JP2021519107A5 - - Google Patents

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Publication number
JP2021519107A5
JP2021519107A5 JP2021500374A JP2021500374A JP2021519107A5 JP 2021519107 A5 JP2021519107 A5 JP 2021519107A5 JP 2021500374 A JP2021500374 A JP 2021500374A JP 2021500374 A JP2021500374 A JP 2021500374A JP 2021519107 A5 JP2021519107 A5 JP 2021519107A5
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JP
Japan
Prior art keywords
nucleic acid
treg
acid molecule
homodimer
molecule according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021500374A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021519107A (ja
JP7404331B2 (ja
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Publication date
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Priority claimed from PCT/IL2019/050324 external-priority patent/WO2019180724A1/en
Publication of JP2021519107A publication Critical patent/JP2021519107A/ja
Publication of JP2021519107A5 publication Critical patent/JP2021519107A5/ja
Priority to JP2023210111A priority Critical patent/JP2024019533A/ja
Application granted granted Critical
Publication of JP7404331B2 publication Critical patent/JP7404331B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2021500374A 2018-03-23 2019-03-22 膜結合型ＩＬ－１０をコードする核酸分子及びそれを発現する遺伝子的にリプログラミングされたＴｒｅｇ Active JP7404331B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023210111A JP2024019533A (ja) 2018-03-23 2023-12-13 膜結合型ＩＬ－１０を発現する遺伝子的にリプログラミングされたＴｒｅｇ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862647084P 2018-03-23 2018-03-23
US62/647,084 2018-03-23
PCT/IL2019/050324 WO2019180724A1 (en) 2018-03-23 2019-03-22 Genetically reprogrammed tregs expressing membrane-bound il-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023210111A Division JP2024019533A (ja) 2018-03-23 2023-12-13 膜結合型ＩＬ－１０を発現する遺伝子的にリプログラミングされたＴｒｅｇ

Publications (3)

Publication Number Publication Date
JP2021519107A JP2021519107A (ja) 2021-08-10
JP2021519107A5 true JP2021519107A5 (https=) 2022-03-31
JP7404331B2 JP7404331B2 (ja) 2023-12-25

Family

ID=66448601

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021500374A Active JP7404331B2 (ja) 2018-03-23 2019-03-22 膜結合型ＩＬ－１０をコードする核酸分子及びそれを発現する遺伝子的にリプログラミングされたＴｒｅｇ
JP2023210111A Pending JP2024019533A (ja) 2018-03-23 2023-12-13 膜結合型ＩＬ－１０を発現する遺伝子的にリプログラミングされたＴｒｅｇ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023210111A Pending JP2024019533A (ja) 2018-03-23 2023-12-13 膜結合型ＩＬ－１０を発現する遺伝子的にリプログラミングされたＴｒｅｇ

Country Status (10)

Country Link
US (1) US20210347843A9 (https=)
EP (1) EP3768699B1 (https=)
JP (2) JP7404331B2 (https=)
KR (1) KR102943105B1 (https=)
CN (1) CN112088164A (https=)
AU (1) AU2019240370B2 (https=)
CA (1) CA3094927A1 (https=)
IL (1) IL277541A (https=)
SG (1) SG11202010454PA (https=)
WO (1) WO2019180724A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114127297A (zh) * 2019-03-26 2022-03-01 加维什-加利里生物应用有限公司 遗传重编程的表达car的treg
WO2023237774A1 (en) * 2022-06-10 2023-12-14 Medizinische Hochschule Hannover Fusion protein for maintenance of regulatory t-cells
EP4289859A1 (en) * 2022-06-10 2023-12-13 Medizinische Hochschule Hannover Fusion protein for maintenance of regulatory t-cells
WO2024028881A1 (en) * 2022-08-03 2024-02-08 Migal Galilee Research Institute Ltd. Chimeric membrane-bound cytokines incorporating costimulatory elements for enhancing anti-inflammatory function
WO2025148750A1 (zh) * 2024-01-08 2025-07-17 上药生物治疗（香港）有限公司 膜表达il-10及其用途
CN119331826B (zh) * 2024-12-18 2025-08-05 智在汉青生物科技(浙江)有限公司 用于增强细胞免疫疗法的表达非分泌型il-10的免疫细胞、制备方法及用途

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Publication number Priority date Publication date Assignee Title
AU5275100A (en) * 1999-05-21 2000-12-12 Regents Of The University Of California, The Fluorescent protein indicators
AU2001264902A1 (en) * 2000-05-24 2001-12-03 Cel-Sci Corporation T cell binding ligand peptides, peptide constructs containing same and use thereof for treatment of immunological disorders
ATE509025T1 (de) 2002-06-12 2011-05-15 Gavish Galilee Bio Appl Ltd ßMIT MHC-KLASSE-I-PEPTIDEPITOPEN KOVALENT VERKN PFTES MEMBRANVERANKERTES BETA2-MIKROGLOBULINß
US20050048587A1 (en) * 2003-07-17 2005-03-03 Tolerrx, Inc. Methods for identifying tolerance modulatory compounds and uses therefor
DE10347710B4 (de) 2003-10-14 2006-03-30 Johannes-Gutenberg-Universität Mainz Rekombinante Impfstoffe und deren Verwendung
EP2126054B1 (en) * 2007-01-31 2016-07-06 Yeda Research And Development Company Limited Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease
GB0715383D0 (en) * 2007-08-08 2007-09-19 Asterion Ltd Interferon
CA2739608A1 (en) 2008-10-07 2010-04-15 The Regents Of The University Of California Recombinant nell protein production
AU2013203561B2 (en) * 2009-05-15 2015-11-26 Irx Therapeutics, Inc. Vaccine immunotherapy
EP2457579A1 (en) * 2010-11-26 2012-05-30 Technische Universität Dresden Covalently linked interleukin -10
EP3147297B1 (en) * 2011-03-31 2018-12-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies directed against icos and uses thereof
GB201317929D0 (en) * 2013-10-10 2013-11-27 Ucl Business Plc Chimeric antigen receptor
MX2018004721A (es) * 2015-10-23 2018-07-06 Eureka Therapeutics Inc Construcciones quimericas anticuerpo/receptor de celulas t y usos de las mismas.
US11814679B2 (en) * 2016-01-11 2023-11-14 Eli Lilly And Company Interleukin-10 production of antigen-specific CD8+ T cells and methods of use of same
IL262061B2 (en) 2016-04-01 2023-03-01 Amgen Inc Chimeric flt-3 receptors and methods of using them
WO2018005226A2 (en) 2016-06-22 2018-01-04 Alkermes, Inc. Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties
CN107216395B (zh) * 2017-07-03 2018-07-20 上海科医联创生物科技有限公司 一种tm4sf1特异性嵌合抗原受体及其应用

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