EA200702202A1 - Идентификация представленных hla-a2 т-клеточных эпитопов, полученных из раково-эмбрионального антиген-незрелого рецепторного белка ламинила, и их применение - Google Patents
Идентификация представленных hla-a2 т-клеточных эпитопов, полученных из раково-эмбрионального антиген-незрелого рецепторного белка ламинила, и их применениеInfo
- Publication number
- EA200702202A1 EA200702202A1 EA200702202A EA200702202A EA200702202A1 EA 200702202 A1 EA200702202 A1 EA 200702202A1 EA 200702202 A EA200702202 A EA 200702202A EA 200702202 A EA200702202 A EA 200702202A EA 200702202 A1 EA200702202 A1 EA 200702202A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- tumor
- present
- cancer
- relates
- laminil
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Настоящее изобретение относится к иммунотерапевтическим методам и молекулам и клеткам для применения в иммунотерапевтических методах. В частности, настоящее изобретение относится к иммунотерапии рака, в частности к нескольким опухолевым формам, включающим гематологические злокачественные опухоли. Настоящее изобретение относится в дальнейшем к опухолеассоциированным пептидным эпитопам Т-хелперных клеток, в отдельности или в комбинации с другими опухолеассоциированными пептидами, которые служат как активные фармацевтические ингредиенты для композиций вакцины, которая стимулирует антиопухолевые иммунные ответы. В частности, настоящее изобретение относится к двум новым пептидным последовательностям, полученным из молекул HLA класса I или II человеческого раково-эмбрионального антиген-незрелого рецептора ламинина (OFA/iLR), который может быть использован в вакцинных композициях для вызывания антиопухолевых иммунных ответов.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05009095A EP1717245B1 (en) | 2005-04-26 | 2005-04-26 | T-cell epitopes from the oncofetal antigen-immature laminin receptor protein and medical uses thereof |
| PCT/EP2006/003888 WO2006114307A1 (en) | 2005-04-26 | 2006-04-26 | T-cell epitopes from the oncofetal antigen-immature laminin receptor protein and medical uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200702202A1 true EA200702202A1 (ru) | 2008-04-28 |
| EA013598B1 EA013598B1 (ru) | 2010-06-30 |
Family
ID=34935739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200702202A EA013598B1 (ru) | 2005-04-26 | 2006-04-26 | Идентификация представленных hla-a2 т-клеточных эпитопов, полученных из раково-эмбрионального антиген-незрелого рецепторного белка ламинина, и их применение |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7968097B2 (ru) |
| EP (2) | EP1717245B1 (ru) |
| JP (1) | JP4870751B2 (ru) |
| CN (1) | CN101166759B (ru) |
| AT (1) | ATE512160T1 (ru) |
| AU (1) | AU2006239505B2 (ru) |
| BR (1) | BRPI0610841A2 (ru) |
| CA (1) | CA2606088C (ru) |
| EA (1) | EA013598B1 (ru) |
| ES (1) | ES2367643T3 (ru) |
| NO (1) | NO20076041L (ru) |
| NZ (1) | NZ563432A (ru) |
| UA (1) | UA97092C2 (ru) |
| WO (1) | WO2006114307A1 (ru) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7718762B2 (en) * | 2002-08-02 | 2010-05-18 | South Alabama Medical Science Foundation | Cancer vaccines containing epitopes of oncofetal antigen |
| US20090004213A1 (en) * | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
| SI2567707T1 (sl) * | 2007-07-27 | 2017-01-31 | Immatics Biotechnologies Gmbh | Sestava s tumorjem povezanih peptidov in zadevnih cepiv proti raku |
| PT2113253E (pt) | 2008-04-30 | 2010-06-15 | Immatics Biotechnologies Gmbh | Formulações novas de peptídeos associados a tumores que se ligam a moléculas de classe i ou ii do antígeno leucocitário humano (hla) para vacinas |
| EP2411415A1 (en) * | 2009-03-26 | 2012-02-01 | Quantum Immunologics, Inc. | Oncofetal antigen/immature laminin receptor antibodies for diagnostic and clinical applications |
| US20130052211A1 (en) * | 2009-07-09 | 2013-02-28 | South Alabama Medical Science | Vaccines with oncofetal antigen/ilrp-loaded autologous dendritic cells and uses thereof |
| EP2471901A4 (en) * | 2009-08-25 | 2013-06-26 | Takara Bio Inc | PROCESS FOR PRODUCING T-CELL POPULATION IN THE PRESENCE OF RETINOIC ACID |
