JPWO2020051139A5 - - Google Patents
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- Publication number
- JPWO2020051139A5 JPWO2020051139A5 JP2021512242A JP2021512242A JPWO2020051139A5 JP WO2020051139 A5 JPWO2020051139 A5 JP WO2020051139A5 JP 2021512242 A JP2021512242 A JP 2021512242A JP 2021512242 A JP2021512242 A JP 2021512242A JP WO2020051139 A5 JPWO2020051139 A5 JP WO2020051139A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- transplant rejection
- lung
- chronic
- pulmonary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010051604 Lung transplant rejection Diseases 0.000 claims description 36
- 150000001875 compounds Chemical class 0.000 claims description 32
- 206010035664 Pneumonia Diseases 0.000 claims description 30
- 206010035742 Pneumonitis Diseases 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 22
- 125000000217 alkyl group Chemical group 0.000 claims description 20
- 230000001684 chronic effect Effects 0.000 claims description 18
- 230000004064 dysfunction Effects 0.000 claims description 18
- 208000023504 respiratory system disease Diseases 0.000 claims description 18
- 230000002685 pulmonary effect Effects 0.000 claims description 17
- 241000124008 Mammalia Species 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 12
- 206010029888 Obliterative bronchiolitis Diseases 0.000 claims description 12
- 206010067472 Organising pneumonia Diseases 0.000 claims description 12
- 230000001154 acute effect Effects 0.000 claims description 12
- 208000006673 asthma Diseases 0.000 claims description 12
- 201000003848 bronchiolitis obliterans Diseases 0.000 claims description 12
- 208000023367 bronchiolitis obliterans with obstructive pulmonary disease Diseases 0.000 claims description 12
- 201000009805 cryptogenic organizing pneumonia Diseases 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 10
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 8
- 210000004072 lung Anatomy 0.000 claims description 7
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims description 6
- 206010006448 Bronchiolitis Diseases 0.000 claims description 6
- 206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 claims description 6
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 6
- 206010014561 Emphysema Diseases 0.000 claims description 6
- 208000027004 Eosinophilic disease Diseases 0.000 claims description 6
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims description 6
- 208000009329 Graft vs Host Disease Diseases 0.000 claims description 6
- 206010061201 Helminthic infection Diseases 0.000 claims description 6
- 206010048643 Hypereosinophilic syndrome Diseases 0.000 claims description 6
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims description 6
- 208000016300 Idiopathic chronic eosinophilic pneumonia Diseases 0.000 claims description 6
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims description 6
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims description 6
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims description 6
- 208000019693 Lung disease Diseases 0.000 claims description 6
- 206010049459 Lymphangioleiomyomatosis Diseases 0.000 claims description 6
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims description 6
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims description 6
- 206010060872 Transplant failure Diseases 0.000 claims description 6
- 206010069351 acute lung injury Diseases 0.000 claims description 6
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims description 6
- 208000006778 allergic bronchopulmonary aspergillosis Diseases 0.000 claims description 6
- 201000009267 bronchiectasis Diseases 0.000 claims description 6
- 206010006451 bronchitis Diseases 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 201000001155 extrinsic allergic alveolitis Diseases 0.000 claims description 6
- 230000002538 fungal effect Effects 0.000 claims description 6
- 208000024908 graft versus host disease Diseases 0.000 claims description 6
- 208000022098 hypersensitivity pneumonitis Diseases 0.000 claims description 6
- 208000013397 idiopathic acute eosinophilic pneumonia Diseases 0.000 claims description 6
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 6
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims description 6
- 230000000527 lymphocytic effect Effects 0.000 claims description 6
