AR114369A1 - Dinucleótidos cíclicos como agentes antineoplásicos - Google Patents

Dinucleótidos cíclicos como agentes antineoplásicos

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Publication number
AR114369A1
AR114369A1 ARP190100352A ARP190100352A AR114369A1 AR 114369 A1 AR114369 A1 AR 114369A1 AR P190100352 A ARP190100352 A AR P190100352A AR P190100352 A ARP190100352 A AR P190100352A AR 114369 A1 AR114369 A1 AR 114369A1
Authority
AR
Argentina
Prior art keywords
nra1ra1
2nra1ra1
nra1s
nra1c
halogen
Prior art date
Application number
ARP190100352A
Other languages
English (en)
Inventor
Libing Chen
Steven J Walker
Lalgudi S Harikrishnan
Muthoni G Kamau
Peter Kinam Park
Lan Qin
- Ruan Zheming Ying
Yufen Zhao
Dharmpal S Dodd
Brian E Fink
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR114369A1 publication Critical patent/AR114369A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Dinucleótidos cíclicos, composiciones farmacéuticas que los comprenden y el uso de los mismos para el tratamiento de diferentes tipos de cáncer y de leucemia. Reivindicación 1: Un compuesto caracterizado por la fórmula (1), en donde X es independientemente O ó S; X¹, X², X³ y X⁴ son, cada uno independientemente, O ó NH; R¹ y R² son independientemente seleccionados del grupo de fórmulas (2); siempre que uno de R¹ y R² sea un compuesto seleccionado del grupo de fórmulas (3); Z¹ es N o CRᵃ; Z² es NRᵇ; Rᵃ es H, halógeno, C₁₋₆ alquilo sustituido con 0 - 6 R⁵, C₃₋₆ cicloalquilo sustituido con 0 - 6 R⁵, CN, NO₂, OH, ORᵃ¹, SRᵃ¹, -C(O)NRᵃ¹Rᵃ¹, -COORᵃ¹, -OC(O)Rᵃ¹, -OC(O)NRᵃ¹Rᵃ¹, -NRᵃ¹Rᵃ¹, -NRᵃ¹C(O)Rᵃ¹, -NRᵃ¹COORᵃ¹, -NRᵃ¹C(O)NRᵃ¹Rᵃ¹, -NRᵃ¹S(O)₂Rᵃ¹, -NRᵃ¹S(O)₂NRᵃ¹Rᵃ¹, -S(O)Rᵃ¹, -S(O)NRᵃ¹Rᵃ¹, -S(O)₂Rᵃ¹, S(O)₂NRᵃ¹Rᵃ¹; Rᵇ es H, C₁₋₆ alquilo sustituido con 0 - 6 R⁵, C₃₋₆ cicloalquilo sustituida con 0 - 6 R⁵, -C(O)Rᵃ¹, -C(O)NRᵃ¹Rᵃ¹, -S(O)₂Rᵃ¹ o S(O)₂NRᵃ¹Rᵃ¹; Rᵃ¹ es H, C₁₋₃ alquilo o C₃₋₆ cicloalquilo; R³ es H, CH₃, halógeno, -NRᵃ¹Rᵃ¹ o ORᵃ¹; R³ᵃ es H, CH₃, halógeno, -NRᵃ¹Rᵃ¹ u ORᵃ¹; o R³ y R³ᵃ se pueden tomar juntos para formar un carbociclo de 3 ó 4 miembros; o R³ y R³ᵃ se pueden tomar juntos para formar un sustituyente de C=CH₂; R⁵ es H, halógeno, C₁₋₃ alquilo, CN, NO₂, OH, ORᵃ¹, SRᵃ¹, -C(O)NRᵃ¹Rᵃ¹, -COORᵃ¹, -OC(O)Rᵃ¹, -OC(O)NRᵃ¹Rᵃ¹, -NRᵃ¹Rᵃ¹, -NRᵃ¹C(O)Rᵃ¹, -NRᵃ¹COORᵃ¹, -NRᵃ¹C(O)NRᵃ¹Rᵃ¹, -NRᵃ¹S(O)₂Rᵃ¹, -NRᵃ¹S(O)₂NRᵃ¹Rᵃ¹, -S(O)Rᵃ¹, -S(O)NRᵃ¹Rᵃ¹, -S(O)₂Rᵃ¹ o S(O)₂NRᵃ¹Rᵃ¹; o dos grupos R⁵ se pueden tomar juntos para formar un grupo heterocíclico o carbocíclico de 5 ó 6 miembros; o R⁵ y R⁶ se pueden tomar juntos para formar un grupo heterocíclico o carbocíclico de 5 ó 6 miembros; R⁵ᵃ es H o C₁₋₃ alquilo; R⁶ es H, halógeno, C₁₋₃ alquilo, CN, NO₂, OH, ORᵃ¹, SRᵃ¹, -C(O)NRᵃ¹Rᵃ¹, -COORᵃ¹, -OC(O)Rᵃ¹, -OC(O)NRᵃ¹Rᵃ¹, -NRᵃ¹Rᵃ¹, -NRᵃ¹C(O)Rᵃ¹, -NRᵃ¹COORᵃ¹, -NRᵃ¹C(O)NRᵃ¹Rᵃ¹, -NRᵃ¹S(O)₂Rᵃ¹, -NRᵃ¹S(O)₂NRᵃ¹Rᵃ¹, -S(O)Rᵃ¹, -S(O)NRᵃ¹Rᵃ¹, -S(O)₂Rᵃ¹ o S(O)₂NRᵃ¹Rᵃ¹; R⁸ es H, halógeno, C₁₋₃ alquilo, CN, NO₂, OH, ORᵃ¹, SRᵃ¹, -C(O)NRᵃ¹Rᵃ¹, -COORᵃ¹, -OC(O)Rᵃ¹, -OC(O)NRᵃ¹Rᵃ¹, -NRᵃ¹Rᵃ¹, -NRᵃ¹C(O)Rᵃ¹, -NRᵃ¹COORᵃ¹, -NRᵃ¹C(O)NRᵃ¹Rᵃ¹, -NRᵃ¹S(O)₂Rᵃ¹, -NRᵃ¹S(O)₂NRᵃ¹Rᵃ¹, -S(O)Rᵃ¹, -S(O)NRᵃ¹Rᵃ¹, -S(O)₂Rᵃ¹ o S(O)₂NRᵃ¹Rᵃ¹; R⁹ es H, halógeno o metilo; Y es CRᵃ o N; m es 0, 1, 2 ó 3; n es 0 ó 1; o una sal, un tautómero o un estereoisómero de aquel aceptables desde el punto de vista farmacéutico.
ARP190100352A 2018-02-13 2019-02-13 Dinucleótidos cíclicos como agentes antineoplásicos AR114369A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862629956P 2018-02-13 2018-02-13

Publications (1)

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AR114369A1 true AR114369A1 (es) 2020-08-26

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ID=67542132

Family Applications (1)

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Country Status (17)

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US (2) US10519187B2 (es)
EP (1) EP3752516B1 (es)
JP (1) JP7296405B2 (es)
KR (1) KR20200120683A (es)
CN (1) CN111902420B (es)
AR (1) AR114369A1 (es)
DK (1) DK3752516T3 (es)
ES (1) ES2909616T3 (es)
HR (1) HRP20220520T1 (es)
HU (1) HUE058662T2 (es)
LT (1) LT3752516T (es)
PL (1) PL3752516T3 (es)
PT (1) PT3752516T (es)
RS (1) RS63128B1 (es)
SI (1) SI3752516T1 (es)
TW (1) TW202003539A (es)
WO (1) WO2019160884A1 (es)

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ES2909616T3 (es) 2022-05-09
LT3752516T (lt) 2022-05-10
EP3752516B1 (en) 2022-02-23
WO2019160884A1 (en) 2019-08-22
EP3752516A1 (en) 2020-12-23
RS63128B1 (sr) 2022-05-31
US20200079815A1 (en) 2020-03-12
TW202003539A (zh) 2020-01-16
HUE058662T2 (hu) 2022-09-28
JP2021513562A (ja) 2021-05-27
SI3752516T1 (sl) 2022-05-31
US20190248828A1 (en) 2019-08-15
DK3752516T3 (da) 2022-04-11
CN111902420A (zh) 2020-11-06
KR20200120683A (ko) 2020-10-21
JP7296405B2 (ja) 2023-06-22
HRP20220520T1 (hr) 2022-05-27
US10519187B2 (en) 2019-12-31
CN111902420B (zh) 2024-02-02
PT3752516T (pt) 2022-03-31
PL3752516T3 (pl) 2022-05-02
US11339185B2 (en) 2022-05-24

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