JPWO2019147831A5 - - Google Patents
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- JPWO2019147831A5 JPWO2019147831A5 JP2020540397A JP2020540397A JPWO2019147831A5 JP WO2019147831 A5 JPWO2019147831 A5 JP WO2019147831A5 JP 2020540397 A JP2020540397 A JP 2020540397A JP 2020540397 A JP2020540397 A JP 2020540397A JP WO2019147831 A5 JPWO2019147831 A5 JP WO2019147831A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- antigen
- seq
- binding protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 28
- 102000025417 antigen binding proteins Human genes 0.000 claims 20
- 108091000829 antigen binding proteins Proteins 0.000 claims 20
- 102000018358 Immunoglobulins Human genes 0.000 claims 13
- 108060003951 Immunoglobulins Proteins 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 229920001184 polypeptide Polymers 0.000 claims 11
- 101710044694 TMPRSS2 Proteins 0.000 claims 10
- 102100011827 TMPRSS2 Human genes 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 102000038129 antigens Human genes 0.000 claims 5
- 108091007172 antigens Proteins 0.000 claims 5
- 229920000023 polynucleotide Polymers 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 4
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 4
- 102000004965 antibodies Human genes 0.000 claims 4
- 108090001123 antibodies Proteins 0.000 claims 4
- 241000712461 unidentified influenza virus Species 0.000 claims 4
- 102100008989 IGHV1-2 Human genes 0.000 claims 3
- 101710003461 IGHV1-2 Proteins 0.000 claims 3
- 101710009640 IGKV1D-8 Proteins 0.000 claims 3
- 101710024481 IGKV2-29 Proteins 0.000 claims 3
- 101710009635 IGKV2D-26 Proteins 0.000 claims 3
- 102100005978 IGKV3-20 Human genes 0.000 claims 3
- 101710024987 IGKV3-20 Proteins 0.000 claims 3
- 101710009651 IGKV3D-15 Proteins 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- TTZHDVOVKQGIBA-IQWMDFIBSA-N sofosbuvir Chemical compound N1([C@@H]2O[C@@H]([C@H]([C@]2(F)C)O)CO[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC=2C=CC=CC=2)C=CC(=O)NC1=O TTZHDVOVKQGIBA-IQWMDFIBSA-N 0.000 claims 3
- 229960002063 sofosbuvir Drugs 0.000 claims 3
- ARAIBEBZBOPLMB-UFGQHTETSA-N (2R,3R,4S)-4-[(diaminomethylidene)amino]-3-acetamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 claims 2
- 241000711549 Hepacivirus C Species 0.000 claims 2
- 208000006572 Human Influenza Diseases 0.000 claims 2
- 102100008763 IFNA2 Human genes 0.000 claims 2
- 206010022000 Influenza Diseases 0.000 claims 2
- 108010047761 Interferon-alpha Proteins 0.000 claims 2
- 102000006992 Interferon-alpha Human genes 0.000 claims 2
- 108010079944 Interferon-alpha2b Proteins 0.000 claims 2
- 241000282567 Macaca fascicularis Species 0.000 claims 2
- VSZGPKBBMSAYNT-RRFJBIMHSA-N Oseltamivir Chemical compound CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1 VSZGPKBBMSAYNT-RRFJBIMHSA-N 0.000 claims 2
- 229960003752 Oseltamivir Drugs 0.000 claims 2
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 2
- 229960000329 Ribavirin Drugs 0.000 claims 2
- 208000001756 Virus Disease Diseases 0.000 claims 2
- 229960001028 Zanamivir Drugs 0.000 claims 2
- 239000003443 antiviral agent Substances 0.000 claims 2
- 229960005486 vaccines Drugs 0.000 claims 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010052360 Colorectal adenocarcinoma Diseases 0.000 claims 1
- 241000711573 Coronaviridae Species 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 241000342334 Human metapneumovirus Species 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 1
