KR20220078557A - 개선된 mrna 로딩된 지질 나노입자 및 이의 제조 방법 - Google Patents

개선된 mrna 로딩된 지질 나노입자 및 이의 제조 방법 Download PDF

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KR20220078557A
KR20220078557A KR1020227004274A KR20227004274A KR20220078557A KR 20220078557 A KR20220078557 A KR 20220078557A KR 1020227004274 A KR1020227004274 A KR 1020227004274A KR 20227004274 A KR20227004274 A KR 20227004274A KR 20220078557 A KR20220078557 A KR 20220078557A
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lipid
mrna
lipids
present
cationic
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Korean (ko)
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슈리랑 카르브
아쉬시 사로데
프랑크 데로사
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트랜슬레이트 바이오 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
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    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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KR1020227004274A 2019-07-08 2020-07-08 개선된 mrna 로딩된 지질 나노입자 및 이의 제조 방법 Pending KR20220078557A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962871513P 2019-07-08 2019-07-08
US62/871,513 2019-07-08
PCT/US2020/041122 WO2021007278A1 (en) 2019-07-08 2020-07-08 Improved mrna-loaded lipid nanoparticles and processes of making the same

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KR20220078557A true KR20220078557A (ko) 2022-06-10

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KR1020227004274A Pending KR20220078557A (ko) 2019-07-08 2020-07-08 개선된 mrna 로딩된 지질 나노입자 및 이의 제조 방법

Country Status (9)

Country Link
US (1) US20230181483A1 (https=)
EP (2) EP3996683B1 (https=)
JP (2) JP7586886B2 (https=)
KR (1) KR20220078557A (https=)
CN (2) CN119454644A (https=)
AU (1) AU2020311364B2 (https=)
CA (1) CA3146369A1 (https=)
ES (2) ES3064716T3 (https=)
WO (1) WO2021007278A1 (https=)

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US20230181483A1 (en) 2023-06-15
CN114390921B (zh) 2024-11-08
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EP4467653A3 (en) 2024-12-18
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EP4467653A2 (en) 2024-11-27
EP4467653C0 (en) 2026-01-21
AU2020311364B2 (en) 2025-12-18
CN114390921A (zh) 2022-04-22
EP3996683A1 (en) 2022-05-18
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