JPWO2019160884A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2019160884A5 JPWO2019160884A5 JP2020564814A JP2020564814A JPWO2019160884A5 JP WO2019160884 A5 JPWO2019160884 A5 JP WO2019160884A5 JP 2020564814 A JP2020564814 A JP 2020564814A JP 2020564814 A JP2020564814 A JP 2020564814A JP WO2019160884 A5 JPWO2019160884 A5 JP WO2019160884A5
- Authority
- JP
- Japan
- Prior art keywords
- coor
- alkyl
- halogen
- substituted
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862629956P | 2018-02-13 | 2018-02-13 | |
| US62/629,956 | 2018-02-13 | ||
| US16/272,172 US10519187B2 (en) | 2018-02-13 | 2019-02-11 | Cyclic dinucleotides as anticancer agents |
| US16/272,172 | 2019-02-11 | ||
| PCT/US2019/017740 WO2019160884A1 (en) | 2018-02-13 | 2019-02-13 | Cyclic dinucleotides as anticancer agents |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021513562A JP2021513562A (ja) | 2021-05-27 |
| JP2021513562A5 JP2021513562A5 (https=) | 2022-05-26 |
| JPWO2019160884A5 true JPWO2019160884A5 (https=) | 2022-05-26 |
| JP7296405B2 JP7296405B2 (ja) | 2023-06-22 |
Family
ID=67542132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564814A Active JP7296405B2 (ja) | 2018-02-13 | 2019-02-13 | 抗がん剤としての環状ジヌクレオチド |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10519187B2 (https=) |
| EP (1) | EP3752516B1 (https=) |
| JP (1) | JP7296405B2 (https=) |
| KR (1) | KR102950614B1 (https=) |
| CN (1) | CN111902420B (https=) |
| AR (1) | AR114369A1 (https=) |
| CY (1) | CY1125159T1 (https=) |
| DK (1) | DK3752516T3 (https=) |
| ES (1) | ES2909616T3 (https=) |
| HR (1) | HRP20220520T1 (https=) |
| HU (1) | HUE058662T2 (https=) |
| LT (1) | LT3752516T (https=) |
| PL (1) | PL3752516T3 (https=) |
| PT (1) | PT3752516T (https=) |
| RS (1) | RS63128B1 (https=) |
| SI (1) | SI3752516T1 (https=) |
| SM (1) | SMT202200168T1 (https=) |
| TW (1) | TW202003539A (https=) |
| WO (1) | WO2019160884A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10966999B2 (en) | 2017-12-20 | 2021-04-06 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| CN111511754B (zh) | 2017-12-20 | 2023-09-12 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| US11110106B2 (en) | 2018-10-29 | 2021-09-07 | Venenum Biodesign, LLC | Sting agonists for treating bladder cancer and solid tumors |
| AU2019371206A1 (en) | 2018-10-29 | 2021-05-27 | Venenum Biodesign, LLC | Novel sting agonists |
| IL294618A (en) * | 2020-01-16 | 2022-09-01 | Bristol Myers Squibb Co | Reagents and their use for the modular synthesis of c-p bonds |
| WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI309240B (en) | 2004-09-17 | 2009-05-01 | Hoffmann La Roche | Anti-ox40l antibodies |
| AU2006230099B2 (en) | 2005-03-25 | 2012-04-19 | Gitr, Inc. | GITR binding molecules and uses therefor |
| PL1879573T3 (pl) | 2005-05-10 | 2013-05-31 | Incyte Holdings Corp | Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania |
| CA2634198C (en) | 2005-12-20 | 2014-06-03 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| ES2444574T3 (es) | 2006-09-19 | 2014-02-25 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de la indolamina 2,3-dioxigenasa |
| EP1987839A1 (en) | 2007-04-30 | 2008-11-05 | I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
| ES2776406T3 (es) | 2007-07-12 | 2020-07-30 | Gitr Inc | Terapias de combinación que emplean moléculas de enlazamiento a GITR |
