JPWO2020033784A5

JPWO2020033784A5 -

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Publication number: JPWO2020033784A5
Authority: JP; Japan
Prior art keywords: methyl; oxo; amino; dimethylamino; dioxohept
Prior art date: 2022-08-18
Legal status : Granted

Application number

JP2021531468A

Other languages

English (en)

Japanese (ja)

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JP7433315B2 (ja

JP2021534240A (ja

Publication date

2022-08-18

2019-08-09 Application filed filed Critical

2019-08-09 Priority claimed from PCT/US2019/045827 external-priority patent/WO2020033784A1/en

2021-12-09 Publication of JP2021534240A publication Critical patent/JP2021534240A/ja

2022-08-18 Publication of JPWO2020033784A5 publication Critical patent/JPWO2020033784A5/ja

2024-02-19 Application granted granted Critical

2024-02-19 Publication of JP7433315B2 publication Critical patent/JP7433315B2/ja

Status Active legal-status Critical Current

2039-08-09 Anticipated expiration legal-status Critical

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-1 pyrrolopyridinyl Chemical group 0.000 claims 176
125000000217 alkyl group Chemical group 0.000 claims 32
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 22
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 17
229910052736 halogen Inorganic materials 0.000 claims 16
150000002367 halogens Chemical class 0.000 claims 16
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 15
150000003839 salts Chemical class 0.000 claims 15
150000001875 compounds Chemical class 0.000 claims 14
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 14
125000001072 heteroaryl group Chemical group 0.000 claims 13
125000000592 heterocycloalkyl group Chemical group 0.000 claims 12
125000000547 substituted alkyl group Chemical group 0.000 claims 9
125000005037 alkyl phenyl group Chemical group 0.000 claims 7
239000008194 pharmaceutical composition Substances 0.000 claims 5
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 4
125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 4
125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 4
125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 claims 4
125000001041 indolyl group Chemical group 0.000 claims 4
229910052757 nitrogen Inorganic materials 0.000 claims 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 4
125000005346 substituted cycloalkyl group Chemical group 0.000 claims 4
125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
125000001188 haloalkyl group Chemical group 0.000 claims 3
YDQGFLDEZROTKJ-LKUPDRCFSA-N methyl N-[(E,2S)-1-[[6-chloro-1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound ClC1=CC=C(C(N1CC=1NC2=C(C(=NC=C2F)CC(C)C)N=1)=O)NC(=O)[C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O YDQGFLDEZROTKJ-LKUPDRCFSA-N 0.000 claims 3
HRNJTSVORIKOKE-CRXAPCCLSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(1-hydroxy-2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2C(C(C)C)O)=O)NC(OC)=O)=O)C HRNJTSVORIKOKE-CRXAPCCLSA-N 0.000 claims 3
VNQQXHATNXETIS-RQMBKDMJSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-6-methyl-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound COC(N[C@@H](CC\C=C\C(=O)N(C)C)C(NC=1C(N(C(=CC=1)C)CC=1NC2=C(C(=NC=C2F)CC(C)C)N=1)=O)=O)=O VNQQXHATNXETIS-RQMBKDMJSA-N 0.000 claims 3
125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
125000006582 (C5-C6) heterocycloalkyl group Chemical group 0.000 claims 2
206010016654 Fibrosis Diseases 0.000 claims 2
NCXARPRSASKNJD-MFUYTVRRSA-N [(E,2S)-1-[[6-chloro-1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@@H](CC\C=C\C(=O)N(C)C)C(NC=1C(N(C(=CC=1)Cl)CC=1NC2=C(C(=NC=C2F)CC(C)C)N=1)=O)=O)=O)C NCXARPRSASKNJD-MFUYTVRRSA-N 0.000 claims 2
QOOXMBZGNDDJFQ-JEAXJQIYSA-N [(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-3-methyl-7-(2-methylpropyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@H](C(=O)NC=1C(N(C=CC=1)CC1=C(C2=NC=C(C(=C2N1)CC(C)C)F)C)=O)CC\C=C\C(=O)N(C)C)=O)C QOOXMBZGNDDJFQ-JEAXJQIYSA-N 0.000 claims 2
AXKUUPUFTXWUAV-CRWWQRIJSA-N [(E,2S)-7-(dimethylamino)-1-[[1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-6-methyl-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@H](C(=O)NC=1C(N(C(=CC=1)C)CC=1NC2=C(C(=NC=C2F)CC(C)C)N=1)=O)CC\C=C\C(=O)N(C)C)=O)C AXKUUPUFTXWUAV-CRWWQRIJSA-N 0.000 claims 2
IMFMFNWNGUZMET-WXQAMHPUSA-N [(E,2S)-7-(dimethylamino)-1-[[6-methyl-1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@H](C(=O)NC=1C(N(C(=CC=1)C)CC1=NC2=C(N1)C(=CC=C2)CC(C)C)=O)CC\C=C\C(=O)N(C)C)=O)C IMFMFNWNGUZMET-WXQAMHPUSA-N 0.000 claims 2
125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
208000030533 eye disease Diseases 0.000 claims 2
230000004761 fibrosis Effects 0.000 claims 2
125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 claims 2
125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 claims 2
UFXKXGLTNMAKHH-UABRLCRWSA-N methyl N-[(E,2S)-1-[[6-chloro-1-[[4-(cyclopropylmethyl)-7-fluoro-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound ClC1=CC=C(C(N1CC1=NC2=C(C(=NC=C2F)CC2CC2)N1)=O)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O UFXKXGLTNMAKHH-UABRLCRWSA-N 0.000 claims 2
VZSXQFOWGOOSJD-YERXGYGTSA-N methyl N-[(E,2S)-1-[[6-chloro-1-[[7-fluoro-4-(3,3,3-trifluoropropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound ClC1=CC=C(C(N1CC1=NC2=C(C(=NC=C2F)CCC(F)(F)F)N1)=O)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O VZSXQFOWGOOSJD-YERXGYGTSA-N 0.000 claims 2
OBSSBNOYCXOADJ-MYHKYFONSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC(C)C)=O)=O)NC(OC)=O)=O)C OBSSBNOYCXOADJ-MYHKYFONSA-N 0.000 claims 2
VOWLKWSIRZMJSS-HSRJRILOSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-3-methyl-7-(2-methylpropyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC1=C(C2=NC=C(C(=C2N1)CC(C)C)F)C)=O)=O)NC(OC)=O)=O)C VOWLKWSIRZMJSS-HSRJRILOSA-N 0.000 claims 2
AWDBCUVGXSRYSA-LKUPDRCFSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxo-6-(trifluoromethyl)pyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C(=CC=1)C(F)(F)F)CC1=NC2=C(C(=NC=C2F)CC(C)C)N1)=O)NC(OC)=O)=O)C AWDBCUVGXSRYSA-LKUPDRCFSA-N 0.000 claims 2
DIIIKYNCMDWFFG-IWHGQQBYSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-fluoro-4-(3,3,3-trifluoropropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-6-methyl-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C(=CC=1)C)CC1=NC2=C(C(=NC=C2F)CCC(F)(F)F)N1)=O)NC(OC)=O)=O)C DIIIKYNCMDWFFG-IWHGQQBYSA-N 0.000 claims 2
QHBAJNYXDHLOHR-LKUPDRCFSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[6-fluoro-1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C(=CC=1)F)CC1=NC2=C(C(=NC=C2F)CC(C)C)N1)=O)NC(OC)=O)=O)C QHBAJNYXDHLOHR-LKUPDRCFSA-N 0.000 claims 2
LFEDUWOFIWIATE-SYZXBLONSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[6-methyl-1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C(=CC=1)C)CC1=NC2=C(N1)C=CC=C2CC(C)C)=O)=O)NC(OC)=O)=O)C LFEDUWOFIWIATE-SYZXBLONSA-N 0.000 claims 2
230000004770 neurodegeneration Effects 0.000 claims 2
208000015122 neurodegenerative disease Diseases 0.000 claims 2
125000003373 pyrazinyl group Chemical group 0.000 claims 2
WSYSKCIBMIJRLB-ARKLPKAPSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(2-hydroxyethoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]indole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=CC=CC=C2C=1)C(=O)OC(C)(C)C)=O)NC(=O)OCCO)=O)C WSYSKCIBMIJRLB-ARKLPKAPSA-N 0.000 claims 2
ZCPJITIANDUFMZ-FIAZFDOBSA-N (2,4-difluorophenyl)methyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoroindole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=CC=C(C=C2C=1)F)C(=O)OCC1=C(C=C(C=C1)F)F)=O)OC(N(C)C)=O)=O)C ZCPJITIANDUFMZ-FIAZFDOBSA-N 0.000 claims 1
XQHIQYQGDHXJFY-HSRJRILOSA-N (E,6S)-6-(dimethylcarbamoylamino)-N'-[1-[[6-fluoro-4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]-N,N-dimethylhept-2-enediamide Chemical compound CN(C(N[C@@H](CC/C=C/C(=O)N(C)C)C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC(=C2)F)CC(C)C)=O)=O)C XQHIQYQGDHXJFY-HSRJRILOSA-N 0.000 claims 1
JBAWYXNZLZTYPE-UBQCRTFRSA-N (E,6S)-6-(dimethylcarbamoylamino)-N'-[1-[[6-fluoro-7-(2-methylpropyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]-N,N-dimethylhept-2-enediamide Chemical compound CN(C(N[C@@H](CC/C=C/C(=O)N(C)C)C(=O)NC=1C(N(C=CC=1)CC1=CC2=NC=C(C(=C2N1)CC(C)C)F)=O)=O)C JBAWYXNZLZTYPE-UBQCRTFRSA-N 0.000 claims 1
VIKZZYKOKQHMFG-BODNZJIQSA-N (E,6S)-6-(dimethylcarbamoylamino)-N,N-dimethyl-N'-[1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]hept-2-enediamide Chemical compound CN(C(N[C@@H](CC/C=C/C(=O)N(C)C)C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC(C)C)=O)=O)C VIKZZYKOKQHMFG-BODNZJIQSA-N 0.000 claims 1
DKHREONPOZSNJF-JTQMXQEVSA-N (E,6S)-6-[(2-fluorobenzoyl)amino]-N,N-dimethyl-N'-[1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]hept-2-enediamide Chemical compound FC1=C(C(=O)N[C@@H](CC/C=C/C(=O)N(C)C)C(=O)NC=2C(N(C=CC=2)CC2=NC3=C(N2)C=CC=C3CC(C)C)=O)C=CC=C1 DKHREONPOZSNJF-JTQMXQEVSA-N 0.000 claims 1
STEVINUACLIUGP-MNTLFOFUSA-N (E,6S)-6-[(2-methoxyacetyl)amino]-N,N-dimethyl-N'-[1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]hept-2-enediamide Chemical compound C(C(C)C)C1=CC=CC2=C1NC(=N2)CN1C(C(=CC=C1)NC([C@H](CC/C=C/C(=O)N(C)C)NC(COC)=O)=O)=O STEVINUACLIUGP-MNTLFOFUSA-N 0.000 claims 1
DZMCZAVOIOXVJS-KMDKVFFASA-N (E,6S)-N'-[1-(1H-benzimidazol-2-ylmethyl)-2-oxopyridin-3-yl]-6-(3-hydroxypropanoylamino)-N,N-dimethylhept-2-enediamide Chemical compound N1C(=NC2=C1C=CC=C2)CN1C(C(=CC=C1)NC([C@H](CC/C=C/C(=O)N(C)C)NC(CCO)=O)=O)=O DZMCZAVOIOXVJS-KMDKVFFASA-N 0.000 claims 1
VPKWFLQYWJHWTA-QILOHQJPSA-N (E,6S)-N'-[1-(1H-benzimidazol-2-ylmethyl)-2-oxopyridin-3-yl]-6-(4-hydroxybutanoylamino)-N,N-dimethylhept-2-enediamide Chemical compound N1C(=NC2=C1C=CC=C2)CN1C(C(=CC=C1)NC([C@H](CC/C=C/C(=O)N(C)C)NC(CCCO)=O)=O)=O VPKWFLQYWJHWTA-QILOHQJPSA-N 0.000 claims 1
HVYUOGUDDQFGPO-GLOIGSRVSA-N (E,6S)-N'-[1-[[4-(2,4-difluorophenoxy)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]-6-[(2-methoxyacetyl)amino]-N,N-dimethylhept-2-enediamide Chemical compound FC1=C(OC2=CC=CC3=C2NC(=N3)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N(C)C)NC(COC)=O)=O)=O)C=CC(=C1)F HVYUOGUDDQFGPO-GLOIGSRVSA-N 0.000 claims 1
VOGSHUNTYXNWFS-NHTJFMIFSA-N (E,6S)-N'-[1-[[4-(2,4-difluorophenoxy)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]-N,N-dimethyl-6-(1,3-oxazole-2-carbonylamino)hept-2-enediamide Chemical compound FC1=C(OC2=CC=CC3=C2NC(=N3)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N(C)C)NC(=O)C=2OC=CN=2)=O)=O)C=CC(=C1)F VOGSHUNTYXNWFS-NHTJFMIFSA-N 0.000 claims 1
QRLWGBXEZURNTI-IVYDRHTBSA-N (E,6S)-N'-[1-[[4-[(2,4-difluorophenyl)methoxy]-6-fluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]-6-[(2-methoxyacetyl)amino]hept-2-enediamide Chemical compound FC1=C(COC2=CC(=CC3=C2NC(=N3)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N)NC(COC)=O)=O)=O)F)C=CC(=C1)F QRLWGBXEZURNTI-IVYDRHTBSA-N 0.000 claims 1
BDXGVEXFBPZUJG-JGZGHEEISA-N (E,6S)-N'-[1-[[4-[(2,4-difluorophenyl)methoxy]-6-fluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]-6-[(5-fluoropyridine-2-carbonyl)amino]hept-2-enediamide Chemical compound FC1=C(COC2=CC(=CC3=C2NC(=N3)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N)NC(C2=NC=C(C=C2)F)=O)=O)=O)F)C=CC(=C1)F BDXGVEXFBPZUJG-JGZGHEEISA-N 0.000 claims 1
WMQQFWZZTTZMOX-UJVYDMDKSA-N (E,6S)-N'-[1-[[6-fluoro-4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]-6-[[2-methoxyethyl(methyl)carbamoyl]amino]-N,N-dimethylhept-2-enediamide Chemical compound FC1=CC2=C(NC(=N2)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N(C)C)NC(=O)N(C)CCOC)=O)=O)C(=C1)CC(C)C WMQQFWZZTTZMOX-UJVYDMDKSA-N 0.000 claims 1
CYJGAIWSLIHTDZ-CVZJYKDUSA-N (E,6S)-N'-[1-[[7-[(2,4-difluorophenyl)methoxy]-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]-6-[(2-fluorobenzoyl)amino]-N,N-dimethylhept-2-enediamide Chemical compound FC1=C(COC2=CC=CC=3N=C(SC=32)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N(C)C)NC(C2=C(C=CC=C2)F)=O)=O)=O)C=CC(=C1)F CYJGAIWSLIHTDZ-CVZJYKDUSA-N 0.000 claims 1
RGTKIAMOFNKGTR-MPWLDEBCSA-N (E,6S)-N'-[1-[[7-[(2,4-difluorophenyl)methoxy]-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]-6-[(2-fluorobenzoyl)amino]hept-2-enediamide Chemical compound FC1=C(COC2=CC=CC=3N=C(SC=32)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N)NC(C2=C(C=CC=C2)F)=O)=O)=O)C=CC(=C1)F RGTKIAMOFNKGTR-MPWLDEBCSA-N 0.000 claims 1
PRMIWTSZKYCCLS-RYXQVQKZSA-N (E,6S)-N'-[1-[[7-[(2,4-difluorophenyl)methoxy]-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]-6-[(2-methoxyacetyl)amino]-N,N-dimethylhept-2-enediamide Chemical compound FC1=C(COC2=CC=CC=3N=C(SC=32)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N(C)C)NC(COC)=O)=O)=O)C=CC(=C1)F PRMIWTSZKYCCLS-RYXQVQKZSA-N 0.000 claims 1
YDSVXCDJAXPNHI-NNBOSUQASA-N (E,6S)-N'-[1-[[7-[(2,4-difluorophenyl)methoxy]-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]-6-[(2-methoxyacetyl)amino]hept-2-enediamide Chemical compound FC1=C(COC2=CC=CC=3N=C(SC=32)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N)NC(COC)=O)=O)=O)C=CC(=C1)F YDSVXCDJAXPNHI-NNBOSUQASA-N 0.000 claims 1
DUVLDTPXGJZCAS-BMJPBMPMSA-N (E,6S)-N'-[1-[[7-[(2,4-difluorophenyl)methoxy]-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]-N,N-dimethyl-6-(1,3-oxazole-2-carbonylamino)hept-2-enediamide Chemical compound FC1=C(COC2=CC=CC=3N=C(SC=32)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N(C)C)NC(=O)C=2OC=CN=2)=O)=O)C=CC(=C1)F DUVLDTPXGJZCAS-BMJPBMPMSA-N 0.000 claims 1
ZLARRZPIODMOMZ-HZGPLKKJSA-N (E,6S)-N'-[1-[[7-[(2,4-difluorophenyl)methoxy]-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]-6-[(2-fluorobenzoyl)amino]-N,N-dimethylhept-2-enediamide Chemical compound FC1=C(COC=2C=CC=C3C=C(NC=23)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N(C)C)NC(C2=C(C=CC=C2)F)=O)=O)=O)C=CC(=C1)F ZLARRZPIODMOMZ-HZGPLKKJSA-N 0.000 claims 1
PGQYTKCYOURIAB-MCGJHWDDSA-N (E,6S)-N'-[1-[[7-[(2,4-difluorophenyl)methoxy]-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]-6-[(2-fluorobenzoyl)amino]hept-2-enediamide Chemical compound FC1=C(COC=2C=CC=C3C=C(NC=23)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N)NC(C2=C(C=CC=C2)F)=O)=O)=O)C=CC(=C1)F PGQYTKCYOURIAB-MCGJHWDDSA-N 0.000 claims 1