- VRTWBAAJJOHBQU-KMWAZVGDSA-N Ledipasvir Chemical compound COC(=O)N[C@@H](C(C)C)C(=O)N([C@@H](C1)C=2NC(=CN=2)C=2C=C3C(F)(F)C4=CC(=CC=C4C3=CC=2)C=2C=C3NC(=NC3=CC=2)[C@H]2N([C@@H]3CC[C@H]2C3)C(=O)[C@@H](NC(=O)OC)C(C)C)CC21CC2 VRTWBAAJJOHBQU-KMWAZVGDSA-N 0.000 claims 1
- 210000004072 Lung Anatomy 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 210000001672 Ovary Anatomy 0.000 claims 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000006265 Renal Cell Carcinoma Diseases 0.000 claims 1
- 206010041823 Squamous cell carcinoma Diseases 0.000 claims 1
- 101000380958 TMPRSS2 Proteins 0.000 claims 1
- 210000001635 Urinary Tract Anatomy 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000022406 human TMPRSS2 protein Human genes 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 229960002461 ledipasvir Drugs 0.000 claims 1
- 201000005249 lung adenocarcinoma Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- YWRYBUCQWKGONV-CABNZSRHSA-N methyl N-[(2S)-1-[(6S)-6-[5-[9,9-difluoro-7-[2-[(1S,2S,4R)-3-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-3-azabicyclo[2.2.1]heptan-2-yl]-3H-benzimidazol-5-yl]fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]heptan-5-yl]-3-methyl-1-oxobutan-2-yl]carbama Chemical compound N1([C@@H]2O[C@@H]([C@H]([C@]2(F)C)O)CO[P@](=O)(N[C@@H](C)C(=O)OC(C)C)OC=2C=CC=CC=2)C=CC(=O)NC1=O.COC(=O)N[C@@H](C(C)C)C(=O)N([C@@H](C1)C=2NC(=CN=2)C=2C=C3C(F)(F)C4=CC(=CC=C4C3=CC=2)C=2C=C3NC(=NC3=CC=2)[C@H]2N([C@@H]3CC[C@H]2C3)C(=O)[C@@H](NC(=O)OC)C(C)C)CC21CC2 YWRYBUCQWKGONV-CABNZSRHSA-N 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 201000005825 prostate adenocarcinoma Diseases 0.000 claims 1
- 230000004224 protection Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023177262A JP2024009962A (ja) | 2018-01-26 | 2023-10-13 | 抗ｔｍｐｒｓｓ２抗体および抗原結合断片 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862622292P | 2018-01-26 | 2018-01-26 | |
| US62/622,292 | 2018-01-26 | ||
| PCT/US2019/014978 WO2019147831A1 (fr) | 2018-01-26 | 2019-01-24 | Anticorps anti-tmprss2 et fragments de liaison à l'antigène |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023177262A Division JP2024009962A (ja) | 2018-01-26 | 2023-10-13 | 抗ｔｍｐｒｓｓ２抗体および抗原結合断片 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021511058A JP2021511058A (ja) | 2021-05-06 |
| JPWO2019147831A5 true JPWO2019147831A5 (fr) | 2022-01-21 |
Family
ID=66102175
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020540397A Pending JP2021511058A (ja) | 2018-01-26 | 2019-01-24 | 抗ｔｍｐｒｓｓ２抗体および抗原結合断片 |
| JP2023177262A Pending JP2024009962A (ja) | 2018-01-26 | 2023-10-13 | 抗ｔｍｐｒｓｓ２抗体および抗原結合断片 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023177262A Pending JP2024009962A (ja) | 2018-01-26 | 2023-10-13 | 抗ｔｍｐｒｓｓ２抗体および抗原結合断片 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US10941213B2 (fr) |
| EP (1) | EP3638698B1 (fr) |
| JP (2) | JP2021511058A (fr) |
| KR (1) | KR20200115576A (fr) |
| CN (1) | CN111936517A (fr) |
| AU (1) | AU2019211406A1 (fr) |
| BR (1) | BR112020015112A2 (fr) |
| CA (1) | CA3089377A1 (fr) |
| CY (1) | CY1124182T1 (fr) |
| DK (1) | DK3638698T3 (fr) |
| ES (1) | ES2864529T3 (fr) |
| HR (1) | HRP20210876T1 (fr) |
| HU (1) | HUE054403T2 (fr) |
| IL (1) | IL276164A (fr) |
| LT (1) | LT3638698T (fr) |
| MA (1) | MA46731B1 (fr) |
| MD (1) | MD3638698T2 (fr) |
| MX (1) | MX2020007888A (fr) |
| PL (1) | PL3638698T3 (fr) |
| PT (1) | PT3638698T (fr) |
| RS (1) | RS61825B1 (fr) |
| SG (1) | SG11202006898TA (fr) |
| SI (1) | SI3638698T1 (fr) |
| WO (1) | WO2019147831A1 (fr) |
| ZA (1) | ZA202004494B (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI702229B (zh) * | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| KR20220069046A (ko) * | 2019-09-23 | 2022-05-26 | 트위스트 바이오사이언스 코포레이션 | 단일 도메인 항체에 대한 변이체 핵산 라이브러리 |