| EP2044949A1 (en) | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
| JP5583592B2 (ja) | 2007-11-30 | 2014-09-03 | ニューリンク ジェネティクス コーポレイション | Ｉｄｏ阻害剤 |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
| EP2473531A4 (en) | 2009-09-03 | 2013-05-01 | Merck Sharp & Dohme | Anti-gitr antibodies |
| US8722720B2 (en) | 2009-10-28 | 2014-05-13 | Newlink Genetics Corporation | Imidazole derivatives as IDO inhibitors |
| PH12012500881A1 (en) | 2009-12-10 | 2017-07-26 | Hoffmann La Roche | Antibodies binding preferentially human csf1r extracellular domain 4 and their use |
| JP5998060B2 (ja) | 2010-03-04 | 2016-09-28 | マクロジェニクス，インコーポレーテッド | Ｂ７−ｈ３と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用 |
| CN102918061B (zh) | 2010-03-05 | 2016-06-08 | 霍夫曼-拉罗奇有限公司 | 针对人csf-1r的抗体及其用途 |
| CA2789076C (en) | 2010-03-05 | 2017-11-21 | F. Hoffmann-La Roche Ag | Antibodies against human colony stimulating factor-1 receptor and uses thereof |
| MX378336B (es) | 2010-05-04 | 2025-03-10 | Five Prime Therapeutics Inc | Anticuerpos que se unen a factor estimulante de colonias 1 (csf1r). |
| PT2614082T (pt) | 2010-09-09 | 2018-12-03 | Pfizer | Moléculas de ligação a 4-1bb |
| NO2694640T3 (https=) | 2011-04-15 | 2018-03-17 | ||
| KR101970025B1 (ko) | 2011-04-20 | 2019-04-17 | 메디뮨 엘엘씨 | Ｂ7-ｈ1 및 ｐｄ-1과 결합하는 항체 및 다른 분자들 |
| BR112014012624A2 (pt) | 2011-12-15 | 2018-10-09 | F Hoffmann-La Roche Ag | anticorpos, composição farmacêutica, ácido nucleico, vetores de expressão, célula hospedeira, método para a produção de um anticorpo recombinante e uso do anticorpo |
| RU2014136332A (ru) | 2012-02-06 | 2016-03-27 | Дженентек, Инк. | Композиции и способы применения ингибиторов csf1r |
| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| EP2847220A1 (en) | 2012-05-11 | 2015-03-18 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
| HK1204557A1 (en) | 2012-05-31 | 2015-11-27 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind pd-l1 |
| AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| CN107759690A (zh) | 2012-08-31 | 2018-03-06 | 戊瑞治疗有限公司 | 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法 |
| JP6742903B2 (ja) | 2013-05-02 | 2020-08-19 | アナプティスバイオ インコーポレイティッド | プログラム死−１（ｐｄ−１）に対する抗体 |
| US9676853B2 (en) | 2013-05-31 | 2017-06-13 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind PD-1 |
| EA034666B1 (ru) | 2013-09-13 | 2020-03-04 | Бейджин Свитзерланд Гмбх | Антитело против pd-1 и его применение для лечения рака или вирусной инфекции и фрагмент антитела |
| MY184154A (en) | 2013-12-12 | 2021-03-23 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| SG10201900002QA (en) | 2014-01-24 | 2019-02-27 | Dana Farber Cancer Institue Inc | Antibody molecules to pd-1 and uses thereof |
| PE20170198A1 (es) * | 2014-06-04 | 2017-04-08 | Glaxosmithkline Ip Dev Ltd | Dinucleotidos ciclicos como moduladores de sting |
| CN108112254B (zh) | 2015-03-13 | 2022-01-28 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| CR20180101A (es) * | 2015-08-13 | 2018-04-12 | Merck Sharp & Dohme | Compuestos di-nucleóticos cíclicos como agonistas de sting |
| RS67188B1 (sr) | 2016-01-11 | 2025-10-31 | Innate Tumor Immunity Inc | Ciklični dinukleotidi za lečenje stanja povezanih sa aktivnošću sting kao što je kancer |
| US11492367B2 (en) * | 2017-01-27 | 2022-11-08 | Janssen Biotech, Inc. | Cyclic dinucleotides as sting agonists |
