JP2021523169A5 - - Google Patents
Info
- Publication number
- JP2021523169A5 JP2021523169A5 JP2020563505A JP2020563505A JP2021523169A5 JP 2021523169 A5 JP2021523169 A5 JP 2021523169A5 JP 2020563505 A JP2020563505 A JP 2020563505A JP 2020563505 A JP2020563505 A JP 2020563505A JP 2021523169 A5 JP2021523169 A5 JP 2021523169A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- composition
- ch2oc
- och3
- sch
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862667540P | 2018-05-06 | 2018-05-06 | |
| US62/667,540 | 2018-05-06 | ||
| PCT/US2019/030771 WO2019217250A1 (en) | 2018-05-06 | 2019-05-05 | Combination compositions comprising bisfluoroalkyl-1,4- benzodiazepinone compounds and methods of use thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021523169A JP2021523169A (ja) | 2021-09-02 |
| JP2021523169A5 true JP2021523169A5 (https=) | 2022-04-19 |
| JPWO2019217250A5 JPWO2019217250A5 (https=) | 2022-04-19 |
| JP7522661B2 JP7522661B2 (ja) | 2024-07-25 |
Family
ID=68468208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020563505A Active JP7522661B2 (ja) | 2018-05-06 | 2019-05-05 | ビスフルオロアルキル－１，４－ベンゾジアゼピノン化合物を含む組み合わせ組成物およびその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20210244745A1 (https=) |
| EP (1) | EP3790552A4 (https=) |
| JP (1) | JP7522661B2 (https=) |
| KR (1) | KR20210005714A (https=) |
| CN (1) | CN112218639A (https=) |
| AU (2) | AU2019266150A1 (https=) |
| BR (1) | BR112020022654A2 (https=) |
| CA (1) | CA3099479A1 (https=) |
| IL (1) | IL278492B2 (https=) |
| MX (1) | MX2020011826A (https=) |
| SG (1) | SG11202011041YA (https=) |
| WO (1) | WO2019217250A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022241095A1 (en) * | 2021-05-13 | 2022-11-17 | Ayala Pharmaceuticals Inc. | Compositions comprising bisfluoroalkyl-1,4-benzodiazepinone compounds for treating cancer |
| US20220339162A1 (en) * | 2018-05-06 | 2022-10-27 | Ayala Pharmaceuticals Inc. | Bisfluoroalkyl-1,4-benzodiazepinone compounds for treating desmoid tumors |
| WO2019215585A1 (en) * | 2018-05-06 | 2019-11-14 | Ayala Pharmaceuticals Inc. | Compositions comprising cd20 inhibitors and bisfluoroalkyl-1,4-benzodiazepinone compounds and methods of use thereof |
| CN118750499A (zh) | 2018-05-15 | 2024-10-11 | 艾雅拉制药公司 | 用于治疗腺样囊性癌的包含双氟烷基-1,4-苯并二氮杂䓬酮化合物的组合物 |
| SG11202011589WA (en) * | 2018-05-24 | 2020-12-30 | Ayala Pharmaceuticals Inc | Compositions comprising bisfluoroalkyl-1,4-benzodiazepinone compounds and immunotherapeutics and methods of use thereof |
| SG11202112061RA (en) * | 2019-05-15 | 2021-11-29 | Ayala Pharmaceuticals Inc | Bisfluoroalkyl-1,4-benzodiazepin one compounds for treating notch-activated breast cancer |
| EP4337204A4 (en) * | 2021-05-13 | 2025-04-16 | Ayala Pharmaceuticals Inc. | COMPOSITIONS COMPRISING BISFLUOROALKYL-1,4-BENZODIAZEPINONE COMPOUNDS FOR THE TREATMENT OF CANCER |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2885B1 (en) * | 2008-12-22 | 2015-03-15 | ايلي ليلي اند كومباني | Protein kinase inhibitors |
| US20140357605A1 (en) * | 2012-03-22 | 2014-12-04 | Bristol-Myers Squibb Company | Bis(fluoroalkyl)-1,4-benzodiazepinone compounds |
