JPWO2019180724A5 - - Google Patents

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Publication number
JPWO2019180724A5
JPWO2019180724A5 JP2021500374A JP2021500374A JPWO2019180724A5 JP WO2019180724 A5 JPWO2019180724 A5 JP WO2019180724A5 JP 2021500374 A JP2021500374 A JP 2021500374A JP 2021500374 A JP2021500374 A JP 2021500374A JP WO2019180724 A5 JPWO2019180724 A5 JP WO2019180724A5
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JP
Japan
Prior art keywords
nucleic acid
acid molecule
treg
homodimer
mammalian
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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JP2021500374A
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English (en)
Japanese (ja)
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JP2021519107A5 (https=
JP2021519107A (ja
JP7404331B2 (ja
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Priority claimed from PCT/IL2019/050324 external-priority patent/WO2019180724A1/en
Publication of JP2021519107A publication Critical patent/JP2021519107A/ja
Publication of JP2021519107A5 publication Critical patent/JP2021519107A5/ja
Publication of JPWO2019180724A5 publication Critical patent/JPWO2019180724A5/ja
Priority to JP2023210111A priority Critical patent/JP2024019533A/ja
Application granted granted Critical
Publication of JP7404331B2 publication Critical patent/JP7404331B2/ja
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JP2021500374A 2018-03-23 2019-03-22 膜結合型ＩＬ－１０をコードする核酸分子及びそれを発現する遺伝子的にリプログラミングされたＴｒｅｇ Active JP7404331B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023210111A JP2024019533A (ja) 2018-03-23 2023-12-13 膜結合型ＩＬ－１０を発現する遺伝子的にリプログラミングされたＴｒｅｇ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862647084P 2018-03-23 2018-03-23
US62/647,084 2018-03-23
PCT/IL2019/050324 WO2019180724A1 (en) 2018-03-23 2019-03-22 Genetically reprogrammed tregs expressing membrane-bound il-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023210111A Division JP2024019533A (ja) 2018-03-23 2023-12-13 膜結合型ＩＬ－１０を発現する遺伝子的にリプログラミングされたＴｒｅｇ

Publications (4)

Publication Number Publication Date
JP2021519107A JP2021519107A (ja) 2021-08-10
JP2021519107A5 JP2021519107A5 (https=) 2022-03-31
JPWO2019180724A5 true JPWO2019180724A5 (https=) 2022-03-31
JP7404331B2 JP7404331B2 (ja) 2023-12-25

Family

ID=66448601

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021500374A Active JP7404331B2 (ja) 2018-03-23 2019-03-22 膜結合型ＩＬ－１０をコードする核酸分子及びそれを発現する遺伝子的にリプログラミングされたＴｒｅｇ
JP2023210111A Pending JP2024019533A (ja) 2018-03-23 2023-12-13 膜結合型ＩＬ－１０を発現する遺伝子的にリプログラミングされたＴｒｅｇ

Family Applications After (1)

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JP2023210111A Pending JP2024019533A (ja) 2018-03-23 2023-12-13 膜結合型ＩＬ－１０を発現する遺伝子的にリプログラミングされたＴｒｅｇ

Country Status (10)

Country Link
US (1) US20210347843A9 (https=)
EP (1) EP3768699B1 (https=)
JP (2) JP7404331B2 (https=)
KR (1) KR102943105B1 (https=)
CN (1) CN112088164A (https=)
AU (1) AU2019240370B2 (https=)
CA (1) CA3094927A1 (https=)
IL (1) IL277541A (https=)
SG (1) SG11202010454PA (https=)
WO (1) WO2019180724A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220186232A1 (en) * 2019-03-26 2022-06-16 Gavish-Galilee Bio Applications Ltd. Genetically reprogrammed tregs expressing cars
EP4536689A1 (en) * 2022-06-10 2025-04-16 Medizinische Hochschule Hannover Fusion protein for maintenance of regulatory t-cells
EP4289859A1 (en) * 2022-06-10 2023-12-13 Medizinische Hochschule Hannover Fusion protein for maintenance of regulatory t-cells
EP4565702A1 (en) * 2022-08-03 2025-06-11 Migal Galilee Research Institute Ltd. Chimeric membrane-bound cytokines incorporating costimulatory elements for enhancing anti-inflammatory function
WO2025148750A1 (zh) * 2024-01-08 2025-07-17 上药生物治疗（香港）有限公司 膜表达il-10及其用途
CN119331826B (zh) * 2024-12-18 2025-08-05 智在汉青生物科技(浙江)有限公司 用于增强细胞免疫疗法的表达非分泌型il-10的免疫细胞、制备方法及用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5275100A (en) * 1999-05-21 2000-12-12 Regents Of The University Of California, The Fluorescent protein indicators
WO2001089286A2 (en) * 2000-05-24 2001-11-29 Cel-Sci Corporation T cell binding ligand peptides, peptide constructs containing same and use thereof for treatment of immunological disorders
AU2003241127A1 (en) * 2002-06-12 2003-12-31 Gavish-Galilee Bio Applications Ltd MEMBRANE-ANCHORED Beta2 MICROGLOBULIN COVALENTLY LINKED TO MHC CLASS I PEPTIDE EPITOPES
US20050048587A1 (en) * 2003-07-17 2005-03-03 Tolerrx, Inc. Methods for identifying tolerance modulatory compounds and uses therefor
DE10347710B4 (de) * 2003-10-14 2006-03-30 Johannes-Gutenberg-Universität Mainz Rekombinante Impfstoffe und deren Verwendung
EP2126054B1 (en) * 2007-01-31 2016-07-06 Yeda Research And Development Company Limited Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease
GB0715383D0 (en) * 2007-08-08 2007-09-19 Asterion Ltd Interferon
CA2739608A1 (en) * 2008-10-07 2010-04-15 The Regents Of The University Of California Recombinant nell protein production
AU2013203561B2 (en) * 2009-05-15 2015-11-26 Irx Therapeutics, Inc. Vaccine immunotherapy
EP2457579A1 (en) * 2010-11-26 2012-05-30 Technische Universität Dresden Covalently linked interleukin -10
ES2612914T3 (es) * 2011-03-31 2017-05-19 Inserm - Institut National De La Santé Et De La Recherche Médicale Anticuerpos dirigidos contra Icos y usos de los mismos
GB201317929D0 (en) * 2013-10-10 2013-11-27 Ucl Business Plc Chimeric antigen receptor
EP3842450A1 (en) * 2015-10-23 2021-06-30 Eureka Therapeutics, Inc. Antibody/t-cell receptor chimeric constructs and uses thereof
MX2018007295A (es) * 2016-01-11 2019-03-28 Armo Biosciences Inc Interleucina 10 en la produccion de linfocitos t cd8+especificos para el antigeno y metodos de uso de estos.
MY210545A (en) * 2016-04-01 2025-09-30 Kite Pharma Inc Chimeric receptors to flt3 and methods of use thereof
JP7084881B2 (ja) * 2016-06-22 2022-06-15 アルカームス インコーポレーテッド Ｉｌ－１０の免疫刺激特性および抗炎症特性を調節するための組成物および方法
CN107216395B (zh) * 2017-07-03 2018-07-20 上海科医联创生物科技有限公司 一种tm4sf1特异性嵌合抗原受体及其应用

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