ATE509025T1 - ßMIT MHC-KLASSE-I-PEPTIDEPITOPEN KOVALENT VERKN PFTES MEMBRANVERANKERTES BETA2-MIKROGLOBULINß - Google Patents
ßMIT MHC-KLASSE-I-PEPTIDEPITOPEN KOVALENT VERKN PFTES MEMBRANVERANKERTES BETA2-MIKROGLOBULINßInfo
- Publication number
- ATE509025T1 ATE509025T1 AT03730447T AT03730447T ATE509025T1 AT E509025 T1 ATE509025 T1 AT E509025T1 AT 03730447 T AT03730447 T AT 03730447T AT 03730447 T AT03730447 T AT 03730447T AT E509025 T1 ATE509025 T1 AT E509025T1
- Authority
- AT
- Austria
- Prior art keywords
- beta2
- mhc class
- ßmembrane
- microglobulinß
- anchored
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 102000015736 beta 2-Microglobulin Human genes 0.000 abstract 2
- 108010081355 beta 2-Microglobulin Proteins 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 229940021995 DNA vaccine Drugs 0.000 abstract 1
- 102000043129 MHC class I family Human genes 0.000 abstract 1
- 108091054437 MHC class I family Proteins 0.000 abstract 1
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 229940030156 cell vaccine Drugs 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38827302P | 2002-06-12 | 2002-06-12 | |
| PCT/IL2003/000501 WO2003106616A2 (en) | 2002-06-12 | 2003-06-12 | MEMBRANE-ANCHORED β2 MICROGLOBULIN COVALENTLY LINKED TO MHC CLASS I PEPTIDE EPITOPES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE509025T1 true ATE509025T1 (de) | 2011-05-15 |
Family
ID=29736450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03730447T ATE509025T1 (de) | 2002-06-12 | 2003-06-12 | ßMIT MHC-KLASSE-I-PEPTIDEPITOPEN KOVALENT VERKN PFTES MEMBRANVERANKERTES BETA2-MIKROGLOBULINß |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20060003315A1 (de) |
| EP (1) | EP1572929B1 (de) |
| AT (1) | ATE509025T1 (de) |
| AU (1) | AU2003241127A1 (de) |
| WO (1) | WO2003106616A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080286312A1 (en) * | 2002-06-12 | 2008-11-20 | Gavish-Galilee Bio Applications Ltd. | Membrane-anchored beta2 microglobulincovalently linked to MHC class I peptide epitopes |
| LT5414B (lt) * | 2005-04-13 | 2007-04-25 | Biotechnologijos Institutas | Monokloninių antikūnų gavimo būdas, hibridomos, gautos šiuo būdu ir rekombinantinės chimerinės į virusus panašios dalelės su įterptais kitų baltymų fragmentais kaip imunogenai hibridomų gavimui šiuo būdu |
| EP2386633A4 (de) * | 2009-01-08 | 2013-04-24 | Int Inst Cancer Immunology Inc | Neues tumorantigen eef2 |
| WO2012127464A2 (en) | 2011-03-23 | 2012-09-27 | Gavish-Galilee Bio Applications Ltd | Constitutively activated t cells for use in adoptive cell therapy |
| CN104661675B (zh) * | 2012-05-16 | 2019-04-30 | 阿德莱德研究创新私人有限公司 | 细胞疫苗和诱导受试者免疫反应的方法 |
| CN103948943B (zh) * | 2013-05-20 | 2017-01-11 | 中国人民解放军军事医学科学院基础医学研究所 | 一种可复制型肾癌治疗性dna疫苗 |
| CN103948944B (zh) * | 2013-05-20 | 2016-06-01 | 中国人民解放军军事医学科学院基础医学研究所 | 一种广谱抗肿瘤双质粒可复制型dna疫苗 |
| GB201520575D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| EP3768699A1 (de) * | 2018-03-23 | 2021-01-27 | Gavish-Galilee Bio Applications, Ltd | Genetisch neu programmierte tregs, die membrangebundenes il-10 exprimieren |
| US20210238255A1 (en) * | 2018-04-23 | 2021-08-05 | Baylor College Of Medicine | Chimeric hla accessory receptor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6080409A (en) * | 1995-12-28 | 2000-06-27 | Dendreon Corporation | Immunostimulatory method |
| CA2286477A1 (en) * | 1997-04-11 | 1998-10-22 | Dendreon Corporation | Composition and method for inducing an immune response against tumour-related antigens |
| ATE325619T1 (de) * | 1997-07-10 | 2006-06-15 | Mannkind Corp | Vorrichtung zur induktion einer ctl-antwort |
| US6194152B1 (en) * | 1997-08-20 | 2001-02-27 | Dendreon Corporation | Prostate tumor polynucleotide compositions and methods of detection thereof |
