JP2022511540A - Ｓｔｉｎｇアゴニストとしての三環式化合物、ならびにその調製方法および医薬用途 - Google Patents

Ｓｔｉｎｇアゴニストとしての三環式化合物、ならびにその調製方法および医薬用途 Download PDF

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Publication number
JP2022511540A
JP2022511540A JP2021532155A JP2021532155A JP2022511540A JP 2022511540 A JP2022511540 A JP 2022511540A JP 2021532155 A JP2021532155 A JP 2021532155A JP 2021532155 A JP2021532155 A JP 2021532155A JP 2022511540 A JP2022511540 A JP 2022511540A
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Japan
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group
alkyl
compound
formula
pharmaceutically acceptable
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JP2021532155A
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English (en)
Japanese (ja)
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JP2022511540A5 (https=
JPWO2020124059A5 (https=
Inventor
ドン リウ
プーフゥイ リ
リンハン チュアン
フェンキ チャン
レイ チェン
シンチュー チャン
チュンイン ソン
スーシン リウ
ミラー マシュー
キユウ フ
ユナ ヤン
ジン リ
フェン ヘ
ウェイカン タオ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
Original Assignee
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of JP2022511540A publication Critical patent/JP2022511540A/ja
Publication of JP2022511540A5 publication Critical patent/JP2022511540A5/ja
Publication of JPWO2020124059A5 publication Critical patent/JPWO2020124059A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2021532155A 2018-12-14 2019-12-14 Ｓｔｉｎｇアゴニストとしての三環式化合物、ならびにその調製方法および医薬用途 Pending JP2022511540A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862779907P 2018-12-14 2018-12-14
US62/779,907 2018-12-14
PCT/US2019/066413 WO2020124059A1 (en) 2018-12-14 2019-12-14 Tricyclic compounds as sting agonists, and preparation methods and medicinal uses thereof

Publications (3)

Publication Number Publication Date
JP2022511540A true JP2022511540A (ja) 2022-01-31
JP2022511540A5 JP2022511540A5 (https=) 2022-12-19
JPWO2020124059A5 JPWO2020124059A5 (https=) 2022-12-19

Family

ID=71077552

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021532155A Pending JP2022511540A (ja) 2018-12-14 2019-12-14 Ｓｔｉｎｇアゴニストとしての三環式化合物、ならびにその調製方法および医薬用途

Country Status (6)

Country Link
US (1) US20220056044A1 (https=)
EP (1) EP3873896A4 (https=)
JP (1) JP2022511540A (https=)
CN (1) CN113195473B (https=)
TW (1) TW202039508A (https=)
WO (1) WO2020124059A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111655682B (zh) * 2018-08-29 2024-05-31 杭州阿诺生物医药科技有限公司 一种高活性sting蛋白激动剂化合物
WO2021206158A1 (ja) 2020-04-10 2021-10-14 小野薬品工業株式会社 がん治療方法
CN119110800A (zh) * 2022-02-21 2024-12-10 健道生物医药有限公司 干扰素基因刺激因子（sting）调节剂及其组合物和方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017175147A1 (en) * 2016-04-07 2017-10-12 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides useful as protein modulators
JP2021530442A (ja) * 2018-06-28 2021-11-11 ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co., Ltd. 縮合三環系複素環化合物およびその治療上の使用
JP2021535909A (ja) * 2018-08-29 2021-12-23 アドライ・ノーティ・バイオファーマ・カンパニー・リミテッドAdlai Nortye Biopharma Co., Ltd. 高活性ｓｔｉｎｇタンパク質アゴニスト化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2747678B1 (fr) * 1996-04-22 1998-05-22 Synthelabo Composes derives d'imidazobenzoxazine, leurs procedes de preparation et leurs utilisations en therapeutique
ECSP003637A (es) * 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
KR20080035576A (ko) * 2005-08-05 2008-04-23 아스트라제네카 아베 트리사이클릭 벤즈이미다졸 및 대사체 글루타메이트 수용체조절제로서 이들의 용도
GB201220157D0 (en) * 2012-11-08 2012-12-26 Selvita Sa Substitute tricyclic benzimidazoles as kinase inhibitors
MX366703B (es) * 2013-03-15 2019-07-22 Incyte Holdings Corp Heterociclos tricíclicos como inhibidores de la proteína bet.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017175147A1 (en) * 2016-04-07 2017-10-12 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides useful as protein modulators
JP2021530442A (ja) * 2018-06-28 2021-11-11 ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co., Ltd. 縮合三環系複素環化合物およびその治療上の使用
JP2021535909A (ja) * 2018-08-29 2021-12-23 アドライ・ノーティ・バイオファーマ・カンパニー・リミテッドAdlai Nortye Biopharma Co., Ltd. 高活性ｓｔｉｎｇタンパク質アゴニスト化合物

Also Published As

Publication number Publication date
US20220056044A1 (en) 2022-02-24
CN113195473A (zh) 2021-07-30
EP3873896A4 (en) 2022-08-31
WO2020124059A1 (en) 2020-06-18
TW202039508A (zh) 2020-11-01
EP3873896A1 (en) 2021-09-08
CN113195473B (zh) 2022-11-22

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