KR102950614B1 - 항암제로서의 시클릭 디뉴클레오티드 - Google Patents

항암제로서의 시클릭 디뉴클레오티드

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Publication number
KR102950614B1
KR102950614B1 KR1020207026044A KR20207026044A KR102950614B1 KR 102950614 B1 KR102950614 B1 KR 102950614B1 KR 1020207026044 A KR1020207026044 A KR 1020207026044A KR 20207026044 A KR20207026044 A KR 20207026044A KR 102950614 B1 KR102950614 B1 KR 102950614B1
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KR20200120683A (ko
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브라이언 이. 핑크
담펄 에스. 도드
유펜 자오
란-잉 친
제밍 루안
랄구디 에스. 하리크리쉬난
무토니 지. 카마우
스티븐 제이. 워커
리빙 첸
피터 기남 박
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브리스톨-마이어스 스큅 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020207026044A 2018-02-13 2019-02-13 항암제로서의 시클릭 디뉴클레오티드 Active KR102950614B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862629956P 2018-02-13 2018-02-13
US62/629,956 2018-02-13
US16/272,172 US10519187B2 (en) 2018-02-13 2019-02-11 Cyclic dinucleotides as anticancer agents
US16/272,172 2019-02-11
PCT/US2019/017740 WO2019160884A1 (en) 2018-02-13 2019-02-13 Cyclic dinucleotides as anticancer agents

Publications (2)

Publication Number Publication Date
KR20200120683A KR20200120683A (ko) 2020-10-21
KR102950614B1 true KR102950614B1 (ko) 2026-04-08

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KR1020207026044A Active KR102950614B1 (ko) 2018-02-13 2019-02-13 항암제로서의 시클릭 디뉴클레오티드

Country Status (19)

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US (2) US10519187B2 (https=)
EP (1) EP3752516B1 (https=)
JP (1) JP7296405B2 (https=)
KR (1) KR102950614B1 (https=)
CN (1) CN111902420B (https=)
AR (1) AR114369A1 (https=)
CY (1) CY1125159T1 (https=)
DK (1) DK3752516T3 (https=)
ES (1) ES2909616T3 (https=)
HR (1) HRP20220520T1 (https=)
HU (1) HUE058662T2 (https=)
LT (1) LT3752516T (https=)
PL (1) PL3752516T3 (https=)
PT (1) PT3752516T (https=)
RS (1) RS63128B1 (https=)
SI (1) SI3752516T1 (https=)
SM (1) SMT202200168T1 (https=)
TW (1) TW202003539A (https=)
WO (1) WO2019160884A1 (https=)

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TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
US11110106B2 (en) 2018-10-29 2021-09-07 Venenum Biodesign, LLC Sting agonists for treating bladder cancer and solid tumors
AU2019371206A1 (en) 2018-10-29 2021-05-27 Venenum Biodesign, LLC Novel sting agonists
IL294618A (en) * 2020-01-16 2022-09-01 Bristol Myers Squibb Co Reagents and their use for the modular synthesis of c-p bonds
WO2021206158A1 (ja) 2020-04-10 2021-10-14 小野薬品工業株式会社 がん治療方法

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HUE058662T2 (hu) 2022-09-28
EP3752516B1 (en) 2022-02-23
PT3752516T (pt) 2022-03-31
SMT202200168T1 (it) 2022-05-12
DK3752516T3 (da) 2022-04-11
US10519187B2 (en) 2019-12-31
TW202003539A (zh) 2020-01-16
CY1125159T1 (el) 2024-12-13
LT3752516T (lt) 2022-05-10
US11339185B2 (en) 2022-05-24
JP2021513562A (ja) 2021-05-27
EP3752516A1 (en) 2020-12-23
JP7296405B2 (ja) 2023-06-22
AR114369A1 (es) 2020-08-26
US20190248828A1 (en) 2019-08-15
PL3752516T3 (pl) 2022-05-02
HRP20220520T1 (hr) 2022-05-27
KR20200120683A (ko) 2020-10-21
CN111902420A (zh) 2020-11-06
WO2019160884A1 (en) 2019-08-22
CN111902420B (zh) 2024-02-02
RS63128B1 (sr) 2022-05-31
US20200079815A1 (en) 2020-03-12
SI3752516T1 (sl) 2022-05-31
ES2909616T3 (es) 2022-05-09

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