| ATE472601T1 (de) * | 2000-03-27 | 2010-07-15 | Technion Res And Dev Of Founda | Einkettige haupthistokompatibilitätskomplexe der klasse i (mhc-i), kodierende konstrukte und methoden ihrer erzeugung |
| IL136511A0 (en) * | 2000-06-01 | 2001-06-14 | Gavish Galilee Bio Appl Ltd | Genetically engineered mhc molecules |
| EP1538900B1 (de) * | 2002-08-02 | 2016-01-06 | South Alabama Medical Science Foundation | Krebsimpfstoffe, die epitope von onkofetalen antigenen enthalten |
-
2003
- 2003-06-12 AT AT03730447T patent/ATE509025T1/de not_active IP Right Cessation
- 2003-06-12 US US10/517,784 patent/US20060003315A1/en not_active Abandoned
- 2003-06-12 WO PCT/IL2003/000501 patent/WO2003106616A2/en not_active Application Discontinuation
- 2003-06-12 AU AU2003241127A patent/AU2003241127A1/en not_active Abandoned
- 2003-06-12 EP EP03730447A patent/EP1572929B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20060003315A1 (en) | 2006-01-05 |
| EP1572929A2 (de) | 2005-09-14 |
| WO2003106616A2 (en) | 2003-12-24 |
| EP1572929B1 (de) | 2011-05-11 |
| AU2003241127A1 (en) | 2003-12-31 |
| WO2003106616A3 (en) | 2006-05-18 |
| AU2003241127A8 (en) | 2003-12-31 |
| EP1572929A4 (de) | 2007-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200501206A1 (ru) | Производные от сурвивина пептиды и их применение | |
| CY1118037T1 (el) | Αντισωματα εναντι του αβητα και h χρηση τους | |
| PE20050712A1 (es) | Anticuerpos rg1 | |
| CY1105597T1 (el) | Ανοσοθεραπευτικες μεθοδοι χρησιμοποιωντας επιτοπους των wt-1 και gata-1 | |
| BR0213565A (pt) | Anticorpo de anti-tnf alfa modificado | |
| DE60032486D1 (de) | Prion protein peptide und deren verwendung | |
| DE602005015990D1 (de) | Immunogene t-helfer epitope von menschlichen tumorantigenen und deren verwendung in immunotherapeutischen methoden | |
| DK0810870T3 (da) | Isolerede, MAGE-2-afledte tumorafstødelsesantigenpræcurserpeptider og anvendelse heraf | |
| EA200702202A1 (ru) | Идентификация представленных hla-a2 т-клеточных эпитопов, полученных из раково-эмбрионального антиген-незрелого рецепторного белка ламинила, и их применение | |
| AR047729A1 (es) | Anticuerpos terapeuticos que se unen a la apolipoproteina e (apoe) | |
| ATE509025T1 (de) | ßMIT MHC-KLASSE-I-PEPTIDEPITOPEN KOVALENT VERKN PFTES MEMBRANVERANKERTES BETA2-MIKROGLOBULINß | |
| ATE460176T1 (de) | Mikrosomvakzin | |
| MX2018013081A (es) | Metodos para predecir la utilidad de proteinas o fragmentos de proteina para inmunoterapia. | |
| CY1117746T1 (el) | Αντιγονα αιμοφιλου της γριπης και αντιστοιχα θραυσματα dna | |
| WO2008041231A3 (en) | MEMBRANE-ANCHORED β2 MICROGLOBULIN COVALENTLY LINKED TO MHC CLASS I PEPTIDE EPITOPES | |
| DE69931482D1 (de) | Isolierte peptide die aminosäuresequenzen von ny-eso-1 entsprechen und an mhc-klasse i und mhc klasse ii moleküle binden, und deren verwendungen | |
| DK1370284T3 (da) | Bakteriofag-medieret immunisering | |
| DE60118359D1 (de) | Humanische pellino-polypeptide | |
| DE69720065T2 (de) | Therapeutische anwendungen von antigenen oder epitopen assoziert mit unvollständiger zellulärer peptidprozesierung , z.b.: exprimiert in rma-s zellen transfiziert mit b7-1 gen | |
| UY26266A1 (es) | Antigeno asociado con tumores (r11) ley 17164 | |
| EP2193804A3 (de) | Rekombinantes Adenylat-Cyclase-Toxin von Bordetella induziert T-Zell-Antworten gegen tumorale Antigene | |
| WO2003106478A3 (en) | ANTIBODIES BINDING TO ALPHAE INTEGRIN | |
| WO2002044202A3 (fr) | Peptides immunogeniques mutes derives de r9m, polynucleotides les codant et leurs usages therapeutiques | |
| UY26170A1 (es) | Antigeno (c42) asociados a tumores | |
| ATE525470T1 (de) | Antigene epitope des faktors viii, inhibitoren dagegen, und deren verwendungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |