JPWO2020056072A5 - - Google Patents
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- Publication number
- JPWO2020056072A5 JPWO2020056072A5 JP2021513958A JP2021513958A JPWO2020056072A5 JP WO2020056072 A5 JPWO2020056072 A5 JP WO2020056072A5 JP 2021513958 A JP2021513958 A JP 2021513958A JP 2021513958 A JP2021513958 A JP 2021513958A JP WO2020056072 A5 JPWO2020056072 A5 JP WO2020056072A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- alkoxy
- deuteroalkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 75
- 125000003545 alkoxy group Chemical group 0.000 claims 28
- 125000000623 heterocyclic group Chemical group 0.000 claims 23
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 229910052799 carbon Inorganic materials 0.000 claims 20
- 125000005345 deuteroalkyl group Chemical group 0.000 claims 20
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 16
- 125000005843 halogen group Chemical group 0.000 claims 16
- 229910052760 oxygen Inorganic materials 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000006712 (C1-C4) deuteroalkyl group Chemical group 0.000 claims 9
- -1 C 1-4 deuteroalkoxy Chemical group 0.000 claims 9
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 9
- 229910052731 fluorine Inorganic materials 0.000 claims 7
- 125000005842 heteroatom Chemical group 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 125000002757 morpholinyl group Chemical group 0.000 claims 5
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 2
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000005347 halocycloalkyl group Chemical group 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 102000005403 Casein Kinases Human genes 0.000 claims 1
- 108010031425 Casein Kinases Proteins 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 101001109145 Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Proteins 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 102100022501 Receptor-interacting serine/threonine-protein kinase 1 Human genes 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 125000006430 alkyl cyclopropyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862730602P | 2018-09-13 | 2018-09-13 | |
| US62/730,602 | 2018-09-13 | ||
| PCT/US2019/050719 WO2020056072A1 (en) | 2018-09-13 | 2019-09-12 | 1h-indazole carboxamides as receptor-interacting protein kinase 1 inhibitors (ripk1) |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022500418A JP2022500418A (ja) | 2022-01-04 |
| JP2022500418A5 JP2022500418A5 (https=) | 2022-09-05 |
| JPWO2020056072A5 true JPWO2020056072A5 (https=) | 2022-09-05 |
| JP7599411B2 JP7599411B2 (ja) | 2024-12-13 |
Family
ID=68073171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021513958A Active JP7599411B2 (ja) | 2018-09-13 | 2019-09-12 | 受容体相互作用タンパク質キナーゼ１阻害剤（ｒｉｐｋ１）としての１ｈ－インダゾールカルボキサミド |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US12172975B2 (https=) |
| EP (1) | EP3849968B1 (https=) |
| JP (1) | JP7599411B2 (https=) |
| KR (1) | KR102906523B1 (https=) |
| CN (1) | CN112673000B (https=) |
| AU (1) | AU2019337612A1 (https=) |
| BR (1) | BR112021004385A2 (https=) |
| CA (1) | CA3112735A1 (https=) |
| EA (1) | EA202190718A1 (https=) |
| ES (1) | ES2936481T3 (https=) |
| IL (1) | IL281370A (https=) |
| MX (1) | MX2021002509A (https=) |
| SG (1) | SG11202102405YA (https=) |
| WO (1) | WO2020056072A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE058292T2 (hu) | 2017-10-30 | 2022-07-28 | Bristol Myers Squibb Co | Aminoimidazopiridazinok mint kináz inhibitorok |
| CN112262139B (zh) | 2018-01-26 | 2023-07-25 | 百时美施贵宝公司 | 作为激酶抑制剂的氨基吡咯并三嗪 |
| AU2019339355A1 (en) | 2018-09-13 | 2021-05-13 | Bristol-Myers Squibb Company | Indazole carboxamides as kinase inhibitors |
| ES2969756T3 (es) * | 2019-10-03 | 2024-05-22 | Bristol Myers Squibb Co | Indazol carboxamidas como inhibidores de cinasas |
| EP4214207A4 (en) | 2020-09-15 | 2024-10-02 | 1st Biotherapeutics, Inc. | 2-AMINO-3-CARBONYL IMIDAZOPYRIDINE AND PYRAZOLOPYRIDINE COMPOUNDS |
| AR123793A1 (es) | 2020-10-19 | 2023-01-11 | Bristol Myers Squibb Co | Compuestos de triazolopiridinilo como inhibidores de quinasas |
| WO2025106362A1 (en) * | 2023-11-16 | 2025-05-22 | Merck Sharp & Dohme Llc | Ripk1 inhibitors and methods of use |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4836788B2 (ja) | 2003-07-23 | 2011-12-14 | エグゼリクシス， インコーポレイテッド | 未分化リンパ腫キナーゼ変調因子及びその使用法 |
| RU2418797C2 (ru) | 2004-12-22 | 2011-05-20 | Мемори Фармасьютиклз Корпорейшн | Лиганды никотинового рецептора альфа-7, их получение и применение |
| UA92083C2 (ru) | 2006-05-19 | 2010-09-27 | Эбботт Леборетриз | Азабициклические алкановые производные, замещенные конденсированным бициклогетероциклом |
| KR101061599B1 (ko) | 2008-12-05 | 2011-09-02 | 한국과학기술연구원 | 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물 |
| WO2010068287A2 (en) | 2008-12-11 | 2010-06-17 | Angion Biomedica Corp. | Small molecule modulators of hepatocyte growth factor (scatter factor) activity |
| EA020017B1 (ru) | 2009-04-30 | 2014-08-29 | Новартис Аг | Производные имидазола и их применение в качестве модуляторов циклинзависимых киназ |
| US8455516B2 (en) | 2010-01-15 | 2013-06-04 | Touro University | HIV-1 fusion inhibitors and methods |
| KR20130077390A (ko) * | 2011-12-29 | 2013-07-09 | 제이더블유중외제약 주식회사 | 단백질 키나아제 저해활성을 가지는 6-아미노-3-카복스아미도인다졸 유도체 |
| RS54539B1 (sr) | 2012-02-21 | 2016-06-30 | Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A. | Upotreba 1h-indazol-3-karboksamidnih jedinjenja kao inhibitora kinaze 3-beta glikogen sintetaze |
| CA2860250C (en) | 2012-02-21 | 2020-11-10 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors |
| WO2014047024A1 (en) | 2012-09-18 | 2014-03-27 | Bristol-Myers Squibb Company | Iap antagonists |
| CN104781251B (zh) * | 2012-11-08 | 2016-12-14 | 百时美施贵宝公司 | 可作为激酶调节剂的经双环杂环取代的吡啶基化合物 |
| MX2016012208A (es) | 2014-03-20 | 2017-01-26 | Samumed Llc | Indazol-3-carboxamidas 5-substituidas y preparacion y uso de las mismas. |
| EP3463355B1 (en) | 2016-05-26 | 2024-08-28 | Sonic Master Limited | Modulators of dux4 for regulation of muscle function |
| MA47460A (fr) | 2017-02-13 | 2019-12-18 | Bristol Myers Squibb Co | Aminotriazolopyridines utilisées en tant qu'inhibiteurs de kinase |
| HUE058292T2 (hu) | 2017-10-30 | 2022-07-28 | Bristol Myers Squibb Co | Aminoimidazopiridazinok mint kináz inhibitorok |
| CN112262139B (zh) | 2018-01-26 | 2023-07-25 | 百时美施贵宝公司 | 作为激酶抑制剂的氨基吡咯并三嗪 |
| AU2019339355A1 (en) | 2018-09-13 | 2021-05-13 | Bristol-Myers Squibb Company | Indazole carboxamides as kinase inhibitors |
| ES2969756T3 (es) | 2019-10-03 | 2024-05-22 | Bristol Myers Squibb Co | Indazol carboxamidas como inhibidores de cinasas |
-
2019
- 2019-09-12 KR KR1020217010498A patent/KR102906523B1/ko active Active
- 2019-09-12 BR BR112021004385-3A patent/BR112021004385A2/pt not_active Application Discontinuation
- 2019-09-12 US US17/274,220 patent/US12172975B2/en active Active
- 2019-09-12 SG SG11202102405YA patent/SG11202102405YA/en unknown
- 2019-09-12 MX MX2021002509A patent/MX2021002509A/es unknown
- 2019-09-12 EA EA202190718A patent/EA202190718A1/ru unknown
- 2019-09-12 ES ES19779240T patent/ES2936481T3/es active Active
- 2019-09-12 WO PCT/US2019/050719 patent/WO2020056072A1/en not_active Ceased
- 2019-09-12 JP JP2021513958A patent/JP7599411B2/ja active Active
- 2019-09-12 AU AU2019337612A patent/AU2019337612A1/en not_active Abandoned
- 2019-09-12 EP EP19779240.1A patent/EP3849968B1/en active Active
- 2019-09-12 CA CA3112735A patent/CA3112735A1/en active Pending
- 2019-09-12 CN CN201980059445.8A patent/CN112673000B/zh active Active
-
2021
- 2021-03-09 IL IL281370A patent/IL281370A/en unknown
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