividad de una molécula inmunofuncional |
| BR0213761A (pt) | 2001-10-25 | 2005-04-12 | Genentech Inc | Composições, preparação farmacêutica, artigo industrializado, método de tratamento de mamìferos, célula hospedeira, método para a produção de uma glicoproteìna e uso da composição |
| CA2766405A1 (en) | 2009-06-22 | 2011-01-13 | Medimmune, Llc | Engineered fc regions for site-specific conjugation |
| ES2732574T3 (es) | 2012-11-30 | 2019-11-25 | Novartis Ag | Métodos para preparar conjugados a partir de proteínas que contienen disulfuro |
| WO2014100762A1 (en) * | 2012-12-21 | 2014-06-26 | Biolliance C.V. | Hydrophilic self-immolative linkers and conjugates thereof |
| PL2953976T3 (pl) | 2013-02-08 | 2021-11-02 | Novartis Ag | Specyficzne miejsca modyfikowania przeciwciał dla wytwarzania immunokoniugatów |
| KR102645430B1 (ko) | 2013-10-15 | 2024-03-11 | 씨젠 인크. | 개선된 리간드-약물 컨쥬게이트 약물동력학을 위한 peg화된 약물-링커 |
| US20190194315A1 (en) | 2015-06-17 | 2019-06-27 | Novartis Ag | Antibody drug conjugates |
| CN108066772B (zh) * | 2016-11-14 | 2021-07-13 | 中国科学院上海药物研究所 | 靶向tacstd2的抗体与药物偶联体(adc)分子 |
| US11135307B2 (en) * | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
-
2020
- 2020-05-19 CN CN202080036837.5A patent/CN113853219A/zh active Pending
- 2020-05-19 US US17/612,280 patent/US20230091510A1/en active Pending
- 2020-05-19 CA CA3140063A patent/CA3140063A1/en active Pending
- 2020-05-19 AU AU2020279731A patent/AU2020279731A1/en active Pending
- 2020-05-19 KR KR1020217041090A patent/KR20220010527A/ko unknown
- 2020-05-19 WO PCT/US2020/033648 patent/WO2020236841A2/en unknown
- 2020-05-19 EP EP20731697.7A patent/EP3972650A2/de active Pending
- 2020-05-19 JP JP2021568944A patent/JP2022533215A/ja active Pending
-
2021
- 2021-10-26 IL IL287596A patent/IL287596A/en unknown
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