CN113195473B - 三环化合物作为sting激动剂及其制备方法和医药用途 - Google Patents

三环化合物作为sting激动剂及其制备方法和医药用途 Download PDF

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Publication number
CN113195473B
CN113195473B CN201980081825.1A CN201980081825A CN113195473B CN 113195473 B CN113195473 B CN 113195473B CN 201980081825 A CN201980081825 A CN 201980081825A CN 113195473 B CN113195473 B CN 113195473B
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China
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compound
formula
alkyl
pharmaceutically acceptable
acceptable salt
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Chinese (zh)
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CN113195473A (zh
Inventor
刘�东
李璞慧
庄凌航
张凤岐
陈磊
张鑫竹
宋春英
刘苏星
马修·米勒
胡齐悦
闫玉娜
李敬
贺峰
陶维康
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201980081825.1A 2018-12-14 2019-12-14 三环化合物作为sting激动剂及其制备方法和医药用途 Active CN113195473B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862779907P 2018-12-14 2018-12-14
US62/779,907 2018-12-14
PCT/US2019/066413 WO2020124059A1 (en) 2018-12-14 2019-12-14 Tricyclic compounds as sting agonists, and preparation methods and medicinal uses thereof

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CN113195473A CN113195473A (zh) 2021-07-30
CN113195473B true CN113195473B (zh) 2022-11-22

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US (1) US20220056044A1 (https=)
EP (1) EP3873896A4 (https=)
JP (1) JP2022511540A (https=)
CN (1) CN113195473B (https=)
TW (1) TW202039508A (https=)
WO (1) WO2020124059A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111655682B (zh) * 2018-08-29 2024-05-31 杭州阿诺生物医药科技有限公司 一种高活性sting蛋白激动剂化合物
WO2021206158A1 (ja) 2020-04-10 2021-10-14 小野薬品工業株式会社 がん治療方法
CN119110800A (zh) * 2022-02-21 2024-12-10 健道生物医药有限公司 干扰素基因刺激因子（sting）调节剂及其组合物和方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111655682A (zh) * 2018-08-29 2020-09-11 杭州阿诺生物医药科技有限公司 一种高活性sting蛋白激动剂化合物
CN112351778A (zh) * 2018-06-28 2021-02-09 江苏恒瑞医药股份有限公司 稠合三环杂环类化合物及其治疗用途

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
FR2747678B1 (fr) * 1996-04-22 1998-05-22 Synthelabo Composes derives d'imidazobenzoxazine, leurs procedes de preparation et leurs utilisations en therapeutique
ECSP003637A (es) * 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
KR20080035576A (ko) * 2005-08-05 2008-04-23 아스트라제네카 아베 트리사이클릭 벤즈이미다졸 및 대사체 글루타메이트 수용체조절제로서 이들의 용도
GB201220157D0 (en) * 2012-11-08 2012-12-26 Selvita Sa Substitute tricyclic benzimidazoles as kinase inhibitors
MX366703B (es) * 2013-03-15 2019-07-22 Incyte Holdings Corp Heterociclos tricíclicos como inhibidores de la proteína bet.
HRP20220936T1 (hr) * 2016-04-07 2022-10-28 Glaxosmithkline Intellectual Property Development Limited Heterociklički amidi korisni kao modulatori proteina

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112351778A (zh) * 2018-06-28 2021-02-09 江苏恒瑞医药股份有限公司 稠合三环杂环类化合物及其治疗用途
CN111655682A (zh) * 2018-08-29 2020-09-11 杭州阿诺生物医药科技有限公司 一种高活性sting蛋白激动剂化合物

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Publication number Publication date
US20220056044A1 (en) 2022-02-24
CN113195473A (zh) 2021-07-30
EP3873896A4 (en) 2022-08-31
WO2020124059A1 (en) 2020-06-18
TW202039508A (zh) 2020-11-01
JP2022511540A (ja) 2022-01-31
EP3873896A1 (en) 2021-09-08

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