JP2025024002A5 - - Google Patents
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- JP2025024002A5 JP2025024002A5 JP2024194073A JP2024194073A JP2025024002A5 JP 2025024002 A5 JP2025024002 A5 JP 2025024002A5 JP 2024194073 A JP2024194073 A JP 2024194073A JP 2024194073 A JP2024194073 A JP 2024194073A JP 2025024002 A5 JP2025024002 A5 JP 2025024002A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- lipid
- lipids
- independently
- mrna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962871513P | 2019-07-08 | 2019-07-08 | |
| US62/871,513 | 2019-07-08 | ||
| PCT/US2020/041122 WO2021007278A1 (en) | 2019-07-08 | 2020-07-08 | Improved mrna-loaded lipid nanoparticles and processes of making the same |
| JP2022500900A JP7586886B2 (ja) | 2019-07-08 | 2020-07-08 | 改善されたｍＲＮＡ装填脂質ナノ粒子、およびそれを作製するプロセス |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022500900A Division JP7586886B2 (ja) | 2019-07-08 | 2020-07-08 | 改善されたｍＲＮＡ装填脂質ナノ粒子、およびそれを作製するプロセス |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025024002A JP2025024002A (ja) | 2025-02-19 |
| JP2025024002A5 true JP2025024002A5 (https=) | 2025-05-19 |
Family
ID=71784731
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022500900A Active JP7586886B2 (ja) | 2019-07-08 | 2020-07-08 | 改善されたｍＲＮＡ装填脂質ナノ粒子、およびそれを作製するプロセス |
| JP2024194073A Pending JP2025024002A (ja) | 2019-07-08 | 2024-11-06 | 改善されたｍＲＮＡ装填脂質ナノ粒子、およびそれを作製するプロセス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022500900A Active JP7586886B2 (ja) | 2019-07-08 | 2020-07-08 | 改善されたｍＲＮＡ装填脂質ナノ粒子、およびそれを作製するプロセス |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230181483A1 (https=) |
| EP (2) | EP4467653B1 (https=) |
| JP (2) | JP7586886B2 (https=) |
| KR (1) | KR20220078557A (https=) |
| CN (2) | CN114390921B (https=) |
| AU (1) | AU2020311364B2 (https=) |
| CA (1) | CA3146369A1 (https=) |
| ES (1) | ES2992127T3 (https=) |
| WO (1) | WO2021007278A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019046809A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | METHODS OF MANUFACTURING LIPID NANOPARTICLES |
| US20230181483A1 (en) * | 2019-07-08 | 2023-06-15 | Translate Bio, Inc. | Improved mrna-loaded lipid nanoparticles and processes of making the same |
| US12053551B2 (en) | 2019-12-20 | 2024-08-06 | Translate Bio, Inc. | Process of preparing mRNA-loaded lipid nanoparticles |
| JP2024527940A (ja) * | 2021-07-26 | 2024-07-26 | モデルナティエックス インコーポレイテッド | ペイロード分子を気道上皮に送達するための脂質ナノ粒子組成物を調製するプロセス |
| MX2024002726A (es) | 2021-09-03 | 2024-03-20 | CureVac SE | Nuevas nanoparticulas lipidicas para la administracion de acidos nucleicos. |
| KR20230053998A (ko) | 2021-10-15 | 2023-04-24 | (주)지노믹트리 | mRNA 발현을 위한 유전자 구조체 |
| WO2023073228A1 (en) | 2021-10-29 | 2023-05-04 | CureVac SE | Improved circular rna for expressing therapeutic proteins |
| US20250099614A1 (en) | 2022-01-28 | 2025-03-27 | CureVac SE | Nucleic acid encoded transcription factor inhibitors |
| WO2023227608A1 (en) | 2022-05-25 | 2023-11-30 | Glaxosmithkline Biologicals Sa | Nucleic acid based vaccine encoding an escherichia coli fimh antigenic polypeptide |
| US20260069713A1 (en) | 2022-08-29 | 2026-03-12 | Vivasor, Inc. | Lipid-Coated Nanoparticles |
| WO2024089638A1 (en) | 2022-10-28 | 2024-05-02 | Glaxosmithkline Biologicals Sa | Nucleic acid based vaccine |
| KR20250153298A (ko) | 2023-03-08 | 2025-10-24 | 큐어백 에스이 | 핵산 전달을 위한 신규의 지질 나노입자 제형 |
| WO2024230934A1 (en) | 2023-05-11 | 2024-11-14 | CureVac SE | Therapeutic nucleic acid for the treatment of ophthalmic diseases |
| EP4722368A1 (en) | 2023-05-26 | 2026-04-08 | Samsung Biologics Co., Ltd. | Novel nucleic acid construct comprising poly(a) tail having secondary or tertiary structure and uses thereof |
| KR20250018367A (ko) | 2023-07-28 | 2025-02-05 | 한국과학기술원 | 히스톤 코드 리더 도메인을 포함하는 폴리펩티드 및 이의 용도 |
| TW202543583A (zh) * | 2024-03-01 | 2025-11-16 | 加拿大商阿奎特斯醫療公司 | 用於將治療劑包覆於脂質奈米顆粒中之材料及方法 |
| CN121265551A (zh) * | 2024-07-02 | 2026-01-06 | 苏州星核迪赛生物技术有限公司 | 一种靶向肝实质细胞的核酸递送载体及其应用 |
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| US1580968A (en) | 1923-01-26 | 1926-04-13 | Brazza Ascanio Di | Firearm with screwed barrel detachable by hand or permanently fixed |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
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| US4415732A (en) | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
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| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