PTMCOLPIJJKEFF-AFSLHWDRSA-N (E,6S)-N'-[1-[[7-[(2,4-difluorophenyl)methoxy]-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]-6-[(2-methoxyacetyl)amino]-N,N-dimethylhept-2-enediamide Chemical compound FC1=C(COC=2C=CC=C3C=C(NC=23)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N(C)C)NC(COC)=O)=O)=O)C=CC(=C1)F PTMCOLPIJJKEFF-AFSLHWDRSA-N 0.000 claims 1
QSURSZRTNUSXEK-PLIHDNKHSA-N (E,6S)-N'-[1-[[7-[(2,4-difluorophenyl)methoxy]-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]-6-[(2-methoxyacetyl)amino]hept-2-enediamide Chemical compound FC1=C(COC=2C=CC=C3C=C(NC=23)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N)NC(COC)=O)=O)=O)C=CC(=C1)F QSURSZRTNUSXEK-PLIHDNKHSA-N 0.000 claims 1
MZNYMLPAKPOLPU-VVJPYVISSA-N (E,6S)-N'-[1-[[7-[(2,4-difluorophenyl)methoxy]-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]-N,N-dimethyl-6-(1,3-oxazole-2-carbonylamino)hept-2-enediamide Chemical compound FC1=C(COC=2C=CC=C3C=C(NC=23)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N(C)C)NC(=O)C=2OC=CN=2)=O)=O)C=CC(=C1)F MZNYMLPAKPOLPU-VVJPYVISSA-N 0.000 claims 1
BPZKMOCTWZABCQ-VVCKJVIVSA-N (E,6S)-N'-[1-[[7-[(2,4-difluorophenyl)methoxy]-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]-N,N-dimethyl-6-(3,3,3-trifluoropropanoylamino)hept-2-enediamide Chemical compound FC1=C(COC=2C=CC=C3C=C(NC=23)CN2C(C(=CC=C2)NC([C@H](CC/C=C/C(=O)N(C)C)NC(CC(F)(F)F)=O)=O)=O)C=CC(=C1)F BPZKMOCTWZABCQ-VVCKJVIVSA-N 0.000 claims 1
JCQMAWICBGGQLT-MTYJKQJESA-N (E,6S)-N,N-dimethyl-N'-[1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]-6-(pyridine-2-carbonylamino)hept-2-enediamide Chemical compound C(C(C)C)C1=CC=CC=2NC(=NC=21)CN1C(C(=CC=C1)NC([C@H](CC/C=C/C(=O)N(C)C)NC(C1=NC=CC=C1)=O)=O)=O JCQMAWICBGGQLT-MTYJKQJESA-N 0.000 claims 1
PREORRGLSIPWJF-JIWMQAFSSA-N 2-(dimethylamino)ethyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-7-(2-methylpropyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC1=CC2=NC=C(C(=C2N1)CC(C)C)F)=O)=O)NC(OCCN(C)C)=O)=O)C PREORRGLSIPWJF-JIWMQAFSSA-N 0.000 claims 1
BETMVTNJANSPAN-VQANOXKBSA-N 2-hydroxyethyl N-[(E,2S)-1-[[1-(1,3-benzothiazol-2-ylmethyl)-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound S1C(=NC2=C1C=CC=C2)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OCCO)=O)=O)=O BETMVTNJANSPAN-VQANOXKBSA-N 0.000 claims 1
FSWQFQJMGOAIKD-AJYURUAUSA-N 2-hydroxyethyl N-[(E,2S)-1-[[1-[(5-fluoro-1H-indol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxo-7-pyrrolidin-1-ylhept-5-en-2-yl]carbamate Chemical compound FC=1C=C2C=C(NC2=CC=1)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(N1CCCC1)=O)NC(OCCO)=O)=O)=O FSWQFQJMGOAIKD-AJYURUAUSA-N 0.000 claims 1
ZNUTVFKZRSFGLX-MPWLDEBCSA-N 2-hydroxyethyl N-[(E,2S)-1-[[1-[[7-(2-methylpropyl)-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxo-7-pyrrolidin-1-ylhept-5-en-2-yl]carbamate Chemical compound C(C(C)C)C=1C=CC=C2C=C(NC=12)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(N1CCCC1)=O)NC(OCCO)=O)=O)=O ZNUTVFKZRSFGLX-MPWLDEBCSA-N 0.000 claims 1
VJLVHNRASWZWCB-SOMHIGCCSA-N 2-hydroxyethyl N-[(E,2S)-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-5-fluoro-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxo-7-pyrrolidin-1-ylhept-5-en-2-yl]carbamate Chemical compound FC1=C(COC=2C=C(C=C3C=C(NC=23)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(N2CCCC2)=O)NC(OCCO)=O)=O)=O)F)C=CC(=C1)F VJLVHNRASWZWCB-SOMHIGCCSA-N 0.000 claims 1
GRWSSVBLRUPTQJ-YUWCZGPHSA-N 2-hydroxyethyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC(C)C)=O)NC(OCCO)=O)=O)C GRWSSVBLRUPTQJ-YUWCZGPHSA-N 0.000 claims 1
GPHFJASYBLNJLT-YUWCZGPHSA-N 2-hydroxyethyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2-methylpropyl)-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1SC2=C(N=1)C=CC=C2CC(C)C)=O)NC(OCCO)=O)=O)C GPHFJASYBLNJLT-YUWCZGPHSA-N 0.000 claims 1
XOHKSMYISDVXQG-YUWCZGPHSA-N 2-hydroxyethyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2-methylpropyl)-1,3-benzoxazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1OC2=C(N=1)C=CC=C2CC(C)C)=O)NC(OCCO)=O)=O)C XOHKSMYISDVXQG-YUWCZGPHSA-N 0.000 claims 1
AOKQJFAQOMRZIY-WJXUGBSRSA-N 2-hydroxyethyl N-[(E,2S)-7-amino-1-[[1-(1,3-benzothiazol-2-ylmethyl)-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1SC2=C(N=1)C=CC=C2)=O)NC(OCCO)=O)=O AOKQJFAQOMRZIY-WJXUGBSRSA-N 0.000 claims 1
RHMVGWRHPYOMPA-WJXUGBSRSA-N 2-hydroxyethyl N-[(E,2S)-7-amino-1-[[1-(1,3-benzoxazol-2-ylmethyl)-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1OC2=C(N=1)C=CC=C2)=O)NC(OCCO)=O)=O RHMVGWRHPYOMPA-WJXUGBSRSA-N 0.000 claims 1
IATFNKLJUOHTIR-COKXLDBZSA-N 2-hydroxyethyl N-[(E,2S)-7-amino-1-[[1-(1H-benzimidazol-2-ylmethyl)-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound OCCOC(N[C@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2)=O)CC\C=C\C(=O)N)=O IATFNKLJUOHTIR-COKXLDBZSA-N 0.000 claims 1
QKCOFPHQNCFGGD-WOHYUNQLSA-N 2-methoxyethyl N-[(E,2S)-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-5-fluoro-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(COC=2C=C(C=C3C=C(NC=23)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OCCOC)=O)=O)=O)F)C=CC(=C1)F QKCOFPHQNCFGGD-WOHYUNQLSA-N 0.000 claims 1
JUYPBVJGAJFKBE-XLIBHFEYSA-N 2-methoxyethyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2,2-dimethylpropyl)-6-fluoro-1-methylbenzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C)C=C(C=C2CC(C)(C)C)F)=O)NC(OCCOC)=O)=O)C JUYPBVJGAJFKBE-XLIBHFEYSA-N 0.000 claims 1
UUSBQHXAAMXWPY-UBQCRTFRSA-N 2-methoxyethyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2,2-dimethylpropyl)-6-fluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=C(C=C2CC(C)(C)C)F)=O)NC(OCCOC)=O)=O)C UUSBQHXAAMXWPY-UBQCRTFRSA-N 0.000 claims 1
XSYQOMSQFFCROI-ISPXXFMDSA-N 2-methoxyethyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-1-methyl-4-(3,3,3-trifluoropropyl)benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C)C=C(C=C2CCC(F)(F)F)F)=O)NC(OCCOC)=O)=O)C XSYQOMSQFFCROI-ISPXXFMDSA-N 0.000 claims 1
AKORIUWBAYNTOU-BVRWQAIYSA-N 2-methoxyethyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-7-(2-methylpropyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC1=CC2=NC=C(C(=C2N1)CC(C)C)F)=O)=O)NC(OCCOC)=O)=O)C AKORIUWBAYNTOU-BVRWQAIYSA-N 0.000 claims 1
RGIBHAUSNNXWAG-ZQDAFOGCSA-N 2-methoxyethyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2,2-dimethylpropyl)-5-fluoro-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=C(C=C(C=C2C=1)F)CC(C)(C)C)=O)NC(OCCOC)=O)=O)C RGIBHAUSNNXWAG-ZQDAFOGCSA-N 0.000 claims 1
HBOMKLOGIJEYLQ-CZIMKVFHSA-N 2-methoxyethyl N-[(E,2S)-7-amino-1-[[1-(1H-benzimidazol-2-ylmethyl)-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound N1C(=NC2=C1C=CC=C2)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N)NC(OCCOC)=O)=O)=O HBOMKLOGIJEYLQ-CZIMKVFHSA-N 0.000 claims 1
125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 1
208000024827 Alzheimer disease Diseases 0.000 claims 1
125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
UNBNOXNKQIQCJZ-UBQCRTFRSA-N CC(C)(C)CC1=C2NC(CN(C=CC=C3NC([C@@H](CC/C=C/C(N(C)C)=O)CN(CCOC)C(O)=O)=O)C3=O)=CC2=CC(F)=C1 Chemical compound CC(C)(C)CC1=C2NC(CN(C=CC=C3NC([C@@H](CC/C=C/C(N(C)C)=O)CN(CCOC)C(O)=O)=O)C3=O)=CC2=CC(F)=C1 UNBNOXNKQIQCJZ-UBQCRTFRSA-N 0.000 claims 1
FYWRFCKBDWQAGE-HSRJRILOSA-N CC(C)(C)CC1=CC(F)=CC2=C1NC(CN(C=CC=C1NC([C@@H](CC/C=C/C(N(C)C)=O)CN(CCOC)C(O)=O)=O)C1=O)=N2 Chemical compound CC(C)(C)CC1=CC(F)=CC2=C1NC(CN(C=CC=C1NC([C@@H](CC/C=C/C(N(C)C)=O)CN(CCOC)C(O)=O)=O)C1=O)=N2 FYWRFCKBDWQAGE-HSRJRILOSA-N 0.000 claims 1
208000002177 Cataract Diseases 0.000 claims 1
208000015943 Coeliac disease Diseases 0.000 claims 1
208000010412 Glaucoma Diseases 0.000 claims 1
208000023105 Huntington disease Diseases 0.000 claims 1
201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 1
206010028980 Neoplasm Diseases 0.000 claims 1
208000018737 Parkinson disease Diseases 0.000 claims 1
108700039882 Protein Glutamine gamma Glutamyltransferase 2 Proteins 0.000 claims 1
102100038095 Protein-glutamine gamma-glutamyltransferase 2 Human genes 0.000 claims 1
206010046851 Uveitis Diseases 0.000 claims 1
NRJXMHRYUYPSLO-LQYYAUOTSA-N [(E,2S)-1-[[1-[(1-benzyl-5-fluorobenzimidazol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@@H](CC\C=C\C(=O)N(C)C)C(NC=1C(N(C=CC=1)CC1=NC2=C(N1CC1=CC=CC=C1)C=CC(=C2)F)=O)=O)=O)C NRJXMHRYUYPSLO-LQYYAUOTSA-N 0.000 claims 1
NJSKHCASNXVFAO-CNXGWSFGSA-N [(E,2S)-1-[[1-[(1-benzyl-5-fluorobenzimidazol-2-yl)methyl]-6-oxopyrimidin-5-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@H](C(=O)NC1=CN=CN(C1=O)CC1=NC2=C(N1CC1=CC=CC=C1)C=CC(=C2)F)CC\C=C\C(=O)N(C)C)=O)C NJSKHCASNXVFAO-CNXGWSFGSA-N 0.000 claims 1
OCQIEYIOBDJZSO-QSUCZNIZSA-N [(E,2S)-1-[[1-[(1-benzyl-5-fluoroindol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=CC=C(C=C2C=1)F)CC1=CC=CC=C1)=O)CC\C=C\C(=O)N(C)C)=O)C OCQIEYIOBDJZSO-QSUCZNIZSA-N 0.000 claims 1
ONQYIPXDMDGOBG-LQYYAUOTSA-N [(E,2S)-1-[[1-[(1-benzyl-6-fluorobenzimidazol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@@H](CC\C=C\C(=O)N(C)C)C(NC=1C(N(C=CC=1)CC1=NC2=C(N1CC1=CC=CC=C1)C=C(C=C2)F)=O)=O)=O)C ONQYIPXDMDGOBG-LQYYAUOTSA-N 0.000 claims 1
ZSKBGVGNWDVGEZ-YFTVHVBSSA-N [(E,2S)-1-[[4-[[1-(cyclopropylmethyl)-5-fluoroindol-2-yl]methyl]-3-oxopyrazin-2-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@H](C(=O)NC1=NC=CN(C1=O)CC=1N(C2=CC=C(C=C2C=1)F)CC1CC1)CC\C=C\C(=O)N(C)C)=O)C ZSKBGVGNWDVGEZ-YFTVHVBSSA-N 0.000 claims 1
WQUQOVFYJBKNHU-AKERNLMBSA-N [(E,2S)-7-(dimethylamino)-1-[[1-[(5-fluoro-1-methylbenzimidazol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@@H](CC\C=C\C(=O)N(C)C)C(NC=1C(N(C=CC=1)CC1=NC2=C(N1C)C=CC(=C2)F)=O)=O)=O)C WQUQOVFYJBKNHU-AKERNLMBSA-N 0.000 claims 1
MXLGMOVTFRTMLS-ZDADTQBUSA-N [(E,2S)-7-(dimethylamino)-1-[[1-[(5-fluoro-1-methylindol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl] N-[2-(dimethylamino)ethyl]-N-methylcarbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC=1N(C2=CC=C(C=C2C=1)F)C)=O)=O)OC(N(C)CCN(C)C)=O)=O)C MXLGMOVTFRTMLS-ZDADTQBUSA-N 0.000 claims 1
BTKGKRUJZFRSCL-ZXFWNXIDSA-N [(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2,2-dimethylpropyl)-6-fluoro-1-methylbenzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@@H](CC\C=C\C(=O)N(C)C)C(NC=1C(N(C=CC=1)CC1=NC2=C(N1C)C=C(C=C2CC(C)(C)C)F)=O)=O)=O)C BTKGKRUJZFRSCL-ZXFWNXIDSA-N 0.000 claims 1
MYRQFXFHSAYITR-NRGMSUJUSA-N [(E,2S)-7-(dimethylamino)-1-[[1-[[5-fluoro-1-(2-methylpropyl)indol-2-yl]methyl]-6-oxopyrimidin-5-yl]amino]-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC1=CN=CN(C1=O)CC=1N(C2=CC=C(C=C2C=1)F)CC(C)C)=O)OC(N(C)C)=O)=O)C MYRQFXFHSAYITR-NRGMSUJUSA-N 0.000 claims 1
AICVYUACRAFKIL-FLVSMNSFSA-N [(E,2S)-7-(dimethylamino)-1-[[1-[[5-fluoro-1-(3,3,3-trifluoropropyl)benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1CCC(F)(F)F)C=CC(=C2)F)=O)CC\C=C\C(=O)N(C)C)=O)C AICVYUACRAFKIL-FLVSMNSFSA-N 0.000 claims 1
NNHZDHYDDBJELP-LNLBBOMNSA-N [(E,2S)-7-(dimethylamino)-1-[[1-[[5-fluoro-7-(3,3,3-trifluoropropyl)-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@@H](CC\C=C\C(=O)N(C)C)C(NC=1C(N(C=CC=1)CC=1NC2=C(C=C(C=C2C=1)F)CCC(F)(F)F)=O)=O)=O)C NNHZDHYDDBJELP-LNLBBOMNSA-N 0.000 claims 1
RMTDVRIGSMVORK-NDEHPHGNSA-N [(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-1-methyl-4-(3,3,3-trifluoropropyl)benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@@H](CC\C=C\C(=O)N(C)C)C(NC=1C(N(C=CC=1)CC1=NC2=C(N1C)C=C(C=C2CCC(F)(F)F)F)=O)=O)=O)C RMTDVRIGSMVORK-NDEHPHGNSA-N 0.000 claims 1
IOYGFEPIODSDEQ-ISPXXFMDSA-N [(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-4-(3,3,3-trifluoropropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC(=C2)F)CCC(F)(F)F)=O)CC\C=C\C(=O)N(C)C)=O)C IOYGFEPIODSDEQ-ISPXXFMDSA-N 0.000 claims 1
IGKVLECQHYRLKJ-RGPNDZKTSA-N [(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-7-(2-methylpropyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl] N-[2-(dimethylamino)ethyl]-N-methylcarbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC1=CC2=NC=C(C(=C2N1)CC(C)C)F)=O)=O)OC(N(C)CCN(C)C)=O)=O)C IGKVLECQHYRLKJ-RGPNDZKTSA-N 0.000 claims 1
ZRTBHVMYIIVAMG-PPJFHAJBSA-N [(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2,2-dimethylpropyl)-5-fluoro-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl] pyrrolidine-1-carboxylate Chemical compound N1(CCCC1)C(=O)O[C@@H](CC\C=C\C(=O)N(C)C)C(NC=1C(N(C=CC=1)CC=1NC2=C(C=C(C=C2C=1)F)CC(C)(C)C)=O)=O ZRTBHVMYIIVAMG-PPJFHAJBSA-N 0.000 claims 1
ISOMCMCYDOXPER-IEJURRBGSA-N [(E,2S)-7-(dimethylamino)-1-[[4-[(5-fluoro-1H-indol-2-yl)methyl]-3-oxopyrazin-2-yl]amino]-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC1=NC=CN(C1=O)CC=1NC2=CC=C(C=C2C=1)F)=O)OC(N(C)C)=O)=O)C ISOMCMCYDOXPER-IEJURRBGSA-N 0.000 claims 1
LSGQESTZJSLMKY-DRBUTMMVSA-N [(E,2S)-7-(dimethylamino)-1-[[4-[[5-fluoro-1-(2-methylpropyl)indol-2-yl]methyl]-3-oxopyrazin-2-yl]amino]-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@@H](CC\C=C\C(=O)N(C)C)C(NC1=NC=CN(C1=O)CC=1N(C2=CC=C(C=C2C=1)F)CC(C)C)=O)=O)C LSGQESTZJSLMKY-DRBUTMMVSA-N 0.000 claims 1
VBTGHDXBOAHKAP-NMXNWIABSA-N [(E,2S)-7-(dimethylamino)-1-[[4-[[7-(2,2-dimethylpropyl)-5-fluoro-1H-indol-2-yl]methyl]-3-oxopyrazin-2-yl]amino]-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@@H](CC\C=C\C(=O)N(C)C)C(NC1=NC=CN(C1=O)CC=1NC2=C(C=C(C=C2C=1)F)CC(C)(C)C)=O)=O)C VBTGHDXBOAHKAP-NMXNWIABSA-N 0.000 claims 1
MLSOFVTVNYWIAU-BFSLETRISA-N [(E,2S)-7-amino-1-[[1-[(5-fluoro-1H-indol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl] N,N-dimethylcarbamate Chemical compound CN(C(O[C@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=CC=C(C=C2C=1)F)=O)CC\C=C\C(=O)N)=O)C MLSOFVTVNYWIAU-BFSLETRISA-N 0.000 claims 1
125000000304 alkynyl group Chemical group 0.000 claims 1
125000005605 benzo group Chemical group 0.000 claims 1
JRCRSYDCDUBRRT-QSUCZNIZSA-N benzyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoroindole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=CC=C(C=C2C=1)F)C(=O)OCC1=CC=CC=C1)=O)OC(N(C)C)=O)=O)C JRCRSYDCDUBRRT-QSUCZNIZSA-N 0.000 claims 1