| KR102709265B1 (ko) * | 2017-07-28 | 2024-09-23 | 브리스톨-마이어스 스큅 컴퍼니 | 항암제로서의 시클릭 디뉴클레오티드 |
| ES2904317T3 (es) * | 2017-08-31 | 2022-04-04 | Bristol Myers Squibb Co | Dinucleótidos cíclicos como agentes anticancerosos |
| US11667663B2 (en) * | 2017-08-31 | 2023-06-06 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
| JP7195317B2 (ja) | 2017-11-10 | 2022-12-23 | 武田薬品工業株式会社 | Ｓｔｉｎｇ調節剤化合物、ならびに製造及び使用する方法 |
-
2019
- 2019-02-11 US US16/272,172 patent/US10519187B2/en active Active
- 2019-02-13 CN CN201980012869.9A patent/CN111902420B/zh active Active
- 2019-02-13 KR KR1020207026044A patent/KR102950614B1/ko active Active
- 2019-02-13 PL PL19707595T patent/PL3752516T3/pl unknown
- 2019-02-13 LT LTEPPCT/US2019/017740T patent/LT3752516T/lt unknown
- 2019-02-13 AR ARP190100352A patent/AR114369A1/es not_active Application Discontinuation
- 2019-02-13 ES ES19707595T patent/ES2909616T3/es active Active
- 2019-02-13 EP EP19707595.5A patent/EP3752516B1/en active Active
- 2019-02-13 SM SM20220168T patent/SMT202200168T1/it unknown
- 2019-02-13 SI SI201930199T patent/SI3752516T1/sl unknown
- 2019-02-13 JP JP2020564814A patent/JP7296405B2/ja active Active
- 2019-02-13 DK DK19707595.5T patent/DK3752516T3/da active
- 2019-02-13 HU HUE19707595A patent/HUE058662T2/hu unknown
- 2019-02-13 RS RS20220372A patent/RS63128B1/sr unknown
- 2019-02-13 PT PT197075955T patent/PT3752516T/pt unknown
- 2019-02-13 WO PCT/US2019/017740 patent/WO2019160884A1/en not_active Ceased
- 2019-02-13 HR HRP20220520TT patent/HRP20220520T1/hr unknown
- 2019-02-13 TW TW108104810A patent/TW202003539A/zh unknown
- 2019-11-14 US US16/683,667 patent/US11339185B2/en active Active
-
2022
- 2022-05-05 CY CY20221100320T patent/CY1125159T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020529400A5 (https=) | ||
| JP2020536897A5 (https=) | ||
| JP2021513562A5 (https=) | ||
| HRP20220520T1 (hr) | Ciklički dinukleotidi kao agensi protiv raka | |
| JP2020536971A5 (https=) | ||
| JP2020532542A5 (https=) | ||
| JP6862495B2 (ja) | Ｊａｋ及びｐｉ３ｋ阻害剤併用によるｂ細胞悪性腫瘍の処置 | |
| US10954249B2 (en) | Macrocyclic compound and uses thereof | |
| JP2020532529A5 (https=) | ||
| JP2013519707A5 (https=) | ||
| JP2020532539A5 (https=) | ||
| JP2022527796A5 (https=) | ||
| HRP20151071T1 (hr) | Spojevi pirolopirimidina kao inhibitori za cdk4/6 | |
| US20020183239A1 (en) | Antineoplastic combinations | |
| MD3773593T2 (ro) | Tratament hidradenitei supurative utilizând inhibitori ai JAK | |
| NZ540047A (en) | Use of combination consisting of rapamycin 42-ester with CCI-779, 5-fluorouracil and/or gemcitabine and optionally leucovorin and/or levofolinate for treating a neoplasm | |
| AU2009271419B2 (en) | Antineoplastic combinations containing HKI-272 and vinorelbine | |
| WO2009151997A1 (en) | Process for producing bicycloaniline derivatives | |
| JPWO2019160884A5 (https=) | ||
| KR102634732B1 (ko) | 마크로시클릭 화합물 및 그의 용도 | |
| AU2021204704B2 (en) | Process for the preparation of tricyclic PI3K inhibitor compounds and methods for using the same for the treatment of cancer | |
| KR20200103032A (ko) | Mtor 저해제 화합물 | |
| KR20160030239A (ko) | 치환된 피라졸로-피리딘아민 | |
| US20210379021A1 (en) | Method for preparing and delivering bisantrene formulations | |
| WO2006060331A1 (en) | Combinations comprising epothilones and protein tyrosine kinase inhibitors and pharmaceutical uses thereof |