SG11202102405YA - 1h-indazole carboxamides as receptor-interacting protein kinase 1 inhibitors (ripk1) - Google Patents
1h-indazole carboxamides as receptor-interacting protein kinase 1 inhibitors (ripk1)Info
- Publication number
- SG11202102405YA SG11202102405YA SG11202102405YA SG11202102405YA SG11202102405YA SG 11202102405Y A SG11202102405Y A SG 11202102405YA SG 11202102405Y A SG11202102405Y A SG 11202102405YA SG 11202102405Y A SG11202102405Y A SG 11202102405YA SG 11202102405Y A SG11202102405Y A SG 11202102405YA
- Authority
- SG
- Singapore
- Prior art keywords
- ripk1
- inhibitors
- receptor
- protein kinase
- interacting protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862730602P | 2018-09-13 | 2018-09-13 | |
| PCT/US2019/050719 WO2020056072A1 (en) | 2018-09-13 | 2019-09-12 | 1h-indazole carboxamides as receptor-interacting protein kinase 1 inhibitors (ripk1) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202102405YA true SG11202102405YA (en) | 2021-04-29 |
Family
ID=68073171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202102405YA SG11202102405YA (en) | 2018-09-13 | 2019-09-12 | 1h-indazole carboxamides as receptor-interacting protein kinase 1 inhibitors (ripk1) |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20220380335A1 (en) |
| EP (1) | EP3849968B1 (en) |
| JP (1) | JP2022500418A (en) |
| KR (1) | KR20210060517A (en) |
| CN (1) | CN112673000A (en) |
| AU (1) | AU2019337612A1 (en) |
| BR (1) | BR112021004385A2 (en) |
| CA (1) | CA3112735A1 (en) |
| EA (1) | EA202190718A1 (en) |
| ES (1) | ES2936481T3 (en) |
| IL (1) | IL281370A (en) |
| MX (1) | MX2021002509A (en) |
| SG (1) | SG11202102405YA (en) |
| WO (1) | WO2020056072A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020003706A (en) | 2017-10-30 | 2020-07-22 | Bristol Myers Squibb Co | Aminoimidazopyridazines as kinase inhibitors. |
| JP7307734B2 (en) | 2018-01-26 | 2023-07-12 | ブリストル－マイヤーズ スクイブ カンパニー | Aminopyrrolotriazines as Kinase Inhibitors |
| MX2022003769A (en) * | 2019-10-03 | 2022-04-20 | Bristol Myers Squibb Co | Indazole carboxamides as kinase inhibitors. |
| AR123793A1 (en) | 2020-10-19 | 2023-01-11 | Bristol Myers Squibb Co | TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2424843E (en) * | 2009-04-30 | 2014-06-02 | Novartis Ag | Imidazole derivatives and their use as modulators of cyclin dependent kinases |
| KR20130077390A (en) * | 2011-12-29 | 2013-07-09 | 제이더블유중외제약 주식회사 | 6-amino-3-carboxamidoindazole derivatives as protein kinase inhibitors |
| US9783573B2 (en) | 2012-09-18 | 2017-10-10 | Bristol-Myers Squibb Company | IAP antagonists |
| EP2922840B1 (en) * | 2012-11-08 | 2016-12-21 | Bristol-Myers Squibb Company | Bicyclic heterocycle substituted pyridyl compounds useful as kinase modulators |
| US20210309633A1 (en) * | 2018-09-13 | 2021-10-07 | Bristol-Myers Squibb Company | Indazole carboxamides as kinase inhibitors |
-
2019
- 2019-09-12 JP JP2021513958A patent/JP2022500418A/en active Pending
- 2019-09-12 ES ES19779240T patent/ES2936481T3/en active Active
- 2019-09-12 BR BR112021004385-3A patent/BR112021004385A2/en not_active Application Discontinuation
- 2019-09-12 EP EP19779240.1A patent/EP3849968B1/en active Active
- 2019-09-12 CN CN201980059445.8A patent/CN112673000A/en active Pending
- 2019-09-12 US US17/274,220 patent/US20220380335A1/en active Pending
- 2019-09-12 CA CA3112735A patent/CA3112735A1/en active Pending
- 2019-09-12 MX MX2021002509A patent/MX2021002509A/en unknown
- 2019-09-12 SG SG11202102405YA patent/SG11202102405YA/en unknown
- 2019-09-12 AU AU2019337612A patent/AU2019337612A1/en not_active Abandoned
- 2019-09-12 KR KR1020217010498A patent/KR20210060517A/en unknown
- 2019-09-12 EA EA202190718A patent/EA202190718A1/en unknown
- 2019-09-12 WO PCT/US2019/050719 patent/WO2020056072A1/en unknown
-
2021
- 2021-03-09 IL IL281370A patent/IL281370A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2936481T3 (en) | 2023-03-17 |
| EP3849968A1 (en) | 2021-07-21 |
| JP2022500418A (en) | 2022-01-04 |
| CA3112735A1 (en) | 2020-03-19 |
| EP3849968B1 (en) | 2022-12-21 |
| BR112021004385A2 (en) | 2021-07-20 |
| CN112673000A (en) | 2021-04-16 |
| KR20210060517A (en) | 2021-05-26 |
| EA202190718A1 (en) | 2021-07-01 |
| IL281370A (en) | 2021-04-29 |
| US20220380335A1 (en) | 2022-12-01 |
| WO2020056072A1 (en) | 2020-03-19 |
| MX2021002509A (en) | 2021-04-28 |
| AU2019337612A1 (en) | 2021-05-13 |
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