XYSIDZYGHZSQLL-CKRLVEJWSA-N benzyl N-[(E,2S)-1-[[1-(1H-benzimidazol-2-ylmethyl)-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound N1C(=NC2=C1C=CC=C2)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OCC1=CC=CC=C1)=O)=O)=O XYSIDZYGHZSQLL-CKRLVEJWSA-N 0.000 claims 1
IYFWNCXBFUXABX-QDEGKUCJSA-N benzyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[1-methyl-7-(2-methylpropoxy)benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C)C(=CC=C2)OCC(C)C)=O)NC(OCC1=CC=CC=C1)=O)=O)C IYFWNCXBFUXABX-QDEGKUCJSA-N 0.000 claims 1
ZFSXWLNOYBFXAH-SVJZIOHQSA-N benzyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC(C)C)=O)NC(OCC1=CC=CC=C1)=O)=O)C ZFSXWLNOYBFXAH-SVJZIOHQSA-N 0.000 claims 1
JWZFRGNVPFIPKA-YLLUOSTHSA-N benzyl N-[(E,2S)-7-amino-1,7-dioxo-1-[[2-oxo-1-[(4-propan-2-yloxy-1H-benzimidazol-2-yl)methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2OC(C)C)=O)NC(OCC1=CC=CC=C1)=O)=O JWZFRGNVPFIPKA-YLLUOSTHSA-N 0.000 claims 1
RBTMVBKXGZDPDG-QEWBYTMYSA-N benzyl N-[(E,2S)-7-amino-1-[[1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC(C)C)=O)NC(OCC1=CC=CC=C1)=O)=O RBTMVBKXGZDPDG-QEWBYTMYSA-N 0.000 claims 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
201000011510 cancer Diseases 0.000 claims 1
208000019425 cirrhosis of liver Diseases 0.000 claims 1
RQWGEYVHDIWVJE-VXFXUCHBSA-N cyclopropylmethyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OCC1CC1)C=CC(=C2)F)=O)OC(N(C)C)=O)=O)C RQWGEYVHDIWVJE-VXFXUCHBSA-N 0.000 claims 1
DIACGSYDIGEYFP-MRSBXDGLSA-N cyclopropylmethyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,6-difluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OCC1CC1)C=C(C(=C2)F)F)=O)NC(=O)OC)=O)C DIACGSYDIGEYFP-MRSBXDGLSA-N 0.000 claims 1
DCHUMNGTGPLBEV-MRSBXDGLSA-N cyclopropylmethyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OCC1CC1)C=CC(=C2)F)=O)NC(=O)OC)=O)C DCHUMNGTGPLBEV-MRSBXDGLSA-N 0.000 claims 1
201000010099 disease Diseases 0.000 claims 1
208000035475 disorder Diseases 0.000 claims 1
BWDZEASBUMXADV-UBQCRTFRSA-N ethyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,6-difluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OCC)C=C(C(=C2)F)F)=O)OC(N(C)C)=O)=O)C BWDZEASBUMXADV-UBQCRTFRSA-N 0.000 claims 1
BDTWZDRTBZTCEI-UBQCRTFRSA-N ethyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OCC)C=CC(=C2)F)=O)OC(N(C)C)=O)=O)C BDTWZDRTBZTCEI-UBQCRTFRSA-N 0.000 claims 1
NSARPAHIEAUFSQ-DBEXCURXSA-N ethyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,6-difluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OCC)C=C(C(=C2)F)F)=O)NC(=O)OC)=O)C NSARPAHIEAUFSQ-DBEXCURXSA-N 0.000 claims 1
RITCWOGYADUFCF-DBEXCURXSA-N ethyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OCC)C=CC(=C2)F)=O)NC(=O)OC)=O)C RITCWOGYADUFCF-DBEXCURXSA-N 0.000 claims 1
125000000262 haloalkenyl group Chemical group 0.000 claims 1
208000036971 interstitial lung disease 2 Diseases 0.000 claims 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
208000002780 macular degeneration Diseases 0.000 claims 1
230000001404 mediated effect Effects 0.000 claims 1
ZYYWVTDMZAUDFG-AKERNLMBSA-N methyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC)C=CC(=C2)F)=O)OC(N(C)C)=O)=O)C ZYYWVTDMZAUDFG-AKERNLMBSA-N 0.000 claims 1
RZUCOZXDRIPWDV-BVRWQAIYSA-N methyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoroindole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=CC=C(C=C2C=1)F)C(=O)OC)=O)OC(N(C)C)=O)=O)C RZUCOZXDRIPWDV-BVRWQAIYSA-N 0.000 claims 1
LYIQJXANMHPFGI-BVBGJJFLSA-N methyl 2-[[5-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-6-oxopyrimidin-1-yl]methyl]-5-fluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC1=CN=CN(C1=O)CC1=NC2=C(N1C(=O)OC)C=CC(=C2)F)NC(=O)OC)=O)C LYIQJXANMHPFGI-BVBGJJFLSA-N 0.000 claims 1
XENZCFKRTLMCHW-YRNVUSSQSA-N methyl N-[(E)-1-[[1-[[4,6-difluoro-7-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-7-oxohept-5-en-2-yl]carbamate Chemical compound FC1=C(C2=C(NC(=N2)CN2C(C(=CC=C2)NCC(CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)C(=C1)F)CC(C)C XENZCFKRTLMCHW-YRNVUSSQSA-N 0.000 claims 1
YRVRDXIELBJMKA-YRNVUSSQSA-N methyl N-[(E)-7-(dimethylamino)-1-[[1-[[7-(2-methylpropyl)-1H-pyrrolo[3,2-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CCC(C(=O)NC=1C(N(C=CC=1)CC1=CC=2C=NC=C(C=2N1)CC(C)C)=O)NC(OC)=O)=O)C YRVRDXIELBJMKA-YRNVUSSQSA-N 0.000 claims 1
OBSSBNOYCXOADJ-NPZXAABXSA-N methyl N-[(E,2R)-7-(dimethylamino)-1-[[1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC(C)C)=O)NC(OC)=O)=O)C OBSSBNOYCXOADJ-NPZXAABXSA-N 0.000 claims 1
YFPLEMJOQYALRP-CZIMKVFHSA-N methyl N-[(E,2S)-1-[[1-(1H-benzimidazol-2-ylmethyl)-2-oxopyridin-3-yl]amino]-7-(2-hydroxyethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound COC(N[C@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2)=O)CC\C=C\C(=O)NCCO)=O YFPLEMJOQYALRP-CZIMKVFHSA-N 0.000 claims 1
VFZYJNSFPXXIIR-UTGRISEESA-N methyl N-[(E,2S)-1-[[1-(1H-benzimidazol-2-ylmethyl)-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound N1C(=NC2=C1C=CC=C2)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O VFZYJNSFPXXIIR-UTGRISEESA-N 0.000 claims 1
IUNSHHJFQZYLMH-NIUUYTMRSA-N methyl N-[(E,2S)-1-[[1-(1H-benzimidazol-2-ylmethyl)-2-oxopyridin-3-yl]amino]-7-(methylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound N1C(=NC2=C1C=CC=C2)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)NC)NC(OC)=O)=O)=O IUNSHHJFQZYLMH-NIUUYTMRSA-N 0.000 claims 1
XYHOIIALCMUWAP-RNRVDGCUSA-N methyl N-[(E,2S)-1-[[1-[(4,6-difluoro-7-phenoxy-1H-benzimidazol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(C2=C(NC(=N2)CN2C(C(=CC=C2)NC(=O)[C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)C(=C1)F)OC1=CC=CC=C1 XYHOIIALCMUWAP-RNRVDGCUSA-N 0.000 claims 1
KSJFXDAMZOVFPA-GXUSPISNSA-N methyl N-[(E,2S)-1-[[1-[(4,6-difluoro-7-phenylmethoxy-1H-benzimidazol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C(C1=CC=CC=C1)OC1=C(C=C(C=2NC(=NC=21)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)F)F KSJFXDAMZOVFPA-GXUSPISNSA-N 0.000 claims 1
OZAQBTCYDSIKKC-RDTXFTJFSA-N methyl N-[(E,2S)-1-[[1-[(5,6-difluoro-1H-benzimidazol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=CC2=C(NC(=N2)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)C=C1F OZAQBTCYDSIKKC-RDTXFTJFSA-N 0.000 claims 1
CSGAKSNSEVSKHG-MXECYCPESA-N methyl N-[(E,2S)-1-[[1-[(5,6-difluoro-4-phenoxy-1H-benzimidazol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=CC2=C(NC(=N2)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)C(=C1F)OC1=CC=CC=C1 CSGAKSNSEVSKHG-MXECYCPESA-N 0.000 claims 1
KTKRPVIBFNHAFB-RNRVDGCUSA-N methyl N-[(E,2S)-1-[[1-[(5,6-difluoro-4-phenylmethoxy-1H-benzimidazol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C(C1=CC=CC=C1)OC1=C(C(=CC2=C1NC(=N2)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)F)F KTKRPVIBFNHAFB-RNRVDGCUSA-N 0.000 claims 1
VAXAIEYJACIIEI-ZBZNSMLMSA-N methyl N-[(E,2S)-1-[[1-[(5,6-difluoro-4-propan-2-yloxy-1H-benzimidazol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=CC2=C(NC(=N2)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)C(=C1F)OC(C)C VAXAIEYJACIIEI-ZBZNSMLMSA-N 0.000 claims 1
SKDCSVDPGFBHEU-NUTIFNJFSA-N methyl N-[(E,2S)-1-[[1-[(5-fluoro-1,3-benzothiazol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxo-7-pyrrolidin-1-ylhept-5-en-2-yl]carbamate Chemical compound FC=1C=CC2=C(N=C(S2)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(N2CCCC2)=O)NC(OC)=O)=O)=O)C=1 SKDCSVDPGFBHEU-NUTIFNJFSA-N 0.000 claims 1
UHEZTLPHADIWEA-LHOVZLELSA-N methyl N-[(E,2S)-1-[[1-[(5-fluoro-1H-indol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxo-7-pyrrolidin-1-ylhept-5-en-2-yl]carbamate Chemical compound FC=1C=C2C=C(NC2=CC=1)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(N1CCCC1)=O)NC(OC)=O)=O)=O UHEZTLPHADIWEA-LHOVZLELSA-N 0.000 claims 1
VWLAUVJGTQYARZ-MXECYCPESA-N methyl N-[(E,2S)-1-[[1-[(6-benzyl-7H-purin-8-yl)methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C(C1=CC=CC=C1)C1=C2N=C(NC2=NC=N1)CN1C(C(=CC=C1)NC(=O)[C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O VWLAUVJGTQYARZ-MXECYCPESA-N 0.000 claims 1
DFMLGPBCPFOAEG-MOXPCZPISA-N methyl N-[(E,2S)-1-[[1-[(6-cyclohexyl-7H-purin-8-yl)methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CCCCC1)C1=C2N=C(NC2=NC=N1)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O DFMLGPBCPFOAEG-MOXPCZPISA-N 0.000 claims 1
PQIGUDNAIMHYHK-OWLMGLOSSA-N methyl N-[(E,2S)-1-[[1-[[1-(2-cyclopropylethyl)-5,6-difluorobenzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CC1)CCN1C(=NC2=C1C=C(C(=C2)F)F)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O PQIGUDNAIMHYHK-OWLMGLOSSA-N 0.000 claims 1
ZUZKVAYEFVJETF-XZXOBPBMSA-N methyl N-[(E,2S)-1-[[1-[[1-(cyclopropylmethyl)-5-fluorobenzimidazol-2-yl]methyl]-6-oxopyrimidin-5-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CC1)CN1C(=NC2=C1C=CC(=C2)F)CN1C=NC=C(C1=O)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O ZUZKVAYEFVJETF-XZXOBPBMSA-N 0.000 claims 1
HXJGSBFZIOOHKJ-HVPBSWBLSA-N methyl N-[(E,2S)-1-[[1-[[1-[(2,4-difluorophenyl)methyl]-5-fluorobenzimidazol-2-yl]methyl]-6-oxopyrimidin-5-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(CN2C(=NC3=C2C=CC(=C3)F)CN2C=NC=C(C2=O)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)C=CC(=C1)F HXJGSBFZIOOHKJ-HVPBSWBLSA-N 0.000 claims 1
DVCKPFNMHAUWSB-OEMHODTASA-N methyl N-[(E,2S)-1-[[1-[[4,6-difluoro-7-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(C2=C(NC(=N2)CN2C(C(=CC=C2)NC(=O)[C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)C(=C1)F)CC(C)C DVCKPFNMHAUWSB-OEMHODTASA-N 0.000 claims 1
DKPJDJKGLXDMJJ-YXOJNZSOSA-N methyl N-[(E,2S)-1-[[1-[[4,6-difluoro-7-(3,3,3-trifluoropropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=CC(=C(C=2NC(=NC=21)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)CCC(F)(F)F)F DKPJDJKGLXDMJJ-YXOJNZSOSA-N 0.000 claims 1
NVYZYOWUUWTFMT-FZVHGAAGSA-N methyl N-[(E,2S)-1-[[1-[[4-(1,1-difluoro-2-hydroxy-2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound COC(N[C@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2C(C(C)(C)O)(F)F)=O)CC\C=C\C(=O)N(C)C)=O NVYZYOWUUWTFMT-FZVHGAAGSA-N 0.000 claims 1
IEFICSMATQCZNV-FZXOMJPYSA-N methyl N-[(E,2S)-1-[[1-[[4-(1,1-difluoro-2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC(C(C)C)(F)C1=CC=CC=2NC(=NC=21)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O IEFICSMATQCZNV-FZXOMJPYSA-N 0.000 claims 1
SDAIGOONLCRPGQ-RDTXFTJFSA-N methyl N-[(E,2S)-1-[[1-[[4-(2,2-difluoroethoxy)-6-fluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC(COC1=CC(=CC=2NC(=NC=21)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)F)F SDAIGOONLCRPGQ-RDTXFTJFSA-N 0.000 claims 1
JEXAGTGKJUHGIZ-FXDWHETJSA-N methyl N-[(E,2S)-1-[[1-[[4-(2,2-dimethylpropyl)-6-fluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxo-7-pyrrolidin-1-ylhept-5-en-2-yl]carbamate Chemical compound FC=1C=C(C2=C(NC(=N2)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(N2CCCC2)=O)NC(OC)=O)=O)=O)C=1)CC(C)(C)C JEXAGTGKJUHGIZ-FXDWHETJSA-N 0.000 claims 1
ISKCEZAYBMTTRP-MXYHBCECSA-N methyl N-[(E,2S)-1-[[1-[[4-(2,4-difluorophenoxy)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(OC2=CC=CC=3NC(=NC=32)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)C=CC(=C1)F ISKCEZAYBMTTRP-MXYHBCECSA-N 0.000 claims 1
WRTONDUVBIQOMB-SQUITACLSA-N methyl N-[(E,2S)-1-[[1-[[4-(2,4-difluorophenoxy)-5,6-difluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(OC2=C(C(=CC=3NC(=NC=32)CN2C(C(=CC=C2)NC(=O)[C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)F)F)C=CC(=C1)F WRTONDUVBIQOMB-SQUITACLSA-N 0.000 claims 1
HBIISILEMJIHHZ-DVZTZUIZSA-N methyl N-[(E,2S)-1-[[1-[[4-(cyclopropylmethoxy)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CC1)COC1=CC=CC2=C1NC(=N2)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O HBIISILEMJIHHZ-DVZTZUIZSA-N 0.000 claims 1
ZVTXEVYNOCKNFO-MXYHBCECSA-N methyl N-[(E,2S)-1-[[1-[[4-(cyclopropylmethyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CC1)CC1=CC=CC=2NC(=NC=21)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O ZVTXEVYNOCKNFO-MXYHBCECSA-N 0.000 claims 1
KGQKLZVVFTUURD-MRSBXDGLSA-N methyl N-[(E,2S)-1-[[1-[[4-(cyclopropylmethyl)-6-fluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CC1)CC1=CC(=CC=2NC(=NC=21)CN1C(C(=CC=C1)NC(=O)[C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)F KGQKLZVVFTUURD-MRSBXDGLSA-N 0.000 claims 1
MGKWCIZLRNVGFC-YXOJNZSOSA-N methyl N-[(E,2S)-1-[[1-[[4-(cyclopropylmethyl)-7-fluoro-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CC1)CC1=NC=C(C2=C1NC(=N2)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)F MGKWCIZLRNVGFC-YXOJNZSOSA-N 0.000 claims 1
ZZXKKPJCGKQCGE-FNQPIQQGSA-N methyl N-[(E,2S)-1-[[1-[[4-(cyclopropylmethyl)-7-fluoro-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-6-methyl-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CC1)CC1=NC=C(C2=C1NC(=N2)CN1C(C(=CC=C1C)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)F ZZXKKPJCGKQCGE-FNQPIQQGSA-N 0.000 claims 1
PKECVYHJNMBVKB-LHRVCSDGSA-N methyl N-[(E,2S)-1-[[1-[[4-[(2,4-difluorophenoxy)methyl]-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(OCC2=CC=CC=3NC(=NC=32)CN2C(C(=CC=C2)NC(=O)[C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)C=CC(=C1)F PKECVYHJNMBVKB-LHRVCSDGSA-N 0.000 claims 1
IWSOSQSZNAKTOV-OWLMGLOSSA-N methyl N-[(E,2S)-1-[[1-[[4-[(2,4-difluorophenyl)methoxy]-5,6-difluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(COC2=C(C(=CC3=C2NC(=N3)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)F)F)C=CC(=C1)F IWSOSQSZNAKTOV-OWLMGLOSSA-N 0.000 claims 1
VAEKNESVMIBCDP-XPUAEESYSA-N methyl N-[(E,2S)-1-[[1-[[4-[(2,4-difluorophenyl)methoxy]-6-fluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(COC2=CC(=CC3=C2NC(=N3)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)F)C=CC(=C1)F VAEKNESVMIBCDP-XPUAEESYSA-N 0.000 claims 1
USMIOCPGSLLLCW-VPVJOJIASA-N methyl N-[(E,2S)-1-[[1-[[4-[(2,4-difluorophenyl)methoxy]-6-fluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(methylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(COC2=CC(=CC=3NC(=NC=32)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)NC)NC(OC)=O)=O)=O)F)C=CC(=C1)F USMIOCPGSLLLCW-VPVJOJIASA-N 0.000 claims 1
KIDSGKBIYJYGGA-AKERNLMBSA-N methyl N-[(E,2S)-1-[[1-[[5,6-difluoro-1-(2-propan-2-yloxyethyl)benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=CC2=C(N(C(=N2)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)CCOC(C)C)C=C1F KIDSGKBIYJYGGA-AKERNLMBSA-N 0.000 claims 1
