JPWO2020097384A5 - - Google Patents
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- Publication number
- JPWO2020097384A5 JPWO2020097384A5 JP2021524374A JP2021524374A JPWO2020097384A5 JP WO2020097384 A5 JPWO2020097384 A5 JP WO2020097384A5 JP 2021524374 A JP2021524374 A JP 2021524374A JP 2021524374 A JP2021524374 A JP 2021524374A JP WO2020097384 A5 JPWO2020097384 A5 JP WO2020097384A5
- Authority
- JP
- Japan
- Prior art keywords
- cationic lipid
- independently
- pharmaceutically acceptable
- acceptable salt
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024069435A JP2024099679A (ja) | 2018-11-09 | 2024-04-23 | 層間エステル、チオエステル、ジスルフィドおよび無水部分を含む２，５－ジオキソピペラジン脂質 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862758179P | 2018-11-09 | 2018-11-09 | |
| US62/758,179 | 2018-11-09 | ||
| US201962871510P | 2019-07-08 | 2019-07-08 | |
| US62/871,510 | 2019-07-08 | ||
| PCT/US2019/060344 WO2020097384A1 (en) | 2018-11-09 | 2019-11-07 | 2,5-dioxopiperazine lipids with intercalated ester, thioester, disulfide and anhydride moieities |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024069435A Division JP2024099679A (ja) | 2018-11-09 | 2024-04-23 | 層間エステル、チオエステル、ジスルフィドおよび無水部分を含む２，５－ジオキソピペラジン脂質 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022512945A JP2022512945A (ja) | 2022-02-07 |
| JP2022512945A5 JP2022512945A5 (https=) | 2022-11-14 |
| JPWO2020097384A5 true JPWO2020097384A5 (https=) | 2022-11-14 |
| JP7483294B2 JP7483294B2 (ja) | 2024-05-15 |
Family
ID=69165524
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021524374A Active JP7483294B2 (ja) | 2018-11-09 | 2019-11-07 | 層間エステル、チオエステル、ジスルフィドおよび無水部分を含む２，５－ジオキソピペラジン脂質 |
| JP2024069435A Pending JP2024099679A (ja) | 2018-11-09 | 2024-04-23 | 層間エステル、チオエステル、ジスルフィドおよび無水部分を含む２，５－ジオキソピペラジン脂質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024069435A Pending JP2024099679A (ja) | 2018-11-09 | 2024-04-23 | 層間エステル、チオエステル、ジスルフィドおよび無水部分を含む２，５－ジオキソピペラジン脂質 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230071228A1 (https=) |
| EP (1) | EP3877368A1 (https=) |
| JP (2) | JP7483294B2 (https=) |
| KR (1) | KR102860605B1 (https=) |
| CN (1) | CN113272282B (https=) |
| AU (1) | AU2019376660B2 (https=) |
| BR (1) | BR112021008974A2 (https=) |
| CA (1) | CA3117882A1 (https=) |
| IL (1) | IL282723B1 (https=) |
| MX (1) | MX2021005482A (https=) |
| WO (1) | WO2020097384A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210220449A1 (en) * | 2018-05-15 | 2021-07-22 | Translate Bio, Inc. | Subcutaneous Delivery of Messenger RNA |
| WO2020227085A1 (en) * | 2019-05-03 | 2020-11-12 | Translate Bio, Inc. | Di-thioester cationic lipids |
| US20230181483A1 (en) * | 2019-07-08 | 2023-06-15 | Translate Bio, Inc. | Improved mrna-loaded lipid nanoparticles and processes of making the same |
| US12605399B2 (en) | 2020-05-07 | 2026-04-21 | Translate Bio, Inc. | Compositions for CFTR MRNA therapy |
| US20230242720A1 (en) * | 2020-06-29 | 2023-08-03 | Zymergen Inc. | Modulus modifiers and films thereof |
| CA3193347A1 (en) * | 2020-09-23 | 2022-03-31 | Saswata KARMAKAR | Piperazine-based cationic lipids |
| EP4313115A1 (en) | 2021-03-25 | 2024-02-07 | Translate Bio, Inc. | Optimized nucleotide sequences encoding the extracellular domain of human ace2 protein or a portion thereof |
| US20240270707A1 (en) * | 2021-04-15 | 2024-08-15 | Translate Bio, Inc. | "Good" buffer-based cationic lipids |
| CN115710196B (zh) * | 2021-08-23 | 2025-06-10 | 广州谷森制药有限公司 | 阳离子脂质化合物 |
| MX2024002726A (es) | 2021-09-03 | 2024-03-20 | CureVac SE | Nuevas nanoparticulas lipidicas para la administracion de acidos nucleicos. |
| WO2023073228A1 (en) | 2021-10-29 | 2023-05-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| WO2023227608A1 (en) | 2022-05-25 | 2023-11-30 | Glaxosmithkline Biologicals Sa | Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide |
| WO2024089638A1 (en) | 2022-10-28 | 2024-05-02 | Glaxosmithkline Biologicals Sa | Nucleic acid based vaccine |
| EP4633673A1 (en) | 2022-12-15 | 2025-10-22 | Sanofi Pasteur Inc. | Mrna encoding influenza virus-like particle |
| WO2024133515A1 (en) | 2022-12-20 | 2024-06-27 | Sanofi | Rhinovirus mrna vaccine |
| KR20250153298A (ko) | 2023-03-08 | 2025-10-24 | 큐어백 에스이 | 핵산 전달을 위한 신규의 지질 나노입자 제형 |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
| WO2025049925A2 (en) * | 2023-09-01 | 2025-03-06 | Poseida Therapeutics, Inc. | Lipidoid compounds and related compositions and uses |
| WO2025164564A1 (ja) * | 2024-01-31 | 2025-08-07 | 公立大学法人名古屋市立大学 | 核酸封入脂質ナノ粒子の製造方法 |
| WO2026008743A1 (en) | 2024-07-02 | 2026-01-08 | Sanofi Pasteur Inc. | Water-soluble polyanionic polymer as adjuvant for carrier-formulated nucleic acid |
