JPWO2020216764A5 - - Google Patents
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- Publication number
- JPWO2020216764A5 JPWO2020216764A5 JP2021562991A JP2021562991A JPWO2020216764A5 JP WO2020216764 A5 JPWO2020216764 A5 JP WO2020216764A5 JP 2021562991 A JP2021562991 A JP 2021562991A JP 2021562991 A JP2021562991 A JP 2021562991A JP WO2020216764 A5 JPWO2020216764 A5 JP WO2020216764A5
- Authority
- JP
- Japan
- Prior art keywords
- same
- different
- pharmaceutically acceptable
- acetamide
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 29
- 150000001875 compounds Chemical class 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 21
- 239000012453 solvate Substances 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 19
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 10
- -1 6-chloro-5-fluoropyridin-3-yl Chemical group 0.000 claims 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 150000004677 hydrates Chemical class 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 4
- 230000001154 acute effect Effects 0.000 claims 3
- 230000001684 chronic effect Effects 0.000 claims 3
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 125000003373 pyrazinyl group Chemical group 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000002098 pyridazinyl group Chemical group 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 125000004504 1,2,4-oxadiazolyl group Chemical group 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical group C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- IVBBBIDJXUVYDT-WBMJQRKESA-N ClC1=C(C=C(OCC(=O)N[C@H]2CO[C@@H](CC2)C=2OC(=NN=2)C2=CC(=NC=C2)C(F)(F)F)C=C1)F Chemical compound ClC1=C(C=C(OCC(=O)N[C@H]2CO[C@@H](CC2)C=2OC(=NN=2)C2=CC(=NC=C2)C(F)(F)F)C=C1)F IVBBBIDJXUVYDT-WBMJQRKESA-N 0.000 claims 1
- POMBSLBTSQDVGH-WBMJQRKESA-N ClC1=C(C=C(OCC(=O)N[C@H]2CO[C@@H](CC2)C=2OC(=NN=2)C=2C=NC(=CC=2)C(F)(F)F)C=C1)F Chemical compound ClC1=C(C=C(OCC(=O)N[C@H]2CO[C@@H](CC2)C=2OC(=NN=2)C=2C=NC(=CC=2)C(F)(F)F)C=C1)F POMBSLBTSQDVGH-WBMJQRKESA-N 0.000 claims 1
- MZAFWAFYNVFRBW-DYVFJYSZSA-N ClC1=C(C=C(OCC(=O)N[C@H]2CO[C@@H](CC2)C=2OC(=NN=2)C=2C=NC=C(C=2)C(F)(F)F)C=C1)F Chemical compound ClC1=C(C=C(OCC(=O)N[C@H]2CO[C@@H](CC2)C=2OC(=NN=2)C=2C=NC=C(C=2)C(F)(F)F)C=C1)F MZAFWAFYNVFRBW-DYVFJYSZSA-N 0.000 claims 1
- FIVLVLOBJROMRT-WBVHZDCISA-N ClC1=CC=C(C=C1)C1=NN=C(O1)[C@@H]1CC[C@H](CO1)NC(COC=1C=NC=C(C=1)C(F)(F)F)=O Chemical compound ClC1=CC=C(C=C1)C1=NN=C(O1)[C@@H]1CC[C@H](CO1)NC(COC=1C=NC=C(C=1)C(F)(F)F)=O FIVLVLOBJROMRT-WBVHZDCISA-N 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- WRYCSMQKUKOKBP-UHFFFAOYSA-N Imidazolidine Chemical compound C1CNCN1 WRYCSMQKUKOKBP-UHFFFAOYSA-N 0.000 claims 1
- 201000006347 Intellectual Disability Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 208000023178 Musculoskeletal disease Diseases 0.000 claims 1
- 208000022873 Ocular disease Diseases 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- 230000006793 arrhythmia Effects 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical group C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 208000036546 leukodystrophy Diseases 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 230000003938 response to stress Effects 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 150000003852 triazoles Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19170502.9 | 2019-04-23 | ||