| EP2330122A1 (en) * | 2009-12-02 | 2011-06-08 | Asklepios Kliniken Hamburg Gmbh | OFA/iLRP derived modified peptide |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
| EP4317432A3 (en) | 2016-12-08 | 2024-04-17 | Immatics Biotechnologies GmbH | T cell receptors with improved pairing |
| MA49122A (fr) * | 2017-04-10 | 2021-03-24 | Immatics Biotechnologies Gmbh | Peptides et combinaisons de peptides destinés à être utilisés en immunothérapie anticancéreuse |
| WO2018224166A1 (en) * | 2017-06-09 | 2018-12-13 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy |
| US20230002730A1 (en) * | 2018-05-18 | 2023-01-05 | Children's National Medical Center | Improved targeted t-cell therapy |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996003144A1 (en) | 1994-07-27 | 1996-02-08 | The Council Of The Queensland Institute Of Medical Research | Polyepitope vaccines |
| PT879282E (pt) | 1996-01-17 | 2003-11-28 | Imp College Innovations Ltd | Imunoterapia utilizando linfocitos t citotoxicos (ctl) |
| US20040236091A1 (en) | 2001-03-28 | 2004-11-25 | Chicz Roman M. | Translational profiling |
| US7718762B2 (en) | 2002-08-02 | 2010-05-18 | South Alabama Medical Science Foundation | Cancer vaccines containing epitopes of oncofetal antigen |
| US20070224201A1 (en) | 2002-10-02 | 2007-09-27 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| US20070166318A1 (en) * | 2003-05-30 | 2007-07-19 | Macina Roberto A | Compositions, splice variants and methods relating to ovarian specific nucleic acids and proteins |
| WO2006014579A2 (en) * | 2004-07-08 | 2006-02-09 | The Regents Of California | Enhancing class i antigen presentation with synthetic sequences |
-
2005
- 2005-04-26 AT AT05009095T patent/ATE512160T1/de not_active IP Right Cessation
- 2005-04-26 ES ES05009095T patent/ES2367643T3/es active Active
- 2005-04-26 EP EP05009095A patent/EP1717245B1/en not_active Not-in-force
-
2006
- 2006-04-26 WO PCT/EP2006/003888 patent/WO2006114307A1/en active Application Filing
- 2006-04-26 CA CA2606088A patent/CA2606088C/en not_active Expired - Fee Related
- 2006-04-26 US US11/912,668 patent/US7968097B2/en active Active
- 2006-04-26 AU AU2006239505A patent/AU2006239505B2/en not_active Ceased
- 2006-04-26 NZ NZ563432A patent/NZ563432A/en not_active IP Right Cessation
- 2006-04-26 EP EP06724593A patent/EP1874810A1/en not_active Ceased
- 2006-04-26 UA UAA200712736A patent/UA97092C2/ru unknown
- 2006-04-26 BR BRPI0610841-5A patent/BRPI0610841A2/pt not_active IP Right Cessation
- 2006-04-26 CN CN2006800141605A patent/CN101166759B/zh not_active Expired - Fee Related
- 2006-04-26 EA EA200702202A patent/EA013598B1/ru not_active IP Right Cessation
- 2006-04-26 JP JP2008508151A patent/JP4870751B2/ja not_active Expired - Fee Related
-
2007
- 2007-11-23 NO NO20076041A patent/NO20076041L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ563432A (en) | 2010-11-26 |
| WO2006114307A1 (en) | 2006-11-02 |
| NO20076041L (no) | 2007-11-23 |
| JP2008538901A (ja) | 2008-11-13 |
| ATE512160T1 (de) | 2011-06-15 |
| CN101166759A (zh) | 2008-04-23 |
| CN101166759B (zh) | 2012-09-05 |
| AU2006239505A1 (en) | 2006-11-02 |
| BRPI0610841A2 (pt) | 2010-07-27 |
| CA2606088A1 (en) | 2006-11-02 |
| EP1874810A1 (en) | 2008-01-09 |
| ES2367643T3 (es) | 2011-11-07 |
| EP1717245A1 (en) | 2006-11-02 |
| US20090041794A1 (en) | 2009-02-12 |
| EP1717245B1 (en) | 2011-06-08 |
| JP4870751B2 (ja) | 2012-02-08 |
| UA97092C2 (ru) | 2012-01-10 |
| AU2006239505B2 (en) | 2012-05-10 |
| US7968097B2 (en) | 2011-06-28 |
| EA013598B1 (ru) | 2010-06-30 |
| CA2606088C (en) | 2015-05-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200702202A1 (ru) | Идентификация представленных hla-a2 т-клеточных эпитопов, полученных из раково-эмбрионального антиген-незрелого рецепторного белка ламинила, и их применение | |
| EA200800676A1 (ru) | Опухолеассоциированные пептиды, связывающиеся с молекулами человеческого лейкоцитарного антигена (hla) i или ii класса, и относящаяся к ним противораковая вакцина | |
| EA200800677A1 (ru) | Опухолеассоциированные пептиды, беспорядочно связывающиеся с молекулами класса ii человеческого лейкоцитарного антигена (hla) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |