JPWO2019186488A5 - - Google Patents
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- Publication number
- JPWO2019186488A5 JPWO2019186488A5 JP2020551481A JP2020551481A JPWO2019186488A5 JP WO2019186488 A5 JPWO2019186488 A5 JP WO2019186488A5 JP 2020551481 A JP2020551481 A JP 2020551481A JP 2020551481 A JP2020551481 A JP 2020551481A JP WO2019186488 A5 JPWO2019186488 A5 JP WO2019186488A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- combination
- fluorophenyl
- fluoro
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000011510 cancer Diseases 0.000 claims description 30
- 206010028980 Neoplasm Diseases 0.000 claims description 24
- 206010009944 Colon cancer Diseases 0.000 claims description 20
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 20
- -1 pyrimidin-1 (2H) -yl Chemical group 0.000 claims description 20
- 239000003814 drug Substances 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 15
- BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 claims description 13
- 229940126062 Compound A Drugs 0.000 claims description 9
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims description 9
- METKIMKYRPQLGS-UHFFFAOYSA-N atenolol Chemical compound CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-UHFFFAOYSA-N 0.000 claims description 9
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 9
- 229940127557 pharmaceutical product Drugs 0.000 claims description 9
- 206010052358 Colorectal cancer metastatic Diseases 0.000 claims description 6
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims description 6
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims description 6
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 6
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 6
- 201000001441 melanoma Diseases 0.000 claims description 6
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 6
- 239000006186 oral dosage form Substances 0.000 claims description 6
- 102200055464 rs113488022 Human genes 0.000 claims description 6
- 201000002510 thyroid cancer Diseases 0.000 claims description 6
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 6
- 125000001207 fluorophenyl group Chemical group 0.000 claims description 5
- 206010004593 Bile duct cancer Diseases 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 206010033128 Ovarian cancer Diseases 0.000 claims description 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 4
- 208000026900 bile duct neoplasm Diseases 0.000 claims description 4
- 229960002465 dabrafenib Drugs 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229960004066 trametinib Drugs 0.000 claims description 4
- LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 210000001672 ovary Anatomy 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 229960001308 trametinib dimethyl sulfoxide Drugs 0.000 claims description 2
- OQUFJVRYDFIQBW-UHFFFAOYSA-N trametinib dimethyl sulfoxide Chemical compound CS(C)=O.CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 OQUFJVRYDFIQBW-UHFFFAOYSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 description 4
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862650744P | 2018-03-30 | 2018-03-30 | |
| US62/650,744 | 2018-03-30 | ||
| PCT/IB2019/052601 WO2019186488A1 (en) | 2018-03-30 | 2019-03-29 | A triple pharmaceutical combination comprising dabrafenib, trametinib and an erk inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021519285A JP2021519285A (ja) | 2021-08-10 |
| JPWO2019186488A5 true JPWO2019186488A5 (https=) | 2022-04-06 |
| JP2021519285A5 JP2021519285A5 (https=) | 2022-04-06 |
Family
ID=66397350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020551481A Pending JP2021519285A (ja) | 2018-03-30 | 2019-03-29 | ダブラフェニブ、トラメチニブ及びｅｒｋ阻害剤を含む医薬品の三重の組合せ |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20210121460A1 (https=) |
| EP (1) | EP3773586A1 (https=) |
| JP (1) | JP2021519285A (https=) |
| KR (1) | KR20200138303A (https=) |
| CN (1) | CN111936141A (https=) |
| AU (1) | AU2019246719B2 (https=) |
| BR (1) | BR112020019577A2 (https=) |
| CA (1) | CA3094780A1 (https=) |
| CL (1) | CL2020002505A1 (https=) |
| IL (1) | IL277380A (https=) |
| MX (1) | MX2020010231A (https=) |
| RU (1) | RU2020135055A (https=) |
| WO (1) | WO2019186488A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021171261A1 (en) * | 2020-02-28 | 2021-09-02 | Novartis Ag | A triple pharmaceutical combination comprising dabrafenib, an erk inhibitor and a shp2 inhibitor |
| EP4110341A2 (en) * | 2020-02-28 | 2023-01-04 | Novartis AG | A triple pharmaceutical combination comprising dabrafenib, an erk inhibitor and a raf inhibitor |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005252110B2 (en) | 2004-06-11 | 2008-09-04 | Shionogi & Co., Ltd. | 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido[2,3-D] pyrimidine derivatives and related compounds for the treatment of cancer |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| AU2014342338B2 (en) * | 2013-11-01 | 2016-12-01 | Novartis Ag | Aminoheteroaryl benzamides as kinase inhibitors |
| CN108368171A (zh) * | 2015-07-10 | 2018-08-03 | 根马布股份公司 | 用于癌症治疗的axl特异性抗体-药物缀合物 |
| AU2017329090B9 (en) * | 2016-09-19 | 2019-09-05 | Novartis Ag | Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor |
-
2019
- 2019-03-29 RU RU2020135055A patent/RU2020135055A/ru unknown
- 2019-03-29 AU AU2019246719A patent/AU2019246719B2/en not_active Ceased
- 2019-03-29 MX MX2020010231A patent/MX2020010231A/es unknown
- 2019-03-29 KR KR1020207030757A patent/KR20200138303A/ko not_active Withdrawn
- 2019-03-29 CA CA3094780A patent/CA3094780A1/en active Pending
- 2019-03-29 WO PCT/IB2019/052601 patent/WO2019186488A1/en not_active Ceased
- 2019-03-29 CN CN201980021573.3A patent/CN111936141A/zh active Pending
- 2019-03-29 EP EP19721810.0A patent/EP3773586A1/en not_active Withdrawn
- 2019-03-29 BR BR112020019577-4A patent/BR112020019577A2/pt not_active Application Discontinuation
- 2019-03-29 US US17/042,591 patent/US20210121460A1/en not_active Abandoned
- 2019-03-29 JP JP2020551481A patent/JP2021519285A/ja active Pending
-
2020
- 2020-09-15 IL IL277380A patent/IL277380A/en unknown
- 2020-09-28 CL CL2020002505A patent/CL2020002505A1/es unknown
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