| EP4103619A1 (fr) | 2020-02-10 | 2022-12-21 | Regeneron Pharmaceuticals, Inc. | Anticorps anti-tmprss2 et fragments de liaison à l'antigène |
| WO2021190980A1 (fr) | 2020-03-22 | 2021-09-30 | Quadrucept Bio Limited | Multimères pour l'évolution d'une souche virale |
| JP7116256B1 (ja) | 2020-04-02 | 2022-08-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗ｓａｒｓ－ｃｏｖ－２－スパイク糖タンパク質抗体および抗原結合断片 |
| EP4136254A4 (fr) * | 2020-04-13 | 2024-05-22 | Maddon Advisors LLC | Compositions ciblant l'ace2 et procédés de traitement de la covid-19 |
| IL297237A (en) | 2020-04-17 | 2022-12-01 | Regeneron Pharma | Detection tests for antibodies that neutralize the corona virus |
| US20230149536A1 (en) | 2020-04-17 | 2023-05-18 | Vyriad, Inc. | Compositions for treating and/or preventing coronavirus infections |
| CA3179819A1 (fr) | 2020-05-26 | 2021-12-02 | Alina Baum | Anticorps anti-glycoproteine spike du sars-cov 2 et leurs fragments de liaison a l'antigene |
| CR20220660A (es) | 2020-06-03 | 2023-02-17 | Regeneron Pharma | Métodos para tratar o prevenir infecciones por sars-cov2 y covid-19 con anticuerpos de glicoproteína espícular anti-sars-cov-2 |
| US20210379091A1 (en) * | 2020-06-08 | 2021-12-09 | Brigham Young University | Use of cationic steroidal antimicrobial compounds to deactivate coronavirus |
| WO2021255217A1 (fr) | 2020-06-19 | 2021-12-23 | Heidelberg Pharma Research Gmbh | Amatoxine et conjugués d'amatoxine destinés à être utilisés dans l'inhibition de la réplication de virus à arn |
| CN111986818A (zh) * | 2020-08-21 | 2020-11-24 | 南通大学 | 一种基于tmprss2的新冠covid-19治疗药物筛选系统 |
| CN112795583A (zh) * | 2020-11-16 | 2021-05-14 | 上海大学 | 重组唾液酸外切酶的制备方法、表达基因、重组表达载体及构建方法 |
| WO2022115503A1 (fr) | 2020-11-25 | 2022-06-02 | Dupont Nutrition Biosciences Aps | Traitement et prévention d'une infection à coronavirus |
| CN112538494A (zh) * | 2020-12-08 | 2021-03-23 | 武汉华美生物工程有限公司 | 一种tmprss2突变体蛋白及其表达载体、表达工程菌和制备方法 |
| WO2022133182A1 (fr) * | 2020-12-18 | 2022-06-23 | Chan Zuckerberg Biohub, Inc. | Procédé de traitement d'une infection au coronavirus |
| WO2022184659A1 (fr) | 2021-03-01 | 2022-09-09 | Quadrucept Bio Limited | Domaines d'anticorps et multimères |
| WO2022187626A1 (fr) | 2021-03-05 | 2022-09-09 | Regeneron Pharmaceuticals, Inc. | Anticorps de glycoprotéine anti-sars-cov-2 à variante spike et fragments de liaison à l'antigène |
| BR112024000744A2 (pt) | 2021-07-14 | 2024-04-30 | Regeneron Pharma | Anticorpos de glicoprotéina spike anti-sars-cov-2 e fragmentos de ligação a antígeno |
| WO2023199943A1 (fr) * | 2022-04-12 | 2023-10-19 | 国立研究開発法人理化学研究所 | Anticorps utilisé pour traiter une infection à coronavirus |
| WO2023220712A1 (fr) * | 2022-05-13 | 2023-11-16 | The Trustees Of Columbia University In The City Of New York | Protéases hôtes essentielles pour la propagation de parainfluenza dans le poumon humain : cibles potentielles pour interventions antivirales |
| CN116003611B (zh) * | 2022-08-17 | 2024-02-27 | 中南大学湘雅医院 | 抗tmprss2抗体及其用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4740461A (en) | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
| US5693489A (en) | 1984-03-30 | 1997-12-02 | Associated Universities, Inc. | Cloning and expression of the gene for bacteriophage T7 RNA polymerase |
| US4952496A (en) | 1984-03-30 | 1990-08-28 | Associated Universities, Inc. | Cloning and expression of the gene for bacteriophage T7 RNA polymerase |
| US4959455A (en) | 1986-07-14 | 1990-09-25 | Genetics Institute, Inc. | Primate hematopoietic growth factors IL-3 and pharmaceutical compositions |
