JPWO2019191444A5 - - Google Patents
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- Publication number
- JPWO2019191444A5 JPWO2019191444A5 JP2020551798A JP2020551798A JPWO2019191444A5 JP WO2019191444 A5 JPWO2019191444 A5 JP WO2019191444A5 JP 2020551798 A JP2020551798 A JP 2020551798A JP 2020551798 A JP2020551798 A JP 2020551798A JP WO2019191444 A5 JPWO2019191444 A5 JP WO2019191444A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- disorder
- disease
- exosome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000010099 disease Diseases 0.000 claims description 72
- 230000001225 therapeutic Effects 0.000 claims description 34
- 102000004169 proteins and genes Human genes 0.000 claims description 31
- 108090000623 proteins and genes Proteins 0.000 claims description 31
- 210000001808 Exosomes Anatomy 0.000 claims description 30
- 201000011510 cancer Diseases 0.000 claims description 16
- 238000002560 therapeutic procedure Methods 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 11
- 210000004027 cells Anatomy 0.000 claims description 10
- 210000001124 Body Fluids Anatomy 0.000 claims description 8
- 208000003432 Bone Disease Diseases 0.000 claims description 8
- 208000006641 Skin Disease Diseases 0.000 claims description 8
- 239000010839 body fluid Substances 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 7
- 150000007523 nucleic acids Chemical class 0.000 claims description 7
- 229920000160 (ribonucleotides)n+m Polymers 0.000 claims description 6
- 102000009465 Growth Factor Receptors Human genes 0.000 claims description 6
- 108010009202 Growth Factor Receptors Proteins 0.000 claims description 6
- 206010061289 Metastatic neoplasm Diseases 0.000 claims description 6
- 210000002966 Serum Anatomy 0.000 claims description 6
- 102000004965 antibodies Human genes 0.000 claims description 6
- 108090001123 antibodies Proteins 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- 230000001394 metastastic Effects 0.000 claims description 6
- 206010003816 Autoimmune disease Diseases 0.000 claims description 4
- 206010005003 Bladder cancer Diseases 0.000 claims description 4
- 210000004369 Blood Anatomy 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 102100013078 CD47 Human genes 0.000 claims description 4
- 101700033237 CD47 Proteins 0.000 claims description 4
- 208000008787 Cardiovascular Disease Diseases 0.000 claims description 4
- 210000001175 Cerebrospinal Fluid Anatomy 0.000 claims description 4
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 210000000416 Exudates and Transudates Anatomy 0.000 claims description 4
- 208000009745 Eye Disease Diseases 0.000 claims description 4
- 206010017758 Gastric cancer Diseases 0.000 claims description 4
- 208000008665 Gastrointestinal Disease Diseases 0.000 claims description 4
- 206010022114 Injury Diseases 0.000 claims description 4
- 208000001083 Kidney Disease Diseases 0.000 claims description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 206010029331 Neuropathy peripheral Diseases 0.000 claims description 4
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims description 4
- 102000030951 Phosphotransferases Human genes 0.000 claims description 4
- 108091000081 Phosphotransferases Proteins 0.000 claims description 4
- 206010060862 Prostate cancer Diseases 0.000 claims description 4
- 206010038038 Rectal cancer Diseases 0.000 claims description 4
- 210000003296 Saliva Anatomy 0.000 claims description 4
- 210000001138 Tears Anatomy 0.000 claims description 4
- 206010057644 Testis cancer Diseases 0.000 claims description 4
- 206010044285 Tracheal cancer Diseases 0.000 claims description 4
- 210000002700 Urine Anatomy 0.000 claims description 4
- 206010046694 Urogenital disease Diseases 0.000 claims description 4
- 210000004291 Uterus Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 201000005216 brain cancer Diseases 0.000 claims description 4
- 201000010881 cervical cancer Diseases 0.000 claims description 4
- 201000009910 diseases by infectious agent Diseases 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229940079593 drugs Drugs 0.000 claims description 4
- 201000004101 esophageal cancer Diseases 0.000 claims description 4
- 201000002146 gastrointestinal system disease Diseases 0.000 claims description 4
- 239000003102 growth factor Substances 0.000 claims description 4
- 201000010536 head and neck cancer Diseases 0.000 claims description 4
- 201000007270 liver cancer Diseases 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 4
- 201000001119 neuropathy Diseases 0.000 claims description 4
- 201000002528 pancreatic cancer Diseases 0.000 claims description 4
- -1 phosphatase Proteins 0.000 claims description 4
- 201000001275 rectum cancer Diseases 0.000 claims description 4
- 230000022983 regulation of cell cycle Effects 0.000 claims description 4
- 201000000849 skin cancer Diseases 0.000 claims description 4
- 150000003384 small molecules Chemical class 0.000 claims description 4
- 201000011549 stomach cancer Diseases 0.000 claims description 4
- 201000003120 testicular cancer Diseases 0.000 claims description 4
- 239000002407 tissue scaffold Substances 0.000 claims description 4
