JPWO2019178116A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2019178116A5 JPWO2019178116A5 JP2020546338A JP2020546338A JPWO2019178116A5 JP WO2019178116 A5 JPWO2019178116 A5 JP WO2019178116A5 JP 2020546338 A JP2020546338 A JP 2020546338A JP 2020546338 A JP2020546338 A JP 2020546338A JP WO2019178116 A5 JPWO2019178116 A5 JP WO2019178116A5
- Authority
- JP
- Japan
- Prior art keywords
- item
- seq
- recombinant polypeptide
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 35
- 229920001184 polypeptide Polymers 0.000 description 27
- 102000004196 processed proteins & peptides Human genes 0.000 description 27
- 108090000765 processed proteins & peptides Proteins 0.000 description 27
- 210000004027 cell Anatomy 0.000 description 18
- 125000003275 alpha amino acid group Chemical group 0.000 description 14
- 230000000694 effects Effects 0.000 description 10
- 239000004383 Steviol glycoside Substances 0.000 description 8
- 229930182488 steviol glycoside Natural products 0.000 description 8
- 235000019411 steviol glycoside Nutrition 0.000 description 8
- 150000008144 steviol glycosides Chemical class 0.000 description 8
- 235000019202 steviosides Nutrition 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 108010055629 Glucosyltransferases Proteins 0.000 description 4
- 102000000340 Glucosyltransferases Human genes 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 108010043934 Sucrose synthase Proteins 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 241000195493 Cryptophyta Species 0.000 description 3
- 241000589516 Pseudomonas Species 0.000 description 3
- 241000187747 Streptomyces Species 0.000 description 3
- 241000589291 Acinetobacter Species 0.000 description 2
- 241000228212 Aspergillus Species 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 2
- 241000588923 Citrobacter Species 0.000 description 2
- 241000186216 Corynebacterium Species 0.000 description 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000588722 Escherichia Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000588748 Klebsiella Species 0.000 description 2
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 2
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 2
- 241000589354 Methylosinus Species 0.000 description 2
- 241001467578 Microbacterium Species 0.000 description 2
- 241000235395 Mucor Species 0.000 description 2
- 241000520272 Pantoea Species 0.000 description 2
- 241000235648 Pichia Species 0.000 description 2
- 241000235070 Saccharomyces Species 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- DRDCJEIZVLVWNC-SLBWPEPYSA-N UDP-beta-L-rhamnose Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 DRDCJEIZVLVWNC-SLBWPEPYSA-N 0.000 description 2
- 230000001851 biosynthetic effect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 241000186063 Arthrobacter Species 0.000 description 1
- 241000722808 Arthrobotrys Species 0.000 description 1
- 241000186146 Brevibacterium Species 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 241000235035 Debaryomyces Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000235649 Kluyveromyces Species 0.000 description 1
