JP7404331B2 - 膜結合型IL-10をコードする核酸分子及びそれを発現する遺伝子的にリプログラミングされたTreg - Google Patents
膜結合型IL-10をコードする核酸分子及びそれを発現する遺伝子的にリプログラミングされたTreg Download PDFInfo
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- JP7404331B2 JP7404331B2 JP2021500374A JP2021500374A JP7404331B2 JP 7404331 B2 JP7404331 B2 JP 7404331B2 JP 2021500374 A JP2021500374 A JP 2021500374A JP 2021500374 A JP2021500374 A JP 2021500374A JP 7404331 B2 JP7404331 B2 JP 7404331B2
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/62—DNA sequences coding for fusion proteins
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/231—Interleukin-10 (IL-10)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
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- Gastroenterology & Hepatology (AREA)
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- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023210111A JP2024019533A (ja) | 2018-03-23 | 2023-12-13 | 膜結合型IL-10を発現する遺伝子的にリプログラミングされたTreg |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862647084P | 2018-03-23 | 2018-03-23 | |
| US62/647,084 | 2018-03-23 | ||
| PCT/IL2019/050324 WO2019180724A1 (en) | 2018-03-23 | 2019-03-22 | Genetically reprogrammed tregs expressing membrane-bound il-10 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023210111A Division JP2024019533A (ja) | 2018-03-23 | 2023-12-13 | 膜結合型IL-10を発現する遺伝子的にリプログラミングされたTreg |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021519107A JP2021519107A (ja) | 2021-08-10 |
| JP2021519107A5 JP2021519107A5 (https=) | 2022-03-31 |
| JPWO2019180724A5 JPWO2019180724A5 (https=) | 2022-03-31 |
| JP7404331B2 true JP7404331B2 (ja) | 2023-12-25 |
Family
ID=66448601
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021500374A Active JP7404331B2 (ja) | 2018-03-23 | 2019-03-22 | 膜結合型IL-10をコードする核酸分子及びそれを発現する遺伝子的にリプログラミングされたTreg |
| JP2023210111A Pending JP2024019533A (ja) | 2018-03-23 | 2023-12-13 | 膜結合型IL-10を発現する遺伝子的にリプログラミングされたTreg |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023210111A Pending JP2024019533A (ja) | 2018-03-23 | 2023-12-13 | 膜結合型IL-10を発現する遺伝子的にリプログラミングされたTreg |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20210347843A9 (https=) |
| EP (1) | EP3768699B1 (https=) |
| JP (2) | JP7404331B2 (https=) |
| KR (1) | KR102943105B1 (https=) |
| CN (1) | CN112088164A (https=) |
| AU (1) | AU2019240370B2 (https=) |
| CA (1) | CA3094927A1 (https=) |
| IL (1) | IL277541A (https=) |
| SG (1) | SG11202010454PA (https=) |
| WO (1) | WO2019180724A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220186232A1 (en) * | 2019-03-26 | 2022-06-16 | Gavish-Galilee Bio Applications Ltd. | Genetically reprogrammed tregs expressing cars |
| EP4536689A1 (en) * | 2022-06-10 | 2025-04-16 | Medizinische Hochschule Hannover | Fusion protein for maintenance of regulatory t-cells |
| EP4289859A1 (en) * | 2022-06-10 | 2023-12-13 | Medizinische Hochschule Hannover | Fusion protein for maintenance of regulatory t-cells |
| EP4565702A1 (en) * | 2022-08-03 | 2025-06-11 | Migal Galilee Research Institute Ltd. | Chimeric membrane-bound cytokines incorporating costimulatory elements for enhancing anti-inflammatory function |
| WO2025148750A1 (zh) * | 2024-01-08 | 2025-07-17 | 上药生物治疗(香港)有限公司 | 膜表达il-10及其用途 |
| CN119331826B (zh) * | 2024-12-18 | 2025-08-05 | 智在汉青生物科技(浙江)有限公司 | 用于增强细胞免疫疗法的表达非分泌型il-10的免疫细胞、制备方法及用途 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2003533542A (ja) | 2000-05-24 | 2003-11-11 | セル−サイ・コーポレーシヨン | T細胞結合リガンド、それを含むペプチド構築物およびそれらの免疫障害を処置するための使用 |
| WO2003106616A2 (en) | 2002-06-12 | 2003-12-24 | Gavish-Galilee Bio Applications Ltd | MEMBRANE-ANCHORED β2 MICROGLOBULIN COVALENTLY LINKED TO MHC CLASS I PEPTIDE EPITOPES |
| JP2008500014A (ja) | 2003-10-14 | 2008-01-10 | ヨハネス・グーテンベルク−ウニヴェルジテート・マインツ・フェルトレーテン・デュルヒ・デン・プレジデンテン | 組換えワクチンおよびその使用 |
| WO2010042654A2 (en) | 2008-10-07 | 2010-04-15 | The Regents Of The University Of California | Recombinant nell protein production |
| US20130316404A1 (en) | 2010-11-26 | 2013-11-28 | The University Of Manchester | Covalently linked interleukin-10 |
| WO2017173410A1 (en) | 2016-04-01 | 2017-10-05 | Amgen Inc. | Chimeric receptors to flt3 and methods of use thereof |
| US20170368144A1 (en) | 2016-06-22 | 2017-12-28 | Alkermes, Inc. | Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5275100A (en) * | 1999-05-21 | 2000-12-12 | Regents Of The University Of California, The | Fluorescent protein indicators |
| US20050048587A1 (en) * | 2003-07-17 | 2005-03-03 | Tolerrx, Inc. | Methods for identifying tolerance modulatory compounds and uses therefor |
| EP2126054B1 (en) * | 2007-01-31 | 2016-07-06 | Yeda Research And Development Company Limited | Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease |
| GB0715383D0 (en) * | 2007-08-08 | 2007-09-19 | Asterion Ltd | Interferon |
| AU2013203561B2 (en) * | 2009-05-15 | 2015-11-26 | Irx Therapeutics, Inc. | Vaccine immunotherapy |
| ES2612914T3 (es) * | 2011-03-31 | 2017-05-19 | Inserm - Institut National De La Santé Et De La Recherche Médicale | Anticuerpos dirigidos contra Icos y usos de los mismos |
| GB201317929D0 (en) * | 2013-10-10 | 2013-11-27 | Ucl Business Plc | Chimeric antigen receptor |
| EP3842450A1 (en) * | 2015-10-23 | 2021-06-30 | Eureka Therapeutics, Inc. | Antibody/t-cell receptor chimeric constructs and uses thereof |
| MX2018007295A (es) * | 2016-01-11 | 2019-03-28 | Armo Biosciences Inc | Interleucina 10 en la produccion de linfocitos t cd8+especificos para el antigeno y metodos de uso de estos. |
| CN107216395B (zh) * | 2017-07-03 | 2018-07-20 | 上海科医联创生物科技有限公司 | 一种tm4sf1特异性嵌合抗原受体及其应用 |
-
2019
- 2019-03-22 EP EP19722960.2A patent/EP3768699B1/en active Active
- 2019-03-22 SG SG11202010454PA patent/SG11202010454PA/en unknown
- 2019-03-22 CA CA3094927A patent/CA3094927A1/en active Pending
- 2019-03-22 CN CN201980021334.8A patent/CN112088164A/zh active Pending
- 2019-03-22 US US17/040,851 patent/US20210347843A9/en active Pending
- 2019-03-22 AU AU2019240370A patent/AU2019240370B2/en active Active
- 2019-03-22 WO PCT/IL2019/050324 patent/WO2019180724A1/en not_active Ceased
- 2019-03-22 KR KR1020207030558A patent/KR102943105B1/ko active Active
- 2019-03-22 JP JP2021500374A patent/JP7404331B2/ja active Active
-
2020
- 2020-09-23 IL IL277541A patent/IL277541A/en unknown
-
2023
- 2023-12-13 JP JP2023210111A patent/JP2024019533A/ja active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003533542A (ja) | 2000-05-24 | 2003-11-11 | セル−サイ・コーポレーシヨン | T細胞結合リガンド、それを含むペプチド構築物およびそれらの免疫障害を処置するための使用 |
| WO2003106616A2 (en) | 2002-06-12 | 2003-12-24 | Gavish-Galilee Bio Applications Ltd | MEMBRANE-ANCHORED β2 MICROGLOBULIN COVALENTLY LINKED TO MHC CLASS I PEPTIDE EPITOPES |
| JP2008500014A (ja) | 2003-10-14 | 2008-01-10 | ヨハネス・グーテンベルク−ウニヴェルジテート・マインツ・フェルトレーテン・デュルヒ・デン・プレジデンテン | 組換えワクチンおよびその使用 |
| WO2010042654A2 (en) | 2008-10-07 | 2010-04-15 | The Regents Of The University Of California | Recombinant nell protein production |
| US20130316404A1 (en) | 2010-11-26 | 2013-11-28 | The University Of Manchester | Covalently linked interleukin-10 |
| WO2017173410A1 (en) | 2016-04-01 | 2017-10-05 | Amgen Inc. | Chimeric receptors to flt3 and methods of use thereof |
| US20170368144A1 (en) | 2016-06-22 | 2017-12-28 | Alkermes, Inc. | Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties |
Non-Patent Citations (5)
| Title |
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| Andolfi G et al,Enforced IL-10 Expression Confers Type 1 Regulatory T Cell (Tr1) Phenotype and Function to Human CD4+ T Cells,Mol Ther,2012年,20・9,1778-1790 |
| Blat D et al,Suppression of Murine Colitis and its Associated Cancer by Carcinoembryonic Antigen-Specific Regulatory T Cells,Mol Ther,2014年,22・5,1018-1028 |
| Jethwa H et al,Use of gene-modified regulatory T-cells to control autoimmune and alloimmune pathology: is now the right time?,Clin Immunol,2014年,150,51-63 |
| Locafaro G et al,IL-10-Engineered Human CD4+ Tr1 Cells Eliminate Myeloid Leukemia in an HLA Class I-Dependent Mechanism,Mol Ther,2017年,25・10,2254-2269 |
| Weinstein-Marom H et al,Membrane-attached Cytokines Expressed by mRNA Electroporation Act as Potent T-Cell Adjuvants,J Immunother,2016年,39・2,60-70 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3768699A1 (en) | 2021-01-27 |
| IL277541A (en) | 2020-11-30 |
| JP2024019533A (ja) | 2024-02-09 |
| WO2019180724A1 (en) | 2019-09-26 |
| US20210040169A1 (en) | 2021-02-11 |
| US20210347843A9 (en) | 2021-11-11 |
| JP2021519107A (ja) | 2021-08-10 |
| EP3768699B1 (en) | 2025-11-12 |
| AU2019240370B2 (en) | 2024-03-07 |
| SG11202010454PA (en) | 2020-11-27 |
| KR20210005602A (ko) | 2021-01-14 |
| AU2019240370A1 (en) | 2020-11-19 |
| CA3094927A1 (en) | 2019-09-26 |
| CN112088164A (zh) | 2020-12-15 |
| KR102943105B1 (ko) | 2026-03-24 |
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