OOYXKPBHFGUTNP-SSVWKNEZSA-N methyl N-[(E,2S)-1-[[1-[[5,6-difluoro-4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=CC2=C(NC(=N2)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)C(=C1F)CC(C)C OOYXKPBHFGUTNP-SSVWKNEZSA-N 0.000 claims 1
MTIJBLSKMLMQRI-MPNRVQBSSA-N methyl N-[(E,2S)-1-[[1-[[5,6-difluoro-4-(3,3,3-trifluoropropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(C2=C(NC(=N2)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)C=C1F)CCC(F)(F)F MTIJBLSKMLMQRI-MPNRVQBSSA-N 0.000 claims 1
MVVVJJOALXIGPX-YGGPNUISSA-N methyl N-[(E,2S)-1-[[1-[[5-fluoro-7-(2-methylpropyl)-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxo-7-pyrrolidin-1-ylhept-5-en-2-yl]carbamate Chemical compound FC=1C=C2C=C(NC2=C(C=1)CC(C)C)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(N1CCCC1)=O)NC(OC)=O)=O)=O MVVVJJOALXIGPX-YGGPNUISSA-N 0.000 claims 1
YXMMVQKTPZLQHZ-BSQRELMASA-N methyl N-[(E,2S)-1-[[1-[[5-fluoro-7-(3,3,3-trifluoropropyl)-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxo-7-pyrrolidin-1-ylhept-5-en-2-yl]carbamate Chemical compound FC=1C=C2C=C(NC2=C(C=1)CCC(F)(F)F)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(N1CCCC1)=O)NC(OC)=O)=O)=O YXMMVQKTPZLQHZ-BSQRELMASA-N 0.000 claims 1
DPMSXNOTZNUUOE-XPUAEESYSA-N methyl N-[(E,2S)-1-[[1-[[6-(2,4-difluorophenoxy)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(OC=2C=CC3=C(NC(=N3)CN3C(C(=CC=C3)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)C=2)C=CC(=C1)F DPMSXNOTZNUUOE-XPUAEESYSA-N 0.000 claims 1
DIDLOJOOOMPYMI-YXOJNZSOSA-N methyl N-[(E,2S)-1-[[1-[[6-(2,4-difluorophenoxy)-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(OC2=C3N=C(NC3=NC=N2)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)C=CC(=C1)F DIDLOJOOOMPYMI-YXOJNZSOSA-N 0.000 claims 1
XCQWMEHFTOQQKV-GXUSPISNSA-N methyl N-[(E,2S)-1-[[1-[[6-(2-cyclohexylethyl)-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CCCCC1)CCC1=C2NC(=NC2=NC=N1)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O XCQWMEHFTOQQKV-GXUSPISNSA-N 0.000 claims 1
VGEUANKFRVTJQD-SQUITACLSA-N methyl N-[(E,2S)-1-[[1-[[6-(2-cyclopropylethyl)-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CC1)CCC1=C2N=C(NC2=NC=N1)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O VGEUANKFRVTJQD-SQUITACLSA-N 0.000 claims 1
SQGFDHRRVCHICV-MXECYCPESA-N methyl N-[(E,2S)-1-[[1-[[6-(cyclohexylmethyl)-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CCCCC1)CC1=C2N=C(NC2=NC=N1)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O SQGFDHRRVCHICV-MXECYCPESA-N 0.000 claims 1
GYWPRNGMEFKSJA-MPNRVQBSSA-N methyl N-[(E,2S)-1-[[1-[[6-(cyclopropylmethyl)-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CC1)CC1=C2N=C(NC2=NC=N1)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O GYWPRNGMEFKSJA-MPNRVQBSSA-N 0.000 claims 1
OHAVIEMVPZWIFY-LUAJHVPRSA-N methyl N-[(E,2S)-1-[[1-[[6-[(2,4-difluorophenyl)methoxy]-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(COC=2C=CC3=C(NC(=N3)CN3C(C(=CC=C3)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)C=2)C=CC(=C1)F OHAVIEMVPZWIFY-LUAJHVPRSA-N 0.000 claims 1
WVABGAKQZPIESH-MRSBXDGLSA-N methyl N-[(E,2S)-1-[[1-[[6-[(2,4-difluorophenyl)methoxy]-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(COC2=C3N=C(NC3=NC=N2)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)C=CC(=C1)F WVABGAKQZPIESH-MRSBXDGLSA-N 0.000 claims 1
BHLQGRUIPWFCKG-RLHLFEAJSA-N methyl N-[(E,2S)-1-[[1-[[6-[(E)-2-cyclopropylethenyl]-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CC1)/C=C/C1=C2N=C(NC2=NC=N1)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O BHLQGRUIPWFCKG-RLHLFEAJSA-N 0.000 claims 1
ZKZNZIUFLBGITL-AKERNLMBSA-N methyl N-[(E,2S)-1-[[1-[[6-chloro-7-(2-methylpropyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound ClC=1C(=C2C(=NC=1)C=C(N2)CN1C(C(=CC=C1)NC(=O)[C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)CC(C)C ZKZNZIUFLBGITL-AKERNLMBSA-N 0.000 claims 1
DEBJDYYFYVLIKT-UTJZZEGQSA-N methyl N-[(E,2S)-1-[[1-[[6-fluoro-4-(3,3,3-trifluoropropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxo-7-pyrrolidin-1-ylhept-5-en-2-yl]carbamate Chemical compound FC=1C=C(C2=C(NC(=N2)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(N2CCCC2)=O)NC(OC)=O)=O)=O)C=1)CCC(F)(F)F DEBJDYYFYVLIKT-UTJZZEGQSA-N 0.000 claims 1
MRCGANOUZLQBII-NBUZRDOWSA-N methyl N-[(E,2S)-1-[[1-[[6-fluoro-4-(3,3,3-trifluoropropyl)-1H-benzimidazol-2-yl]methyl]-6-oxopyrimidin-5-yl]amino]-7-(methylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=CC2=C(NC(=N2)CN2C=NC=C(C2=O)NC([C@H](CC\C=C\C(=O)NC)NC(OC)=O)=O)C(=C1)CCC(F)(F)F MRCGANOUZLQBII-NBUZRDOWSA-N 0.000 claims 1
OGVXJQIMWSBWNA-QJXUFPCYSA-N methyl N-[(E,2S)-1-[[1-[[7-(2,2-difluoroethoxy)-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC(COC1=CC=CC=2N=C(SC=21)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)F OGVXJQIMWSBWNA-QJXUFPCYSA-N 0.000 claims 1
JHSJAKIIEKYRKN-LTMNZSFGSA-N methyl N-[(E,2S)-1-[[1-[[7-(2,2-difluoroethoxy)-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC(COC=1C=CC=C2C=C(NC=12)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)F JHSJAKIIEKYRKN-LTMNZSFGSA-N 0.000 claims 1
WMHYCRWDCYUWBS-SQUITACLSA-N methyl N-[(E,2S)-1-[[1-[[7-(2,2-difluoroethoxy)-5-fluoro-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC(COC=1C=C(C=C2C=C(NC=12)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)F)F WMHYCRWDCYUWBS-SQUITACLSA-N 0.000 claims 1
KXOWIYGJDBYMKL-CHKMETFLSA-N methyl N-[(E,2S)-1-[[1-[[7-(2,2-dimethylpropyl)-5-fluoro-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxo-7-pyrrolidin-1-ylhept-5-en-2-yl]carbamate Chemical compound FC=1C=C2C=C(NC2=C(C=1)CC(C)(C)C)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(N1CCCC1)=O)NC(OC)=O)=O)=O KXOWIYGJDBYMKL-CHKMETFLSA-N 0.000 claims 1
HNXIYZGEUXQEQK-MRSBXDGLSA-N methyl N-[(E,2S)-1-[[1-[[7-(2,4-difluorophenoxy)-4,6-difluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(OC2=C(C=C(C=3NC(=NC=32)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)F)F)C=CC(=C1)F HNXIYZGEUXQEQK-MRSBXDGLSA-N 0.000 claims 1
IQPSNDUOTBOAOO-LXSVDHLJSA-N methyl N-[(E,2S)-1-[[1-[[7-(2-methylpropyl)-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxo-7-pyrrolidin-1-ylhept-5-en-2-yl]carbamate Chemical compound C(C(C)C)C=1C=CC=C2C=C(NC=12)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(N1CCCC1)=O)NC(OC)=O)=O)=O IQPSNDUOTBOAOO-LXSVDHLJSA-N 0.000 claims 1
RIRWJZFFBGPRRX-GLOIGSRVSA-N methyl N-[(E,2S)-1-[[1-[[7-(cyclobutylmethyl)-6-fluoro-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CCC1)CC1=C2C(=NC=C1F)C=C(N2)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O RIRWJZFFBGPRRX-GLOIGSRVSA-N 0.000 claims 1
RVLRJOCXBMUHQY-OWLMGLOSSA-N methyl N-[(E,2S)-1-[[1-[[7-(cyclopropylmethyl)-6-fluoro-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C1(CC1)CC1=C2C(=NC=C1F)C=C(N2)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O RVLRJOCXBMUHQY-OWLMGLOSSA-N 0.000 claims 1
VCGLESAMDZUEIO-LHRVCSDGSA-N methyl N-[(E,2S)-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(COC2=CC=CC=3N=C(SC=32)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)C=CC(=C1)F VCGLESAMDZUEIO-LHRVCSDGSA-N 0.000 claims 1
BVQMOPWVSQBCLH-PYVFBFEOSA-N methyl N-[(E,2S)-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(COC=2C=CC=C3C=C(NC=23)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)C=CC(=C1)F BVQMOPWVSQBCLH-PYVFBFEOSA-N 0.000 claims 1
RUHTZDQPBCHZQH-XPUAEESYSA-N methyl N-[(E,2S)-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-4,6-difluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(COC2=C(C=C(C=3NC(=NC=32)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)F)F)C=CC(=C1)F RUHTZDQPBCHZQH-XPUAEESYSA-N 0.000 claims 1
RRTLGAZYTMEAJQ-VPVJOJIASA-N methyl N-[(E,2S)-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-5-fluoro-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(methylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(COC2=CC(=CC=3N=C(SC=32)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)NC)NC(OC)=O)=O)=O)F)C=CC(=C1)F RRTLGAZYTMEAJQ-VPVJOJIASA-N 0.000 claims 1
DJYPNXWTFOBVTF-YXKVRIJESA-N methyl N-[(E,2S)-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-5-fluoro-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxo-7-pyrrolidin-1-ylhept-5-en-2-yl]carbamate Chemical compound FC1=C(COC=2C=C(C=C3C=C(NC=23)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(N2CCCC2)=O)NC(OC)=O)=O)=O)F)C=CC(=C1)F DJYPNXWTFOBVTF-YXKVRIJESA-N 0.000 claims 1
NPTSHDZVWPISEE-KPPJJKTOSA-N methyl N-[(E,2S)-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-5-fluoro-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(COC=2C=C(C=C3C=C(NC=23)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)F)C=CC(=C1)F NPTSHDZVWPISEE-KPPJJKTOSA-N 0.000 claims 1
YQFYPCBEXPQDIH-LHLOKTHNSA-N methyl N-[(E,2S)-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-5-fluoro-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(methylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(COC=2C=C(C=C3C=C(NC=23)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)NC)NC(OC)=O)=O)=O)F)C=CC(=C1)F YQFYPCBEXPQDIH-LHLOKTHNSA-N 0.000 claims 1
DRZFTVUKLYKMCH-DBEXCURXSA-N methyl N-[(E,2S)-1-[[1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-6-methyl-2-oxopyridin-3-yl]amino]-6-methylsulfonyl-1-oxohex-5-en-2-yl]carbamate Chemical compound FC=1C2=C(C(=NC=1)CC(C)C)NC(=N2)CN1C(C(=CC=C1C)NC([C@H](CC\C=C\S(=O)(=O)C)NC(OC)=O)=O)=O DRZFTVUKLYKMCH-DBEXCURXSA-N 0.000 claims 1
CUBGBZWFJXNKRG-KOEDOTQGSA-N methyl N-[(E,2S)-1-[[5-chloro-1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound ClC=1C=C(C(N(C=1)CC1=NC2=C(C(=NC=C2F)CC(C)C)N1)=O)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O CUBGBZWFJXNKRG-KOEDOTQGSA-N 0.000 claims 1
HJVMNJQUPBVJSC-BESKYLIDSA-N methyl N-[(E,2S)-1-[[6-chloro-1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound ClC1=CC=C(C(N1CC1=NC2=C(N1)C=CC=C2CC(C)C)=O)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O HJVMNJQUPBVJSC-BESKYLIDSA-N 0.000 claims 1
LMXPYNKCDUACKA-JCOOBLOPSA-N methyl N-[(E,2S)-1-[[6-chloro-1-[[4-fluoro-7-(2-methylpropyl)-1H-pyrrolo[2,3-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound ClC1=CC=C(C(N1CC1=CC=2C(=C(N=CC=2F)CC(C)C)N1)=O)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O LMXPYNKCDUACKA-JCOOBLOPSA-N 0.000 claims 1
UWOMFPAKIFBZKP-KOEDOTQGSA-N methyl N-[(E,2S)-1-[[6-chloro-1-[[6-fluoro-7-(2-methylpropyl)-1H-imidazo[4,5-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound ClC1=CC=C(C(N1CC=1NC=2C(=NC=C(C=2CC(C)C)F)N=1)=O)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O UWOMFPAKIFBZKP-KOEDOTQGSA-N 0.000 claims 1
VGZNZFDISBSJLD-JCOOBLOPSA-N methyl N-[(E,2S)-1-[[6-chloro-1-[[6-fluoro-7-(2-methylpropyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound ClC1=CC=C(C(N1CC1=CC2=NC=C(C(=C2N1)CC(C)C)F)=O)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O VGZNZFDISBSJLD-JCOOBLOPSA-N 0.000 claims 1
FFMQLFSKGIEZLE-KUCZMUFWSA-N methyl N-[(E,2S)-7-(dimethylamino)-1,7-dioxo-1-[[2-oxo-1-[(4-phenylmethoxy-1H-benzimidazol-2-yl)methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound C(C1=CC=CC=C1)OC1=CC=CC2=C1NC(=N2)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O FFMQLFSKGIEZLE-KUCZMUFWSA-N 0.000 claims 1
LTVGSNFQHDSTAX-JNMQVBFRSA-N methyl N-[(E,2S)-7-(dimethylamino)-1,7-dioxo-1-[[2-oxo-1-[(6-pentyl-7H-purin-8-yl)methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC=1NC2=NC=NC(=C2N=1)CCCCC)=O)=O)NC(OC)=O)=O)C LTVGSNFQHDSTAX-JNMQVBFRSA-N 0.000 claims 1
FZBICSNHKJUSNF-MOXPCZPISA-N methyl N-[(E,2S)-7-(dimethylamino)-1,7-dioxo-1-[[2-oxo-1-[(6-phenoxy-7H-purin-8-yl)methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC=1NC2=NC=NC(=C2N=1)OC1=CC=CC=C1)=O)=O)NC(OC)=O)=O)C FZBICSNHKJUSNF-MOXPCZPISA-N 0.000 claims 1
GZCMCAPXANEOOJ-MXECYCPESA-N methyl N-[(E,2S)-7-(dimethylamino)-1,7-dioxo-1-[[2-oxo-1-[(6-phenylmethoxy-7H-purin-8-yl)methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound C(C1=CC=CC=C1)OC1=C2N=C(NC2=NC=N1)CN1C(C(=CC=C1)NC(=O)[C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O GZCMCAPXANEOOJ-MXECYCPESA-N 0.000 claims 1
PYCOKFZPPIFRJI-BPLPYTOXSA-N methyl N-[(E,2S)-7-(dimethylamino)-1,7-dioxo-1-[[2-oxo-1-[(6-propan-2-yloxy-7H-purin-8-yl)methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=NC=NC(=C2N=1)OC(C)C)=O)NC(OC)=O)=O)C PYCOKFZPPIFRJI-BPLPYTOXSA-N 0.000 claims 1
LLLTYRCWGAWUCS-LTMNZSFGSA-N methyl N-[(E,2S)-7-(dimethylamino)-1,7-dioxo-1-[[2-oxo-1-[[4-(3,3,3-trifluoropropyl)-1H-benzimidazol-2-yl]methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CCC(F)(F)F)=O)=O)NC(OC)=O)=O)C LLLTYRCWGAWUCS-LTMNZSFGSA-N 0.000 claims 1
BZZNCRUITBWEIV-YXOJNZSOSA-N methyl N-[(E,2S)-7-(dimethylamino)-1,7-dioxo-1-[[2-oxo-1-[[4-(3,3,3-trifluoropropyl)-5H-pyrrolo[3,2-d]pyrimidin-6-yl]methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC1=CC=2N=CN=C(C=2N1)CCC(F)(F)F)=O)=O)NC(OC)=O)=O)C BZZNCRUITBWEIV-YXOJNZSOSA-N 0.000 claims 1
MNDKOIOPRQRNCC-MYHKYFONSA-N methyl N-[(E,2S)-7-(dimethylamino)-1,7-dioxo-1-[[2-oxo-1-[[4-(propan-2-yloxymethyl)-1H-benzimidazol-2-yl]methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2COC(C)C)=O)NC(OC)=O)=O)C MNDKOIOPRQRNCC-MYHKYFONSA-N 0.000 claims 1
BNDSULHYLUYYGF-VRQAPCGNSA-N methyl N-[(E,2S)-7-(dimethylamino)-1,7-dioxo-1-[[2-oxo-1-[[4-[3,3,3-trifluoro-2-(trifluoromethyl)propyl]-1H-benzimidazol-2-yl]methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound COC(N[C@H](C(NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC(C(F)(F)F)C(F)(F)F)=O)=O)CC\C=C\C(=O)N(C)C)=O BNDSULHYLUYYGF-VRQAPCGNSA-N 0.000 claims 1
HIJUVUMXVCNXLC-GXUSPISNSA-N methyl N-[(E,2S)-7-(dimethylamino)-1,7-dioxo-1-[[2-oxo-1-[[6-(2-phenylethyl)-7H-purin-8-yl]methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC1=NC2=NC=NC(=C2N1)CCC1=CC=CC=C1)=O)=O)NC(OC)=O)=O)C HIJUVUMXVCNXLC-GXUSPISNSA-N 0.000 claims 1
HCJLSPUPKADZSD-JFWCEDGVSA-N methyl N-[(E,2S)-7-(dimethylamino)-1,7-dioxo-1-[[2-oxo-1-[[6-[(E)-2-phenylethenyl]-7H-purin-8-yl]methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC=1NC2=NC=NC(=C2N=1)\C=C\C1=CC=CC=C1)=O)=O)NC(OC)=O)=O)C HCJLSPUPKADZSD-JFWCEDGVSA-N 0.000 claims 1