| WO2026033123A1 (en) | 2024-08-08 | 2026-02-12 | Sanofi Pasteur Inc. | Lipid nanoparticle formulations for mrna delivery |
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| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US5132418A (en) | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
| US4668777A (en) | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
| US4415732A (en) | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
| US4973679A (en) | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
| US4373071A (en) | 1981-04-30 | 1983-02-08 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
| US4401796A (en) | 1981-04-30 | 1983-08-30 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
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| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
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| CN104119242B (zh) | 2008-10-09 | 2017-07-07 | 泰米拉制药公司 | 改善的氨基脂质和递送核酸的方法 |
| ES2646630T3 (es) | 2008-11-07 | 2017-12-14 | Massachusetts Institute Of Technology | Lipidoides aminoalcohólicos y usos de los mismos |
| MX342785B (es) | 2009-06-10 | 2016-10-12 | Alnylam Pharmaceuticals Inc | Formulacion mejorada de lipido. |
| HUE042177T2 (hu) | 2009-12-01 | 2019-06-28 | Translate Bio Inc | Szteroidszármazék mRNS szállítására humán genetikai betegségekben |
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| KR102451116B1 (ko) | 2011-10-27 | 2022-10-06 | 메사추세츠 인스티튜트 오브 테크놀로지 | 약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체 |
| ES2762873T3 (es) | 2012-03-29 | 2020-05-26 | Translate Bio Inc | Lípidos catiónicos ionizables |
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| ES2895651T3 (es) | 2013-12-19 | 2022-02-22 | Novartis Ag | Lípidos y composiciones lipídicas para la administración de agentes activos |
| JP6557722B2 (ja) | 2014-05-30 | 2019-08-07 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 核酸の送達のための生分解性脂質 |
| SMT202200502T1 (it) | 2014-06-25 | 2023-01-13 | Acuitas Therapeutics Inc | Nuovi lipidi e formulazioni di nanoparticelle lipidiche per l'erogazione di acidi nucleici |
| BR112016030852A2 (pt) | 2014-07-02 | 2018-01-16 | Shire Human Genetic Therapies | encapsulação de rna mensageiro |
| US9840479B2 (en) | 2014-07-02 | 2017-12-12 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| US20180000953A1 (en) | 2015-01-21 | 2018-01-04 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| WO2016118725A1 (en) | 2015-01-23 | 2016-07-28 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| ES2949540T3 (es) | 2015-06-19 | 2023-09-29 | Massachusetts Inst Technology | 2,5-piperazinadionas sustituidas con alquenilo y su uso en composiciones para suministrar un agente a un sujeto o una célula |
| LT3313829T (lt) | 2015-06-29 | 2024-08-12 | Acuitas Therapeutics Inc. | Lipidai ir lipidų nanodalelių sudėtys, skirtos nukleorūgščių tiekimui |
| US20180256730A1 (en) * | 2015-09-16 | 2018-09-13 | University Of Utah Research Foundation | A polymeric carrier for delivery of a payload to a cell |
| EP4286012A3 (en) | 2015-09-17 | 2024-05-29 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| IL307179A (en) | 2015-10-28 | 2023-11-01 | Acuitas Therapeutics Inc | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| EP3397613A1 (en) | 2015-12-30 | 2018-11-07 | Acuitas Therapeutics Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| TWI773666B (zh) | 2016-03-30 | 2022-08-11 | 美商英特利亞醫療公司 | Crispr/cas 組分之脂質奈米粒子調配物 |
| MX2019005470A (es) | 2016-11-10 | 2019-11-21 | Translate Bio Inc | Formulación de nanopartículas lipídicas basadas en ice mejorada para el suministro de arnm. |
| WO2018089801A1 (en) | 2016-11-10 | 2018-05-17 | Translate Bio, Inc. | Improved process of preparing mrna-loaded lipid nanoparticles |
-
2019
- 2019-11-07 MX MX2021005482A patent/MX2021005482A/es unknown
- 2019-11-07 EP EP19836673.4A patent/EP3877368A1/en active Pending
- 2019-11-07 US US17/291,937 patent/US20230071228A1/en active Pending
- 2019-11-07 IL IL282723A patent/IL282723B1/en unknown
- 2019-11-07 CA CA3117882A patent/CA3117882A1/en active Pending
- 2019-11-07 BR BR112021008974-8A patent/BR112021008974A2/pt unknown
- 2019-11-07 JP JP2021524374A patent/JP7483294B2/ja active Active
- 2019-11-07 CN CN201980088233.2A patent/CN113272282B/zh active Active
- 2019-11-07 AU AU2019376660A patent/AU2019376660B2/en active Active
- 2019-11-07 WO PCT/US2019/060344 patent/WO2020097384A1/en not_active Ceased
- 2019-11-07 KR KR1020217017572A patent/KR102860605B1/ko active Active
-
2024
- 2024-04-23 JP JP2024069435A patent/JP2024099679A/ja active Pending
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