MX2021002484A - Amidas heterociclicas de 5 a 7 miembros como inhibidores de jak. - Google Patents

Amidas heterociclicas de 5 a 7 miembros como inhibidores de jak.

Info

Publication number
MX2021002484A
MX2021002484A MX2021002484A MX2021002484A MX2021002484A MX 2021002484 A MX2021002484 A MX 2021002484A MX 2021002484 A MX2021002484 A MX 2021002484A MX 2021002484 A MX2021002484 A MX 2021002484A MX 2021002484 A MX2021002484 A MX 2021002484A
Authority
MX
Mexico
Prior art keywords
membered heterocyclic
jak inhibitors
heterocyclic amides
compounds
amides
Prior art date
Application number
MX2021002484A
Other languages
English (en)
Inventor
Daniel D Long
Cameron Smith
Corbin Thompson
Original Assignee
Theravance Biopharma R&D Ip Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Biopharma R&D Ip Llc filed Critical Theravance Biopharma R&D Ip Llc
Publication of MX2021002484A publication Critical patent/MX2021002484A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La invención proporciona compuestos de la fórmula (I): (ver Fórmula) (I) donde las variables se definen en la memoria, o una sal farmacéuticamente aceptable de estas, que son útiles como inhibidores de la cinasa JAK. La invención también proporciona composiciones farmacéuticas que comprenden dichos compuestos y métodos de uso de dichos compuestos para tratar las enfermedades respiratorias.
MX2021002484A 2018-09-04 2019-09-03 Amidas heterociclicas de 5 a 7 miembros como inhibidores de jak. MX2021002484A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862726583P 2018-09-04 2018-09-04
PCT/US2019/049342 WO2020051139A1 (en) 2018-09-04 2019-09-03 5 to 7 membered heterocyclic amides as jak inhibitors

Publications (1)

Publication Number Publication Date
MX2021002484A true MX2021002484A (es) 2021-05-12

Family

ID=68051893

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021002484A MX2021002484A (es) 2018-09-04 2019-09-03 Amidas heterociclicas de 5 a 7 miembros como inhibidores de jak.

Country Status (19)

Country Link
US (2) US10836763B2 (es)
EP (1) EP3837010B1 (es)
JP (1) JP7383696B2 (es)
KR (1) KR20210056380A (es)
CN (1) CN112703037B (es)
AR (1) AR116114A1 (es)
AU (1) AU2019335200A1 (es)
BR (1) BR112021004063A2 (es)
CL (1) CL2021000515A1 (es)
CO (1) CO2021002976A2 (es)
EA (1) EA202190686A1 (es)
ES (1) ES2955717T3 (es)
IL (1) IL281150B2 (es)
MX (1) MX2021002484A (es)
PH (1) PH12021550324A1 (es)
SG (1) SG11202101751XA (es)
TW (1) TWI793365B (es)
UA (1) UA127328C2 (es)
WO (1) WO2020051139A1 (es)

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EA037748B1 (ru) 2017-03-09 2021-05-18 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи Конденсированные имидазо-пиперидиновые ингибиторы jak
MX2021002273A (es) 2018-09-04 2021-05-27 Theravance Biopharma R&D Ip Llc Proceso para preparar inhibidores de las jak y productos intermedios de estos.
JP7324836B2 (ja) 2018-09-04 2023-08-10 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Ｊａｋ阻害剤としてのジメチルアミノアゼチジンアミド
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TW202144343A (zh) * 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
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Also Published As

Publication number Publication date
UA127328C2 (uk) 2023-07-19
US20200071325A1 (en) 2020-03-05
IL281150B2 (en) 2024-03-01
EP3837010C0 (en) 2023-07-05
CN112703037B (zh) 2023-10-20
EP3837010B1 (en) 2023-07-05
WO2020051139A1 (en) 2020-03-12
ES2955717T3 (es) 2023-12-05
IL281150B1 (en) 2023-11-01
US11713315B2 (en) 2023-08-01
CO2021002976A2 (es) 2021-05-31
IL281150A (en) 2021-04-29
CN112703037A (zh) 2021-04-23
SG11202101751XA (en) 2021-03-30
TW202024075A (zh) 2020-07-01
US10836763B2 (en) 2020-11-17
AR116114A1 (es) 2021-03-31
PH12021550324A1 (en) 2021-10-04
EP3837010A1 (en) 2021-06-23
JP7383696B2 (ja) 2023-11-20
AU2019335200A1 (en) 2021-03-11
JP2021535174A (ja) 2021-12-16
TWI793365B (zh) 2023-02-21
KR20210056380A (ko) 2021-05-18
CL2021000515A1 (es) 2021-07-23
EA202190686A1 (ru) 2021-07-23
US20210024517A1 (en) 2021-01-28
BR112021004063A2 (pt) 2021-05-25

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