SJXWSXBDMVCLMD-QJXUFPCYSA-N methyl N-[(E,2S)-7-(dimethylamino)-1,7-dioxo-1-[[2-oxo-1-[[7-(2,2,2-trifluoroethoxy)-1,3-benzothiazol-2-yl]methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC=1SC2=C(N=1)C=CC=C2OCC(F)(F)F)=O)=O)NC(OC)=O)=O)C SJXWSXBDMVCLMD-QJXUFPCYSA-N 0.000 claims 1
DVQHADABKBUTTE-RDTXFTJFSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[(5-fluoro-1,3-benzothiazol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound COC(N[C@H](C(=O)NC=1C(N(C=CC=1)CC=1SC2=C(N=1)C=C(C=C2)F)=O)CC\C=C\C(=O)N(C)C)=O DVQHADABKBUTTE-RDTXFTJFSA-N 0.000 claims 1
TYEXUDIHIZWCBC-BVBGJJFLSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[(5-fluoro-1-methylbenzimidazol-2-yl)methyl]-6-oxopyrimidin-5-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC1=CN=CN(C1=O)CC1=NC2=C(N1C)C=CC(=C2)F)=O)NC(OC)=O)=O)C TYEXUDIHIZWCBC-BVBGJJFLSA-N 0.000 claims 1
NWSOQVLAXNUNLC-MRSBXDGLSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[(5-fluoro-1H-indol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=CC=C(C=C2C=1)F)=O)NC(OC)=O)=O)C NWSOQVLAXNUNLC-MRSBXDGLSA-N 0.000 claims 1
IGUBBLXHUXXQGA-MPNRVQBSSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[(6-fluoro-1H-benzimidazol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC(=C2)F)=O)NC(OC)=O)=O)C IGUBBLXHUXXQGA-MPNRVQBSSA-N 0.000 claims 1
YNLBTKOWRRBVDC-QSUDNNBSSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[(6-fluoro-7-phenylmethoxy-1H-pyrrolo[3,2-b]pyridin-2-yl)methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C(C1=CC=CC=C1)OC1=C2C(=NC=C1F)C=C(N2)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O YNLBTKOWRRBVDC-QSUDNNBSSA-N 0.000 claims 1
QHHPBSBCEVUVRB-SSVWKNEZSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[(6-fluoro-7-propan-2-yloxy-1H-pyrrolo[3,2-b]pyridin-2-yl)methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=CC2=NC=C(C(=C2N1)OC(C)C)F)=O)NC(OC)=O)=O)C QHHPBSBCEVUVRB-SSVWKNEZSA-N 0.000 claims 1
ILGVBTARNDGMDK-MEJUDOHFSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[2-methyl-4-(2-methylpropyl)-5H-pyrrolo[3,2-d]pyrimidin-6-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=CC=2N=C(N=C(C=2N1)CC(C)C)C)=O)NC(OC)=O)=O)C ILGVBTARNDGMDK-MEJUDOHFSA-N 0.000 claims 1
ZAPFRYSAUXDIEG-HCWHUNCVSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[2-methyl-6-(2-methylpropyl)-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=NC(=NC(=C2N=1)CC(C)C)C)=O)NC(OC)=O)=O)C ZAPFRYSAUXDIEG-HCWHUNCVSA-N 0.000 claims 1
JRGRIAHGQBETLJ-YCZGGKIKSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(1-fluoro-2,2-dimethylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC=C2)C(C(C)(C)C)F)=O)NC(OC)=O)=O)C JRGRIAHGQBETLJ-YCZGGKIKSA-N 0.000 claims 1
WUVVDGUDCYHNFV-CNXUZWBFSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(1-fluoro-2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC=C2)C(C(C)C)F)=O)NC(OC)=O)=O)C WUVVDGUDCYHNFV-CNXUZWBFSA-N 0.000 claims 1
MZICMIOKQGDRQR-YCZGGKIKSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(1-hydroxy-2,2-dimethylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC=C2)C(C(C)(C)C)O)=O)NC(OC)=O)=O)C MZICMIOKQGDRQR-YCZGGKIKSA-N 0.000 claims 1
CQXTZNJYRTXNEW-OMKLEDIQSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2,2-dimethylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC=C2)CC(C)(C)C)=O)NC(OC)=O)=O)C CQXTZNJYRTXNEW-OMKLEDIQSA-N 0.000 claims 1
HRKVOVKCPJTMNX-BEBFYNPSSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2,2-dimethylpropyl)-5,6-difluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=C(C(=C2CC(C)(C)C)F)F)=O)=O)NC(OC)=O)=O)C HRKVOVKCPJTMNX-BEBFYNPSSA-N 0.000 claims 1
STZUKNVDNXDYQM-MEJUDOHFSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2,2-dimethylpropyl)-6-fluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=C(C=C2CC(C)(C)C)F)=O)NC(OC)=O)=O)C STZUKNVDNXDYQM-MEJUDOHFSA-N 0.000 claims 1
IVYIWFGKZFIYFU-FZXOMJPYSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2-methylpropyl)-1,3-benzoxazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1OC2=C(N=1)C(=CC=C2)CC(C)C)=O)NC(OC)=O)=O)C IVYIWFGKZFIYFU-FZXOMJPYSA-N 0.000 claims 1
OTNFWERYPQYCOZ-SSVWKNEZSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2-methylpropyl)-1H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=C(C(=NC=C2)CC(C)C)N=1)=O)NC(OC)=O)=O)C OTNFWERYPQYCOZ-SSVWKNEZSA-N 0.000 claims 1
MMTGOSSARDDEIT-YYSDWVBWSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2-methylpropyl)-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=CC=CC(=C2C=1)CC(C)C)=O)NC(OC)=O)=O)C MMTGOSSARDDEIT-YYSDWVBWSA-N 0.000 claims 1
FSIHMILQGKQJOL-SSVWKNEZSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2-methylpropyl)-5H-pyrrolo[3,2-d]pyrimidin-6-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC1=CC=2N=CN=C(C=2N1)CC(C)C)=O)=O)NC(OC)=O)=O)C FSIHMILQGKQJOL-SSVWKNEZSA-N 0.000 claims 1
RCCLNUSATAIGJM-AKERNLMBSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-fluoro-7-(2-methylprop-1-enyl)-1H-pyrrolo[2,3-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=CC=2C(=C(N=CC=2F)C=C(C)C)N1)=O)NC(OC)=O)=O)C RCCLNUSATAIGJM-AKERNLMBSA-N 0.000 claims 1
GMWODFFJDWLDQC-AKERNLMBSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-fluoro-7-(2-methylpropyl)-1H-pyrrolo[2,3-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=CC=2C(=C(N=CC=2F)CC(C)C)N1)=O)NC(OC)=O)=O)C GMWODFFJDWLDQC-AKERNLMBSA-N 0.000 claims 1
XDJOTLGCQPTGOA-RCHCNPRSSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-fluoro-7-(2-methylpropyl)-1H-pyrrolo[2,3-c]pyridin-2-yl]methyl]-6-methyl-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C(=CC=1)C)CC1=CC=2C(=C(N=CC=2F)CC(C)C)N1)=O)NC(OC)=O)=O)C XDJOTLGCQPTGOA-RCHCNPRSSA-N 0.000 claims 1
GGBFHIYETZGNRE-XSBJJCPUSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[5-fluoro-1-(2-methylpropyl)benzimidazol-2-yl]methyl]-6-oxopyrimidin-5-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC1=CN=CN(C1=O)CC1=NC2=C(N1CC(C)C)C=CC(=C2)F)NC(OC)=O)=O)C GGBFHIYETZGNRE-XSBJJCPUSA-N 0.000 claims 1
GFQJTKRHPGWKDE-HVPBSWBLSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[5-fluoro-1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]methyl]-6-oxopyrimidin-5-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC1=CN=CN(C1=O)CC1=NC2=C(N1CC1=CC=C(C=C1)F)C=CC(=C2)F)NC(OC)=O)=O)C GFQJTKRHPGWKDE-HVPBSWBLSA-N 0.000 claims 1
BXIHCASWKZUCGK-BVRWQAIYSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[5-fluoro-7-(2-methylpropyl)-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=C(C=C(C=C2C=1)F)CC(C)C)=O)NC(OC)=O)=O)C BXIHCASWKZUCGK-BVRWQAIYSA-N 0.000 claims 1
OHVRAVLCRAZBLR-FUNAXGEOSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-(2,2-dimethylpropyl)-2-methyl-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=NC(=NC(=C2N=1)CC(C)(C)C)C)=O)NC(OC)=O)=O)C OHVRAVLCRAZBLR-FUNAXGEOSA-N 0.000 claims 1
OYNHMYWSEVRUMM-PLLDVRFOSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-(2,2-dimethylpropyl)-2-methyl-9-(oxan-2-yl)purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=NC(=NC(=C2N=1)CC(C)(C)C)C)C1OCCCC1)=O)NC(OC)=O)=O)C OYNHMYWSEVRUMM-PLLDVRFOSA-N 0.000 claims 1
JKYFHNWEKINSBH-UEICXMAYSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-(2,2-dimethylpropyl)-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC=1NC2=NC=NC(=C2N=1)CC(C)(C)C)=O)=O)NC(OC)=O)=O)C JKYFHNWEKINSBH-UEICXMAYSA-N 0.000 claims 1
CQNNDITZDPVXMI-ZBZNSMLMSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-(2-methylprop-1-enyl)-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC=1NC2=NC=NC(=C2N=1)C=C(C)C)=O)=O)NC(OC)=O)=O)C CQNNDITZDPVXMI-ZBZNSMLMSA-N 0.000 claims 1
ATMLOYFJZWLSKX-ZBZNSMLMSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-(2-methylpropoxy)-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=NC=NC(=C2N=1)OCC(C)C)=O)NC(OC)=O)=O)C ATMLOYFJZWLSKX-ZBZNSMLMSA-N 0.000 claims 1
SCKRMUWIGZSHQS-ZBZNSMLMSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-(2-methylpropyl)-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=NC=NC(=C2N=1)CC(C)C)=O)NC(OC)=O)=O)C SCKRMUWIGZSHQS-ZBZNSMLMSA-N 0.000 claims 1
NBYXOBMJBOIYAT-BEBFYNPSSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-(3,3-dimethylbutyl)-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=NC=NC(=C2N=1)CCC(C)(C)C)=O)NC(OC)=O)=O)C NBYXOBMJBOIYAT-BEBFYNPSSA-N 0.000 claims 1
AAYOPTQDFSLRNV-OYJQAMMISA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-(3,3-dimethylbutyl)-9-(oxan-2-yl)purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=NC=NC(=C2N=1)CCC(C)(C)C)C1OCCCC1)=O)NC(OC)=O)=O)C AAYOPTQDFSLRNV-OYJQAMMISA-N 0.000 claims 1
GQYKMCOLXDSUJO-SSVWKNEZSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-(3-methylbutyl)-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=NC=NC(=C2N=1)CCC(C)C)=O)NC(OC)=O)=O)C GQYKMCOLXDSUJO-SSVWKNEZSA-N 0.000 claims 1
JCBFLBNJQSBEGV-RCLKMUNOSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-(dimethylamino)-2-methyl-7H-purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=NC(=NC(=C2N=1)N(C)C)C)=O)NC(OC)=O)=O)C JCBFLBNJQSBEGV-RCLKMUNOSA-N 0.000 claims 1
KVJDCZBXHAXPEC-CRWWQRIJSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-3-methyl-7-(2-methylpropyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-6-methyl-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C(=CC=1)C)CC1=C(C2=NC=C(C(=C2N1)CC(C)C)F)C)=O)NC(OC)=O)=O)C KVJDCZBXHAXPEC-CRWWQRIJSA-N 0.000 claims 1
YPFCHURCIITMQI-BOSPYUDASA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-4-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC(=C2)F)OC(C(F)F)(F)F)=O)NC(OC)=O)=O)C YPFCHURCIITMQI-BOSPYUDASA-N 0.000 claims 1
XSPDVJQQGFPHPZ-RDTXFTJFSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-4-(2,2,2-trifluoroethoxy)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=C(C=C2OCC(F)(F)F)F)=O)NC(OC)=O)=O)C XSPDVJQQGFPHPZ-RDTXFTJFSA-N 0.000 claims 1
DTJNSAAZNATIDZ-OEMHODTASA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=C(C=C2CC(C)C)F)=O)NC(OC)=O)=O)C DTJNSAAZNATIDZ-OEMHODTASA-N 0.000 claims 1
WQIVXRMDJPTYIW-YXOJNZSOSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-4-(3,3,3-trifluoropropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC(=C2)F)CCC(F)(F)F)=O)=O)NC(OC)=O)=O)C WQIVXRMDJPTYIW-YXOJNZSOSA-N 0.000 claims 1
ZKTUWQOFSVXUIQ-HCWHUNCVSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-4-[(2-methylpropan-2-yl)oxy]-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C(C)(C)(C)OC1=CC(=CC2=C1NC(=N2)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)F ZKTUWQOFSVXUIQ-HCWHUNCVSA-N 0.000 claims 1
YIOXGRLWAXWFLO-HSRJRILOSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-5-methyl-7-(2-methylpropyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=CC2=NC(=C(C(=C2N1)CC(C)C)F)C)=O)NC(OC)=O)=O)C YIOXGRLWAXWFLO-HSRJRILOSA-N 0.000 claims 1
JIDJHHMSFUFKKP-OEMHODTASA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-7-(2-methylpropoxy)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=CC2=NC=C(C(=C2N1)OCC(C)C)F)=O)NC(OC)=O)=O)C JIDJHHMSFUFKKP-OEMHODTASA-N 0.000 claims 1
KBWDZPMAUUKQNH-SSVWKNEZSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-7-(2-methylpropyl)-1H-imidazo[4,5-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC=2C(=NC=C(C=2CC(C)C)F)N1)=O)NC(OC)=O)=O)C KBWDZPMAUUKQNH-SSVWKNEZSA-N 0.000 claims 1
AATNJSPELFLSOQ-MFUYTVRRSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-7-(2-methylpropyl)-1H-imidazo[4,5-b]pyridin-2-yl]methyl]-6-methyl-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C(=CC=1)C)CC1=NC=2C(=NC=C(C=2CC(C)C)F)N1)=O)NC(OC)=O)=O)C AATNJSPELFLSOQ-MFUYTVRRSA-N 0.000 claims 1
NNHSFFIPAYZCCS-AKERNLMBSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-7-(2-methylpropyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=CC2=NC=C(C(=C2N1)CC(C)C)F)=O)NC(OC)=O)=O)C NNHSFFIPAYZCCS-AKERNLMBSA-N 0.000 claims 1
IBDFMJZUINPXBG-RCHCNPRSSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-7-(2-methylpropyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-6-methyl-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C(=CC=1)C)CC1=CC2=NC=C(C(=C2N1)CC(C)C)F)=O)=O)NC(OC)=O)=O)C IBDFMJZUINPXBG-RCHCNPRSSA-N 0.000 claims 1
VKESBFBNQASNRY-SQUITACLSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-fluoro-7-(3,3,3-trifluoropropyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=CC2=NC=C(C(=C2N1)CCC(F)(F)F)F)=O)NC(OC)=O)=O)C VKESBFBNQASNRY-SQUITACLSA-N 0.000 claims 1
LOWNCEUSPJSPEM-BEBFYNPSSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-methyl-4-(2-methylprop-1-enyl)-1H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=C(C(=NC(=C2)C)C=C(C)C)N=1)=O)NC(OC)=O)=O)C LOWNCEUSPJSPEM-BEBFYNPSSA-N 0.000 claims 1
RHVDCJCPUODQSI-BEBFYNPSSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[6-methyl-4-(2-methylpropyl)-1H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=C(C(=NC(=C2)C)CC(C)C)N=1)=O)NC(OC)=O)=O)C RHVDCJCPUODQSI-BEBFYNPSSA-N 0.000 claims 1
YFBLJJONVIGDJX-MEJUDOHFSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2,2-dimethylpropyl)-4,6-difluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(C2=C(NC(=N2)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC)=O)=O)=O)C(=C1)F)CC(C)(C)C YFBLJJONVIGDJX-MEJUDOHFSA-N 0.000 claims 1
NYXGYGBWBRMZIA-UJVYDMDKSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2,2-dimethylpropyl)-5-fluoro-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=C(C=C(C=C2C=1)F)CC(C)(C)C)=O)NC(OC)=O)=O)C NYXGYGBWBRMZIA-UJVYDMDKSA-N 0.000 claims 1
HXYXWNADCUDTQB-AKERNLMBSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2-methylprop-1-enyl)-6-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=CC2=NC=C(C(=C2N1)C=C(C)C)C(F)(F)F)=O)NC(OC)=O)=O)C HXYXWNADCUDTQB-AKERNLMBSA-N 0.000 claims 1
JGBWVEUMWPULAH-MYHKYFONSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2-methylpropyl)-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1SC2=C(N=1)C=CC=C2CC(C)C)=O)NC(OC)=O)=O)C JGBWVEUMWPULAH-MYHKYFONSA-N 0.000 claims 1
ZJFIRDPIQCIDHZ-MYHKYFONSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2-methylpropyl)-1,3-benzoxazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1OC2=C(N=1)C=CC=C2CC(C)C)=O)NC(OC)=O)=O)C ZJFIRDPIQCIDHZ-MYHKYFONSA-N 0.000 claims 1
