TW202039508A - 作為sting促效劑之三環化合物及其製備方法及醫藥用途 - Google Patents

作為sting促效劑之三環化合物及其製備方法及醫藥用途 Download PDF

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Publication number
TW202039508A
TW202039508A TW108146054A TW108146054A TW202039508A TW 202039508 A TW202039508 A TW 202039508A TW 108146054 A TW108146054 A TW 108146054A TW 108146054 A TW108146054 A TW 108146054A TW 202039508 A TW202039508 A TW 202039508A
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TW
Taiwan
Prior art keywords
group
compound
alkyl
pharmaceutically acceptable
cis
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TW108146054A
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English (en)
Chinese (zh)
Inventor
東 劉
李璞慧
凌航 莊
鳳岐 張
磊 陳
張鑫竹
宋春英
蘇星 劉
馬修 米勒
齊悅 胡
閆玉娜
敬 李
峰 賀
維康 陶
Original Assignee
美商永恒生物科技公司
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Application filed by 美商永恒生物科技公司 filed Critical 美商永恒生物科技公司
Publication of TW202039508A publication Critical patent/TW202039508A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW108146054A 2018-12-14 2019-12-16 作為sting促效劑之三環化合物及其製備方法及醫藥用途 TW202039508A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862779907P 2018-12-14 2018-12-14
US62/779,907 2018-12-14

Publications (1)

Publication Number Publication Date
TW202039508A true TW202039508A (zh) 2020-11-01

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TW108146054A TW202039508A (zh) 2018-12-14 2019-12-16 作為sting促效劑之三環化合物及其製備方法及醫藥用途

Country Status (6)

Country Link
US (1) US20220056044A1 (https=)
EP (1) EP3873896A4 (https=)
JP (1) JP2022511540A (https=)
CN (1) CN113195473B (https=)
TW (1) TW202039508A (https=)
WO (1) WO2020124059A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111655682B (zh) * 2018-08-29 2024-05-31 杭州阿诺生物医药科技有限公司 一种高活性sting蛋白激动剂化合物
WO2021206158A1 (ja) 2020-04-10 2021-10-14 小野薬品工業株式会社 がん治療方法
CN119110800A (zh) * 2022-02-21 2024-12-10 健道生物医药有限公司 干扰素基因刺激因子(sting)调节剂及其组合物和方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2747678B1 (fr) * 1996-04-22 1998-05-22 Synthelabo Composes derives d'imidazobenzoxazine, leurs procedes de preparation et leurs utilisations en therapeutique
ECSP003637A (es) * 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
KR20080035576A (ko) * 2005-08-05 2008-04-23 아스트라제네카 아베 트리사이클릭 벤즈이미다졸 및 대사체 글루타메이트 수용체조절제로서 이들의 용도
GB201220157D0 (en) * 2012-11-08 2012-12-26 Selvita Sa Substitute tricyclic benzimidazoles as kinase inhibitors
MX366703B (es) * 2013-03-15 2019-07-22 Incyte Holdings Corp Heterociclos tricíclicos como inhibidores de la proteína bet.
HRP20220936T1 (hr) * 2016-04-07 2022-10-28 Glaxosmithkline Intellectual Property Development Limited Heterociklički amidi korisni kao modulatori proteina
JP2021530442A (ja) * 2018-06-28 2021-11-11 ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co., Ltd. 縮合三環系複素環化合物およびその治療上の使用
CN111655682B (zh) * 2018-08-29 2024-05-31 杭州阿诺生物医药科技有限公司 一种高活性sting蛋白激动剂化合物

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Publication number Publication date
US20220056044A1 (en) 2022-02-24
CN113195473A (zh) 2021-07-30
EP3873896A4 (en) 2022-08-31
WO2020124059A1 (en) 2020-06-18
JP2022511540A (ja) 2022-01-31
EP3873896A1 (en) 2021-09-08
CN113195473B (zh) 2022-11-22

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