JP2025024002A5 - - Google Patents
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- JP2025024002A5 JP2025024002A5 JP2024194073A JP2024194073A JP2025024002A5 JP 2025024002 A5 JP2025024002 A5 JP 2025024002A5 JP 2024194073 A JP2024194073 A JP 2024194073A JP 2024194073 A JP2024194073 A JP 2024194073A JP 2025024002 A5 JP2025024002 A5 JP 2025024002A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- lipid
- lipids
- independently
- mrna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962871513P | 2019-07-08 | 2019-07-08 | |
| US62/871,513 | 2019-07-08 | ||
| PCT/US2020/041122 WO2021007278A1 (en) | 2019-07-08 | 2020-07-08 | Improved mrna-loaded lipid nanoparticles and processes of making the same |
| JP2022500900A JP7586886B2 (ja) | 2019-07-08 | 2020-07-08 | 改善されたｍＲＮＡ装填脂質ナノ粒子、およびそれを作製するプロセス |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022500900A Division JP7586886B2 (ja) | 2019-07-08 | 2020-07-08 | 改善されたｍＲＮＡ装填脂質ナノ粒子、およびそれを作製するプロセス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025024002A JP2025024002A (ja) | 2025-02-19 |
| JP2025024002A5 true JP2025024002A5 (https=) | 2025-05-19 |
Family
ID=71784731
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022500900A Active JP7586886B2 (ja) | 2019-07-08 | 2020-07-08 | 改善されたｍＲＮＡ装填脂質ナノ粒子、およびそれを作製するプロセス |
| JP2024194073A Pending JP2025024002A (ja) | 2019-07-08 | 2024-11-06 | 改善されたｍＲＮＡ装填脂質ナノ粒子、およびそれを作製するプロセス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022500900A Active JP7586886B2 (ja) | 2019-07-08 | 2020-07-08 | 改善されたｍＲＮＡ装填脂質ナノ粒子、およびそれを作製するプロセス |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230181483A1 (https=) |
| EP (2) | EP3996683B1 (https=) |
| JP (2) | JP7586886B2 (https=) |
| KR (1) | KR20220078557A (https=) |
| CN (2) | CN119454644A (https=) |
| AU (1) | AU2020311364B2 (https=) |
| CA (1) | CA3146369A1 (https=) |
| ES (2) | ES3064716T3 (https=) |
| WO (1) | WO2021007278A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3675817A1 (en) | 2017-08-31 | 2020-07-08 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| US20230181483A1 (en) * | 2019-07-08 | 2023-06-15 | Translate Bio, Inc. | Improved mrna-loaded lipid nanoparticles and processes of making the same |
| JP2023508881A (ja) | 2019-12-20 | 2023-03-06 | トランスレイト バイオ， インコーポレイテッド | Ｍｒｎａ担持脂質ナノ粒子を調製する改善されたプロセス |
| WO2023009422A1 (en) * | 2021-07-26 | 2023-02-02 | Modernatx, Inc. | Processes for preparing lipid nanoparticle compositions for the delivery of payload molecules to airway epithelium |
| US20240398940A1 (en) | 2021-09-03 | 2024-12-05 | CureVac SE | Novel lipid nanoparticles for delivery of nucleic acids |
| KR20230053998A (ko) | 2021-10-15 | 2023-04-24 | (주)지노믹트리 | mRNA 발현을 위한 유전자 구조체 |
| EP4422698A1 (en) | 2021-10-29 | 2024-09-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| US20250345407A1 (en) | 2022-05-25 | 2025-11-13 | CureVac SE | Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide |
| US20260069713A1 (en) | 2022-08-29 | 2026-03-12 | Vivasor, Inc. | Lipid-Coated Nanoparticles |
| EP4608442A1 (en) | 2022-10-28 | 2025-09-03 | GlaxoSmithKline Biologicals S.A. | Nucleic acid based vaccine |
| WO2024184500A1 (en) | 2023-03-08 | 2024-09-12 | CureVac SE | Novel lipid nanoparticle formulations for delivery of nucleic acids |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
| EP4722368A1 (en) | 2023-05-26 | 2026-04-08 | Samsung Biologics Co., Ltd. | Novel nucleic acid construct comprising poly(a) tail having secondary or tertiary structure and uses thereof |
| KR20250018367A (ko) | 2023-07-28 | 2025-02-05 | 한국과학기술원 | 히스톤 코드 리더 도메인을 포함하는 폴리펩티드 및 이의 용도 |
| WO2025184508A1 (en) * | 2024-03-01 | 2025-09-04 | Acuitas Therapeutics, Inc. | Materials and methods for encapsulating therapeutics in lipid nanoparticles |
| CN121265551A (zh) * | 2024-07-02 | 2026-01-06 | 苏州星核迪赛生物技术有限公司 | 一种靶向肝实质细胞的核酸递送载体及其应用 |
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| US1580968A (en) | 1923-01-26 | 1926-04-13 | Brazza Ascanio Di | Firearm with screwed barrel detachable by hand or permanently fixed |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US5132418A (en) | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
| US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US4668777A (en) | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
| US4415732A (en) | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
| US4973679A (en) | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
| US4401796A (en) | 1981-04-30 | 1983-08-30 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