- 230000003448 neutrophilic effect Effects 0.000 claims description 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 6
- 201000000306 sarcoidosis Diseases 0.000 claims description 6
- 208000011580 syndromic disease Diseases 0.000 claims description 6
- -1 2,5-diazabicyclo[2.2.1]heptanyl Chemical group 0.000 claims description 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000004193 piperazinyl group Chemical group 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 9
- 238000000034 method Methods 0.000 description 13
- 230000000694 effects Effects 0.000 description 1
- 229940043355 kinase inhibitor Drugs 0.000 description 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862726583P | 2018-09-04 | 2018-09-04 | |
| US62/726,583 | 2018-09-04 | ||
| PCT/US2019/049342 WO2020051139A1 (en) | 2018-09-04 | 2019-09-03 | 5 to 7 membered heterocyclic amides as jak inhibitors |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021535174A JP2021535174A (ja) | 2021-12-16 |
| JPWO2020051139A5 true JPWO2020051139A5 (https=) | 2022-08-17 |
| JP2021535174A5 JP2021535174A5 (https=) | 2022-08-17 |
| JP7383696B2 JP7383696B2 (ja) | 2023-11-20 |
Family
ID=68051893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021512242A Active JP7383696B2 (ja) | 2018-09-04 | 2019-09-03 | Ｊａｋ阻害剤としての５員～７員の複素環アミド |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10836763B2 (https=) |
| EP (1) | EP3837010B1 (https=) |
| JP (1) | JP7383696B2 (https=) |
| KR (1) | KR20210056380A (https=) |
| CN (1) | CN112703037B (https=) |
| AR (1) | AR116114A1 (https=) |
| AU (1) | AU2019335200A1 (https=) |
| BR (1) | BR112021004063A2 (https=) |
| CL (1) | CL2021000515A1 (https=) |
| CO (1) | CO2021002976A2 (https=) |
| EA (1) | EA202190686A1 (https=) |
| ES (1) | ES2955717T3 (https=) |
| IL (1) | IL281150B2 (https=) |
| MX (1) | MX2021002484A (https=) |
| PH (1) | PH12021550324A1 (https=) |
| SG (1) | SG11202101751XA (https=) |
| TW (1) | TWI793365B (https=) |
| UA (1) | UA127328C2 (https=) |
| WO (1) | WO2020051139A1 (https=) |
| ZA (1) | ZA202100990B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016004079A1 (en) | 2014-06-30 | 2016-01-07 | Black & Decker Inc. | Battery pack for a cordless power tools |
| HK1252685A1 (zh) | 2015-11-03 | 2019-05-31 | Theravance Biopharma R&D Ip, Llc | 用於治疗呼吸疾病的jak激酶抑制剂化合物 |
| BR112019018648A2 (pt) | 2017-03-09 | 2020-06-16 | Theravance Biopharma R&D Ip, Llc | Inibidores de jak contendo uma amida heterocíclica com 4 membros |
| PT3837258T (pt) | 2018-09-04 | 2024-06-20 | Theravance Biopharma R&D Ip Llc | Amidas de dimetil amino azetidina como inibidores de jak |
| CA3108848A1 (en) | 2018-09-04 | 2020-03-12 | Theravance Biopharma R&D Ip, Llc | Process for preparing jak inhibitors and intermediates thereof |
| WO2020051139A1 (en) * | 2018-09-04 | 2020-03-12 | Theravance Biopharma R&D Ip, Llc | 5 to 7 membered heterocyclic amides as jak inhibitors |
| TW202144343A (zh) | 2020-03-02 | 2021-12-01 | 美商施萬生物製藥研發 Ip有限責任公司 | Jak抑制劑化合物之結晶水合物 |
| WO2022081872A1 (en) * | 2020-10-16 | 2022-04-21 | Gb008, Inc. | Janus kinase inhibitors |
| TW202317550A (zh) | 2021-06-25 | 2023-05-01 | 美商施萬生物製藥研發 Ip有限責任公司 | 作為jak抑制劑之咪唑吲唑化合物 |
| JP7644873B2 (ja) * | 2021-12-17 | 2025-03-12 | デウン ファーマシューティカル カンパニー リミテッド | （２Ｒ，３Ｓ）－２－（３－（４，５－ジクロロ－１Ｈ－ベンゾ［ｄ］イミダゾール－１－イル）プロピル）ピペリジン－３－オールの新規な酸付加塩および結晶形 |
| WO2025172431A1 (en) * | 2024-02-14 | 2025-08-21 | Almirall, S.A. | Stat6 inhibitors and methods of use thereof |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI262914B (en) | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
| JP4836788B2 (ja) | 2003-07-23 | 2011-12-14 | エグゼリクシス， インコーポレイテッド | 未分化リンパ腫キナーゼ変調因子及びその使用法 |
| US20050090529A1 (en) | 2003-07-31 | 2005-04-28 | Pfizer Inc | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
| US7884109B2 (en) | 2005-04-05 | 2011-02-08 | Wyeth Llc | Purine and imidazopyridine derivatives for immunosuppression |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| EP3070090B1 (en) | 2007-06-13 | 2018-12-12 | Incyte Holdings Corporation | Use of salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h- pyrazol-1-yl)-3- cyclopentylpropanenitrile |
| BRPI0909945A2 (pt) | 2008-06-20 | 2015-07-28 | Genentech Inc | "composto, composição farmacêutica, método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak2 quinase em um paciente, kit para o tratamento de uma doença ou distúrbio responsivo à inibição da jak quinase" |