- 241000589344 Methylomonas Species 0.000 description 1
- 241000316848 Rhodococcus <scale insect> Species 0.000 description 1
- QFVOYBUQQBFCRH-UHFFFAOYSA-N Steviol Natural products C1CC2(C3)CC(=C)C3(O)CCC2C2(C)C1C(C)(C(O)=O)CCC2 QFVOYBUQQBFCRH-UHFFFAOYSA-N 0.000 description 1
- 241000192584 Synechocystis Species 0.000 description 1
- 241000235017 Zygosaccharomyces Species 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- QFVOYBUQQBFCRH-VQSWZGCSSA-N steviol Chemical compound C([C@@]1(O)C(=C)C[C@@]2(C1)CC1)C[C@H]2[C@@]2(C)[C@H]1[C@](C)(C(O)=O)CCC2 QFVOYBUQQBFCRH-VQSWZGCSSA-N 0.000 description 1
- 229940032084 steviol Drugs 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Images
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023110059A JP2023126903A (ja) | 2018-03-12 | 2023-07-04 | ステビオール配糖体レバウジオシドｊ及びレバウジオシドｎの生合成による製造 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862641590P | 2018-03-12 | 2018-03-12 | |
| US62/641,590 | 2018-03-12 | ||
| US201862682260P | 2018-06-08 | 2018-06-08 | |
| US62/682,260 | 2018-06-08 | ||
| US201862695252P | 2018-07-09 | 2018-07-09 | |
| US62/695,252 | 2018-07-09 | ||
| PCT/US2019/021876 WO2019178116A1 (en) | 2018-03-12 | 2019-03-12 | Biosynthetic production of steviol glycosides rebaudioside j and rebaudioside n |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023110059A Division JP2023126903A (ja) | 2018-03-12 | 2023-07-04 | ステビオール配糖体レバウジオシドｊ及びレバウジオシドｎの生合成による製造 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021515555A JP2021515555A (ja) | 2021-06-24 |
| JP2021515555A5 JP2021515555A5 (https=) | 2022-02-14 |
| JPWO2019178116A5 true JPWO2019178116A5 (https=) | 2022-02-14 |
| JP7365707B2 JP7365707B2 (ja) | 2023-10-20 |
Family
ID=67908465
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020546338A Active JP7365707B2 (ja) | 2018-03-12 | 2019-03-12 | ステビオール配糖体レバウジオシドｊ及びレバウジオシドｎの生合成による製造 |
| JP2021571495A Active JP7305213B2 (ja) | 2018-03-12 | 2020-07-09 | 変異体酵素を介するステビオール配糖体レバウシオシドｉの生合成的産生 |
| JP2023110059A Pending JP2023126903A (ja) | 2018-03-12 | 2023-07-04 | ステビオール配糖体レバウジオシドｊ及びレバウジオシドｎの生合成による製造 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021571495A Active JP7305213B2 (ja) | 2018-03-12 | 2020-07-09 | 変異体酵素を介するステビオール配糖体レバウシオシドｉの生合成的産生 |
| JP2023110059A Pending JP2023126903A (ja) | 2018-03-12 | 2023-07-04 | ステビオール配糖体レバウジオシドｊ及びレバウジオシドｎの生合成による製造 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US11447808B2 (https=) |
| EP (2) | EP3765627A4 (https=) |
| JP (3) | JP7365707B2 (https=) |
| KR (1) | KR20210153670A (https=) |
| CN (1) | CN111868252B (https=) |
| BR (1) | BR112021021828A2 (https=) |
| MX (1) | MX2021013721A (https=) |
| WO (2) | WO2019178116A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111868252B (zh) | 2018-03-12 | 2025-06-03 | 科纳根公司 | 甜菊糖苷莱苞迪苷j和莱苞迪苷n的生物合成生产 |
| BR112021019470A2 (pt) * | 2019-03-29 | 2021-11-30 | Conagen Inc | Produção biossintética de udp-ramnose |
| CN112080480B (zh) * | 2019-06-14 | 2023-01-03 | 中国科学院分子植物科学卓越创新中心 | 糖基转移酶突变体及其应用 |
| WO2022253282A1 (zh) * | 2021-06-01 | 2022-12-08 | 弈柯莱生物科技(上海)股份有限公司 | 一种糖基转移酶及其应用 |
| US20250051818A1 (en) * | 2021-12-24 | 2025-02-13 | Samyang Corporation | Production of rebaudioside |