| US4373071A (en) | 1981-04-30 | 1983-02-08 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
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| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
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| US5744335A (en) | 1995-09-19 | 1998-04-28 | Mirus Corporation | Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein |
| CA2569664C (en) | 2004-06-07 | 2013-07-16 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering rna |
| CA2740000C (en) | 2008-10-09 | 2017-12-12 | Tekmira Pharmaceuticals Corporation | Improved amino lipids and methods for the delivery of nucleic acids |
| EP3269395A1 (en) | 2008-11-07 | 2018-01-17 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| KR101766408B1 (ko) | 2009-06-10 | 2017-08-10 | 알닐람 파마슈티칼스 인코포레이티드 | 향상된 지질 조성물 |
| EP3318248B1 (en) | 2009-12-01 | 2019-04-10 | Translate Bio, Inc. | Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases |
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| BR112014024131A2 (pt) | 2012-03-29 | 2017-07-25 | Shire Human Genetic Therapies | lipídios catiônicos ionizáveis |
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| HUE060907T2 (hu) | 2014-06-25 | 2023-04-28 | Acuitas Therapeutics Inc | Új lipidek és lipid nanorészecske formulációk nukleinsavak bevitelére |
| US9840479B2 (en) | 2014-07-02 | 2017-12-12 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| BR112016030852A2 (pt) | 2014-07-02 | 2018-01-16 | Shire Human Genetic Therapies | encapsulação de rna mensageiro |
| EP3247363A4 (en) | 2015-01-21 | 2018-10-03 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| EP3247398A4 (en) | 2015-01-23 | 2018-09-26 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
| WO2016205691A1 (en) | 2015-06-19 | 2016-12-22 | Massachusetts Institute Of Technology | Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell |
| PT3313829T (pt) | 2015-06-29 | 2024-07-08 | Acuitas Therapeutics Inc | Formulações de lípidos e de nanopartículas lipídicas para a administração de ácidos nucleicos |
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| HRP20230209T1 (hr) | 2015-10-28 | 2023-04-14 | Acuitas Therapeutics Inc. | Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina |
| WO2017117528A1 (en) | 2015-12-30 | 2017-07-06 | Acuitas Therapeutics, Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| LT3436077T (lt) | 2016-03-30 | 2025-06-25 | Intellia Therapeutics, Inc. | Lipidų nanodalelių vaisto formos, skirtos crispr/cas komponentams |
| EP3315125A1 (en) * | 2016-10-31 | 2018-05-02 | Silence Therapeutics (London) Ltd | Lipid nanoparticle formulation |
| CA3043033A1 (en) | 2016-11-10 | 2018-05-17 | Translate Bio, Inc. | Improved ice-based lipid nanoparticle formulation for delivery of mrna |
| AU2017357758B2 (en) * | 2016-11-10 | 2023-11-16 | Translate Bio, Inc. | Improved process of preparing mRNA-loaded lipid nanoparticles |
| MA47824A (fr) | 2017-03-07 | 2020-01-15 | Translate Bio Inc | Administration polyanionique d'acides nucléiques |
| EP3876914A2 (en) * | 2018-11-09 | 2021-09-15 | Translate Bio, Inc. | Messenger rna therapy for treatment of ocular diseases |
| AU2019376660B2 (en) * | 2018-11-09 | 2025-06-26 | Translate Bio, Inc. | 2,5-dioxopiperazine lipids with intercalated ester, thioester, disulfide and anhydride moieities |
| US20230181483A1 (en) * | 2019-07-08 | 2023-06-15 | Translate Bio, Inc. | Improved mrna-loaded lipid nanoparticles and processes of making the same |
-
2020
- 2020-07-08 US US17/625,507 patent/US20230181483A1/en active Pending
- 2020-07-08 EP EP20745451.3A patent/EP3996683B1/en active Active
- 2020-07-08 AU AU2020311364A patent/AU2020311364B2/en active Active
- 2020-07-08 CN CN202411475913.9A patent/CN119454644A/zh active Pending
- 2020-07-08 CN CN202080062330.7A patent/CN114390921B/zh active Active
- 2020-07-08 KR KR1020227004274A patent/KR20220078557A/ko active Pending
- 2020-07-08 CA CA3146369A patent/CA3146369A1/en active Pending
- 2020-07-08 ES ES24189330T patent/ES3064716T3/es active Active
- 2020-07-08 ES ES20745451T patent/ES2992127T3/es active Active
- 2020-07-08 JP JP2022500900A patent/JP7586886B2/ja active Active
- 2020-07-08 EP EP24189330.4A patent/EP4467653B1/en active Active
- 2020-07-08 WO PCT/US2020/041122 patent/WO2021007278A1/en not_active Ceased
-
2024
- 2024-11-06 JP JP2024194073A patent/JP2025024002A/ja active Pending
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