| EP19170502 | 2019-04-23 | ||
| PCT/EP2020/061148 WO2020216764A1 (en) | 2019-04-23 | 2020-04-22 | Modulators of the integrated stress response pathway |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022530051A JP2022530051A (ja) | 2022-06-27 |
| JPWO2020216764A5 true JPWO2020216764A5 (https=) | 2023-04-27 |
| JP2022530051A5 JP2022530051A5 (https=) | 2023-04-27 |
| JP7588089B2 JP7588089B2 (ja) | 2024-11-21 |
Family
ID=66248567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021562991A Active JP7588089B2 (ja) | 2019-04-23 | 2020-04-22 | 統合ストレス応答経路のモジュレーター |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20220213078A1 (https=) |
| EP (1) | EP3959210A1 (https=) |
| JP (1) | JP7588089B2 (https=) |
| CN (1) | CN114008041A (https=) |
| AU (1) | AU2020262153B2 (https=) |
| BR (1) | BR112021020106A2 (https=) |
| CA (1) | CA3137212A1 (https=) |
| EA (1) | EA202192900A1 (https=) |
| IL (1) | IL287378B2 (https=) |
| MX (1) | MX2021012904A (https=) |
| SG (1) | SG11202111362SA (https=) |
| WO (1) | WO2020216764A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111757739A (zh) | 2017-12-13 | 2020-10-09 | 普拉西斯生物技术有限责任公司 | 整合应激反应路径抑制剂 |
| AU2019282253A1 (en) | 2018-06-05 | 2020-11-26 | Altos Labs, Inc. | Inhibitors of integrated stress response pathway |
| WO2020252207A1 (en) | 2019-06-12 | 2020-12-17 | Praxis Biotech LLC | Modulators of integrated stress response pathway |
| CN115190813B (zh) | 2020-03-11 | 2024-10-15 | 埃沃特克国际有限责任公司 | 整合应激反应途径的调节剂 |
| EP4232153A1 (en) | 2020-10-22 | 2023-08-30 | Evotec International GmbH | Modulators of the integrated stress response pathway |
| RS66455B1 (sr) | 2020-10-22 | 2025-02-28 | Evotec Int Gmbh | Modulatori puta integrisanog odgovora na stres |
| EP4232447A1 (en) | 2020-10-22 | 2023-08-30 | Evotec International GmbH | Modulators of the integrated stress response pathway |
| AU2023384649A1 (en) * | 2022-11-21 | 2025-05-22 | Shenzhen Zhongge Biological Technology Co., Ltd. | Compound, pharmaceutical composition containing same, synthesis method therefor and use thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105209460A (zh) * | 2013-03-14 | 2015-12-30 | 诺华股份有限公司 | 作为突变idh抑制剂的3-嘧啶-4-基-噁唑烷-2-酮化合物 |
| CA2904794C (en) | 2013-03-15 | 2021-11-23 | Peter Walter | Modulators of the eif2alpha pathway |
| TW201808888A (zh) | 2016-05-05 | 2018-03-16 | 嘉來克生命科學有限責任公司 | 整合應激途徑之調節劑 |
| TW201808914A (zh) * | 2016-05-05 | 2018-03-16 | 嘉來克生命科學有限責任公司 | 整合應激途徑之調節劑 |
| TWI763668B (zh) | 2016-05-05 | 2022-05-11 | 美商嘉來克生命科學有限責任公司 | 整合應激途徑之調節劑 |
| TW201808903A (zh) | 2016-05-05 | 2018-03-16 | 嘉來克生命科學有限責任公司 | 整合應激途徑之調節劑 |
| KR20190015492A (ko) | 2016-06-08 | 2019-02-13 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 화학적 화합물 |
| US20190298705A1 (en) * | 2016-06-08 | 2019-10-03 | Glaxosmithkline Intellectual Property Development Limited | Chemical Compounds |
| WO2018225093A1 (en) | 2017-06-07 | 2018-12-13 | Glaxosmithkline Intellectual Property Development Limited | Chemical compounds as atf4 pathway inhibitors |