| US4912040A (en) | 1986-11-14 | 1990-03-27 | Genetics Institute, Inc. | Eucaryotic expression system |
| WO1993004169A1 (fr) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Ciblage de genes dans des cellules animales au moyen de produits de synthese d'adn isogeniques |
| EP1299727B1 (fr) | 2000-07-12 | 2009-04-22 | Agensys, Inc. | Nouvel antigene tumoral utile dans le diagnostic et le traitement de cancers de la vessie, de l'ovaire, du poumon et du rein |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US8354508B2 (en) | 2006-07-21 | 2013-01-15 | Diadexus, Inc. | PRO115 antibody compositions and methods of use |
| US8629244B2 (en) | 2006-08-18 | 2014-01-14 | Ablynx N.V. | Interleukin-6 receptor binding polypeptides |
| RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
| RU2010151725A (ru) | 2008-05-16 | 2012-06-27 | Аблинкс Нв (Be) | Аминокислотные последовательности, направленные против cхcr4 и других gpcr, и соединения, включаюшие их |
| NZ626242A (en) * | 2012-01-31 | 2017-02-24 | Regeneron Pharma | Anti-asic1 antibodies and uses thereof |
| CN104244978A (zh) | 2012-04-16 | 2014-12-24 | 瑞泽恩制药公司 | 通过施用丝氨酸蛋白酶抑制剂治疗或预防流感病毒感染的方法 |
| WO2014022540A1 (fr) | 2012-08-02 | 2014-02-06 | Regeneron Pharmaceuticals, Inc. | Protéines multivalentes de liaison à un antigène |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| CN106589127A (zh) * | 2015-10-16 | 2017-04-26 | 钜川生物医药 | 一种pcsk9抗体及其制备方法和应用 |
| US10070632B2 (en) | 2016-02-29 | 2018-09-11 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized TMPRSS gene |
| AU2018240303A1 (en) | 2017-03-22 | 2019-10-10 | Children's Medical Center Corporation | LRP1 binding agents and uses thereof |
-
2019
- 2019-01-24 MD MDE20200454T patent/MD3638698T2/ro unknown
- 2019-01-24 US US16/256,560 patent/US10941213B2/en active Active
- 2019-01-24 BR BR112020015112-2A patent/BR112020015112A2/pt unknown
- 2019-01-24 DK DK19701428.5T patent/DK3638698T3/da active
- 2019-01-24 MA MA46731A patent/MA46731B1/fr unknown
- 2019-01-24 LT LTEP19701428.5T patent/LT3638698T/lt unknown
- 2019-01-24 JP JP2020540397A patent/JP2021511058A/ja active Pending
- 2019-01-24 HU HUE19701428A patent/HUE054403T2/hu unknown
- 2019-01-24 SI SI201930061T patent/SI3638698T1/sl unknown
- 2019-01-24 PL PL19701428T patent/PL3638698T3/pl unknown
- 2019-01-24 PT PT197014285T patent/PT3638698T/pt unknown
- 2019-01-24 CN CN201980021929.3A patent/CN111936517A/zh active Pending
- 2019-01-24 RS RS20210571A patent/RS61825B1/sr unknown
- 2019-01-24 AU AU2019211406A patent/AU2019211406A1/en active Pending
- 2019-01-24 MX MX2020007888A patent/MX2020007888A/es unknown
- 2019-01-24 EP EP19701428.5A patent/EP3638698B1/fr active Active
- 2019-01-24 WO PCT/US2019/014978 patent/WO2019147831A1/fr unknown
- 2019-01-24 KR KR1020207024526A patent/KR20200115576A/ko active Search and Examination
- 2019-01-24 ES ES19701428T patent/ES2864529T3/es active Active
- 2019-01-24 SG SG11202006898TA patent/SG11202006898TA/en unknown
- 2019-01-24 CA CA3089377A patent/CA3089377A1/fr active Pending
-
2020
- 2020-07-20 IL IL276164A patent/IL276164A/en unknown
- 2020-07-21 ZA ZA2020/04494A patent/ZA202004494B/en unknown
-
2021
- 2021-01-20 US US17/153,684 patent/US11603413B2/en active Active
- 2021-05-27 CY CY20211100461T patent/CY1124182T1/el unknown
- 2021-06-01 HR HRP20210876TT patent/HRP20210876T1/hr unknown
-
2023
- 2023-01-26 US US18/159,827 patent/US20230265216A1/en active Pending
- 2023-10-13 JP JP2023177262A patent/JP2024009962A/ja active Pending
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