- 102000003995 transcription factors Human genes 0.000 claims description 4
- 108090000464 transcription factors Proteins 0.000 claims description 4
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 4
- 238000002512 chemotherapy Methods 0.000 claims description 3
- 238000001794 hormone therapy Methods 0.000 claims description 3
- 238000009169 immunotherapy Methods 0.000 claims description 3
- 239000002679 microRNA Substances 0.000 claims description 3
- 238000001959 radiotherapy Methods 0.000 claims description 3
- 238000001890 transfection Methods 0.000 claims description 3
- 229920000033 CRISPR Polymers 0.000 claims description 2
- 238000010354 CRISPR gene editing Methods 0.000 claims description 2
- 229920002676 Complementary DNA Polymers 0.000 claims description 2
- 108020004999 Messenger RNA Proteins 0.000 claims description 2
- 108020004388 MicroRNAs Proteins 0.000 claims description 2
- 108020004459 Small Interfering RNA Proteins 0.000 claims description 2
- 229920001891 Small hairpin RNA Polymers 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000038129 antigens Human genes 0.000 claims description 2
- 108091007172 antigens Proteins 0.000 claims description 2
- 239000002299 complementary DNA Substances 0.000 claims description 2
- 239000012216 imaging agent Substances 0.000 claims description 2
- 230000003834 intracellular Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229920002106 messenger RNA Polymers 0.000 claims description 2
- 229920001239 microRNA Polymers 0.000 claims description 2
- 239000002924 silencing RNA Substances 0.000 claims description 2
- 239000004055 small Interfering RNA Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 35
- 238000009583 bone marrow aspiration Methods 0.000 claims 2
- 210000001185 Bone Marrow Anatomy 0.000 description 2
- 230000035693 Fab Effects 0.000 description 2
- 210000002751 Lymph Anatomy 0.000 description 2
- 238000004520 electroporation Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006011 modification reaction Methods 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862649057P | 2018-03-28 | 2018-03-28 | |
| US62/649,057 | 2018-03-28 | ||
| PCT/US2019/024603 WO2019191444A1 (en) | 2018-03-28 | 2019-03-28 | Use of exosomes for targeted delivery of therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021519296A JP2021519296A (ja) | 2021-08-10 |
| JPWO2019191444A5 true JPWO2019191444A5 (ko) | 2022-04-04 |
Family
ID=68060505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020551798A Pending JP2021519296A (ja) | 2018-03-28 | 2019-03-28 | 治療用物質を標的送達するためのエキソソームの使用法 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP3773747A4 (ko) |
| JP (1) | JP2021519296A (ko) |
| KR (1) | KR20200136978A (ko) |
| CN (1) | CN112533643A (ko) |
| AU (1) | AU2019243179A1 (ko) |
| CA (1) | CA3095136A1 (ko) |
| WO (1) | WO2019191444A1 (ko) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201900007785A1 (it) * | 2019-05-31 | 2020-12-01 | Univ Degli Studi Milano | Vescicole extracellulari per veicolare farmaci terapeutici o diagnostici |
| US20230013636A1 (en) * | 2019-12-05 | 2023-01-19 | Board Of Regents, The University Of Texas System | Exosomes-based therapy for liver fibrosis and other diseases with fibrosis |
| WO2021119552A1 (en) * | 2019-12-13 | 2021-06-17 | Lawrence Livermore National Security, Llc | Nanotube-vesicle compositions and uses thereof |
| CN114774471A (zh) * | 2022-05-10 | 2022-07-22 | 厦门星际诺康细胞科技有限公司 | 一种呈现il27稳转细胞及其构建方法、呈现il27工程化外泌体及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7473678B2 (en) * | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| US9085778B2 (en) * | 2006-05-03 | 2015-07-21 | VL27, Inc. | Exosome transfer of nucleic acids to cells |
| GB201121069D0 (en) * | 2011-12-07 | 2012-01-18 | Isis Innovation | Delivery system |
| WO2014076137A1 (en) * | 2012-11-13 | 2014-05-22 | Lötvall Jan | Delivery of therapeutic agent |
| BR112015002626A2 (pt) * | 2012-11-29 | 2017-09-26 | Yeda Res & Dev | métodos para prevenção de metástases tumorais, tratamento e prognostico do câncer e identificação dos agentes que são inibidores da metástase putativa |
| EP3076949B1 (en) * | 2013-12-04 | 2019-09-04 | Board of Regents, The University of Texas System | Method for isolating cancer cell-derived exoxomes |
| EP3307890A1 (en) * | 2015-06-10 | 2018-04-18 | Board of Regents, The University of Texas System | Use of exosomes for the treatment of disease |
| JP2019501179A (ja) * | 2015-12-30 | 2019-01-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 細胞由来ベシクルの向上された生成および単離のための方法 |
| TWI601741B (zh) * | 2016-07-11 | 2017-10-11 | 財團法人國家衛生研究院 | 利用前列腺素受體ｅｐ４－拮抗劑誘導幹細胞製造含有高囊泡含物之外泌體囊泡的方法及其應用 |
-
2019
- 2019-03-28 CA CA3095136A patent/CA3095136A1/en active Pending
- 2019-03-28 JP JP2020551798A patent/JP2021519296A/ja active Pending
- 2019-03-28 WO PCT/US2019/024603 patent/WO2019191444A1/en unknown
- 2019-03-28 EP EP19776678.5A patent/EP3773747A4/en active Pending
- 2019-03-28 KR KR1020207030993A patent/KR20200136978A/ko unknown
- 2019-03-28 CN CN201980034058.9A patent/CN112533643A/zh active Pending
- 2019-03-28 AU AU2019243179A patent/AU2019243179A1/en active Pending
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