EP3773747A4 - USE OF EXOSOMES FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS - Google Patents

USE OF EXOSOMES FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS Download PDF

Info

Publication number
EP3773747A4
EP3773747A4 EP19776678.5A EP19776678A EP3773747A4 EP 3773747 A4 EP3773747 A4 EP 3773747A4 EP 19776678 A EP19776678 A EP 19776678A EP 3773747 A4 EP3773747 A4 EP 3773747A4
Authority
EP
European Patent Office
Prior art keywords
exosomes
therapeutic agents
targeted delivery
targeted
delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19776678.5A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3773747A1 (en
Inventor
Raghu Kalluri
Valerie LEBLEU
Pedro CORREA DE SAMPAIO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Publication of EP3773747A1 publication Critical patent/EP3773747A1/en
Publication of EP3773747A4 publication Critical patent/EP3773747A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP19776678.5A 2018-03-28 2019-03-28 USE OF EXOSOMES FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS Pending EP3773747A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862649057P 2018-03-28 2018-03-28
PCT/US2019/024603 WO2019191444A1 (en) 2018-03-28 2019-03-28 Use of exosomes for targeted delivery of therapeutic agents

Publications (2)

Publication Number Publication Date
EP3773747A1 EP3773747A1 (en) 2021-02-17
EP3773747A4 true EP3773747A4 (en) 2022-02-23

Family

ID=68060505

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19776678.5A Pending EP3773747A4 (en) 2018-03-28 2019-03-28 USE OF EXOSOMES FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS

Country Status (7)

Country Link
EP (1) EP3773747A4 (ko)
JP (1) JP2021519296A (ko)
KR (1) KR20200136978A (ko)
CN (1) CN112533643A (ko)
AU (1) AU2019243179A1 (ko)
CA (1) CA3095136A1 (ko)
WO (1) WO2019191444A1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201900007785A1 (it) * 2019-05-31 2020-12-01 Univ Degli Studi Milano Vescicole extracellulari per veicolare farmaci terapeutici o diagnostici
CA3164248A1 (en) * 2019-12-05 2021-06-10 Board Of Regents, The University Of Texas System Exosomes-based therapy for liver fibrosis and other diseases associated with fibrosis
WO2021119552A1 (en) * 2019-12-13 2021-06-17 Lawrence Livermore National Security, Llc Nanotube-vesicle compositions and uses thereof
CN114081960A (zh) * 2021-11-17 2022-02-25 中国人民解放军空军军医大学 一种前列腺癌分子靶向系统及其构建方法和应用
CN114774471A (zh) * 2022-05-10 2022-07-22 厦门星际诺康细胞科技有限公司 一种呈现il27稳转细胞及其构建方法、呈现il27工程化外泌体及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015085096A1 (en) * 2013-12-04 2015-06-11 Board Of Regents, The University Of Texas System Analysis of genomic dna, rna, and proteins in exosomes for diagnosis and theranosis
WO2016201323A1 (en) * 2015-06-10 2016-12-15 Board Of Regents, The University Of Texas System Use of exosomes for the treatment of disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473678B2 (en) * 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US9085778B2 (en) * 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
GB201121069D0 (en) * 2011-12-07 2012-01-18 Isis Innovation Delivery system
JP6391582B2 (ja) * 2012-11-13 2018-09-19 コディアック バイオサイエンシズ インコーポレイテッド 治療剤の送達方法
MX2015004626A (es) * 2012-11-29 2015-07-14 Yeda Res & Dev Metodos para prevenir metastasis de tumor, tratar y pronosticar cancer e identificar agentes que son inhibidores putativos de metastasis.
US20190008902A1 (en) * 2015-12-30 2019-01-10 The Regents Of The University Of California Methods for enhanced production and isolation of cell-derived vesicles
TWI601741B (zh) * 2016-07-11 2017-10-11 財團法人國家衛生研究院 利用前列腺素受體ｅｐ４－拮抗劑誘導幹細胞製造含有高囊泡含物之外泌體囊泡的方法及其應用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015085096A1 (en) * 2013-12-04 2015-06-11 Board Of Regents, The University Of Texas System Analysis of genomic dna, rna, and proteins in exosomes for diagnosis and theranosis
WO2016201323A1 (en) * 2015-06-10 2016-12-15 Board Of Regents, The University Of Texas System Use of exosomes for the treatment of disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2019191444A1 *
SHIN-ICHIRO OHNO ET AL: "Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells", MOLECULAR THERAPY, vol. 21, no. 1, 1 January 2013 (2013-01-01), US, pages 185 - 191, XP055501314, ISSN: 1525-0016, DOI: 10.1038/mt.2012.180 *