| EP3649108A1 (en) | 2017-07-03 | 2020-05-13 | GlaxoSmithKline Intellectual Property Development Limited | 2-(4-chlorophenoxy)-n-((1 -(2-(4-chlorophenoxy)ethynazetidin-3-yl)methyl)acetamide derivatives and related compounds as atf4 inhibitors for treating cancer and other diseases |
| BR112020000122A2 (pt) | 2017-07-03 | 2020-07-07 | Glaxosmithkline Intellectual Property Development Limited | derivados da n-(3-(2-(4-clorofenóxi)acetamido)biciclo[1.1.1] pentan-1-il)-2-ciclobutano-1-carboxamida e compostos relacionados como inibidores do atf4 para tratamento contra o câncer e outras doenças |
| CA3071024A1 (en) | 2017-08-09 | 2019-02-14 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| CN111201245B (zh) * | 2017-09-01 | 2024-04-05 | 戴纳立制药公司 | 化合物、组合物和方法 |
| WO2019090074A1 (en) | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| UY37957A (es) | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| AU2018358157B2 (en) | 2017-11-02 | 2023-03-09 | Abbvie Inc. | Modulators of the integrated stress pathway |
| UY37958A (es) | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| UY37956A (es) | 2017-11-02 | 2019-05-31 | Abbvie Inc | Moduladores de la vía de estrés integrada |
| WO2019090090A1 (en) | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| WO2019090088A1 (en) | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| CA3080808A1 (en) | 2017-11-02 | 2019-05-09 | Calico Life Sciences Llc | Modulators of the integrated stress pathway |
| JP2021501781A (ja) | 2017-11-02 | 2021-01-21 | カリコ ライフ サイエンシーズ エルエルシー | 統合的ストレス経路の調節剤 |
| CN111757739A (zh) | 2017-12-13 | 2020-10-09 | 普拉西斯生物技术有限责任公司 | 整合应激反应路径抑制剂 |
| WO2019183589A1 (en) | 2018-03-23 | 2019-09-26 | Denali Therapeutics Inc. | Modulators of eukaryotic initiation factor 2 |
| WO2019193540A1 (en) | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Heteroaryl derivatives of formula (i) as atf4 inhibitors |
| WO2019193541A1 (en) | 2018-04-06 | 2019-10-10 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic aromatic ring derivatives of formula (i) as atf4 inhibitors |
| WO2020181247A1 (en) * | 2019-03-06 | 2020-09-10 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| EP3959198A1 (en) * | 2019-04-23 | 2022-03-02 | Evotec International GmbH | Modulators of the integrated stress response pathway |
-
2020
- 2020-04-22 MX MX2021012904A patent/MX2021012904A/es unknown
- 2020-04-22 BR BR112021020106A patent/BR112021020106A2/pt unknown
- 2020-04-22 WO PCT/EP2020/061148 patent/WO2020216764A1/en not_active Ceased
- 2020-04-22 CA CA3137212A patent/CA3137212A1/en active Pending
- 2020-04-22 US US17/605,369 patent/US20220213078A1/en active Pending
- 2020-04-22 EA EA202192900A patent/EA202192900A1/ru unknown
- 2020-04-22 EP EP20719209.7A patent/EP3959210A1/en active Pending
- 2020-04-22 JP JP2021562991A patent/JP7588089B2/ja active Active
- 2020-04-22 AU AU2020262153A patent/AU2020262153B2/en active Active
- 2020-04-22 SG SG11202111362SA patent/SG11202111362SA/en unknown
- 2020-04-22 CN CN202080046012.1A patent/CN114008041A/zh active Pending
- 2020-04-22 IL IL287378A patent/IL287378B2/en unknown
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