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| US5744335A (en) | 1995-09-19 | 1998-04-28 | Mirus Corporation | Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein |
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| CN104119242B (zh) | 2008-10-09 | 2017-07-07 | 泰米拉制药公司 | 改善的氨基脂质和递送核酸的方法 |
| ES2646630T3 (es) | 2008-11-07 | 2017-12-14 | Massachusetts Institute Of Technology | Lipidoides aminoalcohólicos y usos de los mismos |
| MX342785B (es) | 2009-06-10 | 2016-10-12 | Alnylam Pharmaceuticals Inc | Formulacion mejorada de lipido. |
| HUE042177T2 (hu) | 2009-12-01 | 2019-06-28 | Translate Bio Inc | Szteroidszármazék mRNS szállítására humán genetikai betegségekben |
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| KR102451116B1 (ko) | 2011-10-27 | 2022-10-06 | 메사추세츠 인스티튜트 오브 테크놀로지 | 약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체 |
| ES2762873T3 (es) | 2012-03-29 | 2020-05-26 | Translate Bio Inc | Lípidos catiónicos ionizables |
| ES2895651T3 (es) | 2013-12-19 | 2022-02-22 | Novartis Ag | Lípidos y composiciones lipídicas para la administración de agentes activos |
| JP6557722B2 (ja) | 2014-05-30 | 2019-08-07 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 核酸の送達のための生分解性脂質 |
| SMT202200502T1 (it) | 2014-06-25 | 2023-01-13 | Acuitas Therapeutics Inc | Nuovi lipidi e formulazioni di nanoparticelle lipidiche per l'erogazione di acidi nucleici |
| US9840479B2 (en) | 2014-07-02 | 2017-12-12 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| BR112016030852A2 (pt) | 2014-07-02 | 2018-01-16 | Shire Human Genetic Therapies | encapsulação de rna mensageiro |
| US20180000953A1 (en) | 2015-01-21 | 2018-01-04 | Moderna Therapeutics, Inc. | Lipid nanoparticle compositions |
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| ES2949540T3 (es) * | 2015-06-19 | 2023-09-29 | Massachusetts Inst Technology | 2,5-piperazinadionas sustituidas con alquenilo y su uso en composiciones para suministrar un agente a un sujeto o una célula |
| LT3313829T (lt) | 2015-06-29 | 2024-08-12 | Acuitas Therapeutics Inc. | Lipidai ir lipidų nanodalelių sudėtys, skirtos nukleorūgščių tiekimui |
| EP4286012A3 (en) | 2015-09-17 | 2024-05-29 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| IL307179A (en) | 2015-10-28 | 2023-11-01 | Acuitas Therapeutics Inc | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| EP3397613A1 (en) | 2015-12-30 | 2018-11-07 | Acuitas Therapeutics Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| TWI773666B (zh) | 2016-03-30 | 2022-08-11 | 美商英特利亞醫療公司 | Crispr/cas 組分之脂質奈米粒子調配物 |
| EP3315125A1 (en) * | 2016-10-31 | 2018-05-02 | Silence Therapeutics (London) Ltd | Lipid nanoparticle formulation |
| WO2018089801A1 (en) | 2016-11-10 | 2018-05-17 | Translate Bio, Inc. | Improved process of preparing mrna-loaded lipid nanoparticles |
| MX2019005470A (es) | 2016-11-10 | 2019-11-21 | Translate Bio Inc | Formulación de nanopartículas lipídicas basadas en ice mejorada para el suministro de arnm. |
| MA47824A (fr) | 2017-03-07 | 2020-01-15 | Translate Bio Inc | Administration polyanionique d'acides nucléiques |
| MX2021005482A (es) * | 2018-11-09 | 2021-09-08 | Translate Bio Inc | Lípidos de 2,5-dioxopiperazina con porciones éster, tioéster, disulfuro y anhidrido intercaladas. |
| WO2020097511A2 (en) * | 2018-11-09 | 2020-05-14 | Translate Bio, Inc. | Messenger rna therapy for treatment of ocular diseases |
| US20230181483A1 (en) * | 2019-07-08 | 2023-06-15 | Translate Bio, Inc. | Improved mrna-loaded lipid nanoparticles and processes of making the same |
-
2020
- 2020-07-08 US US17/625,507 patent/US20230181483A1/en active Pending
- 2020-07-08 EP EP24189330.4A patent/EP4467653B1/en active Active
- 2020-07-08 CN CN202080062330.7A patent/CN114390921B/zh active Active
- 2020-07-08 CA CA3146369A patent/CA3146369A1/en active Pending
- 2020-07-08 WO PCT/US2020/041122 patent/WO2021007278A1/en not_active Ceased
- 2020-07-08 JP JP2022500900A patent/JP7586886B2/ja active Active
- 2020-07-08 ES ES20745451T patent/ES2992127T3/es active Active
- 2020-07-08 AU AU2020311364A patent/AU2020311364B2/en active Active
- 2020-07-08 EP EP20745451.3A patent/EP3996683B1/en active Active
- 2020-07-08 CN CN202411475913.9A patent/CN119454644A/zh active Pending
- 2020-07-08 KR KR1020227004274A patent/KR20220078557A/ko active Pending
-
2024
- 2024-11-06 JP JP2024194073A patent/JP2025024002A/ja active Pending
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