JP2021519285A - ダブラフェニブ、トラメチニブ及びｅｒｋ阻害剤を含む医薬品の三重の組合せ - Google Patents

ダブラフェニブ、トラメチニブ及びｅｒｋ阻害剤を含む医薬品の三重の組合せ Download PDF

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JP2021519285A
JP2021519285A JP2020551481A JP2020551481A JP2021519285A JP 2021519285 A JP2021519285 A JP 2021519285A JP 2020551481 A JP2020551481 A JP 2020551481A JP 2020551481 A JP2020551481 A JP 2020551481A JP 2021519285 A JP2021519285 A JP 2021519285A
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Prior art keywords
cancer
combination
trametinib
dabrafenib
compound
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JP2020551481A
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Japanese (ja)
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JPWO2019186488A5 (https=
JP2021519285A5 (https=
Inventor
ジョン メイヤー，マシュー
ジョン メイヤー，マシュー
ワン，ヨウツェン
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ノバルティス アーゲー
ノバルティス アーゲー
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Publication of JP2021519285A publication Critical patent/JP2021519285A/ja
Publication of JPWO2019186488A5 publication Critical patent/JPWO2019186488A5/ja
Publication of JP2021519285A5 publication Critical patent/JP2021519285A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020551481A 2018-03-30 2019-03-29 ダブラフェニブ、トラメチニブ及びｅｒｋ阻害剤を含む医薬品の三重の組合せ Pending JP2021519285A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862650744P 2018-03-30 2018-03-30
US62/650,744 2018-03-30
PCT/IB2019/052601 WO2019186488A1 (en) 2018-03-30 2019-03-29 A triple pharmaceutical combination comprising dabrafenib, trametinib and an erk inhibitor

Publications (3)

Publication Number Publication Date
JP2021519285A true JP2021519285A (ja) 2021-08-10
JPWO2019186488A5 JPWO2019186488A5 (https=) 2022-04-06
JP2021519285A5 JP2021519285A5 (https=) 2022-04-06

Family

ID=66397350

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020551481A Pending JP2021519285A (ja) 2018-03-30 2019-03-29 ダブラフェニブ、トラメチニブ及びｅｒｋ阻害剤を含む医薬品の三重の組合せ

Country Status (13)

Country Link
US (1) US20210121460A1 (https=)
EP (1) EP3773586A1 (https=)
JP (1) JP2021519285A (https=)
KR (1) KR20200138303A (https=)
CN (1) CN111936141A (https=)
AU (1) AU2019246719B2 (https=)
BR (1) BR112020019577A2 (https=)
CA (1) CA3094780A1 (https=)
CL (1) CL2020002505A1 (https=)
IL (1) IL277380A (https=)
MX (1) MX2020010231A (https=)
RU (1) RU2020135055A (https=)
WO (1) WO2019186488A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021171261A1 (en) * 2020-02-28 2021-09-02 Novartis Ag A triple pharmaceutical combination comprising dabrafenib, an erk inhibitor and a shp2 inhibitor
EP4110341A2 (en) * 2020-02-28 2023-01-04 Novartis AG A triple pharmaceutical combination comprising dabrafenib, an erk inhibitor and a raf inhibitor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016540728A (ja) * 2013-11-01 2016-12-28 ノバルティス アーゲー キナーゼ阻害剤としてのアミノヘテロアリールベンズアミド
WO2018051306A1 (en) * 2016-09-19 2018-03-22 Novartis Ag Therapeutic combinations comprising a raf inhibitor and a erk inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005252110B2 (en) 2004-06-11 2008-09-04 Shionogi & Co., Ltd. 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido[2,3-D] pyrimidine derivatives and related compounds for the treatment of cancer
UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
CN108368171A (zh) * 2015-07-10 2018-08-03 根马布股份公司 用于癌症治疗的axl特异性抗体-药物缀合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016540728A (ja) * 2013-11-01 2016-12-28 ノバルティス アーゲー キナーゼ阻害剤としてのアミノヘテロアリールベンズアミド
WO2018051306A1 (en) * 2016-09-19 2018-03-22 Novartis Ag Therapeutic combinations comprising a raf inhibitor and a erk inhibitor

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CANCER DISCOVERY, vol. 5, no. 4, JPN6023002809, 2015, pages 348 - 350, ISSN: 0004977696 *
CANCER RESEARCH, vol. Vol.76, No.14 Spplement, JPN6023002806, 2016, pages 2150, ISSN: 0004977697 *
MOLECULAR ONCOLOGY, vol. 8, JPN6023002808, 2014, pages 544 - 554, ISSN: 0004977695 *
NATURE MEDICINE, vol. 23, no. 8, JPN6023002807, 2017, pages 929 - 937, ISSN: 0005138717 *

Also Published As

Publication number Publication date
WO2019186488A1 (en) 2019-10-03
CL2020002505A1 (es) 2021-03-05
KR20200138303A (ko) 2020-12-09
CN111936141A (zh) 2020-11-13
IL277380A (en) 2020-11-30
RU2020135055A (ru) 2022-05-05
US20210121460A1 (en) 2021-04-29
MX2020010231A (es) 2020-10-28
AU2019246719A1 (en) 2020-10-01
CA3094780A1 (en) 2019-10-03
EP3773586A1 (en) 2021-02-17
AU2019246719B2 (en) 2022-06-16
BR112020019577A2 (pt) 2021-01-05

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