SG11201507474QA - RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS - Google Patents
RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODSInfo
- Publication number
- SG11201507474QA SG11201507474QA SG11201507474QA SG11201507474QA SG11201507474QA SG 11201507474Q A SG11201507474Q A SG 11201507474QA SG 11201507474Q A SG11201507474Q A SG 11201507474QA SG 11201507474Q A SG11201507474Q A SG 11201507474QA SG 11201507474Q A SG11201507474Q A SG 11201507474QA
- Authority
- SG
- Singapore
- Prior art keywords
- thio
- modified nucleotides
- related methods
- ribonucleic acids
- ribonucleic
- Prior art date
Links
- 239000002773 nucleotide Substances 0.000 title 1
- 229920002477 rna polymer Polymers 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361785098P | 2013-03-14 | 2013-03-14 | |
| PCT/US2014/027422 WO2014152513A1 (en) | 2013-03-14 | 2014-03-14 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201507474QA true SG11201507474QA (en) | 2015-10-29 |
Family
ID=50639964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201507474QA SG11201507474QA (en) | 2013-03-14 | 2014-03-14 | RIBONUCLEIC ACIDs WITH 4'-THIO-MODIFIED NUCLEOTIDES AND RELATED METHODS |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US10266559B2 (en) |
| EP (3) | EP2970351B1 (en) |
| JP (1) | JP6567494B2 (en) |
| KR (1) | KR20150127582A (en) |
| CN (1) | CN105026411A (en) |
| AU (2) | AU2014239562B2 (en) |
| BR (1) | BR112015022507A2 (en) |
| CA (1) | CA2902884C (en) |
| EA (1) | EA201591281A1 (en) |
| ES (2) | ES2797974T3 (en) |
| HK (1) | HK1219955A1 (en) |
| IL (1) | IL240465A0 (en) |
| MX (1) | MX2015011943A (en) |
| SG (1) | SG11201507474QA (en) |
| WO (1) | WO2014152513A1 (en) |
| ZA (1) | ZA201507605B (en) |
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| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| EP2859102A4 (en) | 2012-06-08 | 2016-05-11 | Shire Human Genetic Therapies | Nuclease resistant polynucleotides and uses thereof |
| EP2970955B1 (en) | 2013-03-14 | 2018-11-14 | Translate Bio, Inc. | Methods for purification of messenger rna |
| PT2968586T (en) | 2013-03-14 | 2018-11-13 | Ethris Gmbh | Cftr mrna compositions and related methods and uses |
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| US10005779B2 (en) * | 2013-06-05 | 2018-06-26 | Idenix Pharmaceuticals Llc | 1′,4′-thio nucleosides for the treatment of HCV |
| DK3019619T3 (en) | 2013-07-11 | 2021-10-11 | Modernatx Inc | COMPOSITIONS INCLUDING SYNTHETIC POLYNUCLEOTIDES CODING CRISPR-RELATED PROTEINS, SYNTHETIC SGRNAs, AND USES OF USE |
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| JP2016538829A (en) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | Polynucleotide encoding low density lipoprotein receptor |
| WO2015061491A1 (en) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Mrna therapy for phenylketonuria |
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| SG11201608725YA (en) | 2014-04-25 | 2016-11-29 | Shire Human Genetic Therapies | Methods for purification of messenger rna |
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| US11434486B2 (en) | 2015-09-17 | 2022-09-06 | Modernatx, Inc. | Polynucleotides containing a morpholino linker |
| AU2016369612B2 (en) | 2015-12-17 | 2023-06-01 | Modernatx, Inc. | Polynucleotides encoding methylmalonyl-CoA mutase |
| WO2017127750A1 (en) | 2016-01-22 | 2017-07-27 | Modernatx, Inc. | Messenger ribonucleic acids for the production of intracellular binding polypeptides and methods of use thereof |
| CA3020343A1 (en) * | 2016-04-08 | 2017-10-12 | Translate Bio, Inc. | Multimeric coding nucleic acid and uses thereof |
| WO2017180917A2 (en) | 2016-04-13 | 2017-10-19 | Modernatx, Inc. | Lipid compositions and their uses for intratumoral polynucleotide delivery |
| MA45053A (en) | 2016-05-18 | 2019-03-27 | Modernatx Inc | POLYNUCLEOTIDES CODING FOR A CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR FOR THE TREATMENT OF CYSTIC FIBROSIS |
