CN111655682A - 一种高活性sting蛋白激动剂化合物 - Google Patents

一种高活性sting蛋白激动剂化合物 Download PDF

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CN111655682A
CN111655682A CN201980005220.4A CN201980005220A CN111655682A CN 111655682 A CN111655682 A CN 111655682A CN 201980005220 A CN201980005220 A CN 201980005220A CN 111655682 A CN111655682 A CN 111655682A
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alkylene
membered
alkyl
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ring
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CN111655682B (zh
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陈宇锋
陈凯旋
李磐
刘灿丰
王骥
邱庆崇
路杨
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Hangzhou Arnold Biomedical Technology Co ltd
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
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  • Communicable Diseases (AREA)
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  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

本发明提供式(I)或(II)化合物及其药物组合物，以及使用式(I)或(II)化合物预防和/或治疗免疫相关病症的方法。
Figure DDA0002455916210000011

Description

PCT国内申请，说明书已公开。

Claims (30)

  1. PCT国内申请，权利要求书已公开。
CN201980005220.4A 2018-08-29 2019-08-22 一种高活性sting蛋白激动剂化合物 Active CN111655682B (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN202011587262.4A CN112679523B (zh) 2018-08-29 2019-08-22 高活性sting蛋白偶联剂偶联化合物及其应用
CN202011586151.1A CN112661773B (zh) 2018-08-29 2019-08-22 Sting蛋白激动剂偶联化合物
CN202011595914.9A CN112608331B (zh) 2018-08-29 2019-08-22 中间体及其在合成sting蛋白激动剂化合物中的应用

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CN2018109962310 2018-08-29
CN201810996231 2018-08-29
CN2018114070281 2018-11-23
CN201811407028 2018-11-23
PCT/CN2019/101925 WO2020042995A1 (zh) 2018-08-29 2019-08-22 一种高活性sting蛋白激动剂化合物

Related Child Applications (3)

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CN202011595914.9A Division CN112608331B (zh) 2018-08-29 2019-08-22 中间体及其在合成sting蛋白激动剂化合物中的应用
CN202011587262.4A Division CN112679523B (zh) 2018-08-29 2019-08-22 高活性sting蛋白偶联剂偶联化合物及其应用
CN202011586151.1A Division CN112661773B (zh) 2018-08-29 2019-08-22 Sting蛋白激动剂偶联化合物

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CN111655682A true CN111655682A (zh) 2020-09-11
CN111655682B CN111655682B (zh) 2024-05-31

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113195473A (zh) * 2018-12-14 2021-07-30 江苏恒瑞医药股份有限公司 三环化合物作为sting激动剂及其制备方法和医药用途

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006069155A2 (en) * 2004-12-21 2006-06-29 Bristol-Myers Squibb Company Inhibitors of protein arginine methyl transferases
WO2017049401A1 (en) * 2015-09-25 2017-03-30 Pharmascience Inc. New benzimidazoles derivatives as tec kinases family inhibitors
WO2017175147A1 (en) * 2016-04-07 2017-10-12 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides useful as protein modulators
WO2017175156A1 (en) * 2016-04-07 2017-10-12 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides useful as protein modulators
WO2018032104A1 (en) * 2016-08-17 2018-02-22 Pharmascience Inc. Spirocyclic containing compounds and pharmaceutical uses thereof
CN112351778A (zh) * 2018-06-28 2021-02-09 江苏恒瑞医药股份有限公司 稠合三环杂环类化合物及其治疗用途

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006069155A2 (en) * 2004-12-21 2006-06-29 Bristol-Myers Squibb Company Inhibitors of protein arginine methyl transferases
WO2017049401A1 (en) * 2015-09-25 2017-03-30 Pharmascience Inc. New benzimidazoles derivatives as tec kinases family inhibitors
WO2017175147A1 (en) * 2016-04-07 2017-10-12 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides useful as protein modulators
WO2017175156A1 (en) * 2016-04-07 2017-10-12 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides useful as protein modulators
WO2018032104A1 (en) * 2016-08-17 2018-02-22 Pharmascience Inc. Spirocyclic containing compounds and pharmaceutical uses thereof
CN112351778A (zh) * 2018-06-28 2021-02-09 江苏恒瑞医药股份有限公司 稠合三环杂环类化合物及其治疗用途

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113195473A (zh) * 2018-12-14 2021-07-30 江苏恒瑞医药股份有限公司 三环化合物作为sting激动剂及其制备方法和医药用途
CN113195473B (zh) * 2018-12-14 2022-11-22 江苏恒瑞医药股份有限公司 三环化合物作为sting激动剂及其制备方法和医药用途

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CN112679523B (zh) 2022-03-11
JP2021535909A (ja) 2021-12-23
JP7166028B2 (ja) 2022-11-07
AU2019331993A1 (en) 2021-03-25
CN112661773B (zh) 2022-03-11
CN112608331B (zh) 2022-03-11
EP3848366A4 (en) 2022-03-16
EP3848366A1 (en) 2021-07-14
TW202024063A (zh) 2020-07-01
AU2019331993B2 (en) 2022-06-02
TWI723511B (zh) 2021-04-01
CA3110474C (en) 2024-04-23
KR102653190B1 (ko) 2024-03-29
CA3110474A1 (en) 2020-03-05
WO2020042995A1 (zh) 2020-03-05
KR20210049895A (ko) 2021-05-06
CN112608331A (zh) 2021-04-06
CN112661773A (zh) 2021-04-16
CN112679523A (zh) 2021-04-20

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