Also Published As

Publication number Publication date
JP2021519296A (ja) 2021-08-10
CN112533643A (zh) 2021-03-19
AU2019243179A1 (en) 2020-11-12
EP3773747A1 (en) 2021-02-17
WO2019191444A1 (en) 2019-10-03
KR20200136978A (ko) 2020-12-08
CA3095136A1 (en) 2019-10-03

Similar Documents

Publication Publication Date Title
EP3548005A4 (en) EXOSOMES FOR THE ADMINISTRATION OF THERAPEUTIC AGENTS
EP3840730A4 (en) COMPOSITIONS FOR DELIVERY OF THERAPEUTICS AND METHOD OF USE AND MANUFACTURING THEREOF
IL268999A (en) Compounds and preparations for intracellular administration of medicinal agents
EP3386484A4 (en) COMPOSITIONS AND METHODS FOR ADMINISTERING THERAPEUTIC AGENTS
EP3773747A4 (en) USE OF EXOSOMES FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS
EP3471672B8 (en) Injection device for subretinal delivery of therapeutic agent
EP3749344A4 (en) METHODS OF THERAPEUTIC USE OF EXOSOMES AND YRNA
EP3817747A4 (en) TARGETED DELIVERY OF THERAPEUTIC AGENTS TO HUMAN ADIPOCYTES
EP3512554A4 (en) PLATE COMPOSITION AND METHOD FOR DISPENSING THERAPEUTIC AGENTS
EP3735463A4 (en) THERAPEUTIC AGENT INDUCING CYTOTOXICITY
IL251349B (en) Routing of melanocytes for the transfer of medical or diagnostic substances using nano-cage proteins
EP3927328A4 (en) INHALED THERAPEUTIC
EP4021369A4 (en) MEDICAL DEVICES FOR CONTINUOUS DELIVERY OF THERAPEUTIC AGENTS
EP3525772A4 (en) FORMULATIONS FOR THE ENTERIC ADMINISTRATION OF THERAPEUTIC AGENTS
EP3777893A4 (en) USE OF BIS-IMINOBIOTIN COMPOUND FOR DRUG DELIVERY PURPOSES
IL275690A (en) Nanoparticles for targeted delivery of therapeutic polypeptides
EP3362096A4 (en) OPHTHALMIC TREATMENT COMPOSITION AND CARRIER FOR THE RELEASE OF PHARMACEUTICAL SUBSTANCES OR THERAPEUTICS
EP3773492A4 (en) THERAPEUTIC TARGETING OF ONCOGENS USING EXOSOMES
EP3836866A4 (en) SYSTEMS FOR THE ENTERIC DELIVERY OF THERAPEUTIC AGENTS
EP3171858A4 (en) Method and composition for targeted delivery of therapeutic agents
EP3651741A4 (en) COMPOSITIONS AND METHODS FOR THE TARGETED ADMINISTRATION OF THERAPEUTIC AND / OR DIAGNOSTIC SPECIES
IL284411A (en) Targeted transport of drug molecules
EP3886913A4 (en) IMPROVED TARGETED DELIVERY OF THERAPEUTICS
EP3781194A4 (en) COMPOSITIONS AND METHODS FOR SELECTIVE DELIVERY OF THERAPEUTIC AND IMAGING AGENTS
EP3808356A4 (en) TISSUE THERAPEUTIC AGENT

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20200930

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20220124

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 15/113 20100101ALI20220118BHEP

Ipc: C12N 15/87 20060101ALI20220118BHEP

Ipc: A61K 48/00 20060101AFI20220118BHEP