| JP2010111624A (ja) | 2008-11-06 | 2010-05-20 | Shionogi & Co Ltd | Ｔｔｋ阻害作用を有するインダゾール誘導体 |
| EP2414340A1 (en) | 2009-04-03 | 2012-02-08 | Dainippon Sumitomo Pharma Co., Ltd. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
| EP2515655B1 (en) | 2009-12-21 | 2015-08-05 | Samumed, LLC | 1h-pyrazolo[3,4-beta]pyridines and therapeutic uses thereof |
| US8575336B2 (en) | 2011-07-27 | 2013-11-05 | Pfizer Limited | Indazoles |
| MX368464B (es) | 2013-12-05 | 2019-10-02 | Pfizer | Acrilamidas de pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinil o y pirrolo[2,3-d]piridinilo. |
| CR20160525A (es) | 2014-05-14 | 2016-12-20 | Pfizer | Pirazolopiridinas y pirazolopirimidinas |
| WO2016026078A1 (en) | 2014-08-19 | 2016-02-25 | Changzhou Jiekai Pharmatech Co., Ltd. | Heterocyclic compounds as erk inhibitors |
| KR101663277B1 (ko) | 2015-03-30 | 2016-10-06 | 주식회사 녹십자 | TNIK, IKKε 및 TBK1 억제제로서의 피라졸계 유도체 및 이를 포함하는 약학적 조성물 |
| HK1252685A1 (zh) | 2015-11-03 | 2019-05-31 | Theravance Biopharma R&D Ip, Llc | 用於治疗呼吸疾病的jak激酶抑制剂化合物 |
| US10556901B2 (en) * | 2015-11-03 | 2020-02-11 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as Janus kinase inhibitors |
| EP3712152B1 (en) * | 2015-11-03 | 2021-01-13 | Topivert Pharma Limited | 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors |
| EP3484876A1 (en) * | 2016-07-14 | 2019-05-22 | Pfizer Inc | Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme |
| BR112019018648A2 (pt) | 2017-03-09 | 2020-06-16 | Theravance Biopharma R&D Ip, Llc | Inibidores de jak contendo uma amida heterocíclica com 4 membros |
| US10406148B2 (en) | 2017-05-01 | 2019-09-10 | Theravance Biopharma R&D Ip, Llc | Methods of treatment using a JAK inhibitor compound |
| AR111495A1 (es) | 2017-05-01 | 2019-07-17 | Theravance Biopharma R&D Ip Llc | Compuestos de imidazo-piperidina fusionada como inhibidores de jak |
| CN110603255B (zh) | 2017-05-01 | 2023-02-10 | 施万生物制药研发Ip有限责任公司 | Jak抑制剂化合物的结晶型式 |
| WO2020051139A1 (en) * | 2018-09-04 | 2020-03-12 | Theravance Biopharma R&D Ip, Llc | 5 to 7 membered heterocyclic amides as jak inhibitors |
| PT3837258T (pt) | 2018-09-04 | 2024-06-20 | Theravance Biopharma R&D Ip Llc | Amidas de dimetil amino azetidina como inibidores de jak |
| CA3108848A1 (en) | 2018-09-04 | 2020-03-12 | Theravance Biopharma R&D Ip, Llc | Process for preparing jak inhibitors and intermediates thereof |
| MX2021004582A (es) | 2018-10-29 | 2021-06-15 | Theravance Biopharma R&D Ip Llc | Compuesto 2-azabiciclo hexano inhibidor de jak. |
| FI3932919T3 (fi) | 2019-02-25 | 2024-08-30 | Henan Medinno Pharmaceutical Tech Co Ltd | Jak-inhibiittoriyhdiste ja sen käyttö |
| MA55201A (fr) | 2019-03-05 | 2022-01-12 | Incyte Corp | Inhibiteurs de la voie jak1 pour le traitement d'un dysfonctionnement chronique de l'allogreffe pulmonaire |
| CN112279848A (zh) | 2019-07-25 | 2021-01-29 | 四川海思科制药有限公司 | 一种泛JAKs抑制剂及其用途 |
-
2019
- 2019-09-03 WO PCT/US2019/049342 patent/WO2020051139A1/en not_active Ceased
- 2019-09-03 AR ARP190102519A patent/AR116114A1/es not_active Application Discontinuation
- 2019-09-03 US US16/559,138 patent/US10836763B2/en active Active
- 2019-09-03 TW TW108131710A patent/TWI793365B/zh not_active IP Right Cessation
- 2019-09-03 EP EP19773584.8A patent/EP3837010B1/en active Active
- 2019-09-03 UA UAA202101706A patent/UA127328C2/uk unknown
- 2019-09-03 IL IL281150A patent/IL281150B2/en unknown
- 2019-09-03 ES ES19773584T patent/ES2955717T3/es active Active
- 2019-09-03 JP JP2021512242A patent/JP7383696B2/ja active Active
- 2019-09-03 CN CN201980057601.7A patent/CN112703037B/zh active Active
- 2019-09-03 AU AU2019335200A patent/AU2019335200A1/en not_active Abandoned
- 2019-09-03 KR KR1020217009933A patent/KR20210056380A/ko not_active Withdrawn
- 2019-09-03 BR BR112021004063-3A patent/BR112021004063A2/pt not_active IP Right Cessation
- 2019-09-03 SG SG11202101751XA patent/SG11202101751XA/en unknown
- 2019-09-03 MX MX2021002484A patent/MX2021002484A/es unknown
- 2019-09-03 EA EA202190686A patent/EA202190686A1/ru unknown
-
2020
- 2020-10-13 US US16/949,067 patent/US11713315B2/en active Active
-
2021
- 2021-02-12 ZA ZA2021/00990A patent/ZA202100990B/en unknown
- 2021-02-15 PH PH12021550324A patent/PH12021550324A1/en unknown
- 2021-03-02 CL CL2021000515A patent/CL2021000515A1/es unknown
- 2021-03-04 CO CONC2021/0002976A patent/CO2021002976A2/es unknown
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