| TWI530489B (zh) | 2011-03-22 | 2016-04-21 | 必治妥美雅史谷比公司 | 雙（氟烷基）－１，４－苯二氮呯酮化合物 |
| AR087107A1 (es) * | 2011-07-27 | 2014-02-12 | Lilly Co Eli | Compuesto inhibidor de la señalizacion de la trayectoria notch |
| US9763956B2 (en) | 2012-06-19 | 2017-09-19 | The Broad Institute, Inc. | Diagnostic and treatment methods in subjects having or at risk of developing resistance to cancer therapy |
| WO2014047391A1 (en) * | 2012-09-21 | 2014-03-27 | Bristol-Myers Squibb Company | Prodrugs of 1,4-benzodiazepinone compounds |
| TWI614238B (zh) * | 2012-09-21 | 2018-02-11 | 必治妥美雅史谷比公司 | 雙（氟烷基）－１，４－苯并二氮呯酮化合物及其前藥 |
| WO2014165718A1 (en) * | 2013-04-04 | 2014-10-09 | Bristol-Myers Squibb Company | Combination therapy for the treatment of proliferative diseases |
| WO2015082583A1 (en) * | 2013-12-05 | 2015-06-11 | F. Hoffmann-La Roche Ag | Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality |
| WO2016070051A2 (en) * | 2014-10-31 | 2016-05-06 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| ES3057783T3 (en) * | 2016-03-15 | 2026-03-04 | Oryzon Genomics Sa | Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases |
| ES2881801T3 (es) | 2016-04-12 | 2021-11-30 | Lilly Co Eli | Terapia de combinación con inhibidores de Notch y CDK4/6 para su uso en el tratamiento de cáncer de pulmón |
| US20190185559A1 (en) * | 2016-09-02 | 2019-06-20 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating neoplasias |
| IL268349B2 (en) * | 2017-02-17 | 2024-08-01 | Hutchinson Fred Cancer Res | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| WO2018201056A1 (en) * | 2017-04-28 | 2018-11-01 | Novartis Ag | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
| EP3615068A1 (en) * | 2017-04-28 | 2020-03-04 | Novartis AG | Bcma-targeting agent, and combination therapy with a gamma secretase inhibitor |
| WO2019094626A1 (en) * | 2017-11-08 | 2019-05-16 | Fred Hutchinson Cancer Research Center | Bispecific antibody compositions and related methods for improved pretargeted radioimunotherapies |
-
2019
- 2019-05-05 CA CA3099479A patent/CA3099479A1/en active Pending
- 2019-05-05 KR KR1020207034548A patent/KR20210005714A/ko not_active Ceased
- 2019-05-05 WO PCT/US2019/030771 patent/WO2019217250A1/en not_active Ceased
- 2019-05-05 CN CN201980036073.7A patent/CN112218639A/zh active Pending
- 2019-05-05 JP JP2020563505A patent/JP7522661B2/ja active Active
- 2019-05-05 MX MX2020011826A patent/MX2020011826A/es unknown
- 2019-05-05 US US17/052,812 patent/US20210244745A1/en not_active Abandoned
- 2019-05-05 AU AU2019266150A patent/AU2019266150A1/en not_active Abandoned
- 2019-05-05 BR BR112020022654-8A patent/BR112020022654A2/pt not_active Application Discontinuation
- 2019-05-05 SG SG11202011041YA patent/SG11202011041YA/en unknown
- 2019-05-05 IL IL278492A patent/IL278492B2/en unknown
- 2019-05-05 EP EP19800442.6A patent/EP3790552A4/en not_active Withdrawn
-
2020
- 2020-10-22 US US17/077,857 patent/US12281085B2/en active Active
-
2025
- 2025-03-07 AU AU2025201674A patent/AU2025201674A1/en active Pending
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