| KR102469450B1 (en) | 2016-05-18 | 2022-11-22 | 모더나티엑스, 인크. | Polynucleotides Encoding Interleukin-12 (IL12) and Uses Thereof |
| EP3458590B9 (en) | 2016-05-18 | 2021-08-18 | ModernaTX, Inc. | Polynucleotides encoding -galactosidase a for the treatment of fabry disease |
| WO2018157154A2 (en) | 2017-02-27 | 2018-08-30 | Translate Bio, Inc. | Novel codon-optimized cftr mrna |
| WO2018157141A1 (en) | 2017-02-27 | 2018-08-30 | Translate Bio, Inc. | Methods for purification of messenger rna |
| EP3971291A1 (en) | 2017-02-27 | 2022-03-23 | Translate Bio, Inc. | Methods for purification of messenger rna |
| EP3592728A1 (en) | 2017-03-07 | 2020-01-15 | Translate Bio, Inc. | Polyanionic delivery of nucleic acids |
| EP3624824A1 (en) | 2017-05-16 | 2020-03-25 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding cftr |
| CN110719954B (en) | 2017-05-31 | 2023-12-26 | 奥特吉尼克斯制药公司 | Therapeutic agent for glycogen storage disease type III |
| MA49393A (en) | 2017-06-12 | 2020-04-22 | Translate Bio Inc | POLY (PHOSPHOESTERS) INTENDED FOR THE ADMINISTRATION OF NUCLEIC ACIDS |
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| JP7423522B2 (en) | 2017-11-22 | 2024-01-29 | モダーナティエックス・インコーポレイテッド | Polynucleotide encoding ornithine transcarbamylase for the treatment of urea cycle disorders |
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| JP7384832B2 (en) | 2018-05-16 | 2023-11-21 | トランスレイト バイオ， インコーポレイテッド | Ribose cationic lipid |
| EP3802487A1 (en) | 2018-05-24 | 2021-04-14 | Translate Bio, Inc. | Thioester cationic lipids |
| AU2019277361A1 (en) * | 2018-05-30 | 2020-12-17 | Translate Bio, Inc. | Messenger RNA vaccines and uses thereof |
| US20210206739A1 (en) | 2018-05-30 | 2021-07-08 | Translate Bio, Inc. | Vitamin Cationic Lipids |
| CN112424214A (en) | 2018-05-30 | 2021-02-26 | 川斯勒佰尔公司 | Cationic lipids comprising steroidal moieties |
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| AU2019309940A1 (en) * | 2018-07-23 | 2021-02-04 | Translate Bio, Inc. | Dry power formulations for messenger RNA |
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| US20210322575A1 (en) | 2018-09-28 | 2021-10-21 | Nutcracker Therapeutics, Inc. | Lipid nanoparticle formulations comprising lipidated cationic peptide compounds for nucleic acid delivery |
| BR112021006539A2 (en) | 2018-10-09 | 2021-07-06 | Univ British Columbia | compositions and competent systems of vesicles competent for transfection free of organic solvents and detergents and related methods |
| EP3877538A1 (en) | 2018-11-08 | 2021-09-15 | Translate Bio, Inc. | Methods and compositions for messenger rna purification |
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| KR20210102248A (en) | 2018-11-09 | 2021-08-19 | 트랜슬레이트 바이오 인코포레이티드 | 2,5-dioxopiperazine with intercalated ester, thioester, disulfide, and anhydride moieties |
| EP3883917B1 (en) | 2018-11-21 | 2024-01-24 | Translate Bio, Inc. | Cationic lipid compounds and compositions thereof for use in the delivery of messenger rna |
| EP3956303A1 (en) | 2019-04-18 | 2022-02-23 | Translate Bio, Inc. | Cystine cationic lipids |
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| EP3962902A1 (en) | 2019-05-03 | 2022-03-09 | Translate Bio, Inc. | Di-thioester cationic lipids |
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| JP2022537580A (en) | 2019-06-21 | 2022-08-26 | トランスレイト バイオ， インコーポレイテッド | tricine and citrate lipids |
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| CN111041025B (en) | 2019-12-17 | 2021-06-18 | 深圳市瑞吉生物科技有限公司 | mRNA targeting molecule based on combination of N-acetylgalactosamine polypeptide and preparation method thereof |
| WO2021202788A2 (en) * | 2020-04-03 | 2021-10-07 | Ionis Pharmaceuticals, Inc. | Modified oligomeric compounds and uses thereof |
| EP4149556A1 (en) | 2020-05-14 | 2023-03-22 | Translate Bio, Inc. | Peg lipidoid compounds |
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| CN114736260A (en) * | 2022-03-29 | 2022-07-12 | 上海吉量医药工程有限公司 | Preparation method of nucleotide triphosphate |