CJJNNUQIHYSBRD-SSVWKNEZSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2-methylpropyl)-1H-imidazo[4,5-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC=2C(=NC=CC=2CC(C)C)N1)=O)NC(OC)=O)=O)C CJJNNUQIHYSBRD-SSVWKNEZSA-N 0.000 claims 1
BBTUZJZGTFEFKB-HANTZDOSSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2-methylpropyl)-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=C(C=CC=C2C=1)CC(C)C)=O)NC(OC)=O)=O)C BBTUZJZGTFEFKB-HANTZDOSSA-N 0.000 claims 1
PMCOKTAGMFOSMM-AKERNLMBSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2-methylpropyl)-1H-pyrrolo[2,3-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC1=CC=2C(=C(N=CC=2)CC(C)C)N1)=O)=O)NC(OC)=O)=O)C PMCOKTAGMFOSMM-AKERNLMBSA-N 0.000 claims 1
VPVALSNLQQXMSS-AKERNLMBSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2-methylpropyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=CC2=NC=CC(=C2N1)CC(C)C)=O)NC(OC)=O)=O)C VPVALSNLQQXMSS-AKERNLMBSA-N 0.000 claims 1
RZJWJNZCOIDOBM-SSVWKNEZSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(C=NC=C2CC(C)C)N1)=O)NC(OC)=O)=O)C RZJWJNZCOIDOBM-SSVWKNEZSA-N 0.000 claims 1
ZKVXJMIQOFVXEJ-AKERNLMBSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-(2-methylpropyl)-6-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=CC2=NC=C(C(=C2N1)CC(C)C)C(F)(F)F)=O)NC(OC)=O)=O)C ZKVXJMIQOFVXEJ-AKERNLMBSA-N 0.000 claims 1
SDPSTXNVVLSDRD-DBEXCURXSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-fluoro-4-(2-methylprop-1-enyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=C(C(=NC=C2F)C=C(C)C)N=1)=O)NC(OC)=O)=O)C SDPSTXNVVLSDRD-DBEXCURXSA-N 0.000 claims 1
ABPBBJZJZYHFTC-BQYDLMEBSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxo-6-propan-2-ylpyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C(=CC=1)C(C)C)CC1=NC2=C(C(=NC=C2F)CC(C)C)N1)=O)NC(OC)=O)=O)C ABPBBJZJZYHFTC-BQYDLMEBSA-N 0.000 claims 1
ZPXRRULBHYORFR-ZRFOIIEFSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxo-6-propylpyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C(=CC=1)CCC)CC1=NC2=C(C(=NC=C2F)CC(C)C)N1)=O)NC(OC)=O)=O)C ZPXRRULBHYORFR-ZRFOIIEFSA-N 0.000 claims 1
IQGLVLGZLFYCEB-DBEXCURXSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=C(C(=NC=C2F)CC(C)C)N=1)=O)NC(OC)=O)=O)C IQGLVLGZLFYCEB-DBEXCURXSA-N 0.000 claims 1
MJDNRBAGHKHMRJ-BQYDLMEBSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-5,6-dimethyl-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C(=C(C=1)C)C)CC1=NC2=C(C(=NC=C2F)CC(C)C)N1)=O)NC(OC)=O)=O)C MJDNRBAGHKHMRJ-BQYDLMEBSA-N 0.000 claims 1
PIPIUKXXYGOUMG-RQMBKDMJSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-5-methyl-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=C(C=1)C)CC1=NC2=C(C(=NC=C2F)CC(C)C)N1)=O)=O)NC(OC)=O)=O)C PIPIUKXXYGOUMG-RQMBKDMJSA-N 0.000 claims 1
FAWKZTLGCYTLQH-CRWWQRIJSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-6-(2-methylpropyl)-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C(=CC=1)CC(C)C)CC1=NC2=C(C(=NC=C2F)CC(C)C)N1)=O)NC(OC)=O)=O)C FAWKZTLGCYTLQH-CRWWQRIJSA-N 0.000 claims 1
SCQSQZMTWHYDBQ-XSBJJCPUSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-6-(hydroxymethyl)-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C(=CC=1)CO)CC1=NC2=C(C(=NC=C2F)CC(C)C)N1)=O)NC(OC)=O)=O)C SCQSQZMTWHYDBQ-XSBJJCPUSA-N 0.000 claims 1
ICYSWWQXIHOKBU-MFUYTVRRSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-6-(methoxymethyl)-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C(=CC=1)COC)CC1=NC2=C(C(=NC=C2F)CC(C)C)N1)=O)NC(OC)=O)=O)C ICYSWWQXIHOKBU-MFUYTVRRSA-N 0.000 claims 1
UNHHHMJIQNMMMY-MPNRVQBSSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[7-fluoro-4-(3,3,3-trifluoropropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(C(=NC=C2F)CCC(F)(F)F)N1)=O)NC(OC)=O)=O)C UNHHHMJIQNMMMY-MPNRVQBSSA-N 0.000 claims 1
OUUROYATMZOTHU-QEFZMVBHSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[9-(oxan-2-yl)-6-(3,3,3-trifluoropropyl)purin-8-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC=1N(C2=NC=NC(=C2N=1)CCC(F)(F)F)C1OCCCC1)=O)=O)NC(OC)=O)=O)C OUUROYATMZOTHU-QEFZMVBHSA-N 0.000 claims 1
SCMRSPANKUOHBZ-KOEDOTQGSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[5-fluoro-1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=C(C=1)F)CC1=NC2=C(C(=NC=C2F)CC(C)C)N1)=O)NC(OC)=O)=O)C SCMRSPANKUOHBZ-KOEDOTQGSA-N 0.000 claims 1
ISLHMQQEWPJKQS-RQMBKDMJSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[5-fluoro-1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-6-methyl-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C(=C(C=1)F)C)CC1=NC2=C(C(=NC=C2F)CC(C)C)N1)=O)NC(OC)=O)=O)C ISLHMQQEWPJKQS-RQMBKDMJSA-N 0.000 claims 1
RUQSTLODYAGHGY-BQYDLMEBSA-N methyl N-[(E,2S)-7-(dimethylamino)-1-[[6-ethyl-1-[[7-fluoro-4-(2-methylpropyl)-3H-imidazo[4,5-c]pyridin-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C(=CC=1)CC)CC1=NC2=C(C(=NC=C2F)CC(C)C)N1)=O)NC(OC)=O)=O)C RUQSTLODYAGHGY-BQYDLMEBSA-N 0.000 claims 1
STPZLXQWTFMJPE-JCRIEJSWSA-N methyl N-[(E,2S)-7-(methylamino)-1-[[1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C(C(C)C)C1=CC=CC=2NC(=NC=21)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)NC)NC(OC)=O)=O)=O STPZLXQWTFMJPE-JCRIEJSWSA-N 0.000 claims 1
NPTSHDZVWPISEE-FSPJUHEYSA-N methyl N-[(E,2S)-7-[bis(trideuteriomethyl)amino]-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-5-fluoro-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound C([2H])([2H])([2H])N(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=C(C=C(C=C2C=1)F)OCC1=C(C=C(C=C1)F)F)=O)NC(OC)=O)=O)C([2H])([2H])[2H] NPTSHDZVWPISEE-FSPJUHEYSA-N 0.000 claims 1
TWRHHXPKRFXIQA-DIKFHFTNSA-N methyl N-[(E,2S)-7-amino-1,7-dioxo-1-[[2-oxo-1-[(4-phenoxy-1H-benzimidazol-2-yl)methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2OC1=CC=CC=C1)=O)=O)NC(OC)=O)=O TWRHHXPKRFXIQA-DIKFHFTNSA-N 0.000 claims 1
FQLUWEHBWQHCAV-QMNUCZKJSA-N methyl N-[(E,2S)-7-amino-1,7-dioxo-1-[[2-oxo-1-[(4-phenylmethoxy-1H-benzimidazol-2-yl)methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC=C2)OCC1=CC=CC=C1)=O)NC(OC)=O)=O FQLUWEHBWQHCAV-QMNUCZKJSA-N 0.000 claims 1
MJIZJOWCYBVHLR-QJXUFPCYSA-N methyl N-[(E,2S)-7-amino-1,7-dioxo-1-[[2-oxo-1-[(4-propan-2-yloxy-1H-benzimidazol-2-yl)methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2OC(C)C)=O)NC(OC)=O)=O MJIZJOWCYBVHLR-QJXUFPCYSA-N 0.000 claims 1
ISGRXESTOJFECW-QYSIDVQXSA-N methyl N-[(E,2S)-7-amino-1,7-dioxo-1-[[2-oxo-1-[[4-(3,3,3-trifluoropropyl)-1H-benzimidazol-2-yl]methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CCC(F)(F)F)=O)=O)NC(OC)=O)=O ISGRXESTOJFECW-QYSIDVQXSA-N 0.000 claims 1
BTNZJRLZAXYZSF-JBJDWBBVSA-N methyl N-[(E,2S)-7-amino-1,7-dioxo-1-[[2-oxo-1-[[7-(1,1,2,2-tetrafluoroethoxy)-1,3-benzothiazol-2-yl]methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC=1SC2=C(N=1)C=CC=C2OC(C(F)F)(F)F)=O)=O)NC(OC)=O)=O BTNZJRLZAXYZSF-JBJDWBBVSA-N 0.000 claims 1
FDGASKLLBQHUBO-GMLHSMKSSA-N methyl N-[(E,2S)-7-amino-1,7-dioxo-1-[[2-oxo-1-[[7-(2,2,2-trifluoroethoxy)-1,3-benzothiazol-2-yl]methyl]pyridin-3-yl]amino]hept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC=1SC2=C(N=1)C=CC=C2OCC(F)(F)F)=O)=O)NC(OC)=O)=O FDGASKLLBQHUBO-GMLHSMKSSA-N 0.000 claims 1
KXWUGBRGNUPKAB-WQRDJFRPSA-N methyl N-[(E,2S)-7-amino-1-[[1-(1H-benzimidazol-2-ylmethyl)-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound N1C(=NC2=C1C=CC=C2)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N)NC(OC)=O)=O)=O KXWUGBRGNUPKAB-WQRDJFRPSA-N 0.000 claims 1
SPNDIQFOTZRSIL-RRFAQUSLSA-N methyl N-[(E,2S)-7-amino-1-[[1-[(5-fluoro-1,3-benzothiazol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1SC2=C(N=1)C=C(C=C2)F)=O)NC(OC)=O)=O SPNDIQFOTZRSIL-RRFAQUSLSA-N 0.000 claims 1
JCFZOOVMUBCDQR-VRQAPCGNSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[4-(1,1-difluoro-2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2C(C(C)C)(F)F)=O)NC(OC)=O)=O JCFZOOVMUBCDQR-VRQAPCGNSA-N 0.000 claims 1
IIKCCPBCZQZFGJ-LIMRLLDOSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[4-(1-fluoro-2,2-dimethylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2C(C(C)(C)C)F)=O)NC(OC)=O)=O IIKCCPBCZQZFGJ-LIMRLLDOSA-N 0.000 claims 1
DUJFJZTZWIZRJO-LIMRLLDOSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[4-(1-hydroxy-2,2-dimethylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC=C2)C(C(C)(C)C)O)=O)NC(OC)=O)=O DUJFJZTZWIZRJO-LIMRLLDOSA-N 0.000 claims 1
GZRDKTGORJLIPR-JEWDKHCNSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[4-(1-hydroxy-2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2C(C(C)C)O)=O)NC(OC)=O)=O GZRDKTGORJLIPR-JEWDKHCNSA-N 0.000 claims 1
UCCHWDWAOUXWQT-RRFAQUSLSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[4-(2,2-difluoroethoxy)-6-fluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=C(C=C2OCC(F)F)F)=O)NC(OC)=O)=O UCCHWDWAOUXWQT-RRFAQUSLSA-N 0.000 claims 1
BDGBDFRKACSUGG-HBYKMFCXSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[4-(2,2-dimethylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC=C2)CC(C)(C)C)=O)NC(OC)=O)=O BDGBDFRKACSUGG-HBYKMFCXSA-N 0.000 claims 1
IUZZOWRKXRDXCE-VRQAPCGNSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[4-(2-methylpropoxy)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC=C2)OCC(C)C)=O)NC(OC)=O)=O IUZZOWRKXRDXCE-VRQAPCGNSA-N 0.000 claims 1
DCWJDIZJKMSIDY-VRQAPCGNSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[4-(2-methylpropyl)-1,3-benzoxazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1OC2=C(N=1)C(=CC=C2)CC(C)C)=O)NC(OC)=O)=O DCWJDIZJKMSIDY-VRQAPCGNSA-N 0.000 claims 1
LBMDALSPLYQWGG-LTMNZSFGSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC(C)C)=O)NC(OC)=O)=O LBMDALSPLYQWGG-LTMNZSFGSA-N 0.000 claims 1
LHVOUYBYNIFANP-IZHJOOQXSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[4-(cyclopropylmethoxy)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC=C2)OCC1CC1)=O)NC(OC)=O)=O LHVOUYBYNIFANP-IZHJOOQXSA-N 0.000 claims 1
MJNGBSMPKYJJBD-OHSBUDFJSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[4-(cyclopropylmethyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC1CC1)=O)NC(OC)=O)=O MJNGBSMPKYJJBD-OHSBUDFJSA-N 0.000 claims 1
FUHUKABBQCCBBI-BEGIUABZSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[4-[(2,4-difluorophenyl)methoxy]-6-fluoro-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC(=C2)F)OCC1=C(C=C(C=C1)F)F)=O)NC(OC)=O)=O FUHUKABBQCCBBI-BEGIUABZSA-N 0.000 claims 1
ZVJASKBUDXVZHU-RRFAQUSLSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[6-fluoro-4-(2,2,2-trifluoroethoxy)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=C(C=C2OCC(F)(F)F)F)=O)NC(OC)=O)=O ZVJASKBUDXVZHU-RRFAQUSLSA-N 0.000 claims 1
TYERGAGEOZXWFA-DHINHOHASA-N methyl N-[(E,2S)-7-amino-1-[[1-[[6-fluoro-4-[(2-methylpropan-2-yl)oxy]-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC(=C2)F)OC(C)(C)C)=O)NC(OC)=O)=O TYERGAGEOZXWFA-DHINHOHASA-N 0.000 claims 1
OSHFTGVNCFIZBY-GMLHSMKSSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[7-(2,2-difluoroethoxy)-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1SC2=C(N=1)C=CC=C2OCC(F)F)=O)NC(OC)=O)=O OSHFTGVNCFIZBY-GMLHSMKSSA-N 0.000 claims 1
MKKZRAAAYXININ-QYSIDVQXSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[7-(2,2-difluoroethoxy)-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=C(C=CC=C2C=1)OCC(F)F)=O)NC(OC)=O)=O MKKZRAAAYXININ-QYSIDVQXSA-N 0.000 claims 1
OYGQDUSLRCAZNO-GALSZHCDSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[7-(2,2-difluoroethoxy)-5-fluoro-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=C(C=C(C=C2C=1)F)OCC(F)F)=O)NC(OC)=O)=O OYGQDUSLRCAZNO-GALSZHCDSA-N 0.000 claims 1
RDCFVFHTNUVFTI-LTMNZSFGSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[7-(2-methylpropyl)-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1SC2=C(N=1)C=CC=C2CC(C)C)=O)NC(OC)=O)=O RDCFVFHTNUVFTI-LTMNZSFGSA-N 0.000 claims 1
YBUBBLQEFKORON-LTMNZSFGSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[7-(2-methylpropyl)-1,3-benzoxazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1OC2=C(N=1)C=CC=C2CC(C)C)=O)NC(OC)=O)=O YBUBBLQEFKORON-LTMNZSFGSA-N 0.000 claims 1
JDHSQDTWJHRVIE-WVEJUQGRSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1SC2=C(N=1)C=CC=C2OCC1=C(C=C(C=C1)F)F)=O)NC(OC)=O)=O JDHSQDTWJHRVIE-WVEJUQGRSA-N 0.000 claims 1
ZOEMCSCUQGSKNN-NVFKUSHMSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=C(C=CC=C2C=1)OCC1=C(C=C(C=C1)F)F)=O)NC(OC)=O)=O ZOEMCSCUQGSKNN-NVFKUSHMSA-N 0.000 claims 1
UEYXATSEDCLNGP-BEGIUABZSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-5-fluoro-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1SC2=C(N=1)C=C(C=C2OCC1=C(C=C(C=C1)F)F)F)=O)NC(OC)=O)=O UEYXATSEDCLNGP-BEGIUABZSA-N 0.000 claims 1
VXZKHWSHDHAMLR-HORZDZNUSA-N methyl N-[(E,2S)-7-amino-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-5-fluoro-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1NC2=C(C=C(C=C2C=1)F)OCC1=C(C=C(C=C1)F)F)=O)NC(OC)=O)=O VXZKHWSHDHAMLR-HORZDZNUSA-N 0.000 claims 1
XHBCBLMNVVGSDC-FESLSTPNSA-N oxan-4-ylmethyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2,2-dimethylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC=C2)CC(C)(C)C)=O)NC(OCC1CCOCC1)=O)=O)C XHBCBLMNVVGSDC-FESLSTPNSA-N 0.000 claims 1
DGGSPANRFZKWLP-RYXQVQKZSA-N oxan-4-ylmethyl N-[(E,2S)-7-amino-1-[[1-[[4-(2,2-dimethylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC(C)(C)C)=O)NC(OCC1CCOCC1)=O)=O DGGSPANRFZKWLP-RYXQVQKZSA-N 0.000 claims 1
HUAOJDRUSIQJQE-POKWNMCHSA-N oxolan-3-yl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2,2-dimethylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC(C)(C)C)=O)NC(OC1COCC1)=O)=O)C HUAOJDRUSIQJQE-POKWNMCHSA-N 0.000 claims 1
PBBCXBFIZAFEMD-UOZDQRIMSA-N oxolan-3-yl N-[(E,2S)-7-amino-1-[[1-[[4-(2,2-dimethylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC(C)(C)C)=O)NC(OC1COCC1)=O)=O PBBCXBFIZAFEMD-UOZDQRIMSA-N 0.000 claims 1
XEKBUGNOJCJMGT-YTSFOSOMSA-N oxolan-3-yl N-[(E,2S)-7-amino-1-[[1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC(C)C)=O)NC(OC1COCC1)=O)=O XEKBUGNOJCJMGT-YTSFOSOMSA-N 0.000 claims 1
GVYXWAQCYPKRRY-PPGLGBNOSA-N oxolan-3-ylmethyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC(C)C)=O)NC(OCC1COCC1)=O)=O)C GVYXWAQCYPKRRY-PPGLGBNOSA-N 0.000 claims 1
