PL3752516T3 - Dinukleotydy cykliczne jako środki przeciwnowotworowe - Google Patents

Dinukleotydy cykliczne jako środki przeciwnowotworowe

Info

Publication number
PL3752516T3
PL3752516T3 PL19707595T PL19707595T PL3752516T3 PL 3752516 T3 PL3752516 T3 PL 3752516T3 PL 19707595 T PL19707595 T PL 19707595T PL 19707595 T PL19707595 T PL 19707595T PL 3752516 T3 PL3752516 T3 PL 3752516T3
Authority
PL
Poland
Prior art keywords
anticancer agents
cyclic dinucleotides
dinucleotides
cyclic
anticancer
Prior art date
Application number
PL19707595T
Other languages
English (en)
Inventor
Brian E. Fink
Dharmpal S. Dodd
Yufen Zhao
Lan-Ying Qin
Zheming Ruan
Lalgudi S. Harikrishnan
Muthoni G. Kamau
Steven J. Walker
Libing Chen
Peter Kinam Park
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of PL3752516T3 publication Critical patent/PL3752516T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL19707595T 2018-02-13 2019-02-13 Dinukleotydy cykliczne jako środki przeciwnowotworowe PL3752516T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862629956P 2018-02-13 2018-02-13
US16/272,172 US10519187B2 (en) 2018-02-13 2019-02-11 Cyclic dinucleotides as anticancer agents
EP19707595.5A EP3752516B1 (en) 2018-02-13 2019-02-13 Cyclic dinucleotides as anticancer agents
PCT/US2019/017740 WO2019160884A1 (en) 2018-02-13 2019-02-13 Cyclic dinucleotides as anticancer agents

Publications (1)

Publication Number Publication Date
PL3752516T3 true PL3752516T3 (pl) 2022-05-02

Family

ID=67542132

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19707595T PL3752516T3 (pl) 2018-02-13 2019-02-13 Dinukleotydy cykliczne jako środki przeciwnowotworowe

Country Status (17)

Country Link
US (2) US10519187B2 (pl)
EP (1) EP3752516B1 (pl)
JP (1) JP7296405B2 (pl)
KR (1) KR20200120683A (pl)
CN (1) CN111902420B (pl)
AR (1) AR114369A1 (pl)
DK (1) DK3752516T3 (pl)
ES (1) ES2909616T3 (pl)
HR (1) HRP20220520T1 (pl)
HU (1) HUE058662T2 (pl)
LT (1) LT3752516T (pl)
PL (1) PL3752516T3 (pl)
PT (1) PT3752516T (pl)
RS (1) RS63128B1 (pl)
SI (1) SI3752516T1 (pl)
TW (1) TW202003539A (pl)
WO (1) WO2019160884A1 (pl)

Families Citing this family (8)

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CN111511754B (zh) 2017-12-20 2023-09-12 捷克共和国有机化学与生物化学研究所 活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸
CA3084569A1 (en) 2017-12-20 2019-06-27 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
US11161864B2 (en) 2018-10-29 2021-11-02 Venenum Biodesign, LLC Sting agonists
US11110106B2 (en) 2018-10-29 2021-09-07 Venenum Biodesign, LLC Sting agonists for treating bladder cancer and solid tumors
WO2021146391A1 (en) * 2020-01-16 2021-07-22 Bristol-Myers Squibb Company Reagents and their use for modular enantiodivergent synthesis of c–p bonds
EP4134098A4 (en) 2020-04-10 2024-05-15 ONO Pharmaceutical Co., Ltd. CANCER THERAPY METHODS

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TWI382974B (zh) 2005-12-20 2013-01-21 Incyte Corp 作為吲哚胺２，３-二氧化酶調節劑之ｎ-羥基甲脒基雜環化物
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EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
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Also Published As

Publication number Publication date
US11339185B2 (en) 2022-05-24
HUE058662T2 (hu) 2022-09-28
ES2909616T3 (es) 2022-05-09
KR20200120683A (ko) 2020-10-21
CN111902420A (zh) 2020-11-06
TW202003539A (zh) 2020-01-16
US20200079815A1 (en) 2020-03-12
AR114369A1 (es) 2020-08-26
JP7296405B2 (ja) 2023-06-22
SI3752516T1 (sl) 2022-05-31
DK3752516T3 (da) 2022-04-11
US20190248828A1 (en) 2019-08-15
JP2021513562A (ja) 2021-05-27
CN111902420B (zh) 2024-02-02
EP3752516B1 (en) 2022-02-23
RS63128B1 (sr) 2022-05-31
LT3752516T (lt) 2022-05-10
EP3752516A1 (en) 2020-12-23
PT3752516T (pt) 2022-03-31
HRP20220520T1 (hr) 2022-05-27
WO2019160884A1 (en) 2019-08-22
US10519187B2 (en) 2019-12-31

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