JPWO2019131829A5 - - Google Patents
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- JPWO2019131829A5 JPWO2019131829A5 JP2019562142A JP2019562142A JPWO2019131829A5 JP WO2019131829 A5 JPWO2019131829 A5 JP WO2019131829A5 JP 2019562142 A JP2019562142 A JP 2019562142A JP 2019562142 A JP2019562142 A JP 2019562142A JP WO2019131829 A5 JPWO2019131829 A5 JP WO2019131829A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- rna
- nucleic acid
- cell
- guide rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017254798 | 2017-12-28 | ||
| JP2017254798 | 2017-12-28 | ||
| PCT/JP2018/048034 WO2019131829A1 (ja) | 2017-12-28 | 2018-12-27 | 標的遺伝子改変用組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2019131829A1 JPWO2019131829A1 (ja) | 2021-02-04 |
| JPWO2019131829A5 true JPWO2019131829A5 (https=) | 2022-01-12 |
| JP7288282B2 JP7288282B2 (ja) | 2023-06-07 |
Family
ID=67067613
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019562142A Active JP7288282B2 (ja) | 2017-12-28 | 2018-12-27 | 標的遺伝子改変用組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US12031130B2 (https=) |
| EP (1) | EP3733844B1 (https=) |
| JP (1) | JP7288282B2 (https=) |
| KR (1) | KR102799255B1 (https=) |
| CN (1) | CN111527204B (https=) |
| AU (1) | AU2018397951B2 (https=) |
| CA (1) | CA3086885A1 (https=) |
| TW (1) | TWI825057B (https=) |
| WO (1) | WO2019131829A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| WO2016130600A2 (en) | 2015-02-09 | 2016-08-18 | Duke University | Compositions and methods for epigenome editing |
| KR102787119B1 (ko) | 2015-11-30 | 2025-03-27 | 듀크 유니버시티 | 유전자 편집에 의한 인간 디스트로핀 유전자의 교정을 위한 치료용 표적 및 사용 방법 |
| US20190127713A1 (en) | 2016-04-13 | 2019-05-02 | Duke University | Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use |
| JP7490211B2 (ja) | 2016-07-19 | 2024-05-27 | デューク ユニバーシティ | Ｃｐｆ１に基づくゲノム編集の治療適用 |
| US20200331841A1 (en) | 2017-12-28 | 2020-10-22 | Takeda Pharmaceutical Company Limited | Cationic lipids |
| EP3740580A4 (en) | 2018-01-19 | 2021-10-20 | Duke University | GENOME ENGINEERING WITH CRISPR-CAS SYSTEMS IN EUKARYONTS |
| EP3842538A4 (en) * | 2018-08-10 | 2022-06-08 | Kyoto University | METHOD OF TRANSFECTION INTO CARDIOMYOCYTES USING CATIONIC LIPID |
| US12479791B2 (en) | 2018-08-10 | 2025-11-25 | Takeda Pharmaceutical Company Limited | Cationic lipid |
| TW202208626A (zh) * | 2020-04-24 | 2022-03-01 | 美商生命編輯公司 | Rna引導核酸酶及其活性片段與變體，以及使用方法 |
| EP4225907A4 (en) * | 2020-10-12 | 2025-01-22 | Duke University | CRISPR/CAS-BASED BASE EDITING COMPOSITION TO RESTORE DYSTROPHIN FUNCTION |
| CN113528437B (zh) * | 2021-07-07 | 2023-08-25 | 中国医学科学院血液病医院(中国医学科学院血液学研究所) | 一种增强基因编辑效率的试剂盒及其应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7223887B2 (en) | 2001-12-18 | 2007-05-29 | The University Of British Columbia | Multivalent cationic lipids and methods of using same in the production of lipid particles |
| AU2003240978A1 (en) | 2002-05-31 | 2003-12-19 | Genteric, Inc. | Multi-functional polyamines for delivery of biologically-active polynucleotides |
| US8969543B2 (en) | 2003-04-03 | 2015-03-03 | Bioneer Corporation | SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof |
| CA2532228C (en) | 2003-07-16 | 2017-02-14 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering rna |
| JP4764426B2 (ja) | 2004-06-07 | 2011-09-07 | プロチバ バイオセラピューティクス インコーポレイティッド | カチオン性脂質および使用方法 |
| CN107028886A (zh) | 2009-11-04 | 2017-08-11 | 不列颠哥伦比亚大学 | 含有核酸的脂质粒子及相关的方法 |
| KR101773643B1 (ko) | 2010-04-28 | 2017-08-31 | 교와 핫꼬 기린 가부시키가이샤 | 양이온성 지질 |
| WO2012028524A2 (en) | 2010-08-30 | 2012-03-08 | F. Hoffmann-La Roche Ag | Method for producing a lipid particle, the lipid particle itself and its use |
| JP6108197B2 (ja) | 2012-07-02 | 2017-04-05 | 日油株式会社 | 三級アミノ基含有脂質の製造方法 |
| WO2014197748A2 (en) | 2013-06-05 | 2014-12-11 | Duke University | Rna-guided gene editing and gene regulation |
| EP3470089A1 (en) * | 2013-12-12 | 2019-04-17 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components |
| EP3093283B1 (en) | 2014-01-09 | 2018-12-19 | Eisai R&D Management Co., Ltd. | Cationic lipid |
| US20170015994A1 (en) * | 2014-02-24 | 2017-01-19 | Massachusetts Institute Of Technology | Methods for in vivo genome editing |
| CN104116643B (zh) * | 2014-07-10 | 2016-08-24 | 上海应用技术学院 | 一种包覆曲酸双棕榈酸酯的纳米固体脂质载体及制备方法 |
| KR101882634B1 (ko) | 2014-08-07 | 2018-07-26 | 다케다 야쿠힝 고교 가부시키가이샤 | 양이온성 지질 |
| CN106714845A (zh) | 2014-08-11 | 2017-05-24 | 得克萨斯州大学系统董事会 | 通过crispr/cas9介导的基因编辑预防肌营养不良 |
| JP7242180B2 (ja) * | 2014-09-07 | 2023-03-20 | セレクタ バイオサイエンシーズ インコーポレーテッド | 抗ウイルス導入ベクター免疫応答を減弱化するための方法および組成物 |
| EP3275448B1 (en) | 2015-03-24 | 2025-10-29 | Kyowa Kirin Co., Ltd. | Nucleic acid-containing lipid nanoparticles |
| CN104873976B (zh) | 2015-05-08 | 2016-04-20 | 厦门成坤生物技术有限公司 | 一类阳离子类脂化合物的应用 |
| WO2016197133A1 (en) * | 2015-06-04 | 2016-12-08 | Protiva Biotherapeutics, Inc. | Delivering crispr therapeutics with lipid nanoparticles |
| AU2016344609B2 (en) | 2015-10-28 | 2022-05-12 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of duchenne muscular dystrophy |
| TWI894123B (zh) | 2017-12-27 | 2025-08-21 | 日商武田藥品工業有限公司 | 含核酸之脂質奈米粒子及其用途 |
-
2018
- 2018-12-27 EP EP18894951.5A patent/EP3733844B1/en active Active
- 2018-12-27 CN CN201880084068.9A patent/CN111527204B/zh active Active
- 2018-12-27 CA CA3086885A patent/CA3086885A1/en active Pending
- 2018-12-27 KR KR1020207018909A patent/KR102799255B1/ko active Active
- 2018-12-27 JP JP2019562142A patent/JP7288282B2/ja active Active
- 2018-12-27 TW TW107147444A patent/TWI825057B/zh active
- 2018-12-27 WO PCT/JP2018/048034 patent/WO2019131829A1/ja not_active Ceased
- 2018-12-27 AU AU2018397951A patent/AU2018397951B2/en active Active
- 2018-12-27 US US16/958,006 patent/US12031130B2/en active Active
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