| CN119842657B (zh) * | 2025-03-18 | 2025-05-27 | 青岛奔月生物技术有限公司 | 蔗糖合酶突变体及其应用 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL128193A (en) * | 1999-01-22 | 2008-03-20 | Yeda Res & Dev | Rhamnosyl-transferase gene and uses thereof |
| US20060143729A1 (en) * | 2004-06-30 | 2006-06-29 | Ceres, Inc. | Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics |
| US8791253B2 (en) * | 2006-06-19 | 2014-07-29 | The Coca-Cola Company | Rebaudioside A composition and method for purifying rebaudioside A |
| BRPI1014253A2 (pt) * | 2009-07-02 | 2016-04-12 | Merz Pharma Gmbh & Co Kgaa | polinucleotídeo codificado um polipeptídeo de neurotoxina, vetor, célula hospedeira, anticorpo, uso de um polinucleotídeo, método para a fabricação de um polipeptídeo de neurotoxina e método para a fabricação de um medicamento |
| CA3128532A1 (en) * | 2011-08-08 | 2013-02-14 | Evolva Sa | Recombinant production of steviol glycosides |
| US9752174B2 (en) * | 2013-05-28 | 2017-09-05 | Purecircle Sdn Bhd | High-purity steviol glycosides |
| MX395285B (es) * | 2012-05-22 | 2025-03-25 | Purecircle Sdn Bhd | Glucosidos de esteviol de alta pureza. |
| MY199452A (en) * | 2013-02-06 | 2023-10-30 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| US9522929B2 (en) | 2014-05-05 | 2016-12-20 | Conagen Inc. | Non-caloric sweetener |
| EP3683315A1 (en) | 2014-08-19 | 2020-07-22 | Purecircle SDN BHD | Method for preparing rebaudioside m |
| US11202461B2 (en) * | 2014-09-02 | 2021-12-21 | Purecircle Sdn Bhd | Stevia extracts |
| BR112017006163B1 (pt) * | 2014-10-03 | 2022-04-05 | Conagen Inc | Produto de consumo oral e método para adoçar o mesmo |
| CN107109453A (zh) | 2014-11-05 | 2017-08-29 | 马努斯生物合成股份有限公司 | 甜菊醇糖苷的微生物产生 |
| KR102569053B1 (ko) | 2015-04-14 | 2023-08-21 | 코나겐 인크. | 조작된 전체 세포 촉매를 사용한 비칼로리 감미료의 제조 |
| US10612065B2 (en) * | 2015-05-29 | 2020-04-07 | Cargill, Incorporated | Heat treatment to produce glycosides |
| EP3387136B1 (en) * | 2015-12-10 | 2022-01-05 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| JP6771937B2 (ja) * | 2016-04-21 | 2020-10-21 | キヤノンメディカルシステムズ株式会社 | 医用画像表示装置および医用画像管理システム |
| PT3497222T (pt) * | 2016-08-12 | 2022-02-09 | Amyris Inc | Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos |
| BR112019007504B1 (pt) * | 2016-10-14 | 2023-05-09 | Conagen Inc | Método de preparação de uma composição de glicosídeo de esteviol |
| CN116574775A (zh) | 2016-10-21 | 2023-08-11 | 百事可乐公司 | 一种酶法制备瑞鲍迪甙j的方法 |
| CN111868252B (zh) | 2018-03-12 | 2025-06-03 | 科纳根公司 | 甜菊糖苷莱苞迪苷j和莱苞迪苷n的生物合成生产 |
| MY204735A (en) * | 2018-07-16 | 2024-09-11 | Manus Bio Inc | Production of steviol glycosides through whole cell biotransformation |
| BR112021019470A2 (pt) * | 2019-03-29 | 2021-11-30 | Conagen Inc | Produção biossintética de udp-ramnose |
| WO2020264179A1 (en) * | 2019-06-25 | 2020-12-30 | Manus Bio, Inc. | Uridine diphosphate-dependent glycosyltransferase enzyme |
| US20240148037A1 (en) * | 2019-10-16 | 2024-05-09 | Sweegen, Inc. | Steviol glycoside formulations for food and beverages |
-
2019
- 2019-03-12 CN CN201980018867.0A patent/CN111868252B/zh active Active
- 2019-03-12 WO PCT/US2019/021876 patent/WO2019178116A1/en not_active Ceased
- 2019-03-12 JP JP2020546338A patent/JP7365707B2/ja active Active
- 2019-03-12 EP EP19767823.8A patent/EP3765627A4/en active Pending
- 2019-07-09 US US16/506,892 patent/US11447808B2/en active Active
- 2019-11-08 US US16/679,032 patent/US10883130B2/en active Active
-
2020
- 2020-07-09 WO PCT/US2020/041394 patent/WO2021007423A1/en not_active Ceased
- 2020-07-09 JP JP2021571495A patent/JP7305213B2/ja active Active
- 2020-07-09 EP EP20836091.7A patent/EP3997233A4/en active Pending
- 2020-07-09 BR BR112021021828A patent/BR112021021828A2/pt unknown
- 2020-07-09 KR KR1020217037306A patent/KR20210153670A/ko not_active Ceased
- 2020-07-09 MX MX2021013721A patent/MX2021013721A/es unknown
- 2020-12-02 US US17/109,473 patent/US11441165B2/en active Active
-
2022
- 2022-08-12 US US17/819,423 patent/US20220411843A1/en active Pending
-
2023
- 2023-07-04 JP JP2023110059A patent/JP2023126903A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021515555A5 (https=) | ||
| US9580732B2 (en) | Oxidation and amination of primary alcohols | |
| Saha et al. | Biotechnological production of mannitol and its applications | |
| Hummel et al. | Dehydrogenases for the synthesis of chiral compounds | |
| CA2948696C (en) | Methods of producing rhamnolipids | |
| CN107849521A (zh) | 用于由羧酸合成聚合物前体的过程和微生物 | |
| Yonaha et al. | Distribution of ω-amino acid: pyruvate transaminase and aminobutyrate: α-ketoglutarate transaminase in microorganisms | |
| JPWO2019178116A5 (https=) | ||
| WO2012105495A1 (ja) | フェニルピルビン酸還元酵素並びに本酵素を用いた光学活性フェニル乳酸及び４－ヒドロキシ－フェニル乳酸の製造方法 | |
| Saito et al. | Intracellular degradation of poly (3-hydroxybutyrate) granules of Zoogloea ramigera I-16-M | |
| EP2623595B1 (en) | Novel transaminase showing high activity for glutamic acid, gene encoding same, and method for utilization thereof | |
| JP5878871B2 (ja) | 新規アミノ基転移酵素、およびこれをコードする遺伝子、ならびにこれらの利用法 | |
| US7250278B2 (en) | α-keto acid reductase, method for producing the same, and method for producing optically active α-hydroxy acids using the same | |
| CN113846127B (zh) | 一种泛解酸、泛酸、泛醇及其盐的制备方法 | |
| KR20150108809A (ko) | 락토바실러스 에시도필러스 유래 13-리놀레산 수화효소에 의한 13-수산화 지방산의 생산 및 월토마이세스 리포퍼를 이용한 델타-데카락톤의 제조방법 및 그 조성물 | |
| JP6964314B2 (ja) | 組換え微生物、組換え微生物を用いたピリドキサミン又はその塩の製造方法、及び組換え微生物を用いたピリドキサール又はその塩の製造方法 | |
| CN118109429A (zh) | 天然覆盆子酮合成的催化蛋白组合物、菌株及其使用方法 | |
| US20080145904A1 (en) | Method For Producing Primary Alcohols | |
| Sakamoto et al. | Partial purification and some properties of extracellular asparaginase from Candida utilis | |
| Li et al. | The carboxylic acid reduction pathway in Nocardia. Purification and characterization of the aldehyde reductase | |
| JP2010130912A (ja) | 光学活性３−キヌクリジノールの製造方法 | |
| Nidetzky et al. | Simultaneous enzymatic synthesis of gluconic acid and sorbitol: production, purification, and application of glucose-fructose oxidoreductase and gluconolactonase | |
| Esaki et al. | Fungal thermostable α-dialkylamino acid aminotransferase: occurrence, purification and characterization | |
| JPH05328972A (ja) | 新規なアミノアシラーゼおよびその製造方法 | |
| CN116135981B (zh) | 一种合成丙二酸的方法及应用 |