| KR20230170587A (en) * | 2022-06-10 | 2023-12-19 | 주식회사 피노바이오 | Preparing Method of 4'-thio-5-aza-2'-deoxycytidine |
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| FR2687679B1 (en) | 1992-02-05 | 1994-10-28 | Centre Nat Rech Scient | OLIGOTHIONUCLEOTIDES. |
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| WO2008103276A2 (en) * | 2007-02-16 | 2008-08-28 | Merck & Co., Inc. | Compositions and methods for potentiated activity of biologicaly active molecules |
| JP6087504B2 (en) | 2008-11-07 | 2017-03-01 | マサチューセッツ インスティテュート オブ テクノロジー | Amino alcohol lipidoids and uses thereof |
| DE102009032885A1 (en) | 2009-07-13 | 2011-02-03 | Siemens Aktiengesellschaft | Ring-shaped rotor for an electric machine |
| PL3338765T3 (en) * | 2009-12-01 | 2019-06-28 | Translate Bio, Inc. | Steroid derivative for the delivery of mrna in human genetic diseases |
| EP4043025A1 (en) | 2011-06-08 | 2022-08-17 | Translate Bio, Inc. | Lipid nanoparticle compositions and methods for mrna delivery |
| CN103748078B (en) | 2011-06-08 | 2016-11-09 | 夏尔人类遗传性治疗公司 | Cleavable lipid |
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-
2014
- 2014-03-14 KR KR1020157021965A patent/KR20150127582A/en not_active Application Discontinuation
- 2014-03-14 ES ES17189627T patent/ES2797974T3/en active Active
- 2014-03-14 US US14/776,506 patent/US10266559B2/en active Active
- 2014-03-14 BR BR112015022507A patent/BR112015022507A2/en not_active IP Right Cessation
- 2014-03-14 WO PCT/US2014/027422 patent/WO2014152513A1/en active Application Filing
- 2014-03-14 JP JP2016502430A patent/JP6567494B2/en active Active
- 2014-03-14 EA EA201591281A patent/EA201591281A1/en unknown
- 2014-03-14 CA CA2902884A patent/CA2902884C/en active Active
- 2014-03-14 ES ES14721635.2T patent/ES2647832T3/en active Active
- 2014-03-14 CN CN201480010106.8A patent/CN105026411A/en active Pending
- 2014-03-14 SG SG11201507474QA patent/SG11201507474QA/en unknown
- 2014-03-14 MX MX2015011943A patent/MX2015011943A/en unknown
- 2014-03-14 AU AU2014239562A patent/AU2014239562B2/en active Active
- 2014-03-14 EP EP14721635.2A patent/EP2970351B1/en active Active
- 2014-03-14 EP EP17189627.7A patent/EP3301102B1/en active Active
- 2014-03-14 EP EP20169380.1A patent/EP3750903A1/en active Pending
-
2015
- 2015-08-10 IL IL240465A patent/IL240465A0/en unknown
- 2015-10-13 ZA ZA2015/07605A patent/ZA201507605B/en unknown
-
2016
- 2016-07-07 HK HK16107939.1A patent/HK1219955A1/en unknown
-
2018
- 2018-06-05 AU AU2018203985A patent/AU2018203985B2/en active Active
-
2019
- 2019-02-21 US US16/282,106 patent/US10822368B2/en active Active
-
2020
- 2020-09-25 US US17/032,485 patent/US11447520B2/en active Active
-
2022
- 2022-08-10 US US17/818,858 patent/US20230192753A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2970351B1 (en) | 2017-09-13 |
| EP3301102A1 (en) | 2018-04-04 |
| CA2902884C (en) | 2021-05-25 |
| US20160031928A1 (en) | 2016-02-04 |
| EP3750903A1 (en) | 2020-12-16 |
| BR112015022507A2 (en) | 2017-10-24 |
| US20210009629A1 (en) | 2021-01-14 |
| JP6567494B2 (en) | 2019-08-28 |
| ES2797974T3 (en) | 2020-12-04 |
| CN105026411A (en) | 2015-11-04 |
| US10822368B2 (en) | 2020-11-03 |
| US20190263850A1 (en) | 2019-08-29 |
| AU2014239562B2 (en) | 2018-07-05 |
| KR20150127582A (en) | 2015-11-17 |
| ES2647832T3 (en) | 2017-12-26 |
| US20230192753A1 (en) | 2023-06-22 |
| AU2014239562A1 (en) | 2015-08-27 |
| EA201591281A1 (en) | 2016-02-29 |
| CA2902884A1 (en) | 2014-09-25 |
| IL240465A0 (en) | 2015-09-24 |
| JP2016513470A (en) | 2016-05-16 |
| US10266559B2 (en) | 2019-04-23 |
| HK1219955A1 (en) | 2017-04-21 |
| MX2015011943A (en) | 2015-12-01 |
| AU2018203985B2 (en) | 2019-09-19 |
| US11447520B2 (en) | 2022-09-20 |
| ZA201507605B (en) | 2017-01-25 |
| WO2014152513A1 (en) | 2014-09-25 |
| AU2018203985A1 (en) | 2018-06-21 |
| EP2970351A1 (en) | 2016-01-20 |
| EP3301102B1 (en) | 2020-04-15 |
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