PL3752516T3 - Cyclic dinucleotides as anticancer agents - Google Patents

Cyclic dinucleotides as anticancer agents

Info

Publication number
PL3752516T3
PL3752516T3 PL19707595T PL19707595T PL3752516T3 PL 3752516 T3 PL3752516 T3 PL 3752516T3 PL 19707595 T PL19707595 T PL 19707595T PL 19707595 T PL19707595 T PL 19707595T PL 3752516 T3 PL3752516 T3 PL 3752516T3
Authority
PL
Poland
Prior art keywords
anticancer agents
cyclic dinucleotides
dinucleotides
cyclic
anticancer
Prior art date
Application number
PL19707595T
Other languages
Polish (pl)
Inventor
Brian E. Fink
Dharmpal S. Dodd
Yufen Zhao
Lan-Ying Qin
Zheming Ruan
Lalgudi S. Harikrishnan
Muthoni G. Kamau
Steven J. Walker
Libing Chen
Peter Kinam Park
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of PL3752516T3 publication Critical patent/PL3752516T3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL19707595T 2018-02-13 2019-02-13 Cyclic dinucleotides as anticancer agents PL3752516T3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862629956P 2018-02-13 2018-02-13
US16/272,172 US10519187B2 (en) 2018-02-13 2019-02-11 Cyclic dinucleotides as anticancer agents
PCT/US2019/017740 WO2019160884A1 (en) 2018-02-13 2019-02-13 Cyclic dinucleotides as anticancer agents
EP19707595.5A EP3752516B1 (en) 2018-02-13 2019-02-13 Cyclic dinucleotides as anticancer agents

Publications (1)

Publication Number Publication Date
PL3752516T3 true PL3752516T3 (en) 2022-05-02

Family

ID=67542132

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19707595T PL3752516T3 (en) 2018-02-13 2019-02-13 Cyclic dinucleotides as anticancer agents

Country Status (17)

Country Link
US (2) US10519187B2 (en)
EP (1) EP3752516B1 (en)
JP (1) JP7296405B2 (en)
KR (1) KR20200120683A (en)
CN (1) CN111902420B (en)
AR (1) AR114369A1 (en)
DK (1) DK3752516T3 (en)
ES (1) ES2909616T3 (en)
HR (1) HRP20220520T1 (en)
HU (1) HUE058662T2 (en)
LT (1) LT3752516T (en)
PL (1) PL3752516T3 (en)
PT (1) PT3752516T (en)
RS (1) RS63128B1 (en)
SI (1) SI3752516T1 (en)
TW (1) TW202003539A (en)
WO (1) WO2019160884A1 (en)

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US11203610B2 (en) 2017-12-20 2021-12-21 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
CA3093888A1 (en) 2018-04-06 2019-10-10 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3'-cyclic dinucleotides
TWI818007B (en) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-cyclic dinucleotides
WO2020092127A1 (en) 2018-10-29 2020-05-07 Venenum Biodesign, LLC Novel sting agonists
US11110106B2 (en) 2018-10-29 2021-09-07 Venenum Biodesign, LLC Sting agonists for treating bladder cancer and solid tumors
CA3166855A1 (en) * 2020-01-16 2021-07-22 Bristol-Myers Squibb Company Reagents and their use for modular enantiodivergent synthesis of c-p bonds
WO2021206158A1 (en) 2020-04-10 2021-10-14 小野薬品工業株式会社 Method of cancer therapy

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Also Published As

Publication number Publication date
JP2021513562A (en) 2021-05-27
LT3752516T (en) 2022-05-10
EP3752516A1 (en) 2020-12-23
RS63128B1 (en) 2022-05-31
EP3752516B1 (en) 2022-02-23
HUE058662T2 (en) 2022-09-28
US20200079815A1 (en) 2020-03-12
TW202003539A (en) 2020-01-16
US11339185B2 (en) 2022-05-24
ES2909616T3 (en) 2022-05-09
HRP20220520T1 (en) 2022-05-27
CN111902420B (en) 2024-02-02
WO2019160884A1 (en) 2019-08-22
JP7296405B2 (en) 2023-06-22
DK3752516T3 (en) 2022-04-11
US20190248828A1 (en) 2019-08-15
KR20200120683A (en) 2020-10-21
SI3752516T1 (en) 2022-05-31
PT3752516T (en) 2022-03-31
CN111902420A (en) 2020-11-06
AR114369A1 (en) 2020-08-26
US10519187B2 (en) 2019-12-31

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