JPWO2020124059A5 - - Google Patents
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- Publication number
- JPWO2020124059A5 JPWO2020124059A5 JP2021532155A JP2021532155A JPWO2020124059A5 JP WO2020124059 A5 JPWO2020124059 A5 JP WO2020124059A5 JP 2021532155 A JP2021532155 A JP 2021532155A JP 2021532155 A JP2021532155 A JP 2021532155A JP WO2020124059 A5 JPWO2020124059 A5 JP WO2020124059A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- cycloalkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 26
- 125000003118 aryl group Chemical group 0.000 claims 21
- 125000001072 heteroaryl group Chemical group 0.000 claims 21
- 125000000753 cycloalkyl group Chemical group 0.000 claims 20
- 125000000623 heterocyclic group Chemical group 0.000 claims 18
- 125000001188 haloalkyl group Chemical group 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 125000003545 alkoxy group Chemical group 0.000 claims 14
- 239000000651 prodrug Substances 0.000 claims 14
- 229940002612 prodrug Drugs 0.000 claims 14
- 239000012453 solvate Substances 0.000 claims 14
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 150000002367 halogens Chemical group 0.000 claims 12
- -1 nitro, hydroxy Chemical group 0.000 claims 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 12
- 150000002431 hydrogen Chemical class 0.000 claims 9
- DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical compound NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 claims 8
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000011057 Breast sarcoma Diseases 0.000 claims 1
- 208000005243 Chondrosarcoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 201000008808 Fibrosarcoma Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010061332 Paraganglion neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 101710196623 Stimulator of interferon genes protein Proteins 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 208000007312 paraganglioma Diseases 0.000 claims 1
- 201000009530 periosteal chondrosarcoma Diseases 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 201000008205 supratentorial primitive neuroectodermal tumor Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862779907P | 2018-12-14 | 2018-12-14 | |
| US62/779,907 | 2018-12-14 | ||
| PCT/US2019/066413 WO2020124059A1 (en) | 2018-12-14 | 2019-12-14 | Tricyclic compounds as sting agonists, and preparation methods and medicinal uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022511540A JP2022511540A (ja) | 2022-01-31 |
| JP2022511540A5 JP2022511540A5 (https=) | 2022-12-19 |
| JPWO2020124059A5 true JPWO2020124059A5 (https=) | 2022-12-19 |
Family
ID=71077552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021532155A Pending JP2022511540A (ja) | 2018-12-14 | 2019-12-14 | Ｓｔｉｎｇアゴニストとしての三環式化合物、ならびにその調製方法および医薬用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20220056044A1 (https=) |
| EP (1) | EP3873896A4 (https=) |
| JP (1) | JP2022511540A (https=) |
| CN (1) | CN113195473B (https=) |
| TW (1) | TW202039508A (https=) |
| WO (1) | WO2020124059A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111655682B (zh) * | 2018-08-29 | 2024-05-31 | 杭州阿诺生物医药科技有限公司 | 一种高活性sting蛋白激动剂化合物 |
| WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
| CN119110800A (zh) * | 2022-02-21 | 2024-12-10 | 健道生物医药有限公司 | 干扰素基因刺激因子（sting）调节剂及其组合物和方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2747678B1 (fr) * | 1996-04-22 | 1998-05-22 | Synthelabo | Composes derives d'imidazobenzoxazine, leurs procedes de preparation et leurs utilisations en therapeutique |
| ECSP003637A (es) * | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
| KR20080035576A (ko) * | 2005-08-05 | 2008-04-23 | 아스트라제네카 아베 | 트리사이클릭 벤즈이미다졸 및 대사체 글루타메이트 수용체조절제로서 이들의 용도 |
| GB201220157D0 (en) * | 2012-11-08 | 2012-12-26 | Selvita Sa | Substitute tricyclic benzimidazoles as kinase inhibitors |
| MX366703B (es) * | 2013-03-15 | 2019-07-22 | Incyte Holdings Corp | Heterociclos tricíclicos como inhibidores de la proteína bet. |
| HRP20220936T1 (hr) * | 2016-04-07 | 2022-10-28 | Glaxosmithkline Intellectual Property Development Limited | Heterociklički amidi korisni kao modulatori proteina |
| JP2021530442A (ja) * | 2018-06-28 | 2021-11-11 | ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co., Ltd. | 縮合三環系複素環化合物およびその治療上の使用 |
| CN111655682B (zh) * | 2018-08-29 | 2024-05-31 | 杭州阿诺生物医药科技有限公司 | 一种高活性sting蛋白激动剂化合物 |
-
2019
- 2019-12-14 WO PCT/US2019/066413 patent/WO2020124059A1/en not_active Ceased
- 2019-12-14 EP EP19895133.7A patent/EP3873896A4/en not_active Withdrawn
- 2019-12-14 US US17/413,287 patent/US20220056044A1/en not_active Abandoned
- 2019-12-14 CN CN201980081825.1A patent/CN113195473B/zh active Active
- 2019-12-14 JP JP2021532155A patent/JP2022511540A/ja active Pending
- 2019-12-16 TW TW108146054A patent/TW202039508A/zh unknown
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