YQIUJOVXRJVMEN-XRJSVPPCSA-N oxolan-3-ylmethyl N-[(E,2S)-7-amino-1-[[1-[[4-(2-methylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C=CC=C2CC(C)C)=O)NC(OCC1COCC1)=O)=O YQIUJOVXRJVMEN-XRJSVPPCSA-N 0.000 claims 1
239000000546 pharmaceutical excipient Substances 0.000 claims 1
201000002793 renal fibrosis Diseases 0.000 claims 1
125000005017 substituted alkenyl group Chemical group 0.000 claims 1
125000004426 substituted alkynyl group Chemical group 0.000 claims 1
YDHGEYGZVNPLHI-JKJFSGGSSA-N tert-butyl 2-[[3-[[(E)-3,3-dideuterio-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoroindole-1-carboxylate Chemical compound CN(C(/C=C/CC(C(C(=O)NC=1C(N(C=CC=1)CC=1N(C2=CC=C(C=C2C=1)F)C(=O)OC(C)(C)C)=O)OC(N(C)C)=O)([2H])[2H])=O)C YDHGEYGZVNPLHI-JKJFSGGSSA-N 0.000 claims 1
CQKNUFVLEVMQJH-UJVYDMDKSA-N tert-butyl 2-[[3-[[(E,2S)-2-(dimethylcarbamoyloxy)-7-(methylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoro-7-(3,3,3-trifluoropropyl)benzimidazole-1-carboxylate Chemical compound CN(C(=O)O[C@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C(=CC(=C2)F)CCC(F)(F)F)=O)CC\C=C\C(=O)NC)C CQKNUFVLEVMQJH-UJVYDMDKSA-N 0.000 claims 1
SDTQEYHQIRFHKM-ZQDAFOGCSA-N tert-butyl 2-[[3-[[(E,2S)-2-(dimethylcarbamoyloxy)-7-(methylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoro-7-(3,3,3-trifluoropropyl)indole-1-carboxylate Chemical compound CN(C(=O)O[C@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=C(C=C2C=1)F)CCC(F)(F)F)C(=O)OC(C)(C)C)=O)CC\C=C\C(=O)NC)C SDTQEYHQIRFHKM-ZQDAFOGCSA-N 0.000 claims 1
VXDOPTMJVZPSHE-NAVGAYGYSA-N tert-butyl 2-[[3-[[(E,2S)-2-(methoxycarbonylamino)-7-(methylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2-methylpropyl)benzimidazole-1-carboxylate Chemical compound C(C(C)C)C1=CC=CC=2N(C(=NC=21)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)NC)NC(=O)OC)=O)=O)C(=O)OC(C)(C)C VXDOPTMJVZPSHE-NAVGAYGYSA-N 0.000 claims 1
ROUIIJRQSYIZBW-POUQMFDLSA-N tert-butyl 2-[[3-[[(E,2S)-2-(methoxycarbonylamino)-7-(methylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]benzimidazole-1-carboxylate Chemical compound COC(=O)N[C@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2)=O)CC\C=C\C(=O)NC ROUIIJRQSYIZBW-POUQMFDLSA-N 0.000 claims 1
HTXGPJFAKWPKAV-GPLAWQGUSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(2-hydroxyethoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-7-(2-methylpropyl)indole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=CC=C2C=1)CC(C)C)C(=O)OC(C)(C)C)=O)NC(=O)OCCO)=O)C HTXGPJFAKWPKAV-GPLAWQGUSA-N 0.000 claims 1
HITKJPIRKGVBSP-KAAOTHNJSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2-methylpropyl)benzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2CC(C)C)=O)NC(=O)N(C)C)=O)C HITKJPIRKGVBSP-KAAOTHNJSA-N 0.000 claims 1
CTWPZQHBZCIQGH-MXWQMBOOSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-6-fluoro-4-(2-methylpropyl)benzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C=C2CC(C)C)F)=O)NC(=O)N(C)C)=O)C CTWPZQHBZCIQGH-MXWQMBOOSA-N 0.000 claims 1
IBLDVNHPQPBJJO-ZOBSEURRSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyrazin-1-yl]methyl]-4-(2,2-dimethylpropyl)-6-fluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CN=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C=C2CC(C)(C)C)F)=O)OC(N(C)C)=O)=O)C IBLDVNHPQPBJJO-ZOBSEURRSA-N 0.000 claims 1
BSQGPTKMUZOZAM-LJTKGQTQSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyrazin-1-yl]methyl]-5-fluoro-7-(3,3,3-trifluoropropyl)indole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CN=1)CC=1N(C2=C(C=C(C=C2C=1)F)CCC(F)(F)F)C(=O)OC(C)(C)C)=O)OC(N(C)C)=O)=O)C BSQGPTKMUZOZAM-LJTKGQTQSA-N 0.000 claims 1
SRZMSUGBCRXFBG-NMXNWIABSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyrazin-1-yl]methyl]-5-fluoroindole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CN=1)CC=1N(C2=CC=C(C=C2C=1)F)C(=O)OC(C)(C)C)=O)OC(N(C)C)=O)=O)C SRZMSUGBCRXFBG-NMXNWIABSA-N 0.000 claims 1
ARUYPOBZAGVNNV-FIUWIIBXSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyrazin-1-yl]methyl]-7-(2,2-dimethylpropyl)-5-fluoroindole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CN=1)CC=1N(C2=C(C=C(C=C2C=1)F)CC(C)(C)C)C(=O)OC(C)(C)C)=O)OC(N(C)C)=O)=O)C ARUYPOBZAGVNNV-FIUWIIBXSA-N 0.000 claims 1
NCUHVVZHMKYWIX-ZTBKZUISSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2,2-dimethylpropyl)-5,6-difluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C(=C2CC(C)(C)C)F)F)=O)OC(N(C)C)=O)=O)C NCUHVVZHMKYWIX-ZTBKZUISSA-N 0.000 claims 1
UVTAPLUBPJLWCN-RCLIWOIXSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2,2-dimethylpropyl)-6-methoxybenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C=C2CC(C)(C)C)OC)=O)OC(N(C)C)=O)=O)C UVTAPLUBPJLWCN-RCLIWOIXSA-N 0.000 claims 1
NWMRMGLKLHCUOM-HYSUNIORSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2-methylpropyl)benzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2CC(C)C)=O)OC(N(C)C)=O)=O)C NWMRMGLKLHCUOM-HYSUNIORSA-N 0.000 claims 1
IRTFOPYCRNPROD-XHTZSRGPSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,6-difluoro-4-(2-methylpropyl)benzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C(=C2CC(C)C)F)F)=O)OC(N(C)C)=O)=O)C IRTFOPYCRNPROD-XHTZSRGPSA-N 0.000 claims 1
QBZHYESRYKIGGO-XLIBHFEYSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,7-difluoro-4-(3,3,3-trifluoropropyl)benzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C(=CC(=C2CCC(F)(F)F)F)F)=O)OC(N(C)C)=O)=O)C QBZHYESRYKIGGO-XLIBHFEYSA-N 0.000 claims 1
OBRYEEZBGVEBBU-JEAXJQIYSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoro-7-(trifluoromethyl)indole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=C(C=C2C=1)F)C(F)(F)F)C(=O)OC(C)(C)C)=O)OC(N(C)C)=O)=O)C OBRYEEZBGVEBBU-JEAXJQIYSA-N 0.000 claims 1
MYRHJWCGDODFBJ-OKQJEPBTSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-6-fluoro-4-(2-methylpropyl)benzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C=C2CC(C)C)F)=O)OC(N(C)C)=O)=O)C MYRHJWCGDODFBJ-OKQJEPBTSA-N 0.000 claims 1
FFWRPKUKWBMOCC-QMUTUGEISA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2,2-dimethylpropyl)-5,6-difluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C(=C2CC(C)(C)C)F)F)=O)NC(=O)OC)=O)C FFWRPKUKWBMOCC-QMUTUGEISA-N 0.000 claims 1
JKGFQEXGENZTDE-FWRIEMNASA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2,2-dimethylpropyl)-5,7-difluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C(=CC(=C2CC(C)(C)C)F)F)=O)NC(=O)OC)=O)C JKGFQEXGENZTDE-FWRIEMNASA-N 0.000 claims 1
LBGAVOOBJJNQTB-KUDIEGTJSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2,2-dimethylpropyl)benzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2CC(C)(C)C)=O)NC(=O)OC)=O)C LBGAVOOBJJNQTB-KUDIEGTJSA-N 0.000 claims 1
CYCYFXBMQABYKA-FADXNGITSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2-methylpropyl)benzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2CC(C)C)=O)NC(=O)OC)=O)C CYCYFXBMQABYKA-FADXNGITSA-N 0.000 claims 1
UUIDXMPNVUORLE-OQHXPNFOSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2-methylpropyl)imidazo[4,5-c]pyridine-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C(=NC=C2)CC(C)C)N=1)C(=O)OC(C)(C)C)=O)NC(=O)OC)=O)C UUIDXMPNVUORLE-OQHXPNFOSA-N 0.000 claims 1
MGKOXCCFTSOOMU-NTCLMWMPSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2-methylpropyl)indole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=CC=CC(=C2C=1)CC(C)C)C(=O)OC(C)(C)C)=O)NC(=O)OC)=O)C MGKOXCCFTSOOMU-NTCLMWMPSA-N 0.000 claims 1
DHKRIBFATANKAO-JKBVIGQESA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-phenoxybenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2OC1=CC=CC=C1)=O)NC(=O)OC)=O)C DHKRIBFATANKAO-JKBVIGQESA-N 0.000 claims 1
BNVRBKFIYGSRBO-GWECRGSCSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,6-difluoro-4-(2-methylpropyl)benzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C(=C2CC(C)C)F)F)=O)NC(=O)OC)=O)C BNVRBKFIYGSRBO-GWECRGSCSA-N 0.000 claims 1
KQJRGFKSCKPAPE-MEJUDOHFSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,6-difluoro-4-(3,3,3-trifluoropropyl)benzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C(=C2CCC(F)(F)F)F)F)=O)NC(=O)OC)=O)C KQJRGFKSCKPAPE-MEJUDOHFSA-N 0.000 claims 1
GEJWZTLDDIYVJH-HZUJZGFBSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,6-difluoro-4-phenoxybenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C(=C2OC1=CC=CC=C1)F)F)=O)NC(=O)OC)=O)C GEJWZTLDDIYVJH-HZUJZGFBSA-N 0.000 claims 1
APHRPPIYUBDQNO-HKFHZZIHSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,6-difluoro-4-propan-2-yloxybenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C(=C2OC(C)C)F)F)=O)NC(=O)OC)=O)C APHRPPIYUBDQNO-HKFHZZIHSA-N 0.000 claims 1
ZCXHUJSWFRIJLZ-BEBFYNPSSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,6-difluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C(=C2)F)F)=O)NC(=O)OC)=O)C ZCXHUJSWFRIJLZ-BEBFYNPSSA-N 0.000 claims 1
BFFSEFMULRPCNH-XFKHSMSJSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,7-difluoro-4-(2-methylpropyl)benzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C(=CC(=C2CC(C)C)F)F)=O)NC(=O)OC)=O)C BFFSEFMULRPCNH-XFKHSMSJSA-N 0.000 claims 1
RNGDGVJDKYEVRS-OBZJUVQRSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,7-difluoro-4-phenoxybenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C(=CC(=C2OC1=CC=CC=C1)F)F)=O)NC(=O)OC)=O)C RNGDGVJDKYEVRS-OBZJUVQRSA-N 0.000 claims 1
DAMOSXQUCBZVJR-OQHXPNFOSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,7-difluoro-4-propan-2-yloxybenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C(=CC(=C2OC(C)C)F)F)=O)NC(=O)OC)=O)C DAMOSXQUCBZVJR-OQHXPNFOSA-N 0.000 claims 1
BQWOKZYKBULHPD-MQVOTRGWSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoro-7-(2-methylpropyl)indole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=C(C=C2C=1)F)CC(C)C)C(=O)OC(C)(C)C)=O)NC(=O)OC)=O)C BQWOKZYKBULHPD-MQVOTRGWSA-N 0.000 claims 1
OJVIXYZKIIKRHQ-JIWMQAFSSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoro-7-(3,3,3-trifluoropropyl)indole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=C(C=C2C=1)F)CCC(F)(F)F)C(=O)OC(C)(C)C)=O)NC(=O)OC)=O)C OJVIXYZKIIKRHQ-JIWMQAFSSA-N 0.000 claims 1
PEAXABAWLZNIRO-HSRJRILOSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-6-fluoro-4-(3,3,3-trifluoropropyl)benzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C=C2CCC(F)(F)F)F)=O)NC(=O)OC)=O)C PEAXABAWLZNIRO-HSRJRILOSA-N 0.000 claims 1
CVJLXXJQKWRXMX-GWECRGSCSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-7-(2-methylpropyl)imidazo[4,5-b]pyridine-3-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC=2C(=NC=CC=2CC(C)C)N1C(=O)OC(C)(C)C)=O)NC(=O)OC)=O)C CVJLXXJQKWRXMX-GWECRGSCSA-N 0.000 claims 1
PPTLGSGZURPGDS-NTCLMWMPSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-7-(2-methylpropyl)indole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=CC=C2C=1)CC(C)C)C(=O)OC(C)(C)C)=O)NC(=O)OC)=O)C PPTLGSGZURPGDS-NTCLMWMPSA-N 0.000 claims 1
JWFYSBWIJFBPDE-NHHXKRIFSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-7-(2-methylpropyl)indole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=CC=C2C=1)CC(C)C)C(=O)OC(C)(C)C)=O)OC(NC)=O)=O)C JWFYSBWIJFBPDE-NHHXKRIFSA-N 0.000 claims 1
QPUKCEXILSGHIQ-HWGVJAQFSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-(oxan-4-ylmethoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2,2-dimethylpropyl)benzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2CC(C)(C)C)=O)NC(=O)OCC1CCOCC1)=O)C QPUKCEXILSGHIQ-HWGVJAQFSA-N 0.000 claims 1
WKAZJPKLHSDCKO-OOZHPRAUSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2-methylpropyl)benzimidazole-1-carboxylate Chemical compound C(C)(C)(C)OC(=O)N[C@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2CC(C)C)=O)CC\C=C\C(=O)N(C)C WKAZJPKLHSDCKO-OOZHPRAUSA-N 0.000 claims 1
GURVUAIWEPYXEY-JMOSNPTESA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]benzimidazole-1-carboxylate Chemical compound C(C)(C)(C)OC(=O)N[C@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2)=O)CC\C=C\C(=O)N(C)C GURVUAIWEPYXEY-JMOSNPTESA-N 0.000 claims 1
NLOOFNWJGIHWAJ-DMHSOGNXSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-7-oxo-2-(phenylmethoxycarbonylamino)hept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2-methylpropyl)benzimidazole-1-carboxylate Chemical compound C(C1=CC=CC=C1)OC(=O)N[C@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2CC(C)C)=O)CC\C=C\C(=O)N(C)C NLOOFNWJGIHWAJ-DMHSOGNXSA-N 0.000 claims 1
VZHIDWWKGOMGRS-KVPOCMPMSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-7-oxo-2-(pyrrolidine-1-carbonyloxy)hept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-7-(2,2-dimethylpropyl)-5-fluoroindole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=C(C=C2C=1)F)CC(C)(C)C)C(=O)OC(C)(C)C)=O)OC(=O)N1CCCC1)=O)C VZHIDWWKGOMGRS-KVPOCMPMSA-N 0.000 claims 1
VTWPENQODCDCDW-PJYBQQLWSA-N tert-butyl 2-[[3-[[(E,2S)-7-(dimethylamino)-7-oxo-2-(pyrrolidine-1-carbonyloxy)hept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-7-(2-methylpropyl)indole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=CC=C2C=1)CC(C)C)C(=O)OC(C)(C)C)=O)OC(=O)N1CCCC1)=O)C VTWPENQODCDCDW-PJYBQQLWSA-N 0.000 claims 1
OQQUHKRLRXQTBH-OOTGMETQSA-N tert-butyl 2-[[3-[[(E,2S)-7-[bis(trideuteriomethyl)amino]-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-7-[(2,4-difluorophenyl)methoxy]-5-fluoroindole-1-carboxylate Chemical compound C([2H])([2H])([2H])N(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=C(C=C2C=1)F)OCC1=C(C=C(C=C1)F)F)C(=O)OC(C)(C)C)=O)NC(=O)OC)=O)C([2H])([2H])[2H] OQQUHKRLRXQTBH-OOTGMETQSA-N 0.000 claims 1
WWFYYAKSASXIBB-RZBOESAMSA-N tert-butyl 2-[[3-[[(E,2S)-7-amino-2-(2-hydroxyethoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]indole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=CC=CC=C2C=1)C(=O)OC(C)(C)C)=O)NC(=O)OCCO)=O WWFYYAKSASXIBB-RZBOESAMSA-N 0.000 claims 1
JDJDHZPZUYLJNN-MXECYCPESA-N tert-butyl 2-[[3-[[(E,2S)-7-amino-2-(2-methoxyethoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]benzimidazole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2)=O)NC(=O)OCCOC)=O JDJDHZPZUYLJNN-MXECYCPESA-N 0.000 claims 1
KUYUHDNQVNOESI-BVRWQAIYSA-N tert-butyl 2-[[3-[[(E,2S)-7-amino-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoroindole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=CC=C(C=C2C=1)F)C(=O)OC(C)(C)C)=O)OC(N(C)C)=O)=O KUYUHDNQVNOESI-BVRWQAIYSA-N 0.000 claims 1
FMTRUOSJHVCSSJ-JUALLIRVSA-N tert-butyl 2-[[3-[[(E,2S)-7-amino-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2,2-dimethylpropyl)benzimidazole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2CC(C)(C)C)=O)NC(=O)OC)=O FMTRUOSJHVCSSJ-JUALLIRVSA-N 0.000 claims 1
MZLOMNTZGWMGGG-OMKLEDIQSA-N tert-butyl 2-[[3-[[(E,2S)-7-amino-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2-methylpropyl)benzimidazole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2CC(C)C)=O)NC(=O)OC)=O MZLOMNTZGWMGGG-OMKLEDIQSA-N 0.000 claims 1
JRBQSXCKQBKMHC-ZJRYQZHFSA-N tert-butyl 2-[[3-[[(E,2S)-7-amino-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2-methylpropyl)indole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=CC=CC(=C2C=1)CC(C)C)C(=O)OC(C)(C)C)=O)NC(=O)OC)=O JRBQSXCKQBKMHC-ZJRYQZHFSA-N 0.000 claims 1
LMPAVCLAKOPBOX-VGZTZGLTSA-N tert-butyl 2-[[3-[[(E,2S)-7-amino-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(cyclopropylmethyl)benzimidazole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2CC1CC1)=O)NC(=O)OC)=O LMPAVCLAKOPBOX-VGZTZGLTSA-N 0.000 claims 1
ZGHVKTUPDRGBPM-FXVWLTTGSA-N tert-butyl 2-[[3-[[(E,2S)-7-amino-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-7-(2,2-difluoroethoxy)-5-fluoroindole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=C(C=C2C=1)F)OCC(F)F)C(=O)OC(C)(C)C)=O)NC(=O)OC)=O ZGHVKTUPDRGBPM-FXVWLTTGSA-N 0.000 claims 1
VACJQCQCUVGEEH-ZJRYQZHFSA-N tert-butyl 2-[[3-[[(E,2S)-7-amino-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-7-(2-methylpropyl)indole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=CC=C2C=1)CC(C)C)C(=O)OC(C)(C)C)=O)NC(=O)OC)=O VACJQCQCUVGEEH-ZJRYQZHFSA-N 0.000 claims 1
NMSMKHLJWYMSPI-JORPFSLRSA-N tert-butyl 2-[[3-[[(E,2S)-7-amino-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-7-[(2,4-difluorophenyl)methoxy]-5-fluoroindole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=C(C=C2C=1)F)OCC1=C(C=C(C=C1)F)F)C(=O)OC(C)(C)C)=O)NC(=O)OC)=O NMSMKHLJWYMSPI-JORPFSLRSA-N 0.000 claims 1
IDUVPYNZHNJWLG-VMTASVPJSA-N tert-butyl 2-[[3-[[(E,2S)-7-amino-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-7-[(2,4-difluorophenyl)methoxy]indole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=CC=C2C=1)OCC1=C(C=C(C=C1)F)F)C(=O)OC(C)(C)C)=O)NC(=O)OC)=O IDUVPYNZHNJWLG-VMTASVPJSA-N 0.000 claims 1
RFOXEXKJCAMHLV-UFCYUWOPSA-N tert-butyl 2-[[3-[[(E,2S)-7-amino-2-(oxan-4-ylmethoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2,2-dimethylpropyl)benzimidazole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2CC(C)(C)C)=O)NC(=O)OCC1CCOCC1)=O RFOXEXKJCAMHLV-UFCYUWOPSA-N 0.000 claims 1
LSCAFDIXLMKCCM-HYGYTNKZSA-N tert-butyl 2-[[3-[[(E,2S)-7-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-7-[(2,4-difluorophenyl)methoxy]indole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=C(C=CC=C2C=1)OCC1=C(C=C(C=C1)F)F)C(=O)OC(C)(C)C)=O)NC(=O)OC(C)(C)C)=O LSCAFDIXLMKCCM-HYGYTNKZSA-N 0.000 claims 1
DUBHBSAUZGYPKF-QDEGKUCJSA-N tert-butyl 2-[[3-[[(E,2S)-7-amino-7-oxo-2-(phenylmethoxycarbonylamino)hept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-4-(2-methylpropyl)benzimidazole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=CC=C2CC(C)C)=O)NC(=O)OCC1=CC=CC=C1)=O DUBHBSAUZGYPKF-QDEGKUCJSA-N 0.000 claims 1
XOYGZEZKZQONIR-DRBUTMMVSA-N tert-butyl 2-[[5-[[(E,2S)-2-(dimethylcarbamoyloxy)-7-(methylamino)-7-oxohept-5-enoyl]amino]-6-oxopyrimidin-1-yl]methyl]-5-fluoro-7-(3,3,3-trifluoropropyl)indole-1-carboxylate Chemical compound CN(C(=O)O[C@H](C(=O)NC1=CN=CN(C1=O)CC=1N(C2=C(C=C(C=C2C=1)F)CCC(F)(F)F)C(=O)OC(C)(C)C)CC\C=C\C(=O)NC)C XOYGZEZKZQONIR-DRBUTMMVSA-N 0.000 claims 1
FQWCDMFBMNPQEQ-OSVJCPFSSA-N tert-butyl 2-[[5-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-6-oxopyridazin-1-yl]methyl]-4-(2,2-dimethylpropyl)-6-fluorobenzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC1=CC=NN(C1=O)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C=C2CC(C)(C)C)F)OC(N(C)C)=O)=O)C FQWCDMFBMNPQEQ-OSVJCPFSSA-N 0.000 claims 1
LSGHRCAIKGATEV-UKEJNIAMSA-N tert-butyl 2-[[5-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-6-oxopyrimidin-1-yl]methyl]-5-fluoro-7-(3,3,3-trifluoropropyl)indole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC1=CN=CN(C1=O)CC=1N(C2=C(C=C(C=C2C=1)F)CCC(F)(F)F)C(=O)OC(C)(C)C)OC(N(C)C)=O)=O)C LSGHRCAIKGATEV-UKEJNIAMSA-N 0.000 claims 1
PMUOACLPHCSCBH-ZCUZSRHZSA-N tert-butyl 2-[[5-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-6-oxopyrimidin-1-yl]methyl]-7-(2,2-dimethylpropyl)-5-fluoroindole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC1=CN=CN(C1=O)CC=1N(C2=C(C=C(C=C2C=1)F)CC(C)(C)C)C(=O)OC(C)(C)C)OC(N(C)C)=O)=O)C PMUOACLPHCSCBH-ZCUZSRHZSA-N 0.000 claims 1
TTYBOANUWTUVHE-MFUYTVRRSA-N tert-butyl 2-[[5-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-6-oxopyrimidin-1-yl]methyl]-6-fluoro-4-(3,3,3-trifluoropropyl)benzimidazole-1-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC1=CN=CN(C1=O)CC1=NC2=C(N1C(=O)OC(C)(C)C)C=C(C=C2CCC(F)(F)F)F)NC(=O)OC)=O)C TTYBOANUWTUVHE-MFUYTVRRSA-N 0.000 claims 1
OREKJPHMIJXFKD-UBQCRTFRSA-N tert-butyl 4-(2,4-difluorophenoxy)-2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,6-difluorobenzimidazole-1-carboxylate Chemical compound FC1=C(OC2=C(C(=CC=3N(C(=NC=32)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(=O)OC)=O)=O)C(=O)OC(C)(C)C)F)F)C=CC(=C1)F OREKJPHMIJXFKD-UBQCRTFRSA-N 0.000 claims 1
QHYUSGGZPMKARP-UJVYDMDKSA-N tert-butyl 4-(2,4-difluorophenoxy)-2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,7-difluorobenzimidazole-1-carboxylate Chemical compound FC1=C(OC2=C(C=C(C=3N(C(=NC=32)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(=O)OC)=O)=O)C(=O)OC(C)(C)C)F)F)C=CC(=C1)F QHYUSGGZPMKARP-UJVYDMDKSA-N 0.000 claims 1
AZMMGINCPODXLW-UJVYDMDKSA-N tert-butyl 4-(cyclopropylmethyl)-2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-6-fluorobenzimidazole-1-carboxylate Chemical compound C1(CC1)CC1=CC(=CC=2N(C(=NC=21)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(=O)OC)=O)=O)C(=O)OC(C)(C)C)F AZMMGINCPODXLW-UJVYDMDKSA-N 0.000 claims 1
LLTJKZMHCDUMJA-RGPNDZKTSA-N tert-butyl 4-[(2,4-difluorophenyl)methoxy]-2-[[3-[[(E,2S)-7-(dimethylamino)-2-(dimethylcarbamoyloxy)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,6-difluorobenzimidazole-1-carboxylate Chemical compound FC1=C(COC2=C(C(=CC=3N(C(=NC=32)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)OC(N(C)C)=O)=O)=O)C(=O)OC(C)(C)C)F)F)C=CC(=C1)F LLTJKZMHCDUMJA-RGPNDZKTSA-N 0.000 claims 1
YBKFGHFZPXIDCZ-JIWMQAFSSA-N tert-butyl 4-[(2,4-difluorophenyl)methoxy]-2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5,6-difluorobenzimidazole-1-carboxylate Chemical compound FC1=C(COC2=C(C(=CC=3N(C(=NC=32)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(=O)OC)=O)=O)C(=O)OC(C)(C)C)F)F)C=CC(=C1)F YBKFGHFZPXIDCZ-JIWMQAFSSA-N 0.000 claims 1
ZYVXQMIJJQTTHY-YGGPNUISSA-N tert-butyl 5-fluoro-2-[[3-[[(E,2S)-2-(2-hydroxyethoxycarbonylamino)-7-oxo-7-pyrrolidin-1-ylhept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]indole-1-carboxylate Chemical compound FC=1C=C2C=C(N(C2=CC=1)C(=O)OC(C)(C)C)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(N1CCCC1)=O)NC(=O)OCCO)=O)=O ZYVXQMIJJQTTHY-YGGPNUISSA-N 0.000 claims 1
NYQNGDMXFQCEDM-XFADDWSHSA-N tert-butyl 5-fluoro-2-[[3-[[(E,2S)-2-(methoxycarbonylamino)-7-oxo-7-pyrrolidin-1-ylhept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-7-(2-methylpropyl)indole-1-carboxylate Chemical compound FC=1C=C2C=C(N(C2=C(C=1)CC(C)C)C(=O)OC(C)(C)C)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(N1CCCC1)=O)NC(=O)OC)=O)=O NYQNGDMXFQCEDM-XFADDWSHSA-N 0.000 claims 1
BTEJGAGOQKTVBP-HSRJRILOSA-N tert-butyl 6-(2,4-difluorophenoxy)-8-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]purine-9-carboxylate Chemical compound FC1=C(OC2=C3N=C(N(C3=NC=N2)C(=O)OC(C)(C)C)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(=O)OC)=O)=O)C=CC(=C1)F BTEJGAGOQKTVBP-HSRJRILOSA-N 0.000 claims 1
HHEYTVRCPYVVOT-XSBJJCPUSA-N tert-butyl 6-fluoro-2-[[5-[[(E,2S)-2-(methoxycarbonylamino)-7-(methylamino)-7-oxohept-5-enoyl]amino]-6-oxopyrimidin-1-yl]methyl]-4-(3,3,3-trifluoropropyl)benzimidazole-1-carboxylate Chemical compound FC=1C=C(C2=C(N(C(=N2)CN2C=NC=C(C2=O)NC([C@H](CC\C=C\C(=O)NC)NC(=O)OC)=O)C(=O)OC(C)(C)C)C=1)CCC(F)(F)F HHEYTVRCPYVVOT-XSBJJCPUSA-N 0.000 claims 1
RYVYEQLSMJRFRX-UBQCRTFRSA-N tert-butyl 7-(2,2-difluoroethoxy)-2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoroindole-1-carboxylate Chemical compound FC(COC=1C=C(C=C2C=C(N(C=12)C(=O)OC(C)(C)C)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(=O)OC)=O)=O)F)F RYVYEQLSMJRFRX-UBQCRTFRSA-N 0.000 claims 1
WRHAQAASZZINPB-BODNZJIQSA-N tert-butyl 7-(2,2-difluoroethoxy)-2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]indole-1-carboxylate Chemical compound FC(COC=1C=CC=C2C=C(N(C=12)C(=O)OC(C)(C)C)CN1C(C(=CC=C1)NC([C@H](CC\C=C\C(=O)N(C)C)NC(=O)OC)=O)=O)F WRHAQAASZZINPB-BODNZJIQSA-N 0.000 claims 1
DTDXFACYEZIPLE-FYEGEGBDSA-N tert-butyl 7-[(2,4-difluorophenyl)methoxy]-2-[[3-[[(E,2S)-2-(dimethylcarbamoyloxy)-7-oxo-7-pyrrolidin-1-ylhept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoroindole-1-carboxylate Chemical compound FC1=C(COC=2C=C(C=C3C=C(N(C=23)C(=O)OC(C)(C)C)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(N2CCCC2)=O)OC(N(C)C)=O)=O)=O)F)C=CC(=C1)F DTDXFACYEZIPLE-FYEGEGBDSA-N 0.000 claims 1
YGEOEKQYINYKMU-CRZWDPOYSA-N tert-butyl 7-[(2,4-difluorophenyl)methoxy]-2-[[3-[[(E,2S)-7-(dimethylamino)-2-(2-methoxyethoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoroindole-1-carboxylate Chemical compound FC1=C(COC=2C=C(C=C3C=C(N(C=23)C(=O)OC(C)(C)C)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(=O)OCCOC)=O)=O)F)C=CC(=C1)F YGEOEKQYINYKMU-CRZWDPOYSA-N 0.000 claims 1
OQQUHKRLRXQTBH-PDAIQNRNSA-N tert-butyl 7-[(2,4-difluorophenyl)methoxy]-2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoroindole-1-carboxylate Chemical compound FC1=C(COC=2C=C(C=C3C=C(N(C=23)C(=O)OC(C)(C)C)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(=O)OC)=O)=O)F)C=CC(=C1)F OQQUHKRLRXQTBH-PDAIQNRNSA-N 0.000 claims 1
RFIUWHVJRNBMRD-HYGYTNKZSA-N tert-butyl 7-[(2,4-difluorophenyl)methoxy]-2-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]indole-1-carboxylate Chemical compound FC1=C(COC=2C=CC=C3C=C(N(C=23)C(=O)OC(C)(C)C)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(=O)OC)=O)=O)C=CC(=C1)F RFIUWHVJRNBMRD-HYGYTNKZSA-N 0.000 claims 1
LYROWAAVGPKTCA-JBVJNPJHSA-N tert-butyl 7-[(2,4-difluorophenyl)methoxy]-2-[[3-[[(E,2S)-7-(dimethylamino)-2-[2-methoxyethyl(methyl)carbamoyl]oxy-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoroindole-1-carboxylate Chemical compound FC1=C(COC=2C=C(C=C3C=C(N(C=23)C(=O)OC(C)(C)C)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)OC(N(C)CCOC)=O)=O)=O)F)C=CC(=C1)F LYROWAAVGPKTCA-JBVJNPJHSA-N 0.000 claims 1
BMQNWPBKCIDCGG-FYEGEGBDSA-N tert-butyl 7-[(2,4-difluorophenyl)methoxy]-2-[[3-[[(E,2S)-7-(dimethylamino)-7-oxo-2-(pyrrolidine-1-carbonyloxy)hept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-5-fluoroindole-1-carboxylate Chemical compound FC1=C(COC=2C=C(C=C3C=C(N(C=23)C(=O)OC(C)(C)C)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)OC(=O)N2CCCC2)=O)=O)F)C=CC(=C1)F BMQNWPBKCIDCGG-FYEGEGBDSA-N 0.000 claims 1
HBODSQBQJIUHDN-AHXGSBRSSA-N tert-butyl 7-[(2,4-difluorophenyl)methoxy]-5-fluoro-2-[[3-[[(E,2S)-2-(methoxycarbonylamino)-7-(methylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]indole-1-carboxylate Chemical compound FC1=C(COC=2C=C(C=C3C=C(N(C=23)C(=O)OC(C)(C)C)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)NC)NC(=O)OC)=O)=O)F)C=CC(=C1)F HBODSQBQJIUHDN-AHXGSBRSSA-N 0.000 claims 1
LQBPXWOKPXRYBC-JCRIEJSWSA-N tert-butyl 7-[[3-[[(E,2S)-7-amino-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]indole-1-carboxylate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1C=CC=C2C=CN(C=12)C(=O)OC(C)(C)C)=O)NC(=O)OC)=O LQBPXWOKPXRYBC-JCRIEJSWSA-N 0.000 claims 1
MODRINUFPSZBIP-GLHYLFFDSA-N tert-butyl 8-[[3-[[(E,2S)-7-(dimethylamino)-2-(methoxycarbonylamino)-7-oxohept-5-enoyl]amino]-2-oxopyridin-1-yl]methyl]-2-methyl-6-(2-methylpropyl)purine-9-carboxylate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1N(C2=NC(=NC(=C2N=1)CC(C)C)C)C(=O)OC(C)(C)C)=O)NC(=O)OC)=O)C MODRINUFPSZBIP-GLHYLFFDSA-N 0.000 claims 1
HBWCGKVKRIDFBX-GEJZUGHGSA-N tert-butyl N-[(E,2S)-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(COC2=CC=CC=3N=C(SC=32)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC(C)(C)C)=O)=O)=O)C=CC(=C1)F HBWCGKVKRIDFBX-GEJZUGHGSA-N 0.000 claims 1
PZVQAJDRAWMGPX-QSVQOIOGSA-N tert-butyl N-[(E,2S)-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-1H-indol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-7-(dimethylamino)-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound FC1=C(COC=2C=CC=C3C=C(NC=23)CN2C(C(=CC=C2)NC([C@H](CC\C=C\C(=O)N(C)C)NC(OC(C)(C)C)=O)=O)=O)C=CC(=C1)F PZVQAJDRAWMGPX-QSVQOIOGSA-N 0.000 claims 1
UIHFYTJVNCIEPF-SIQAJXIBSA-N tert-butyl N-[(E,2S)-7-(dimethylamino)-1-[[1-[[4-(1-hydroxy-2,2-dimethylpropyl)-1H-benzimidazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound CN(C(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC1=NC2=C(N1)C(=CC=C2)C(C(C)(C)C)O)=O)NC(OC(C)(C)C)=O)=O)C UIHFYTJVNCIEPF-SIQAJXIBSA-N 0.000 claims 1
MZYFDUPLCHSRCV-LHRVCSDGSA-N tert-butyl N-[(E,2S)-7-amino-1-[[1-[[7-[(2,4-difluorophenyl)methoxy]-1,3-benzothiazol-2-yl]methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]carbamate Chemical compound NC(/C=C/CC[C@@H](C(=O)NC=1C(N(C=CC=1)CC=1SC2=C(N=1)C=CC=C2OCC1=C(C=C(C=C1)F)F)=O)NC(OC(C)(C)C)=O)=O MZYFDUPLCHSRCV-LHRVCSDGSA-N 0.000 claims 1
YVCXYWJGCYXVIF-GGRWDMAWSA-N tert-butyl N-[2-[[(E,2S)-7-(dimethylamino)-1-[[1-[(5-fluoro-1-methylindol-2-yl)methyl]-2-oxopyridin-3-yl]amino]-1,7-dioxohept-5-en-2-yl]oxycarbonyl-methylamino]ethyl]-N-methylcarbamate Chemical compound CN(C(/C=C/CC[C@@H](C(NC=1C(N(C=CC=1)CC=1N(C2=CC=C(C=C2C=1)F)C)=O)=O)OC(N(C)CCN(C)C(=O)OC(C)(C)C)=O)=O)C YVCXYWJGCYXVIF-GGRWDMAWSA-N 0.000 claims 1
238000002560 therapeutic procedure Methods 0.000 claims 1
125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 claims 1

JP2021531468A 2018-08-10 2019-08-09 トランスグルタミナーゼ２（ｔｇ２）阻害剤 Active JP7433315B2 (ja)